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International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 09 Issue: 07 | July 2022 www.irjet.net p-ISSN: 2395-0072
© 2022, IRJET | Impact Factor value: 7.529 | ISO 9001:2008 Certified Journal | Page 2093
Parkinson’s Disease Detection Using Transfer Learning
Dr. Hamsa S, B Murali mohan, P Ram Charan, T Abhinash Reddy, S Bramha Teja
M. Tech (VLSI and Embedded Systems Design), Assistant Professor, B.E(Electronics and Communication),
Jain university, Bangalore, India
--------------------------------------------------------------------------***--------------------------------------------------------------------
Abstract: Parkinson’s disease (PD) is an incurable neurological disorder disease. But there is no still no standard
medical provision to identify Parkinson’s disease. In this study, a fine motor symptom that is sketching has been
studied. The experiments are done on a significant number of PD patients and healthy group (Without PD). We
proposed a system that can determine the sketching and report whether a PD patient’s sketch or not. Deep
learning algorithms can deal with the solution of different brain generalizing neural networks with the same
design. Thus we applied Transfer Learning to classify sketched images to discriminate or identify Parkinson’s
Disease (PD) affected patients from the regular healthy group. The experiment was done on different
convolutional models with transfer learning method and applying on spiral and wave sketched data. By using
Inception v3 and Resnet50 model with spiral sketching and wave sketching, the accuracy is more for the Inception
v3. We have used the transfer learning which enhanced the model performance.
Keywords: Parkinson’s disease, Deep learning, Convolutional Neural Network, Transfer Learning
I. INTRODUCTION
In this era, more than seven million people worldwide are affected by Parkinson’s disease (PD), according to a recent
study. Nowadays, this incurable disease is increasing tremendously. This disease gets its name from James Parkinson, who
earlier described it as a paralysis agitans and later gave his surname was known as a PD. Parkinson’s disease causes a
diverse set of symptoms ranging from tremor to cognitive impairment, hallucination, dementia, sleep disorders, etc. It is
the most common neurodegenerative disease among aged people who are more than 50 years old.
Till now, there is no complete cure. This paper aims the predict Parkinson’s disorder. To avoid the significant negative
impact on PD patients, identification of PD in the premier stage is mandatory.
Previous clinicians and researchers already used Handwriting and Spiral sketching to identify PD patients successfully in
the premier stages. Spiral and wave sketching, and handwriting could be easily differentiated from healthy person
(without PD) to a person affected by PD and the measurement of those sketching & handwriting are non-invasive.
Parkinson’s disease symptoms are broadly divided into two groups. One is Motor symptoms another one is Non motor
symptoms. Motor symptoms are tremor (involuntary movement of the legs/ hands), stiffness (difficulty in moving the
parts of the body), slowness in daily activities, impaired balance, shuffling gait. On the other hand, non-motor symptoms
are difficulties with memory, slowness of thought, anxiety and depression, insomnia and fatigue, vision problem,
hallucinations and delusions, speech and swallowing problems.
II. Methodology
Data Collection: We collected data from Kaggle’s dataset. This dataset is a set of spiral and wave sketches from 55
subjects where 28 subjects from the healthy control group (without PD) and 27 subjects from the Parkinson’s group. The
dataset contains 102 spiral sketching images and 102 wave sketching images. A tablet, A3 size paper, and a pen were used
to record sketching. Sample Images of the sketches for Healthy (without PD) and Parkinson Group.
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 09 Issue: 07 | July 2022 www.irjet.net p-ISSN: 2395-0072
© 2022, IRJET | Impact Factor value: 7.529 | ISO 9001:2008 Certified Journal | Page 2094
Fig. 1. (a) Healthy Spiral and Wave
Fig. 1. (b) Parkinson Spiral and Wave
Inception V3: The inception V3 is a deep learning model on Convolution Neural Networks, which is used for image
classification. The inception V3 is a superior version of the basic model Inception V1 which was introduced as Google Net
in 2014. The inception V3 model was released in the year 2015, it has a total of 42 layers and 16,000 parameters.
Fig. 2. Inception V3 Architecture
ResNet50: ResNet50 has 50 layers with 25 million parameters. In 2015, ResNet was the winner of the ImageNet challenge.
It can train extremely deep neural networks successfully. Residual learning tries to learn some residual instead of trying to
learn some features. ResNet used shortcut connections and created a residual block. The residual intermediate block
learns how to adapt with input for high quality features. ResNet is introducing a “identity shortcut connection” which skips
one or more layers. ResNet 50 architecture with two types of blocks; one is Convolutional block, and another one is
identity block.
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 09 Issue: 07 | July 2022 www.irjet.net p-ISSN: 2395-0072
© 2022, IRJET | Impact Factor value: 7.529 | ISO 9001:2008 Certified Journal | Page 2095
Fig. 3. ResNet50 Architecture
Transfer Learning: Transfer learning is a well-known and prominent technique that can use as a pre-trained model.
When a model was trained with large-size benchmark datasets (e.g., ImageNet dataset) to solve a problem then it’s called a
pretrained model. Transferring knowledge of old tasks into a new job, when a new job is learned it is called transfer
learning. We can reuse a model for different tasks by using transfer learning.
III. CONCLUSION AND FUTURE SCOPE
In this research, a system is developed to classify whether a person who attempted the sketching test is affected by
Parkinson’s disease or not based on Transfer Learning architecture. The work mostly took advantage of spiral and wave
image data performed by healthy subjects and Parkinson’s patients forclassification purposes. This research proposed
here transfer learning with Inception V3 and ResNet50 architecture. The approach that has been applied: Inception V3
model provides satisfactory result with 92.83% accuracy to distinguish the sketches made by healthy subjects and
Parkinson’s patients using transfer learning. We will further improve the methodology and the performance of the
classifier in this research. Though this study depends on built-in CNN architecture, there has a broad scope in the future to
propose a new model using transfer learning. Also, improvement can be done on datasets with a wide variety of features
that could play an important role to detect the disease.
IV. REFERENCES
[1] Can, M. (2019). Diagnosis of Parkinson’s Disease by Boosted Neural Networks. South East Europe Journal of Soft
Computing.
[2] Wan, X., Yang, C., Yang, Q., Xue, H., Tang, N. L., & Yu, W.(2014). Mega SNP Hunter: a learning approach to detect disease
predisposition SNPs and high-level interactions in genome wide association study. BMC bioinformatics.
[3] Yadav, G., Kumar, Y., & Sahoo, G. A. D. A. D. H. A. R. (2019). Predication of Parkinson's disease using data mining
methods: A comparative analysis of tree, statistical, and support vector machine classifiers. Indian journal of medical
sciences.
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 09 Issue: 07 | July 2022 www.irjet.net p-ISSN: 2395-0072
© 2022, IRJET | Impact Factor value: 7.529 | ISO 9001:2008 Certified Journal | Page 2096
[4] Das, R. (2020). A comparison of multiple classification methods for diagnosis of Parkinson disease. Expert Systems
with Applications.
[5] Chen, A. H., Lin, C. H., & Cheng, C. H. New approaches to improve the performance of disease classification using
nested–random forest and nested– support vector machine classifiers.
[6] Rustempasic, I., & Can, M. (2016). Diagnosis of Parkinson’s disease using principal component analysis and boosting
committee machines. South East Europe Journal of Soft Computing. Srishti Grover, Saloni Bhartia, Akshama,
Abhilasha Yadav, Seeja K. R. (2018).
[7] Predicting Severity Of Parkinson's Disease Using Deep Learning. International Conference on Computational
Intelligence and Data Science (ICCIDS 2018)
[8] C. R. Pereira, D. R. Pereira, S. A.Weber, C. Hook,V. H. C. de Albuquerque, and J. P. Papa, ``A survey on computer-
assisted Parkinson's disease diagnosis,''Artif. Intell Med, vol. 95, pp. 48_63, Apr. 2019
[9] C. R. Pereira, D. R. Pereira, F. A. Silva, J. P. Masieiro, S. A. Weber, C. Hook, and J. P. Papa. (2016). Handpd Dataset.
Accessed: Jan. 15, 2019. [Online]. Available: http://wwwp.fc.unesp.br/~papa/pub/datasets/Handpd/
[10] Anurag D, Siuli Roy and SomprakashBandyopadhyay, “Agro-Sense: PrecisionAgriculture using Sensor-based
Wireless Mesh Networks”, ITU-T “Innovationin NGN”, Kaleidoscope Conference, Geneva 12-13 May 2008.
[11] Wearable device to measure heart beat using loT S Jayanth, MB Poorvi, R Shreyas, B Padmaja, MP Sunil 2017
International Conference on Inventive Systems and Control (ICISC), 1-5
[12] Embedded System Interfacing with GNSS User Receiver for Transport Applications MU Bagali Editorial Preface
From the Desk of Managing Editor
[14] Achieving energy efficiency using novel scalar multiplication based ECC for android devices in Internet of
Things environments KS Kumar, R Sukumar Cluster Computing
[13] Embedded Board Development Interfaced with GPS/IRNSS/NaviC Receiver for Disaster Applications MU
Bagali, NP Bhatta Proceedings of International Conference on Sustainable Computing in Science.
[15] Sensors Lifetime nhancement Techniques in Wireless Sensor Networks - A Critical Review C.Karthik Sendhil
Kumar R.Sukumar M.Nageswari
[16] An approach by adopting multi-objective clustering and data collection along with node sleep scheduling for
energy efficient and delay aware WSN B Guruprakash, C Balasubramanian, R Sukumar - Peer-to-Peer Networking
and Applications, 2020
[17] Thomas, M.; Lenka, A.; Kumar Pal, P. Handwriting Analysis in Parkinson’s Disease: Current Status and Future
Directions. Mov. Disord. Clin. Pract. 2017, 4, 806–818.
[18] Hamsa S, Ananth A.G and Thangadurai N, A study of semiconductor memory technology by comparing volatile
and non-volatile memories. J. Adv. Res. Dyn. Control Syst., 2018, 10(4), 1252- 1258.
[19] Hamsa S, N. Thangadurai and A.G Ananth, Composition of magnetic tunnel junction-based magnetoresistive
random access memory for Field-Programmable Gate Array, Research Communications, Current Science, 2020,
119(1), 119-123.
[20] Hamsa S, Basavaraj H, Ananth A.G, Design of SRAM Array using Reversible Logic for Low Power Non-volatile
applications, Int. J of Elec.and Computational Syst, 2017,6(8), 159-164.

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Parkinson’s Disease Detection Using Transfer Learning

  • 1. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 09 Issue: 07 | July 2022 www.irjet.net p-ISSN: 2395-0072 © 2022, IRJET | Impact Factor value: 7.529 | ISO 9001:2008 Certified Journal | Page 2093 Parkinson’s Disease Detection Using Transfer Learning Dr. Hamsa S, B Murali mohan, P Ram Charan, T Abhinash Reddy, S Bramha Teja M. Tech (VLSI and Embedded Systems Design), Assistant Professor, B.E(Electronics and Communication), Jain university, Bangalore, India --------------------------------------------------------------------------***-------------------------------------------------------------------- Abstract: Parkinson’s disease (PD) is an incurable neurological disorder disease. But there is no still no standard medical provision to identify Parkinson’s disease. In this study, a fine motor symptom that is sketching has been studied. The experiments are done on a significant number of PD patients and healthy group (Without PD). We proposed a system that can determine the sketching and report whether a PD patient’s sketch or not. Deep learning algorithms can deal with the solution of different brain generalizing neural networks with the same design. Thus we applied Transfer Learning to classify sketched images to discriminate or identify Parkinson’s Disease (PD) affected patients from the regular healthy group. The experiment was done on different convolutional models with transfer learning method and applying on spiral and wave sketched data. By using Inception v3 and Resnet50 model with spiral sketching and wave sketching, the accuracy is more for the Inception v3. We have used the transfer learning which enhanced the model performance. Keywords: Parkinson’s disease, Deep learning, Convolutional Neural Network, Transfer Learning I. INTRODUCTION In this era, more than seven million people worldwide are affected by Parkinson’s disease (PD), according to a recent study. Nowadays, this incurable disease is increasing tremendously. This disease gets its name from James Parkinson, who earlier described it as a paralysis agitans and later gave his surname was known as a PD. Parkinson’s disease causes a diverse set of symptoms ranging from tremor to cognitive impairment, hallucination, dementia, sleep disorders, etc. It is the most common neurodegenerative disease among aged people who are more than 50 years old. Till now, there is no complete cure. This paper aims the predict Parkinson’s disorder. To avoid the significant negative impact on PD patients, identification of PD in the premier stage is mandatory. Previous clinicians and researchers already used Handwriting and Spiral sketching to identify PD patients successfully in the premier stages. Spiral and wave sketching, and handwriting could be easily differentiated from healthy person (without PD) to a person affected by PD and the measurement of those sketching & handwriting are non-invasive. Parkinson’s disease symptoms are broadly divided into two groups. One is Motor symptoms another one is Non motor symptoms. Motor symptoms are tremor (involuntary movement of the legs/ hands), stiffness (difficulty in moving the parts of the body), slowness in daily activities, impaired balance, shuffling gait. On the other hand, non-motor symptoms are difficulties with memory, slowness of thought, anxiety and depression, insomnia and fatigue, vision problem, hallucinations and delusions, speech and swallowing problems. II. Methodology Data Collection: We collected data from Kaggle’s dataset. This dataset is a set of spiral and wave sketches from 55 subjects where 28 subjects from the healthy control group (without PD) and 27 subjects from the Parkinson’s group. The dataset contains 102 spiral sketching images and 102 wave sketching images. A tablet, A3 size paper, and a pen were used to record sketching. Sample Images of the sketches for Healthy (without PD) and Parkinson Group.
  • 2. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 09 Issue: 07 | July 2022 www.irjet.net p-ISSN: 2395-0072 © 2022, IRJET | Impact Factor value: 7.529 | ISO 9001:2008 Certified Journal | Page 2094 Fig. 1. (a) Healthy Spiral and Wave Fig. 1. (b) Parkinson Spiral and Wave Inception V3: The inception V3 is a deep learning model on Convolution Neural Networks, which is used for image classification. The inception V3 is a superior version of the basic model Inception V1 which was introduced as Google Net in 2014. The inception V3 model was released in the year 2015, it has a total of 42 layers and 16,000 parameters. Fig. 2. Inception V3 Architecture ResNet50: ResNet50 has 50 layers with 25 million parameters. In 2015, ResNet was the winner of the ImageNet challenge. It can train extremely deep neural networks successfully. Residual learning tries to learn some residual instead of trying to learn some features. ResNet used shortcut connections and created a residual block. The residual intermediate block learns how to adapt with input for high quality features. ResNet is introducing a “identity shortcut connection” which skips one or more layers. ResNet 50 architecture with two types of blocks; one is Convolutional block, and another one is identity block.
  • 3. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 09 Issue: 07 | July 2022 www.irjet.net p-ISSN: 2395-0072 © 2022, IRJET | Impact Factor value: 7.529 | ISO 9001:2008 Certified Journal | Page 2095 Fig. 3. ResNet50 Architecture Transfer Learning: Transfer learning is a well-known and prominent technique that can use as a pre-trained model. When a model was trained with large-size benchmark datasets (e.g., ImageNet dataset) to solve a problem then it’s called a pretrained model. Transferring knowledge of old tasks into a new job, when a new job is learned it is called transfer learning. We can reuse a model for different tasks by using transfer learning. III. CONCLUSION AND FUTURE SCOPE In this research, a system is developed to classify whether a person who attempted the sketching test is affected by Parkinson’s disease or not based on Transfer Learning architecture. The work mostly took advantage of spiral and wave image data performed by healthy subjects and Parkinson’s patients forclassification purposes. This research proposed here transfer learning with Inception V3 and ResNet50 architecture. The approach that has been applied: Inception V3 model provides satisfactory result with 92.83% accuracy to distinguish the sketches made by healthy subjects and Parkinson’s patients using transfer learning. We will further improve the methodology and the performance of the classifier in this research. Though this study depends on built-in CNN architecture, there has a broad scope in the future to propose a new model using transfer learning. Also, improvement can be done on datasets with a wide variety of features that could play an important role to detect the disease. IV. REFERENCES [1] Can, M. (2019). Diagnosis of Parkinson’s Disease by Boosted Neural Networks. South East Europe Journal of Soft Computing. [2] Wan, X., Yang, C., Yang, Q., Xue, H., Tang, N. L., & Yu, W.(2014). Mega SNP Hunter: a learning approach to detect disease predisposition SNPs and high-level interactions in genome wide association study. BMC bioinformatics. [3] Yadav, G., Kumar, Y., & Sahoo, G. A. D. A. D. H. A. R. (2019). Predication of Parkinson's disease using data mining methods: A comparative analysis of tree, statistical, and support vector machine classifiers. Indian journal of medical sciences.
  • 4. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 09 Issue: 07 | July 2022 www.irjet.net p-ISSN: 2395-0072 © 2022, IRJET | Impact Factor value: 7.529 | ISO 9001:2008 Certified Journal | Page 2096 [4] Das, R. (2020). A comparison of multiple classification methods for diagnosis of Parkinson disease. Expert Systems with Applications. [5] Chen, A. H., Lin, C. H., & Cheng, C. H. New approaches to improve the performance of disease classification using nested–random forest and nested– support vector machine classifiers. [6] Rustempasic, I., & Can, M. (2016). Diagnosis of Parkinson’s disease using principal component analysis and boosting committee machines. South East Europe Journal of Soft Computing. Srishti Grover, Saloni Bhartia, Akshama, Abhilasha Yadav, Seeja K. R. (2018). [7] Predicting Severity Of Parkinson's Disease Using Deep Learning. International Conference on Computational Intelligence and Data Science (ICCIDS 2018) [8] C. R. Pereira, D. R. Pereira, S. A.Weber, C. Hook,V. H. C. de Albuquerque, and J. P. Papa, ``A survey on computer- assisted Parkinson's disease diagnosis,''Artif. Intell Med, vol. 95, pp. 48_63, Apr. 2019 [9] C. R. Pereira, D. R. Pereira, F. A. Silva, J. P. Masieiro, S. A. Weber, C. Hook, and J. P. Papa. (2016). Handpd Dataset. Accessed: Jan. 15, 2019. [Online]. Available: http://wwwp.fc.unesp.br/~papa/pub/datasets/Handpd/ [10] Anurag D, Siuli Roy and SomprakashBandyopadhyay, “Agro-Sense: PrecisionAgriculture using Sensor-based Wireless Mesh Networks”, ITU-T “Innovationin NGN”, Kaleidoscope Conference, Geneva 12-13 May 2008. [11] Wearable device to measure heart beat using loT S Jayanth, MB Poorvi, R Shreyas, B Padmaja, MP Sunil 2017 International Conference on Inventive Systems and Control (ICISC), 1-5 [12] Embedded System Interfacing with GNSS User Receiver for Transport Applications MU Bagali Editorial Preface From the Desk of Managing Editor [14] Achieving energy efficiency using novel scalar multiplication based ECC for android devices in Internet of Things environments KS Kumar, R Sukumar Cluster Computing [13] Embedded Board Development Interfaced with GPS/IRNSS/NaviC Receiver for Disaster Applications MU Bagali, NP Bhatta Proceedings of International Conference on Sustainable Computing in Science. [15] Sensors Lifetime nhancement Techniques in Wireless Sensor Networks - A Critical Review C.Karthik Sendhil Kumar R.Sukumar M.Nageswari [16] An approach by adopting multi-objective clustering and data collection along with node sleep scheduling for energy efficient and delay aware WSN B Guruprakash, C Balasubramanian, R Sukumar - Peer-to-Peer Networking and Applications, 2020 [17] Thomas, M.; Lenka, A.; Kumar Pal, P. Handwriting Analysis in Parkinson’s Disease: Current Status and Future Directions. Mov. Disord. Clin. Pract. 2017, 4, 806–818. [18] Hamsa S, Ananth A.G and Thangadurai N, A study of semiconductor memory technology by comparing volatile and non-volatile memories. J. Adv. Res. Dyn. Control Syst., 2018, 10(4), 1252- 1258. [19] Hamsa S, N. Thangadurai and A.G Ananth, Composition of magnetic tunnel junction-based magnetoresistive random access memory for Field-Programmable Gate Array, Research Communications, Current Science, 2020, 119(1), 119-123. [20] Hamsa S, Basavaraj H, Ananth A.G, Design of SRAM Array using Reversible Logic for Low Power Non-volatile applications, Int. J of Elec.and Computational Syst, 2017,6(8), 159-164.