This document summarizes the various negative health effects of smoking on the body's major systems. It discusses how smoking can damage the lungs and respiratory system, increasing risks of infections, COPD, and lung cancer. It also outlines smoking's impacts on the cardiovascular system like restricting blood flow, raising blood pressure and cholesterol, and increasing risks of heart disease and stroke. Additionally, it notes smoking's effects on other systems like the skin, mouth, digestive system, and reproductive organs, as well as links to various cancers and other health issues.