Collecting blood samples and other biological specimens is crucial to the understanding, prevention, and treatment of disease. However, from the patient’s perspective, it can also be painful, unnerving, frightening, and inconvenient.
Collecting blood samples and other biological specimens is crucial to the understanding, prevention, and treatment of disease. However, from the patient’s perspective, it can also be painful, unnerving, frightening, and inconvenient.
Clotting time - Coagulation of whole bloodSHRUTHI VASAN
Coagulation of blood - Clotting Time - Introduction - Methods - Capillary Method - Tube Method - Lee White Method - Procedure - Normal Range - Discussion.
how to select a healthy donor & care of donor .A healthy donor is one of the most vital part of transfusion medicine for safe transfusion of blood & blood product
Clotting time - Coagulation of whole bloodSHRUTHI VASAN
Coagulation of blood - Clotting Time - Introduction - Methods - Capillary Method - Tube Method - Lee White Method - Procedure - Normal Range - Discussion.
how to select a healthy donor & care of donor .A healthy donor is one of the most vital part of transfusion medicine for safe transfusion of blood & blood product
All about blood collection and handling, lecture notes to Medical Laboratory Students at Medical Laboratory Technology, Middle Technical University, Baqubah, Iraq
Immunology lab manual for MLT students
Ethics of Laboratory
Collection of the blood sample by vein puncture, separation and preservation of serum
Widal Test
VDRL (including Antigen Preparation)
ASO (Anti streptolysin ‘O’)
C-Reactive Protein (Latex agglutination)
Rheumatoid factor (RF) Latex agglutination
Demonstration of antigen / antibody, determination by Immuno fluorescence (IF), Immuno diffusion, precipitation
in Agarose gel (Ouchterlony)
Demonstration of ELISA
Demonstration of SDS – PAGE
Preparation of Vaccination schedule
Our bodies are constantly under attack by an army of microorganisms, toxins, allergens and other substances that are recognized as foreign (non-self).
The ways in which the body protects itself from pathogens can be thought of as an army consisting of three lines of defense.
Immune system consists of two organs primary and secondary lymphoid organs.
1-Primary (Central) lymphoid organs.
2-Secondary (Peripheral) lymphoid organs.
1-Thymus Gland.
2-Bone Marrow.
They consist of ….
Spleen.
Lymph nodes.
Mucosa- associated lymphoid tissue.
The sites of immune cell birth and the locations where they mature are considered primary lymphatic organs.
Locations in the body where immune cells become activated, reside, or carry out their functions are called secondary lymphatic organs
The cells of the immune system arise from a pluripotent Hematopoietic Stem Cells (HSCs) through a process known as haematopoiesis.
Hematopoiesis involves the production, development, differentiation, and maturation of the blood cells (erythrocytes, megakaryocytes and leukocytes) from HSCs.
Differentiation of the HSC will occur along one of two pathways, giving rise to either a common myeloid progenitor or a common lymphoid progenitor cells in the presence of specific cytokines or soluble mediates (growth factor).
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
1. Practical Immunology and Serology
Hawler Medical University
College of Health Sciences
Clinical Biochemistry Dept.
Ass. Lec. Amer Ali Khaleel
(M.Sc. Clinical Immunology)
Lab.1 : Phlebotomy
2. Phlebotomy
:
•Phlebotomy is the process of making an
incision in a vein with a needle.
•The procedure is known as a venipuncture.
•A person who performs phlebotomy is called a
phlebotomist, although doctors, nurses &
medical laboratory scientists.
3. Blood Specimen Collection and
Processing:
•The first step in acquiring a quality lab. Test
result for any patient is the specimen collection
procedure.
• Blood specimens are obtained through capillary
skin punctures (finger, toe, heel), arterial or
venous sampling.
•Capillary / dermal /skin puncture, earlobe stick,
finger stick, heel stick (infants).
•Venous puncture (direct puncture of vein by
4. An Introduction
Venipuncture:
•Venipuncture is the process of obtaining
blood samples from veins for laboratory
testing, It is probably the most common
procedure in the medical field, usually
performed for the following reasons:…
5. 1. To obtain blood samples in order to perform
diagnostics.
2. To collect blood for later use should the patient’s
condition requires transfusions.
3. To remove blood that was found with excessive
levels of erythrocytes or iron.
An Introduction
Venipuncture:
6.
7. Venipuncture Procedure Steps:
1.Explain the procedure and purpose for the patient.
2.Assess the patient's physical disposition (i.e. diet,
exercise).
3.Position the patient - sitting or lying (NEVER allow the
patient to sit upright on a high stool or standing due to the
possibility of syncope).
4.Check the requisition form for requested tests, patient
information, and any special requirements.
8. Venipuncture Procedure Steps:
5. Select a suitable site for venipuncture.
6. Prepare the equipment, the patient and the puncture site.
7. Perform the venipuncture.
8. Collect the sample in the appropriate container.
9. While the tube fills, remove the tourniquet.
10. Label the collection tubes at the drawing area.
11. Immediately send the specimens with the requisition to the
9. Order of draw:
• Blood collection tubes must be drawn in a specific order to
avoid cross-contamination of additives between tubes.
• A Vacutainer blood collection tube is a sterile glass or plastic
tube with a closure that is evacuated to create a vacuum inside
the tube facilitating the draw of a predetermined volume of
liquid.
• The recommended order of draw for plastic vacutainer tubes is:
……..
10. Order of draw Stopper color Additives Laboratory Use
1 Plain Tube Red Top Tube no additive
Drug levels,
blood bank
2 EDTA Tube Lavender Top Tube EDTA* CBC*,HbA1c
3 Heparin Tube Green Top Tube Sodium Heparin
Plasma chemistry
,ammonia level
4 ESR Tube Black Top Tube Sodium citrate
Westergren
sedimentation rate
5 Glucose Tube Grey Top Tube Sodium fluoride
glucose tolerance
testing, alcohol level
6 PT Tube Blue Tube Sodium citrate PT*,PTT*
7 Serum Tube Yellow Top Tube
ACD*
SPS*
Whole blood
determination
8 Thrombin Tube Orange Top Tube Thrombin Chemical testing
9 Gel Yellow tube Serum Gel Tube
contains a clot
activator and serum
gel separator
various laboratory
tests
EDTA=Ethylene diamine tetraacetic acid, ACD= Acid citrate dextrose, CBC=Complete blood
count,PT=Prothrombin times, PTT=Partial thrombinplastin times, SPS=sodium polyanethol sulfonate
11. Notes:
• Additives preserve the specimen, prevent deterioration and
coagulation, or block action of certain enzymes in blood cells.
• After the tube has been filled with blood, immediately invert the
tube several times to prevent coagulation.
• Tubes with anticoagulants should be gently and completely
inverted (end over end) 4 to 6 times after collection. This process
ensures complete mixing of anticoagulants with the blood
sample and prevents clot formation.
• Complete filling of this tube is essential to obtain accurate
results.Some evacuate tubes contains mark line , you must fill
the tube into this mark line.
12. Specimens may be rejected for the
following reasons (Unacceptable
Specimens):
1. There is a patient name or file number discrepancy
between specimen label and request form.
2. There is no patient name or other unique identifier on
specimen.
3. Specimen is too old when received.
4. There is apparently no specimen in container.
5. The expiration date of the transport medium has been
exceeded.
13. Avoid performing a venipuncture on
1. Arm on side of mastectomy. If drawn here, the test results
could be inaccurate because of lymph edema.
2. Scarred or burned areas. Performing a venipuncture at these
sites is more difficult due to the scar tissue.
3. Arm in which blood is being transfusion / IV cannula. The
fluid in the IV could dilute the specimen.
321
14. 4. A hematoma (A hematoma is an abnormal collection of blood
outside of a blood vessel. It occurs because the wall of a blood
vessel wall, artery, vein, or capillary, has been damaged and blood
has leaked into tissues ) If drawn here, could cause incorrect test
results.
5. Edematous (Edema is swelling caused by fluid retention)
should be avoid because the accumulated fluid could alter test
results.
15. New vein finder devices :
• Devices that utilize laser/infrared technology for Vein Viewer (vein finders(.
Veinlite AccuVein VeinViewer Flex
16. New Device for Infant Blood Collection:
Innovac Quick-Draw
17. New Device for Infant Blood Collection:
•Automatic sample mixing reduces repeat collections
due to clots and hemolysis.
•Collect even the smallest drops from the puncture
site with no squeezing, scooping, or stopping to mix
the sample blood immediately.