This document discusses the rule for determining if two lines are perpendicular based on their gradients. It explains that for perpendicular lines, the product of their gradients (m1 and m2) equals -1. Several examples are provided of calculating the gradients of lines from points on each line and verifying that the lines are perpendicular when m1 × m2 = -1. The document also discusses how to determine if lines are parallel based on having equal gradients.