This document discusses the negative health effects of smoking cigarettes. It begins by stating that smoking was once socially acceptable but is now recognized as hazardous. It then outlines over 4000 chemicals in cigarette smoke that are carcinogenic or mutagenic, especially nicotine, tar, and carbon monoxide. The rest of the document is organized by body system and discusses how smoking can cause or increase risks of diseases like cancer, heart disease, lung disease, premature aging and more. It emphasizes smoking harms not just smokers but those around them due to secondhand smoke.