The skeletal and muscular systems are closely integrated because they work together to enable movement. The skeletal system has 206 bones divided into the axial skeleton (bones of the head, trunk and vertebral column) and appendicular skeleton (bones of the limbs and girdles). Bones are classified by shape and composition. Joints connect bones and allow various ranges of motion. The skeletal system provides structure, protection, movement, mineral storage and blood cell formation.
Throughout history, the symbol of the skull and crossbones has served as a representation of mortality, likely owing to the fact that following death and decay, bones are the sole remnants. Many individuals perceive bones as inert, desiccated, and fragile. While these attributes accurately portray the bones of a preserved skeleton, the bones within a living human being are profoundly alive. Living bones exhibit strength and flexibility, serving as the primary components of the skeletal system.
A detail account of Bones, their histological features, classification, composition, Formation, blood and nerve supply, functions, plus some interesting facts about bones.
Throughout history, the symbol of the skull and crossbones has served as a representation of mortality, likely owing to the fact that following death and decay, bones are the sole remnants. Many individuals perceive bones as inert, desiccated, and fragile. While these attributes accurately portray the bones of a preserved skeleton, the bones within a living human being are profoundly alive. Living bones exhibit strength and flexibility, serving as the primary components of the skeletal system.
A detail account of Bones, their histological features, classification, composition, Formation, blood and nerve supply, functions, plus some interesting facts about bones.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
How to Give Better Lectures: Some Tips for Doctors
overview of A AND PHY.pptx
1. REVIEW OF ANATOMY AND PHYSIOLOGY OF MSS
It is the second largest system in the body.
The skeletal and muscular systems considered one system
because they work together to enable the body to move.
Their functions are highly integrated
Therefore, disease in or injury to one adversely affects the others.
For instance, an infection in a joint (septic arthritis)
causes degeneration of the articular surfaces
2. The skeleton is subdivided into two divisions:
• The axial skeleton, the bones that form the
longitudinal axis of the body, and
• The appendicular skeleton, the bones of the limbs
and girdles.
3. Classification of skeletal system…
Arranged in two
divisions:
• Axial skeleton ( 80
bones)
• Appendicular
skeleton (126 bones)
4.
5. Classification of Bones
• The adult skeleton is composed of 206 bones
• there are two basic types of osseous, or bone,
tissue:
• compact bone
• spongy bone
• are classified into four groups according to shape:
• long,
• short,
• flat
• irregular.
6.
7. Classification of skeletal system…
I. The axial skeleton
• Form the axis of the body
• Support and protect the organs of the head, neck, and trunk.
Skull:22bones
• Cranial(8)
• Facial bones(14)
Auditory ossicles: 6 ear bones
Hyoid bone =1bone
9. Classification of skeletal system…
• Bones of the upper
• Lower extremities and
• Bony girdles that anchor the appendages
to the axial skeleton
II. The Appendicular skeleton
10. Classification of skeletal system…
Pectoral girdle/shoulder Girdle
• Paired scapulae (“shoulder blades)
• Paired clavicles (“collarbones”)
Upper extremities =60 Bones
• Each upper extremity contains
• Humerus
• Ulna and Radius,
• Carpal bones,
• Metacarpal bones, and
• Phalanges (“finger bones”) of the hand.
12. Bones
• Provide a framework to support and protect the body
• Point of attachment with muscles
• Held close together at the joint by ligaments, which
are flexible bands of fibrous tissue
• Store calcium and other minerals
• Produce blood cells within bone marrow
13. Muscle Tissue
Skeletal muscle
Striated in appearance ,multi- nucleated
Under voluntary nervous control.
Smooth or visceral muscle
Located in the walls of organs
No striations, & under involuntary control.
Cardiac muscle
Located only in the heart, striated ,1-3 central nuclei &
involuntary control.
14.
15. Joints
Joints, also called articulations, have two
functions:
• They hold the bones together securely
• Give the rigid skeleton mobility.
Classification. Joints are classified in two
• functionally
• structurally
16. Functional classification.
• The functional classification focuses on the amount of
movement the joint allows.
Types of functional joints.
• Synarthroses or immovable joints;
• Amphiarthroses, or slightly movable joints, and
• Diarthrosis, or freely movable joints
17. Diarthroses.
• Freely movable joints predominate in the limbs, where
mobility is important.
Synarthroses and amphiarthroses.
• Immovable and slightly movable joints are restricted mainly to the
axial skeleton, where firm attachments and protection of internal
organs are priorities.
18. Structural classification.
• Fibrous,
• Cartilaginous, and
• Synovial joints;
These classifications are based on whether
they separates the bony regions at the joint.
19. In fibrous joints, the bones are united by fibrous tissue
• The best examples of this type of joint are the sutures of the skull
In cartilaginous joints, the bone ends are connected by
cartilage
• Examples of this joint type that are slightly movable are the pubic
symphysis of the pelvis and the intervertebral joints of the spinal
column
Synovial joints are joints in which the articulating bone
ends are separated by a joint cavity containing a synovial
fluid; they account for all joints of the limbs.
20. Articular cartilage. Articular cartilage covers the ends of the bones
forming the joints.
Fibrous articular capsule. The joint surfaces are enclosed by a sleeve or
a capsule of fibrous connective tissue, and their capsule is lined with a
smooth synovial membrane (the reason these joints are called synovial
joints).
Joint cavity. The articular capsule encloses a cavity, called the joint
cavity, which contains lubricating synovial fluid.
21. Reinforcing ligaments. The fibrous capsule is usually reinforced with
ligaments
Bursae. Bursae are flattened fibrous sacs lined with synovial membrane and
containing a thin film of synovial fluid; they are common where ligaments,
muscles, skin, tendons, or bones rub together
Tendon sheath. A tendon sheath is essentially an elongated bursa that wraps
completely around a tendon subjected to friction, like a bun around a hotdog.
22. Functions of the Skeletal System
• Support;-the bones of the legs act as pillars to support the body trunk
when we stand, and the rib cage supports the thoracic wall.
• Protection;-Bones protect soft body organs; for example, the fused
bones of the skull provide a snug enclosure for the brain, the vertebrae
surround the spinal cord, and the rib cage helps protect the vital organs
of the thorax.
• Movement. Skeletal muscles, attached to bones by tendons, use the
bones as levers to move the body and its parts.
• Storage. Fat is stored in the internal cavities of bones; bone itself serves
as a storehouse for minerals, the most important of which are calcium
and phosphorus
• Blood cell formation. Blood cell formation, or hematopoiesis, occurs
within the marrow cavities of certain bones.
Editor's Notes
Bones of upper & lower limbs and the girdles (shoulder bones and hip bones) that attach them to the axial skeleton.
Involved in locomotion and manipulation of the environment.