The document discusses osmotic drug delivery systems (ODDS). It begins by defining osmosis and describing how osmotic pressure drives the movement of water across a semi-permeable membrane. It then discusses the advantages of ODDS such as zero-order delivery kinetics and independence from gastric pH. The document classifies several types of ODDS including elementary osmotic pumps, controlled porosity pumps, and push-pull pumps. It also describes components like the semi-permeable membrane and osmotic agents. In vitro evaluation methods and factors affecting ODDS performance are briefly covered.
OSMOTIC AND ENZYMATIC DRUG DELIVERY SYSTEMAravindgowda6
This document provides an overview of osmotic and enzymatic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the principles of osmotic drug delivery systems, which use osmotic pressure to release drugs in a controlled manner. The document classifies different types of osmotic pumps and discusses formulation considerations like drugs, semipermeable membranes, and osmogens. It also briefly introduces enzymatic drug delivery systems that rely on enzymatic activation to release drugs. Examples of marketed osmotic drug delivery products are also mentioned.
This document provides an overview of osmotic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the basic components and classifications of osmotic pumps, including elementary osmotic pumps, multi-chamber osmotic pumps, and controlled porosity osmotic pumps. Factors that can affect drug release from these systems are discussed, such as solubility, osmotic pressure, membrane properties, and use of excipients. Approaches to modify drug solubility for osmotic systems are also summarized.
Osmotic drug delivery uses the osmotic pressure of drug or other solutes (osmogens or osmagents) for controlled delivery of drugs. Osmotic drug delivery has come a long way since Australian physiologists Rose and Nelson developed an implantable pump in 1955.
This document provides an overview of osmotic drug delivery systems. It discusses the basic components and principles of osmosis that osmotic drug delivery systems utilize. The key components discussed include the drug, osmogen, semipermeable membrane, and factors that affect drug release such as solubility, osmotic pressure, delivery orifice size, and membrane type. A variety of osmotic pump designs are also briefly mentioned.
This document provides an overview of three types of rate controlled drug delivery systems: hydrodynamically balanced systems, osmotic pressure controlled systems, and pH dependent/independent systems.
Hydrodynamically balanced systems, also known as floating drug delivery systems, remain buoyant in the stomach for prolonged periods of time to increase bioavailability. Osmotic pressure controlled systems use osmotic pressure to provide zero-order drug release kinetics over extended times. pH dependent systems target drug delivery to specific regions of the GI tract based on pH, while pH independent systems aim to release drugs at a constant rate regardless of varying GI pH.
OSMOTIC drug delivery system slideshare.pptxPratik Shinde
Introduction of osmotic drug delivery system.
Mechanism of osmosis.
Basic Components of Osmotic drug delivery System.
Classification of Osmotic Drug Delivery System.
Advantage & Disadvantage of Osmotic drug delivery system.
Newer technology in Osmotic drug delivery system.
Evaluation parameters of osmotic drug delivery system.
Marketed Formulations of Osmotic drug delivery system.
Case Study about osmotic drug delivery system.
OSMOTIC AND ENZYMATIC DRUG DELIVERY SYSTEMAravindgowda6
This document provides an overview of osmotic and enzymatic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the principles of osmotic drug delivery systems, which use osmotic pressure to release drugs in a controlled manner. The document classifies different types of osmotic pumps and discusses formulation considerations like drugs, semipermeable membranes, and osmogens. It also briefly introduces enzymatic drug delivery systems that rely on enzymatic activation to release drugs. Examples of marketed osmotic drug delivery products are also mentioned.
This document provides an overview of osmotic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the basic components and classifications of osmotic pumps, including elementary osmotic pumps, multi-chamber osmotic pumps, and controlled porosity osmotic pumps. Factors that can affect drug release from these systems are discussed, such as solubility, osmotic pressure, membrane properties, and use of excipients. Approaches to modify drug solubility for osmotic systems are also summarized.
Osmotic drug delivery uses the osmotic pressure of drug or other solutes (osmogens or osmagents) for controlled delivery of drugs. Osmotic drug delivery has come a long way since Australian physiologists Rose and Nelson developed an implantable pump in 1955.
This document provides an overview of osmotic drug delivery systems. It discusses the basic components and principles of osmosis that osmotic drug delivery systems utilize. The key components discussed include the drug, osmogen, semipermeable membrane, and factors that affect drug release such as solubility, osmotic pressure, delivery orifice size, and membrane type. A variety of osmotic pump designs are also briefly mentioned.
This document provides an overview of three types of rate controlled drug delivery systems: hydrodynamically balanced systems, osmotic pressure controlled systems, and pH dependent/independent systems.
Hydrodynamically balanced systems, also known as floating drug delivery systems, remain buoyant in the stomach for prolonged periods of time to increase bioavailability. Osmotic pressure controlled systems use osmotic pressure to provide zero-order drug release kinetics over extended times. pH dependent systems target drug delivery to specific regions of the GI tract based on pH, while pH independent systems aim to release drugs at a constant rate regardless of varying GI pH.
OSMOTIC drug delivery system slideshare.pptxPratik Shinde
Introduction of osmotic drug delivery system.
Mechanism of osmosis.
Basic Components of Osmotic drug delivery System.
Classification of Osmotic Drug Delivery System.
Advantage & Disadvantage of Osmotic drug delivery system.
Newer technology in Osmotic drug delivery system.
Evaluation parameters of osmotic drug delivery system.
Marketed Formulations of Osmotic drug delivery system.
Case Study about osmotic drug delivery system.
This document provides an overview of osmotic drug delivery systems. It discusses the introduction, advantages, mechanism, principle, and factors affecting the release rate of osmotic systems. The document also describes the formulation of osmotic drug delivery systems, including the core components like drugs, osmogens, and polymers, as well as coating components such as semipermeable membranes, plasticizers, and pore forming agents. The goal of the seminar is to discuss osmotic drug delivery and its application in pharmaceuticals for controlled drug release.
The document discusses osmotic drug delivery systems. It defines osmosis and osmotic pressure, and describes the basic components of osmotic drug delivery systems including semipermeable membranes, osmogens, and drug formulations. It classifies osmotic systems as implantable or oral, and describes several types of oral osmotic pumps including elementary, modified, multi-chamber, controlled porosity, and monolithic systems. Key factors that affect drug release are also outlined. The document concludes by listing several marketed osmotic products.
This document provides an overview of osmotic drug delivery systems. It defines osmotic pressure and discusses how osmotic pumps use osmotic pressure to control drug delivery over extended periods of time. The key components of osmotic systems are a drug core containing an osmogen, a semipermeable membrane coating, and a delivery orifice. Factors like solubility, osmotic pressure, membrane properties, and orifice size influence drug release rates. Various polymers, osmogens, and other excipients are discussed for formulating different osmotic pump designs.
This document discusses osmotic drug delivery systems. It begins with an introduction to how osmotic drug delivery uses osmotic pressure for controlled drug delivery. It then covers the basic principles of osmosis, classification of osmotic delivery systems, factors affecting drug release, and basic components. The document lists advantages like achievable zero-order release and independence from gastric conditions. Disadvantages include potential for dose dumping. Materials used in formulation are also outlined.
This document provides an overview of osmotic activated drug delivery systems. It begins with an introduction that explains osmotic pressure is used to release drugs in a controlled manner from these systems. The basic components, advantages, and disadvantages are then outlined. Several types of osmotic pumps are described in detail, including how they work and their applications. In summary, this document serves as a comprehensive review of osmotic drug delivery systems, their design principles, and performance characteristics.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Osmotically controlled drug delivery systems use osmotic pressure to control the release of drugs from a semipermeable membrane. When exposed to fluids, water flows across the membrane due to osmotic pressure differences. This causes the drug formulation to release through an orifice at a controlled, zero-order rate. There are several types of osmotic pumps including elementary, push-pull, and controlled porosity pumps. They offer advantages like controlled drug release independent of the environment or drug properties. However, these systems can be expensive to manufacture due to complex coating processes required.
it is consist osmotic drug delivery system. and its new approaches. its advantage & disadvantage.. principle. etc
and basic camponents and osmotic pump......
Osmotically Regulated Control System By Ashish Guptaashishmedatwal87
This document provides an overview of osmotically controlled drug delivery systems. It begins with an introduction to novel drug delivery systems and their advantages. It then discusses the principles of osmosis and factors that affect drug release rates from these systems such as osmotic pressure, membrane properties, and orifice size. The document classifies different types of osmotic delivery systems including oral, implantable, and advanced systems. It provides examples of components, commercially available products, and evaluation methods. In summary, the document reviews the fundamentals and design of osmotically controlled drug delivery to provide sustained and targeted drug release.
This document defines osmosis and osmotic pressure, and describes how osmotic systems utilize these principles for controlled drug delivery. It discusses the basic components of osmotic systems, including drugs, osmotic agents, semi-permeable membranes, and plasticizers. It also describes various types of osmotic systems for both oral and implantable drug delivery, including elementary osmotic pumps, push-pull osmotic pumps, and implantable mini-osmotic pumps. The document provides equations to describe drug release from these systems driven by osmotic pressure.
Osmotic drug delivery uses osmotic pressure to control drug release rates. It offers advantages like zero-order release kinetics and delivery rates unaffected by environmental conditions. The document discusses the principles of osmosis, components of osmotic pumps like drugs, osmogens, and semipermeable membranes. It also describes early osmotic pumps developed by Rose and Nelson as well as various types of modern osmotic pumps and some reported cases of adverse effects.
Controlled Release Oral Drug Delivery System
Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
This document discusses general methods for designing and evaluating osmotic pumps. It begins by introducing osmotic pumps and their advantages over other controlled drug delivery systems. It then describes the process of osmosis and differentiates it from diffusion. Various materials used in formulating osmotic pumps are outlined, including semi-permeable membranes, polymers, wicking agents, osmogens, and others. Different types of osmotic pumps are explained, such as implantable pumps and orally administered pumps. Specific examples of osmotic pumps are provided.
Osmotic activated Drug Delivery System Seminar(DDS).pptxankushawatale09
The document discusses osmotic activated drug delivery systems, which use osmotic pressure to control drug release through semi-permeable membranes. It describes the basic components, types including implantable pumps and oral pumps, marketed products, advantages of controlled release and improved compliance, and disadvantages like potential toxicity. Examples of marketed products incorporating various pump technologies are provided.
This document discusses osmotic controlled oral delivery systems. It provides advantages like continuous drug delivery at predictable rates independent of gastric conditions. Components include drugs, osmotic agents, and semipermeable membranes. Various osmotic pump types are described like elementary, push-pull, bursting. Applications include Glucotrol XL, Procardia XL, and other marketed products that use this technology to provide extended release of drugs.
Osmotic drug delivery system by Mr. kailash vilegaveKailash Vilegave
INTRODUCTION
ADVANTAGES OF OSMOTIC DRUG DELIVERY SYSTEM
DISADVANTAGES OF OSMOTIC DRUG DELIVERY SYSTEM
REPORTED CASES REGARDING LIMITATIONS AND ADVERSE EFFECTS OF OSMOTIC DRUG DELIVERY SYSTEM
PRINCIPLE OF OSMOSIS
BASIC COMPONENTS OF OSMOTIC PUMP
Osmotic drug delivery system by Mr. kailash vilegaveKailash Vilegave
This document provides an overview of osmotic drug delivery systems. It discusses the advantages such as achievable zero-order delivery and independence from gastric conditions. Potential disadvantages include dose dumping and rapid tolerance development. The document explains the principles of osmosis and key components of osmotic pumps such as drugs, osmotic agents, and semipermeable membranes. Various osmotic pump designs are also outlined including multi-chamber and elementary osmotic pumps.
The document discusses osmotic drug delivery systems (ODDS). It begins with an introduction that explains how ODDS use osmotic pressure to control drug release independently of physiological factors. It then covers key topics such as the concept of osmosis, principles of osmosis, basic components of ODDS, classification into implantable and oral systems, factors influencing design, and evaluation parameters. The document provides an overview of the technology and science behind ODDS for controlled drug delivery.
This document summarizes several controlled release oral drug delivery systems, including osmotic pressure controlled systems, hydrodynamically balanced systems, and pH-activated systems. Osmotic systems use a semipermeable membrane to control the rate of drug release based on osmotic pressure differences. Hydrodynamically balanced systems remain floating in the stomach for extended periods using gel polymers or effervescent components. pH-activated systems target drug delivery to specific regions of the GI tract based on pH-sensitive polymer coatings.
09osmotic drug delivery system ppt..pptx 2.pptxPadmineePatil
This document provides an overview of osmotic controlled drug delivery systems and enzyme activated drug delivery systems. It discusses the principles of osmosis, mechanisms of osmotic controlled release, basic components of osmotic drug delivery systems, factors affecting their design, types of osmotic pumps, marketed products, advantages and disadvantages. It also briefly describes enzyme activated systems, which rely on enzymatic hydrolysis to activate the release of drugs entrapped or bound in biopolymers at target tissues. The document was presented by Sonal Sunil Salunke to Dr. Avinash Hosmani of the Department of Pharmaceutics at GCOP Karad.
Proteins are polymers of amino acids linked by amide bonds. They serve nutritional and structural functions. Amino acids contain ionizable groups that exist as zwitterions at neutral pH. The three levels of protein structure are primary, secondary, and tertiary/quaternary. Primary structure is the amino acid sequence. Secondary structure includes alpha helices and beta sheets formed by hydrogen bonding. Tertiary/quaternary structure is the final 3D structure formed by interactions between R groups. Common methods to analyze proteins include Kjeldahl for nitrogen content, dye binding assays, Biuret reaction, and UV/fluorescence spectroscopy.
Vaccine drug delivery systems can target the mucosal immune system. Mucosal vaccines are administered through mucosal surfaces but face barriers. Delivery approaches include absorption enhancers, liposomes, virosomes, and controlled release microspheres. Skin is a potential site for vaccine delivery using methods like microneedles, powder injection, or topical adjuvants. Oral vaccines target the gut immune system but antigens face degradation; microencapsulation in polymers aids delivery. Non-viral polymer carriers like nanoparticles protect antigens and control their release. Novel approaches include thermostable nanopatches coated with vaccine for skin delivery to immune cells.
This document provides an overview of osmotic drug delivery systems. It discusses the introduction, advantages, mechanism, principle, and factors affecting the release rate of osmotic systems. The document also describes the formulation of osmotic drug delivery systems, including the core components like drugs, osmogens, and polymers, as well as coating components such as semipermeable membranes, plasticizers, and pore forming agents. The goal of the seminar is to discuss osmotic drug delivery and its application in pharmaceuticals for controlled drug release.
The document discusses osmotic drug delivery systems. It defines osmosis and osmotic pressure, and describes the basic components of osmotic drug delivery systems including semipermeable membranes, osmogens, and drug formulations. It classifies osmotic systems as implantable or oral, and describes several types of oral osmotic pumps including elementary, modified, multi-chamber, controlled porosity, and monolithic systems. Key factors that affect drug release are also outlined. The document concludes by listing several marketed osmotic products.
This document provides an overview of osmotic drug delivery systems. It defines osmotic pressure and discusses how osmotic pumps use osmotic pressure to control drug delivery over extended periods of time. The key components of osmotic systems are a drug core containing an osmogen, a semipermeable membrane coating, and a delivery orifice. Factors like solubility, osmotic pressure, membrane properties, and orifice size influence drug release rates. Various polymers, osmogens, and other excipients are discussed for formulating different osmotic pump designs.
This document discusses osmotic drug delivery systems. It begins with an introduction to how osmotic drug delivery uses osmotic pressure for controlled drug delivery. It then covers the basic principles of osmosis, classification of osmotic delivery systems, factors affecting drug release, and basic components. The document lists advantages like achievable zero-order release and independence from gastric conditions. Disadvantages include potential for dose dumping. Materials used in formulation are also outlined.
This document provides an overview of osmotic activated drug delivery systems. It begins with an introduction that explains osmotic pressure is used to release drugs in a controlled manner from these systems. The basic components, advantages, and disadvantages are then outlined. Several types of osmotic pumps are described in detail, including how they work and their applications. In summary, this document serves as a comprehensive review of osmotic drug delivery systems, their design principles, and performance characteristics.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Osmotically controlled drug delivery systems use osmotic pressure to control the release of drugs from a semipermeable membrane. When exposed to fluids, water flows across the membrane due to osmotic pressure differences. This causes the drug formulation to release through an orifice at a controlled, zero-order rate. There are several types of osmotic pumps including elementary, push-pull, and controlled porosity pumps. They offer advantages like controlled drug release independent of the environment or drug properties. However, these systems can be expensive to manufacture due to complex coating processes required.
it is consist osmotic drug delivery system. and its new approaches. its advantage & disadvantage.. principle. etc
and basic camponents and osmotic pump......
Osmotically Regulated Control System By Ashish Guptaashishmedatwal87
This document provides an overview of osmotically controlled drug delivery systems. It begins with an introduction to novel drug delivery systems and their advantages. It then discusses the principles of osmosis and factors that affect drug release rates from these systems such as osmotic pressure, membrane properties, and orifice size. The document classifies different types of osmotic delivery systems including oral, implantable, and advanced systems. It provides examples of components, commercially available products, and evaluation methods. In summary, the document reviews the fundamentals and design of osmotically controlled drug delivery to provide sustained and targeted drug release.
This document defines osmosis and osmotic pressure, and describes how osmotic systems utilize these principles for controlled drug delivery. It discusses the basic components of osmotic systems, including drugs, osmotic agents, semi-permeable membranes, and plasticizers. It also describes various types of osmotic systems for both oral and implantable drug delivery, including elementary osmotic pumps, push-pull osmotic pumps, and implantable mini-osmotic pumps. The document provides equations to describe drug release from these systems driven by osmotic pressure.
Osmotic drug delivery uses osmotic pressure to control drug release rates. It offers advantages like zero-order release kinetics and delivery rates unaffected by environmental conditions. The document discusses the principles of osmosis, components of osmotic pumps like drugs, osmogens, and semipermeable membranes. It also describes early osmotic pumps developed by Rose and Nelson as well as various types of modern osmotic pumps and some reported cases of adverse effects.
Controlled Release Oral Drug Delivery System
Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
This document discusses general methods for designing and evaluating osmotic pumps. It begins by introducing osmotic pumps and their advantages over other controlled drug delivery systems. It then describes the process of osmosis and differentiates it from diffusion. Various materials used in formulating osmotic pumps are outlined, including semi-permeable membranes, polymers, wicking agents, osmogens, and others. Different types of osmotic pumps are explained, such as implantable pumps and orally administered pumps. Specific examples of osmotic pumps are provided.
Osmotic activated Drug Delivery System Seminar(DDS).pptxankushawatale09
The document discusses osmotic activated drug delivery systems, which use osmotic pressure to control drug release through semi-permeable membranes. It describes the basic components, types including implantable pumps and oral pumps, marketed products, advantages of controlled release and improved compliance, and disadvantages like potential toxicity. Examples of marketed products incorporating various pump technologies are provided.
This document discusses osmotic controlled oral delivery systems. It provides advantages like continuous drug delivery at predictable rates independent of gastric conditions. Components include drugs, osmotic agents, and semipermeable membranes. Various osmotic pump types are described like elementary, push-pull, bursting. Applications include Glucotrol XL, Procardia XL, and other marketed products that use this technology to provide extended release of drugs.
Osmotic drug delivery system by Mr. kailash vilegaveKailash Vilegave
INTRODUCTION
ADVANTAGES OF OSMOTIC DRUG DELIVERY SYSTEM
DISADVANTAGES OF OSMOTIC DRUG DELIVERY SYSTEM
REPORTED CASES REGARDING LIMITATIONS AND ADVERSE EFFECTS OF OSMOTIC DRUG DELIVERY SYSTEM
PRINCIPLE OF OSMOSIS
BASIC COMPONENTS OF OSMOTIC PUMP
Osmotic drug delivery system by Mr. kailash vilegaveKailash Vilegave
This document provides an overview of osmotic drug delivery systems. It discusses the advantages such as achievable zero-order delivery and independence from gastric conditions. Potential disadvantages include dose dumping and rapid tolerance development. The document explains the principles of osmosis and key components of osmotic pumps such as drugs, osmotic agents, and semipermeable membranes. Various osmotic pump designs are also outlined including multi-chamber and elementary osmotic pumps.
The document discusses osmotic drug delivery systems (ODDS). It begins with an introduction that explains how ODDS use osmotic pressure to control drug release independently of physiological factors. It then covers key topics such as the concept of osmosis, principles of osmosis, basic components of ODDS, classification into implantable and oral systems, factors influencing design, and evaluation parameters. The document provides an overview of the technology and science behind ODDS for controlled drug delivery.
This document summarizes several controlled release oral drug delivery systems, including osmotic pressure controlled systems, hydrodynamically balanced systems, and pH-activated systems. Osmotic systems use a semipermeable membrane to control the rate of drug release based on osmotic pressure differences. Hydrodynamically balanced systems remain floating in the stomach for extended periods using gel polymers or effervescent components. pH-activated systems target drug delivery to specific regions of the GI tract based on pH-sensitive polymer coatings.
09osmotic drug delivery system ppt..pptx 2.pptxPadmineePatil
This document provides an overview of osmotic controlled drug delivery systems and enzyme activated drug delivery systems. It discusses the principles of osmosis, mechanisms of osmotic controlled release, basic components of osmotic drug delivery systems, factors affecting their design, types of osmotic pumps, marketed products, advantages and disadvantages. It also briefly describes enzyme activated systems, which rely on enzymatic hydrolysis to activate the release of drugs entrapped or bound in biopolymers at target tissues. The document was presented by Sonal Sunil Salunke to Dr. Avinash Hosmani of the Department of Pharmaceutics at GCOP Karad.
Proteins are polymers of amino acids linked by amide bonds. They serve nutritional and structural functions. Amino acids contain ionizable groups that exist as zwitterions at neutral pH. The three levels of protein structure are primary, secondary, and tertiary/quaternary. Primary structure is the amino acid sequence. Secondary structure includes alpha helices and beta sheets formed by hydrogen bonding. Tertiary/quaternary structure is the final 3D structure formed by interactions between R groups. Common methods to analyze proteins include Kjeldahl for nitrogen content, dye binding assays, Biuret reaction, and UV/fluorescence spectroscopy.
Vaccine drug delivery systems can target the mucosal immune system. Mucosal vaccines are administered through mucosal surfaces but face barriers. Delivery approaches include absorption enhancers, liposomes, virosomes, and controlled release microspheres. Skin is a potential site for vaccine delivery using methods like microneedles, powder injection, or topical adjuvants. Oral vaccines target the gut immune system but antigens face degradation; microencapsulation in polymers aids delivery. Non-viral polymer carriers like nanoparticles protect antigens and control their release. Novel approaches include thermostable nanopatches coated with vaccine for skin delivery to immune cells.
Soft gelatin capsules are one-piece, hermetically sealed capsules made of gelatin containing a liquid, suspension, or semisolid active ingredient. They vary in shape (oblong, oval, round) and size. The gelatin shell is composed of gelatin, a plasticizer like glycerin or sorbitol, and water. Softgels can encapsulate suspensions, solutions, or semisolids below 45°C and may be enteric coated. The gelatin mass is produced by mixing gelatin, water, and plasticizer then adding other ingredients. Softgels are manufactured using a rotary die process where two gelatin ribbons are formed and filled before being sealed to form individual
Microencapsulation involves coating tiny particles or droplets of active ingredients with a thin polymeric film. There are two main types: microcapsules, which have a reservoir structure, and microspheres, which have a matrix structure. Various methods can be used for microencapsulation including pan coating, spray drying, solvent evaporation, coacervation, and centrifugal extrusion. The choice of coating material and method depends on the properties of the core ingredient and desired release characteristics. Microencapsulation provides benefits such as masking tastes, sustained release of ingredients, and protection from moisture, oxygen, and light.
This document provides information about capsules, including hard gelatin capsules and soft gelatin capsules. It discusses the main components of capsules, which are gelatin and the enclosed drug. Gelatin is derived from animal sources and provides a soluble shell. The document outlines the advantages and disadvantages of capsules as a dosage form and describes the sizes, shapes, raw materials used, and manufacturing process for gelatin capsules.
Hard gelatin capsules are typically made from gelatin and contain powdered ingredients. They consist of a lower body section that is filled and then sealed using a higher diameter cap. Hard gelatin capsules contain gelatin and other ingredients like preservatives, colorants, and plasticizers. They allow flexibility in formulation of ingredients not possible with tablets. Various machines are used to manufacture empty capsule shells and to fill capsules, ranging from small manual machines to large automated industrial machines that can fill thousands of capsules per hour.
This document provides an introduction and overview of polymers. It discusses that polymers are macromolecules composed of monomer units linked by covalent bonds that can be natural or synthetic. The structure of polymers can be linear, branched, or cross-linked. Polymers can be classified based on their source, structure, type of polymerization reaction, monomers used, and molecular forces. Key properties of polymers discussed include crystallinity, molecular weight, glass transition temperature, melting point, strength, elongation, and plasticity. Factors that influence properties like glass transition temperature are also outlined.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
2. INTRODUCTION
Osmosis refers to the process of movement of solvent from lower
concentration of solute towards higher concentration of solute
across a semi permeable membrane till the equilibrium achieved.
Osmotic pressure is the pressure which, if applied to the more
concentrated solution, would prevent transport of water across the
semipermeable membrane.
2
3. INTRODUCTION
Π = p c RT
Where,
p = Osmotic pressure
Π = osmotic coefficient
c = molar concentration
R = gas constant
T = Absolute temperature
3
4.
5. ADVANTAGES
The delivery rate of zero-order is achievable with osmotic systems.
Delivery may be delayed or pulsed, if desired.
Higher release rates are possible with osmotic systems compared
with conventional diffusion-controlled drug delivery systems.
The release rate of osmotic systems is highly predictable and can be
programmed by modulating the release control parameters.
For oral osmotic systems, drug release is independent of gastric pH
and hydrodynamic conditions.
The release from osmotic systems is minimally affected by the
presence of food in gastrointestinal tract.
A high degree of in vivo- in vitro correlation (IVIVC) is obtained
in osmotic systems.
5
8. CRITERIA FOR SELECTION OF A DRUG
Short biological Half-life (2- 6 hrs)
High potency
Required for prolonged treatment
(e.g: Nifedipine, Glipizide, Verapamil and Chlorpromazine
hydrochloride).
8
9. BASIC COMPONENTS
Drug
Osmotic agent
Semipermeable membrane
Coating material
Hyrophilic and hydrophobic polymers
Wicking agents
Pore forming agents
9
10. OSMOTIC AGENTS
Osmotic pressures for concentrated solution of soluble solutes
commonly used in controlled release formulations are extremely
high, ranging from 30 atm for sodium phosphate up to 500 atm for a
lactose-fructose mixture.
These osmotic pressures can produce high water flows across
semipermeable membranes .
10
11. OSMOTIC AGENTS
The osmotic water flow across a membrane is given by the equation,
dv/dt = Aθ∆π
l
Where,
dv/dt, is the rate of water flow across the membrane of area A,
thickness l, permeability θ in cm3, and ∆π.
11
12. OSMOTIC PRESSURE OF SATURATED SOLUTIONS OF COMMONLY
USED PHARMACEUTICAL SOLUTES
12
13. OSMOTIC PRESSURE OF SATURATED SOLUTIONS OF COMMONLY
USED PHARMACEUTICAL SOLUTES
13
14. SEMIPERMEABLE MEMBRANE
The membrane must possess certain performance criteria such as:
Sufficient wet strength and water permeability
Should be biocompatible
Rigid and non-swelling
Should be sufficient thick to withstand the pressure within the
device.
Any polymer that is permeable to water but impermeable to solute
can be used as a coating material in osmotic devices. e.g. Cellulose
esters like cellulose acetate, cellulose acetate butyrate, cellulose
triacetate and ethyl cellulose and Eudragits.
14
15. COATING MATERIAL
Different types and amount of plasticizers used in coating membrane
also have a significant importance in the formulation
of osmotic systems. They can change visco-elastic behavior of
polymers and these changes may affect the permeability of the
polymeric films. Some of the plasticizers used are as below:
Polyethylene glycols
Ethylene glycol monoacetate; and diacetate- for low permeability
Triethyl citrate
Diethyl tartarate or Diacetin- for more permeable films
15
16. HYDROPHILIC AND HYDROPHOBIC
POLYMERS
These polymers are used in the formulation development of osmotic
systems containing matrix core.
The selection of polymer is based on the solubility of drug as well as
the amount and rate of drug to be released from the pump.
16
17. WICKING AGENTS
The function of the wicking agent is to draw water to
surfaces inside the core of the tablet, thereby creating
channels or a network of increased surface area.
Examples are colloidon silicon dioxide, kaolin, titanium
dioxide, alumina, niacinamide, sodium lauryl sulphate
(SLS), low molecular weight polyvinyl pyrrolidone
(PVP), bentonite, magnesium aluminium silicate,
polyester and polyethylene, etc. 17
18. PORE FORMING AGENT
These agents are particularly used in the pumps
developed for poorly water soluble drug and in the
development of controlled porosity or multiparticulate
osmotic pumps.
The pore formers can be inorganic or organic and solid
or liquid in nature. Like,
Alkaline metal salts such as sodium chloride, sodium
bromide, potassium chloride, etc.
Alkaline earth metals such as calcium chloride and
calcium nitrate
Carbohydrates such as glucose, fructose, Lactose, etc.
18
20. RECENTLY IN USE OSMOTIC PUMP
20
Drug solution leaving via delivery portal
Removable cap
Flow moderator
Semipermeable membrane
Osmotic agent
Flexible impermeable reservoir wall
Reservoir
21. 21
Fig. : EOP
Limitations:
• SPM should be 200-300μm thick to withstand pressure
• Thick coatings lowers the water permeation rate
• Applicable mostly for water soluble drugs
ELEMENTRY OSMOTIC PUMP (EOP)
22. CONTROLLED POROSITY OSMOTIC PUMP
22
It is laser or micro driven orifice. When Controlled Porosity Osmotic
pump is placed in aqueous environment the water soluble component of
coating dissolves and forms micropores in membrane and water diffuses inside
the core through microporous membrane, setting up an osmotic gradiant and
thereby controlling the release of drug.
23. OSMOTIC BURSTING OSMOTIC PUMP
Core: API ± osmogents
Coat: Semi permeable membrane without delivery orifice
When placed in aqueous environment, water is imbibed and
hydraulic pressure is built up inside the system, then wall ruptures
and the contents are released.
It is used for pulsated release.
23
24. PUSH-PULL OSMOTIC PUMP (PPOP)
Core Tablet:
Layer 1: API ± osmogents
Layer 2: Polymeric osmotic agents
Coat: Semi permeable membrane with delivery orifice.
It is a bilayer tablet coated with semi permeable membrane.
The PPOP system consists of two compartments separated usually
by an elastic diaphragm. The upper compartment contains the drug
and is connected to the outside environment via a small delivery
orifice.
24
27. SANDWICHED OSMOTIC TABLETS (SOTS)
It is composed of polymeric push layer sandwiched between two
drug layers with two delivery orifices.
When placed in the aqueous environment the middle push layer
containing the swelling agents, swells and the drug is released from
the delivery orifices.
Advantage : the drug is released from the two orifices situated on
opposite sides of the tablet
27
30. DUROS OSMOTIC PUMP
30
Design :
Implantable drug-dispensing osmotic pump, shaped as a small
rod with titanium housing.
Mechanism : Through osmosis, water from the body is slowly drawn
through the semi-permeable membrane into the pump by osmotic
agent residing in the engine compartment, which expands the
osmotic agent and displaces a piston to dispense small amounts of
drug formulation from the drug reservoir through the orifice.
Application: Systemic or site-specific administration of a drug
33. ALZET OSMOTIC PUMP
33
Design: Empty reservoir within the core of the pump is filled with
the drug or hormone solution to be delivered and is surrounded by
salt chamber with impermeable layer between them.
Mechanism: Water enters into the salt chamber through
semipermeable membrane and causes compression of flexible
reservoir and delivery of drug solution.
Application: To deliver drugs, hormones, and other test agents
continuously at controlled rates from one day to six weeks.
39. FACTORS AFFECTING THE PERFORMANCE
OF OSMOTIC DRUG DELIVERY SYSTEM
Physico-chemical properties of the drug
Solubility
Solid or liquid
Viscosity (Liquids)
Rheological properties
Properties of osmotic agent
Osmotic pressure difference generated by the agent which
ultimately will decide the water influx and in turn the delivery
of active.
Membrane type and characteristics
Wet strength
Water permeability
Size of delivery orifice
Characteristics of the polymer used (e.g. Hydration,
Swelling etc.)
40. IN VITRO EVALUATION
The in vitro release of drugs from oral osmotic systems
has been evaluated by the conventional USP paddle and
basket type apparatus.
The dissolution medium is generally distilled water as
well as simulated gastric fluid (for first 2-4 h) and
intestinal fluids (for subsequent hours) have been used.
The standard specifications, which are followed for the
oral controlled drug delivery systems are equivalently
applicable for oral osmotic pumps.
In vivo evaluation of oral osmotic systems has been
carried out mostly in dogs. Monkeys can also be used but
in most of the studies the dogs are preferred.
41.
42. QUESTION BANK
What is ODDS? Why it is required? Enumerate recent advance in
controlled osmotic drug delivery system with their approaches.
What are ideal properties of semi permeable membrane? Suggest
few materials for this. Wright note on evaluation of osmotic pump.
Write a note on principle of osmotic drug delivery system.
Give advantage and disadvantage of osmotic drug delivery system.
Give name of osmotic pumps. Give detail on elementary osmotic
pump.
42
43. REFERENCES
43
Gupta Roop, Gupta Rakesh, Basniwal Pawan k, Rathore Garvendras,
Osmotically controlled oral drug delivery systems: a review, int. J. Ph. Sci.,
2009, 1(2), 269-275.
Gohel M.C Parikh .R.K, Shah. N.Y Osmotic drug delivery- an update,
pharmainfo.net, 2009, 7(2).
Lachman L., Liberman H. A., Kanig J. L., The theory and practise of
industrial pharmacy. 2nd Edition 1991, Varghese publishing house,
Pg. 455.
Aulton M. E., pharmaceutics the science of dosage form design. 2nd
Edition 2002, Churchill livingstone, Pg. 38, 39, 74, 304, 417.
Ajay Babu, M. Prasada Rao, Vijaya Ratna J, Controlled-porosity osmotic
pump tablets-an overview, jprhc.
Shailesh Sharma. Osmotic controlled drug delivery. Pharmainfo.net. 2008;
6(3).
44. Y. W. Chien, (2005), Novel Drug Delivery System,
2nd edition, Marcel Dekker,Inc., 1-3, 17-18, 33-36.
N. K. Jain and S. K. Jain, (1997), Controlled and
novel Drug Delivery, 1st edition, C.B.S. publishers
and distributors, 1-2.
M. C. Gohel, R. K. Parikh, N.Y. Shah, (2009),
Osmotic Drug Delivery: An Update.
R. K. Verma, D. M. Krishna and S. Garg, (2002),
Review article on Formulation aspects in the
development of osmotically controlled oral drug
delivery systems, J. Control. Release, 79, 7-27.
N. S. Parmar S. K. Vyas, N. Vaya, (2003),
Advances in Controlled and Novel Drug Delivery,
CBS publishers, 18-32
44
45. S. P. Vyas, R. K. Khar, Controlled Drug Delivery
Concepts and Advances, (2001), Vallabh
Prakashan, 170.
A.G. Thombre, A.R. DeNoto and D.G. Gibbes,
(1999), Delivery of glipizide from asymmetric
membrane capsules using encapsulated excipients,
J. Control. Release, 60, 333-341.
Partha Gan Chaudhuri, Satya Prakash Singh, A
Review Of Hydrogel-A Novel Drug Delivery
System.
X. Li and B.R. Osmotic Controlled Drug Delivery
Systems, In: Design of controlled release of drug
delivery systems, McGraw Hill, 203-229.
45