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Parylene coating in biomedical applications
- 1. Parylene Coating inBiomedical Applications Under the supervision of Dr. Ramesh P SCTIMST Trivandrum Mohammad Ansar & Firoz khan
- 2. Contents • Introduction • BasicRequirements For Biomedical coating materials • Why Parylene in Medical applications ? • What is Parylene ? • History of Parylene • Coating Process • Notable features of Parylene coating • Types of Parylene • Properties of Parylene • Applications
- 3. Introduction • Requirement ofsafety increases with development of new devices • The Medical devices are getting smaller as the technology development but requirement of coating goes up • In order to make device very combat coatings should be denser and thinner without compromising its functional requirement • Coating process should be acceptable for devices • Higher temperature integrity
- 4. Basic Requirements ForBiomedical coating materials 1. Adhesion, Total coverage conformity and uniformity 2. No delamination, blistering, flaking or chemical reaction 3. Low moisture and vapor transmission rate and low water absorption 4. Protection from corrosion 5. High purity 6. No outgassing, leaching or extraction 7. Non nutrient (Resistant to micro organism) 8. Low/No stress 9. Electrical Properties(Excellent insulation resistant, dielectric constant, dissipation factor, dielectric breakdown voltage) 10. UV and Ionizing radiation stability 11. Biocompatibility and Bio stability
- 5. Why Parylene inMedical applications • Bio compactable • Excellent barrier material to fluid, moisture, dielectric and drugs • It complete pin hole free encapsulation, conformal, uniform, inert continues film • No catalyst or solvent used (Nothing to extract) • Low coefficient of friction comparable to PTFE • Can operate 350℃ and short period at 450℃ • Excellent dielectric • Striation tolerant( Chemical ,Steam, Eto, γ,autoclave, plasma and H2O2 Courtesy – SCS coating
- 6. What is Parylene(POLY(PARA-XYLYLENE) • The chemical structure is highly ordered so that surface is very smooth with coefficient of friction 0.13 to 0.31 where as for glass it is 1 • Transparent like glass , • Most tight fitting conformal coating in the world with exceptional penetration power • It can be coated up to 10% thickness of Human hair Courtesy Global advanced technologies
- 7. History of Parylene •First synthesized by Michael Szwarc from simple groups containing toluene and xylene in 1947 • In 1967 Dr. Gorham synthesized Parylene from Dimer by chemical Vapor Deposition Technique • First Commercialization done by Nova Tran Corp. in 1971 and Now they known as Specialty Coating systems
- 8. Coating Process- Chemicalvapor deposition Courtesy center for micro Nano technology Sublimation/vaporization Pyrolysis Polymerization/Coating Courtesy Parylene Engineering
- 9. Types of Parylene ParyleneN C D HT/AF4 F/VT4 Structure Application Elastomer coating, Space applications Medical application chemical resistant coatings weather resistant applications high temperature Properties low permeability combination of electrical properties and moisture resistance electrical properties resistant to UV and high Temp high temperature stability, low dielectric constant and low coefficient of friction Courtesy Global advanced technologies
- 10. General Properties Courtesy Globaladvanced technologies
- 11. Applications Catheters Sensors andTransducers Drug delivery devices Stents Brain probes Pharma containers Electro surgical devices Biochips Hearing Aids Ocular Implants Seals, O-rings, tubing Guide wires Pulse generators, pacemakers, Neuro stimulators Epidermal probes Micro chips Electrodes Ultra sound transducers Cannaulae assemblies Prosthetic devices Molded products Medical electronics Cardiac assist devices Mandrels Needles
- 12. Products available onmarket Device name Manufacturer Brand name Deep brain stimulator Medtronics ENTERRA 2 ACTIVA Inflatable Penile Prosthesis Boston scientific AMS 700 Pedicle device DePuySynthes Sentio MMG Insertable cardiac monitor Abbot Confirm Rx Spinal Device Styker Medical, USA K140400 Stryker Spine - ES2®
- 13. Products available onmarketDevice name Manufacturer Brand name Spinal Assembly Zimmer Biomet, USA K132373 Biomet Spine Cardiac Resynchronization Therapy(CRT) Devices St. Jude medical, USA Quadra Assura CRT-D Model CD3365-40C Unify Assura CRT-D Model CD3357-40C Implantable Cardiovascular Defibrillator(ICD) Devices St. Jude medical, USA Ellipse DR Model CD2411-36C Fortify Assura DR Model CD2357-40C Implantable Cardiovascular Defibrillator(ICD) Devices St. Jude medical, USA Ellipse VR Model CD1411-36C
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