PCR is a technique for amplifying a specific DNA sequence. It involves repeated cycles of heating and cooling DNA in the presence of primers and DNA polymerase to selectively amplify the target sequence. Kary Mullis developed PCR in 1983 and won the Nobel Prize in Chemistry for this work. PCR has many applications including forensic analysis, detecting genetic diseases and transgenes, and quantifying pathogens. It has become a fundamental tool in molecular biology.