Oxygen therapy is essential for preventing or relieving tissue hypoxia by delivering oxygen at concentrations higher than ambient air, significantly improving mortality, sleep quality, and exercise tolerance. Safety measures include no smoking around oxygen sources, using designated signs, and ensuring proper equipment functioning, as oxygen is highly combustible. Various delivery methods such as nasal cannulas, masks, and humidifiers cater to patient needs, while monitoring for complications like oxygen toxicity and hypoventilation is critical.