This document provides an overview of osmotic and enzymatic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the principles of osmotic drug delivery systems, which use osmotic pressure to release drugs in a controlled manner. The document classifies different types of osmotic pumps and discusses formulation considerations like drugs, semipermeable membranes, and osmogens. It also briefly introduces enzymatic drug delivery systems that rely on enzymatic activation to release drugs. Examples of marketed osmotic drug delivery products are also mentioned.
This document provides an overview of protein and peptide drug delivery. It begins with definitions of proteins and peptides and descriptions of protein structure. It then discusses protein functions and challenges with delivering proteins and peptides. These challenges include low permeability, enzyme degradation, short half-life, and immunogenicity. The document outlines various barriers to protein delivery, including enzymatic barriers and barriers at the intestinal epithelium, capillary endothelium, and blood-brain barrier. It also discusses physicochemical properties of proteins and peptides that impact delivery. Finally, it reviews various routes of delivery such as parenteral, pulmonary, and transdermal routes and technologies used for delivery like liposomes, hydrogels, emulsions, and pumps.
This document discusses three types of triggered drug delivery systems: bioerosion regulated, bioresponsive, and self-regulating. Bioerosion regulated systems use an immobilized enzyme on the surface of a polymer matrix to increase pH and degrade the polymer in the presence of a triggering agent. Bioresponsive systems control drug permeability through a bioresponsive membrane based on local biochemical concentrations. Self-regulating systems use competitive binding within a polymer encapsulated reservoir to activate drug release when triggered by a membrane permeable agent. Examples of insulin delivery are provided for the bioresponsive and self-regulating systems.
introduction to rate controlled drug delivery system , feedback & types of feedback regulated drug delivery system, example of each type of feedback regulated drug delivery system.
NIOSOMES , GENERAL CHARACTERISTICS OF NIOSOME , TYPES OF NIOSOMES , OTHERS TYPES OF NIOSOMES , NIOSOMES VS LIPOSOMES , COMPONENTS OF NIOSOMES , Non-ionic surfactant , Cholesterol , Charge inducing molecule , METHOD OF PREPARATION , preparation of small unilamellar vesicles , Sonication , Micro fluidization , preparation of large unilamellar vesicles , Reverse Phase Evaporation , Ether Injection , preparation of Multilamellar vesicles , Hand shaking method , Trans membrane pH gradient drug uptake process (remote loading) , Miscellaneous method :Multiple membrane extrusion method , The “Bubble” Method , Formation of Niosomes From Proniosomes , SEPARATION OF UNENTRAPPED DRUGS , Gel Filtration , Dialysis , Centrifugation , FACTORS AFFECTING THE PHYSICOCHEMICAL PROPERTIES OF NIOSOMES , Membrane Additives , Temperature of Hydration , PROPERTIES OF DRUGS , AMOUNT AND TYPE OF SURFACTANT
Structure of Surfactants , Resistance to Osmotic Stress , Characterization of niosomes ,Therapeutic applications of Niosomes , For Controlled Release of Drugs , To Improve the Stability and Physical Properties of the Drugs , For Targeting and Retention of Drug in Blood Circulation , Proniosomes , Aspasomes , Vesicles in Water and Oil System (v/w/o) ,Bola - niosomes , Discomes , Deformable niosomes or elastic niosomes , According to the nature of lamellarity ,Small Unilamellar vesicles (SUV) 25 – 500 nm in size.,Large Unilamellar vesicles (LUV) 0.1 – 1μm in size , Multilamellar vesicles (MLV) 1-5 μm in size , According to the size:Small Niosomes (100 nm – 200 nm) , Large Niosomes (800 nm – 900 nm),Big Niosomes (2 μm – 4 μm)
This document discusses various analytical techniques used to evaluate protein and peptide drug formulations, including stability testing, bioassays, UV spectroscopy, Bradford assay, differential scanning calorimetry, chromatography, and electrophoresis. Stability testing evaluates how environmental factors affect the quality of a drug over time. Bioassays assess potency by monitoring the in vitro or in vivo pharmacological response to the protein. UV spectroscopy, Bradford assay, and electrophoresis can be used to detect and quantify the amount of protein present in a sample. Chromatography and differential scanning calorimetry provide information about stability and conformational changes of proteins.
pH-activated and Enzyme-activated drug delivery systemSakshiSharma250807
As per the syllabus of M.Pharma (1st sem.) I have presented the topic pH-activated and Enzyme-activated. This comes under rate-controlled drug delivery system under the subject Drug delivery system. Best wishes from Sakshi Sharma
Description about a type of activation modulated drug delivery system, which a type of control drug delivery system.
Also, give a detailed description about each subclassification.
CrDDS is one which delivers the drug at a predetermined rate, for locally or systematically, for a prolong period of time.
This document provides information on pulmonary drug delivery systems and aerosols. It discusses the advantages of pulmonary drug delivery such as localized drug deposition reducing systemic exposure and avoidance of first-pass metabolism. Aerosols are defined as colloidal systems containing liquid/solid particles suspended in a propellant. The document outlines the manufacturing process, components, and quality control tests of aerosols including pressure filling, cold filling, and compressed gas filling apparatuses. Evaluation tests like flash point and flame projection are also mentioned.
This document provides an overview of protein and peptide drug delivery. It begins with definitions of proteins and peptides and descriptions of protein structure. It then discusses protein functions and challenges with delivering proteins and peptides. These challenges include low permeability, enzyme degradation, short half-life, and immunogenicity. The document outlines various barriers to protein delivery, including enzymatic barriers and barriers at the intestinal epithelium, capillary endothelium, and blood-brain barrier. It also discusses physicochemical properties of proteins and peptides that impact delivery. Finally, it reviews various routes of delivery such as parenteral, pulmonary, and transdermal routes and technologies used for delivery like liposomes, hydrogels, emulsions, and pumps.
This document discusses three types of triggered drug delivery systems: bioerosion regulated, bioresponsive, and self-regulating. Bioerosion regulated systems use an immobilized enzyme on the surface of a polymer matrix to increase pH and degrade the polymer in the presence of a triggering agent. Bioresponsive systems control drug permeability through a bioresponsive membrane based on local biochemical concentrations. Self-regulating systems use competitive binding within a polymer encapsulated reservoir to activate drug release when triggered by a membrane permeable agent. Examples of insulin delivery are provided for the bioresponsive and self-regulating systems.
introduction to rate controlled drug delivery system , feedback & types of feedback regulated drug delivery system, example of each type of feedback regulated drug delivery system.
NIOSOMES , GENERAL CHARACTERISTICS OF NIOSOME , TYPES OF NIOSOMES , OTHERS TYPES OF NIOSOMES , NIOSOMES VS LIPOSOMES , COMPONENTS OF NIOSOMES , Non-ionic surfactant , Cholesterol , Charge inducing molecule , METHOD OF PREPARATION , preparation of small unilamellar vesicles , Sonication , Micro fluidization , preparation of large unilamellar vesicles , Reverse Phase Evaporation , Ether Injection , preparation of Multilamellar vesicles , Hand shaking method , Trans membrane pH gradient drug uptake process (remote loading) , Miscellaneous method :Multiple membrane extrusion method , The “Bubble” Method , Formation of Niosomes From Proniosomes , SEPARATION OF UNENTRAPPED DRUGS , Gel Filtration , Dialysis , Centrifugation , FACTORS AFFECTING THE PHYSICOCHEMICAL PROPERTIES OF NIOSOMES , Membrane Additives , Temperature of Hydration , PROPERTIES OF DRUGS , AMOUNT AND TYPE OF SURFACTANT
Structure of Surfactants , Resistance to Osmotic Stress , Characterization of niosomes ,Therapeutic applications of Niosomes , For Controlled Release of Drugs , To Improve the Stability and Physical Properties of the Drugs , For Targeting and Retention of Drug in Blood Circulation , Proniosomes , Aspasomes , Vesicles in Water and Oil System (v/w/o) ,Bola - niosomes , Discomes , Deformable niosomes or elastic niosomes , According to the nature of lamellarity ,Small Unilamellar vesicles (SUV) 25 – 500 nm in size.,Large Unilamellar vesicles (LUV) 0.1 – 1μm in size , Multilamellar vesicles (MLV) 1-5 μm in size , According to the size:Small Niosomes (100 nm – 200 nm) , Large Niosomes (800 nm – 900 nm),Big Niosomes (2 μm – 4 μm)
This document discusses various analytical techniques used to evaluate protein and peptide drug formulations, including stability testing, bioassays, UV spectroscopy, Bradford assay, differential scanning calorimetry, chromatography, and electrophoresis. Stability testing evaluates how environmental factors affect the quality of a drug over time. Bioassays assess potency by monitoring the in vitro or in vivo pharmacological response to the protein. UV spectroscopy, Bradford assay, and electrophoresis can be used to detect and quantify the amount of protein present in a sample. Chromatography and differential scanning calorimetry provide information about stability and conformational changes of proteins.
pH-activated and Enzyme-activated drug delivery systemSakshiSharma250807
As per the syllabus of M.Pharma (1st sem.) I have presented the topic pH-activated and Enzyme-activated. This comes under rate-controlled drug delivery system under the subject Drug delivery system. Best wishes from Sakshi Sharma
Description about a type of activation modulated drug delivery system, which a type of control drug delivery system.
Also, give a detailed description about each subclassification.
CrDDS is one which delivers the drug at a predetermined rate, for locally or systematically, for a prolong period of time.
This document provides information on pulmonary drug delivery systems and aerosols. It discusses the advantages of pulmonary drug delivery such as localized drug deposition reducing systemic exposure and avoidance of first-pass metabolism. Aerosols are defined as colloidal systems containing liquid/solid particles suspended in a propellant. The document outlines the manufacturing process, components, and quality control tests of aerosols including pressure filling, cold filling, and compressed gas filling apparatuses. Evaluation tests like flash point and flame projection are also mentioned.
Nucleic acid based therapeutic drug delivery systemtadisriteja9
Nucleic acid based Drug delivery system is one of the trending research area, which i have taken and made as Powerpoint for easy and quick learning purpose
This document discusses single shot vaccines that can provide protection against multiple diseases with only one injection. It describes how single shot vaccines work by combining an antigen, adjuvant, and microsphere component that encapsulates and slowly releases the antigen. Key factors in developing these vaccines include controlling particle size, optimizing encapsulation efficiency, and regulating antigen release from the biodegradable microspheres. Single shot vaccines offer advantages like improved patient compliance and lower costs compared to traditional multi-dose vaccines.
Vaccines improve immunity to diseases. Single shot vaccines provide protection against 4-6 diseases with a single injection using microspheres to encapsulate antigens and provide delayed release for booster immunization. They are more economical and convenient than traditional multi-dose vaccines. However, single shot vaccines may be less effective than multi-dose vaccines and carry risks of stimulating the immune system or causing illness from live components.
This document discusses descriptive versus mechanistic modelling in the pharmaceutical industry. Descriptive models are used to describe data without understanding the underlying mechanism, while mechanistic models attempt to understand the data-generating process. Examples are provided of using non-parametric techniques like kernel regression for descriptive modelling and differential equation models for mechanistic modelling of tumor growth curves. The conclusion emphasizes that mechanistic models going beyond simple data fitting to incorporate scientific knowledge can help justify models and improve understanding of biological processes.
The document provides guidelines on validation of analytical procedures from the International Conference on Harmonisation (ICH) and the World Health Organization (WHO). It discusses validation characteristics like accuracy, precision, specificity, linearity, range, detection limit and quantitation limit that should be considered when validating identification tests, assays, and tests for impurities. It provides definitions for key terms and recommendations on how validation of these characteristics should be performed.
Pharmacokinetic, pharmacodynamic and biodistribution following oralOsaid Al Meanazel
This document summarizes the pharmacokinetic, pharmacodynamic and biodistribution profiles of orally administered nanoparticles containing peptide and protein drugs. It examines how nanoparticle formulations can alter the absorption, distribution, metabolism and excretion of peptides and proteins. The document discusses how physicochemical properties like size, charge and surface properties influence nanoparticle behavior. It also reviews existing data on the pharmacokinetics and pharmacodynamics of orally delivered peptide-loaded nanoparticles and discusses regulatory challenges and the need for more comprehensive studies.
This document discusses proteins and peptides. It defines proteins and peptides, noting that proteins are made of 50 or more amino acids linked by peptide bonds, while peptides are shorter polymers of amino acids. The document outlines several barriers to delivering proteins and peptides as drugs, including enzymatic barriers in the gastrointestinal tract, the intestinal epithelial barrier, the capillary endothelial barrier, and the blood-brain barrier. It also describes various mechanisms of transporting peptides and proteins across these barriers, such as passive and active transport, endocytosis, and movement through tight cell junctions.
The document discusses drug product performance evaluation through in vitro dissolution testing. It provides details on factors that influence drug dissolution like drug substance properties, formulation composition, manufacturing process, and dissolution test conditions. The key goals of in vitro drug product testing are to characterize drug potency and release rate from oral dosage forms, provide information for formulation development, and ensure quality, comparability and stability over time. Common tests include disintegration testing and dissolution testing using apparatus specified in pharmacopeias to simulate gastrointestinal conditions. The results of in vitro testing aid product development and assessment of shelf-life and quality.
This presentation includes the detail information about the physics of tablet compression and compaction, Compression, Effect of friction, distribution of forces, compaction profiles,solubility.
This document provides an overview of buccal drug delivery systems. It discusses the concepts, advantages, and disadvantages of buccal drug delivery. Key points include that the buccal mucosa is an ideal site for localized and systemic drug delivery. Advantages include avoidance of first-pass metabolism and selective delivery of peptides/proteins. The document reviews the anatomy and permeability of the oral mucosa, factors affecting transmucosal permeability, and ideal drug candidates. It also discusses mimosa membrane, permeability enhancers, and the mechanisms of mucoadhesion and drug absorption for buccal delivery systems.
This document discusses different types of rate controlled drug delivery systems. It begins by introducing controlled release drug delivery and distinguishing it from sustained release. It then classifies controlled release systems into three main categories: rate programmed, activation modulated, and feedback regulated systems. Within each category it describes several examples of systems, identifying how drug release is controlled in each case. Key factors that can affect controlled release are also listed. The document aims to provide an overview of controlled drug delivery technologies with classifications and examples.
This document discusses mechanical and pH activated drug delivery systems. Mechanical systems include metered dose inhalers, dry powder inhalers, and nebulizers which deliver drugs through physical activation. pH activated systems target drug delivery based on pH ranges in different body regions. They are classified as hydrogels, nanoparticles, microspheres, and microgels which protect drugs from gastric conditions and release them in the intestines based on pH changes. The advantages are site-specific delivery and protection of drugs, while disadvantages include non-biodegradability of polymers and lack of specificity between similar pH regions.
This document discusses mechanically activated drug delivery devices, specifically metered dose inhalers, dry powder inhalers, and nebulizers. Metered dose inhalers precisely deliver medication in aerosol form via inhalation. Dry powder inhalers use breath activation to deliver dry powder medication. Nebulizers convert liquid medication into an inhalable mist using compressed air or ultrasonic power. Each device type has advantages like precision or not requiring compressed gas, but also disadvantages such as potential waste or lower efficiency.
This document provides an overview of vaccine delivery systems. It discusses various types of delivery systems including particulate adjuvants like aluminum salts, virosomes, and cytokines. It also describes mucosal vaccine delivery systems and strategies for mucosal delivery including emulsion-type delivery, liposome-based delivery, and polymeric nano particles. The key advantages and disadvantages of different delivery approaches are highlighted.
Liposomes are spherical vesicles composed of a lipid bilayer membrane enclosing an aqueous core. They can encapsulate both hydrophilic and hydrophobic drugs. Liposomes offer several advantages for drug delivery such as increased drug efficacy, reduced toxicity, and ability to target specific tissues. They are classified based on lamellarity and size. Common preparation methods include thin film hydration, reverse phase evaporation, and detergent removal. Key properties evaluated include particle size, surface charge, drug encapsulation efficiency, and drug release kinetics. Liposomes have applications as carriers for drugs, proteins, genes, and imaging agents.
Aquasomes are nanoparticle carrier systems composed of a solid nanocrystalline core coated with polyhydroxy oligomers. They are able to protect fragile biological molecules through water-like properties and high surface exposure. Aquasomes are prepared through a self-assembly process involving interaction of charged groups, hydrogen bonding, and structural stability. This allows active loading of molecules like proteins, antigens, and genes. Characterization techniques confirm the structure, drug loading, and release kinetics of aquasomes, which have applications in delivery of vaccines, hemoglobin, insulin, and enzymes orally and intravenously.
Osmotic drug delivery uses the osmotic pressure of drug or other solutes (osmogens or osmagents) for controlled delivery of drugs. Osmotic drug delivery has come a long way since Australian physiologists Rose and Nelson developed an implantable pump in 1955.
The document discusses osmotic drug delivery systems (ODDS). It begins by defining osmosis and describing how osmotic pressure drives the movement of water across a semi-permeable membrane. It then discusses the advantages of ODDS such as zero-order delivery kinetics and independence from gastric pH. The document classifies several types of ODDS including elementary osmotic pumps, controlled porosity pumps, and push-pull pumps. It also describes components like the semi-permeable membrane and osmotic agents. In vitro evaluation methods and factors affecting ODDS performance are briefly covered.
OSMOTIC drug delivery system slideshare.pptxPratik Shinde
Introduction of osmotic drug delivery system.
Mechanism of osmosis.
Basic Components of Osmotic drug delivery System.
Classification of Osmotic Drug Delivery System.
Advantage & Disadvantage of Osmotic drug delivery system.
Newer technology in Osmotic drug delivery system.
Evaluation parameters of osmotic drug delivery system.
Marketed Formulations of Osmotic drug delivery system.
Case Study about osmotic drug delivery system.
Nucleic acid based therapeutic drug delivery systemtadisriteja9
Nucleic acid based Drug delivery system is one of the trending research area, which i have taken and made as Powerpoint for easy and quick learning purpose
This document discusses single shot vaccines that can provide protection against multiple diseases with only one injection. It describes how single shot vaccines work by combining an antigen, adjuvant, and microsphere component that encapsulates and slowly releases the antigen. Key factors in developing these vaccines include controlling particle size, optimizing encapsulation efficiency, and regulating antigen release from the biodegradable microspheres. Single shot vaccines offer advantages like improved patient compliance and lower costs compared to traditional multi-dose vaccines.
Vaccines improve immunity to diseases. Single shot vaccines provide protection against 4-6 diseases with a single injection using microspheres to encapsulate antigens and provide delayed release for booster immunization. They are more economical and convenient than traditional multi-dose vaccines. However, single shot vaccines may be less effective than multi-dose vaccines and carry risks of stimulating the immune system or causing illness from live components.
This document discusses descriptive versus mechanistic modelling in the pharmaceutical industry. Descriptive models are used to describe data without understanding the underlying mechanism, while mechanistic models attempt to understand the data-generating process. Examples are provided of using non-parametric techniques like kernel regression for descriptive modelling and differential equation models for mechanistic modelling of tumor growth curves. The conclusion emphasizes that mechanistic models going beyond simple data fitting to incorporate scientific knowledge can help justify models and improve understanding of biological processes.
The document provides guidelines on validation of analytical procedures from the International Conference on Harmonisation (ICH) and the World Health Organization (WHO). It discusses validation characteristics like accuracy, precision, specificity, linearity, range, detection limit and quantitation limit that should be considered when validating identification tests, assays, and tests for impurities. It provides definitions for key terms and recommendations on how validation of these characteristics should be performed.
Pharmacokinetic, pharmacodynamic and biodistribution following oralOsaid Al Meanazel
This document summarizes the pharmacokinetic, pharmacodynamic and biodistribution profiles of orally administered nanoparticles containing peptide and protein drugs. It examines how nanoparticle formulations can alter the absorption, distribution, metabolism and excretion of peptides and proteins. The document discusses how physicochemical properties like size, charge and surface properties influence nanoparticle behavior. It also reviews existing data on the pharmacokinetics and pharmacodynamics of orally delivered peptide-loaded nanoparticles and discusses regulatory challenges and the need for more comprehensive studies.
This document discusses proteins and peptides. It defines proteins and peptides, noting that proteins are made of 50 or more amino acids linked by peptide bonds, while peptides are shorter polymers of amino acids. The document outlines several barriers to delivering proteins and peptides as drugs, including enzymatic barriers in the gastrointestinal tract, the intestinal epithelial barrier, the capillary endothelial barrier, and the blood-brain barrier. It also describes various mechanisms of transporting peptides and proteins across these barriers, such as passive and active transport, endocytosis, and movement through tight cell junctions.
The document discusses drug product performance evaluation through in vitro dissolution testing. It provides details on factors that influence drug dissolution like drug substance properties, formulation composition, manufacturing process, and dissolution test conditions. The key goals of in vitro drug product testing are to characterize drug potency and release rate from oral dosage forms, provide information for formulation development, and ensure quality, comparability and stability over time. Common tests include disintegration testing and dissolution testing using apparatus specified in pharmacopeias to simulate gastrointestinal conditions. The results of in vitro testing aid product development and assessment of shelf-life and quality.
This presentation includes the detail information about the physics of tablet compression and compaction, Compression, Effect of friction, distribution of forces, compaction profiles,solubility.
This document provides an overview of buccal drug delivery systems. It discusses the concepts, advantages, and disadvantages of buccal drug delivery. Key points include that the buccal mucosa is an ideal site for localized and systemic drug delivery. Advantages include avoidance of first-pass metabolism and selective delivery of peptides/proteins. The document reviews the anatomy and permeability of the oral mucosa, factors affecting transmucosal permeability, and ideal drug candidates. It also discusses mimosa membrane, permeability enhancers, and the mechanisms of mucoadhesion and drug absorption for buccal delivery systems.
This document discusses different types of rate controlled drug delivery systems. It begins by introducing controlled release drug delivery and distinguishing it from sustained release. It then classifies controlled release systems into three main categories: rate programmed, activation modulated, and feedback regulated systems. Within each category it describes several examples of systems, identifying how drug release is controlled in each case. Key factors that can affect controlled release are also listed. The document aims to provide an overview of controlled drug delivery technologies with classifications and examples.
This document discusses mechanical and pH activated drug delivery systems. Mechanical systems include metered dose inhalers, dry powder inhalers, and nebulizers which deliver drugs through physical activation. pH activated systems target drug delivery based on pH ranges in different body regions. They are classified as hydrogels, nanoparticles, microspheres, and microgels which protect drugs from gastric conditions and release them in the intestines based on pH changes. The advantages are site-specific delivery and protection of drugs, while disadvantages include non-biodegradability of polymers and lack of specificity between similar pH regions.
This document discusses mechanically activated drug delivery devices, specifically metered dose inhalers, dry powder inhalers, and nebulizers. Metered dose inhalers precisely deliver medication in aerosol form via inhalation. Dry powder inhalers use breath activation to deliver dry powder medication. Nebulizers convert liquid medication into an inhalable mist using compressed air or ultrasonic power. Each device type has advantages like precision or not requiring compressed gas, but also disadvantages such as potential waste or lower efficiency.
This document provides an overview of vaccine delivery systems. It discusses various types of delivery systems including particulate adjuvants like aluminum salts, virosomes, and cytokines. It also describes mucosal vaccine delivery systems and strategies for mucosal delivery including emulsion-type delivery, liposome-based delivery, and polymeric nano particles. The key advantages and disadvantages of different delivery approaches are highlighted.
Liposomes are spherical vesicles composed of a lipid bilayer membrane enclosing an aqueous core. They can encapsulate both hydrophilic and hydrophobic drugs. Liposomes offer several advantages for drug delivery such as increased drug efficacy, reduced toxicity, and ability to target specific tissues. They are classified based on lamellarity and size. Common preparation methods include thin film hydration, reverse phase evaporation, and detergent removal. Key properties evaluated include particle size, surface charge, drug encapsulation efficiency, and drug release kinetics. Liposomes have applications as carriers for drugs, proteins, genes, and imaging agents.
Aquasomes are nanoparticle carrier systems composed of a solid nanocrystalline core coated with polyhydroxy oligomers. They are able to protect fragile biological molecules through water-like properties and high surface exposure. Aquasomes are prepared through a self-assembly process involving interaction of charged groups, hydrogen bonding, and structural stability. This allows active loading of molecules like proteins, antigens, and genes. Characterization techniques confirm the structure, drug loading, and release kinetics of aquasomes, which have applications in delivery of vaccines, hemoglobin, insulin, and enzymes orally and intravenously.
Osmotic drug delivery uses the osmotic pressure of drug or other solutes (osmogens or osmagents) for controlled delivery of drugs. Osmotic drug delivery has come a long way since Australian physiologists Rose and Nelson developed an implantable pump in 1955.
The document discusses osmotic drug delivery systems (ODDS). It begins by defining osmosis and describing how osmotic pressure drives the movement of water across a semi-permeable membrane. It then discusses the advantages of ODDS such as zero-order delivery kinetics and independence from gastric pH. The document classifies several types of ODDS including elementary osmotic pumps, controlled porosity pumps, and push-pull pumps. It also describes components like the semi-permeable membrane and osmotic agents. In vitro evaluation methods and factors affecting ODDS performance are briefly covered.
OSMOTIC drug delivery system slideshare.pptxPratik Shinde
Introduction of osmotic drug delivery system.
Mechanism of osmosis.
Basic Components of Osmotic drug delivery System.
Classification of Osmotic Drug Delivery System.
Advantage & Disadvantage of Osmotic drug delivery system.
Newer technology in Osmotic drug delivery system.
Evaluation parameters of osmotic drug delivery system.
Marketed Formulations of Osmotic drug delivery system.
Case Study about osmotic drug delivery system.
This document provides an overview of three types of rate controlled drug delivery systems: hydrodynamically balanced systems, osmotic pressure controlled systems, and pH dependent/independent systems.
Hydrodynamically balanced systems, also known as floating drug delivery systems, remain buoyant in the stomach for prolonged periods of time to increase bioavailability. Osmotic pressure controlled systems use osmotic pressure to provide zero-order drug release kinetics over extended times. pH dependent systems target drug delivery to specific regions of the GI tract based on pH, while pH independent systems aim to release drugs at a constant rate regardless of varying GI pH.
This document provides an overview of osmotic drug delivery systems. It defines key terms like osmosis and osmotic pressure. It describes the basic components and classifications of osmotic pumps, including elementary osmotic pumps, multi-chamber osmotic pumps, and controlled porosity osmotic pumps. Factors that can affect drug release from these systems are discussed, such as solubility, osmotic pressure, membrane properties, and use of excipients. Approaches to modify drug solubility for osmotic systems are also summarized.
Osmotically controlled drug delivery systems use osmotic pressure to control the release of drugs from a semipermeable membrane. When exposed to fluids, water flows across the membrane due to osmotic pressure differences. This causes the drug formulation to release through an orifice at a controlled, zero-order rate. There are several types of osmotic pumps including elementary, push-pull, and controlled porosity pumps. They offer advantages like controlled drug release independent of the environment or drug properties. However, these systems can be expensive to manufacture due to complex coating processes required.
The document discusses osmotic drug delivery systems (ODDS). It begins with an introduction that explains how ODDS use osmotic pressure to control drug release independently of physiological factors. It then covers key topics such as the concept of osmosis, principles of osmosis, basic components of ODDS, classification into implantable and oral systems, factors influencing design, and evaluation parameters. The document provides an overview of the technology and science behind ODDS for controlled drug delivery.
This document provides an overview of osmotic activated drug delivery systems. It begins with an introduction that explains osmotic pressure is used to release drugs in a controlled manner from these systems. The basic components, advantages, and disadvantages are then outlined. Several types of osmotic pumps are described in detail, including how they work and their applications. In summary, this document serves as a comprehensive review of osmotic drug delivery systems, their design principles, and performance characteristics.
The document discusses osmotic drug delivery systems. It defines osmosis and osmotic pressure, and describes the basic components of osmotic drug delivery systems including semipermeable membranes, osmogens, and drug formulations. It classifies osmotic systems as implantable or oral, and describes several types of oral osmotic pumps including elementary, modified, multi-chamber, controlled porosity, and monolithic systems. Key factors that affect drug release are also outlined. The document concludes by listing several marketed osmotic products.
This document discusses general methods for designing and evaluating osmotic pumps. It begins by introducing osmotic pumps and their advantages over other controlled drug delivery systems. It then describes the process of osmosis and differentiates it from diffusion. Various materials used in formulating osmotic pumps are outlined, including semi-permeable membranes, polymers, wicking agents, osmogens, and others. Different types of osmotic pumps are explained, such as implantable pumps and orally administered pumps. Specific examples of osmotic pumps are provided.
This document provides an overview of osmotic drug delivery systems. It discusses the introduction, advantages, mechanism, principle, and factors affecting the release rate of osmotic systems. The document also describes the formulation of osmotic drug delivery systems, including the core components like drugs, osmogens, and polymers, as well as coating components such as semipermeable membranes, plasticizers, and pore forming agents. The goal of the seminar is to discuss osmotic drug delivery and its application in pharmaceuticals for controlled drug release.
Osmotic activated Drug Delivery System Seminar(DDS).pptxankushawatale09
The document discusses osmotic activated drug delivery systems, which use osmotic pressure to control drug release through semi-permeable membranes. It describes the basic components, types including implantable pumps and oral pumps, marketed products, advantages of controlled release and improved compliance, and disadvantages like potential toxicity. Examples of marketed products incorporating various pump technologies are provided.
This document discusses osmotic controlled oral delivery systems. It provides advantages like continuous drug delivery at predictable rates independent of gastric conditions. Components include drugs, osmotic agents, and semipermeable membranes. Various osmotic pump types are described like elementary, push-pull, bursting. Applications include Glucotrol XL, Procardia XL, and other marketed products that use this technology to provide extended release of drugs.
This document discusses general methods for designing and evaluating osmotic pumps. It begins by introducing osmotic pumps and their advantages over other drug delivery systems. It then describes the key components of osmotic pumps including semi-permeable membranes, osmogens, and polymers. Finally, it discusses various types of osmotic pumps including elementary osmotic pumps, push-pull osmotic pumps, and controlled porosity osmotic pumps. The document provides an overview of the materials and mechanisms involved in osmotic pump drug delivery systems.
This document provides an overview of osmotic drug delivery systems. It discusses the basic components and principles of osmosis that osmotic drug delivery systems utilize. The key components discussed include the drug, osmogen, semipermeable membrane, and factors that affect drug release such as solubility, osmotic pressure, delivery orifice size, and membrane type. A variety of osmotic pump designs are also briefly mentioned.
Osmotic Drug Delivery System and basic components of Osmotic systemDhanashreeDavare
Introduction to Osmotic Drug Delivery System . Various Advantages and Disadvantages. Principle of osmosis.Basic components of Osmotic System. Osmotic Pumps
This document discusses osmotic drug delivery systems, specifically ALZET pumps. It begins by defining osmosis and osmotic pressure, and explaining how these principles are used in osmotic drug delivery. The basic components of osmotic drug delivery systems are then outlined, including the drug, semipermeable membrane, osmogens, and coatings. ALZET pumps are introduced as implantable osmotic pumps used in laboratory animals. Factors that affect drug release from these systems include drug solubility, osmotic pressure, delivery orifice size, and membrane properties. Evaluation methods and advantages like zero-order release and long duration of action are also summarized.
Osmotically Regulated Control System By Ashish Guptaashishmedatwal87
This document provides an overview of osmotically controlled drug delivery systems. It begins with an introduction to novel drug delivery systems and their advantages. It then discusses the principles of osmosis and factors that affect drug release rates from these systems such as osmotic pressure, membrane properties, and orifice size. The document classifies different types of osmotic delivery systems including oral, implantable, and advanced systems. It provides examples of components, commercially available products, and evaluation methods. In summary, the document reviews the fundamentals and design of osmotically controlled drug delivery to provide sustained and targeted drug release.
This document defines osmosis and osmotic pressure, and describes how osmotic systems utilize these principles for controlled drug delivery. It discusses the basic components of osmotic systems, including drugs, osmotic agents, semi-permeable membranes, and plasticizers. It also describes various types of osmotic systems for both oral and implantable drug delivery, including elementary osmotic pumps, push-pull osmotic pumps, and implantable mini-osmotic pumps. The document provides equations to describe drug release from these systems driven by osmotic pressure.
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1. OSMOTIC AND ENZYMATIC DRUG
DELIVERY SYSTEM
SUBMITTED BY:-
ARAVINDA D
1ST SEM M PHARM
Dept of pharmaceutics
V . V. Puram college of pharmacy
Bangalore-70
SUBMITTED TO:-
Dr. KALAVATHY D J
Professor dept of
pharmaceutics
V.V. Puram college of
pharmacy
Bangalore-70
1
3. INTRODUCTION
Osmotic systems are the most reliable controlled drug delivery systems
(CDDS) and can be employed as oral drug delivery systems.
Osmotic pressure is used as the driving force in ODDS to release the drug
a controlled manner.
3
4. Osmosis :-
It refers to the process of movement of solvent from lower
concentration of solute towards higher concentration of solute across the
semipermeable membrane.
Osmotic pressure:
The pressure exerted by the flow of water through a semipermeable
membrane separating two solutions with different concentrations of solute.
These systems can be used for both route of administration i.e. oral and
parenteral. 4
5. PRINCIPLE OF ODDS:-
ODDS works on the principle of osmosis. i.e. movement of water across a
selectively permeable membrane driven by a difference in osmotic
across the membrane.
On the basis of this principle osmotic drug delivery gives better drug
not depends on concentration of drug and better results than any other
controlled release system.
The mechanism in this involves ,when exposed to water, semipermeable
membrane permeable to water into the core , causes dissolution of soluble
the core, and pumping of the solution out of the orifice taken place.
5
6. For the drug delivery system containing a solution formulation, the intrinsic rate
of drug release is defined by,
𝑸
𝒕
=
𝑷𝒘𝑨𝒎
𝒉𝒎
𝝅𝒔 − 𝝅𝑬
For the drug delivery system containing a solid formulation, the intrinsic rate of
drug release is defined by ,
𝑸
𝒕
=
𝑷𝒘𝑨𝒎
𝒉𝒎
𝝅𝒔 − 𝝅𝑬 Sd
6
7. Where,
Q/t - rate of drug release
Pw - permeability of semipermeable housing
Am -effective of semipermeable housing
hm - thickness of semipermeable housing
(π s - π e ) – Differential osmotic pressure b/w DDS with osmotic pressure πs & environmental
osmotic pressure πe
Sd – Aqueous solubility of drug contained in the solid formulation.
7
8. ADVANTAGES:-
They typically give a zero order release profile after an initial lag.
Drug release is independent of gastric pH and hydrodynamic condition.
Decrease dosing frequency.
Increased safety margin of high potency drugs.
Drug release from the OCODDSs exhibits significant in vitro-in vivo
correlation [IVIVC] within specific limits.
Release rate of drug is highly predictable and programmable.
Enhanced bioavailability of drug.
8
9. DISADVANTAGES:-
It is Highly expensive.
If the coating process is not well controlled there is a risk of film defects,
which results in dose dumping.
Retrieval of therapy is not possible in the case of unexpected adverse event
Rapid development of tolerance.
Release of drug depends on : -
• size of drug port
• surface area
• thickness and composition of membrane
9
11. DRUGS :-
Drugs should have short half life (2-6 hrs.),highly potent and used for
prolonged treatment
Solubility of drug should be moderate i.e. not very high or very low.
Ex:- Diltiazem HCL , Metoprolol , Glipizide , Verapamil ,etc.….
SEMIPERMEABLE MEMBRANE:-
SPM must possess certain performances criteria:-
It must be sufficient wet strength and wet modules.
This membrane should be more permeable to water.
It should be sufficient thick to withstand the pressure within the device
It is made up of polymer hence that is permeable to water but impermeable
solute(drug and excipients)
Ex:- Cellulose Acetate, Cellulose Triacetate and Ethyl Cellulose.
11
12. OSMOGENS OR OSMOTIC AGENTS:-
These are used to achieve the constant osmotic pressure in the compartment.
These are classified into two types:-
a) Water soluble salts of inorganic acids
Ex:- Magnesium chloride, potassium or sodium chloride , sodium or
potassium hydrogen phosphate etc…
b) Water soluble salts of organic acids
Ex:- Sodium and potassium acetate , magnesium succinate , sodium
benzoate, sodium citrate etc…
c)Carbohydrates
Ex:-mannose, sucrose , maltose, lactose etc…
12
13. POLYMERS:-
These are used for making drug containing matrix core.
Ex:- Hydrophilic polymers are hydroxy ethyl cellulose, carboxy
methylcellulose,
hpmc etc.…
Hydrophobic polymers are ethyl cellulose wax materials etc..
SOLUBILIZING AGENTS:-
Agents that inhibits crystal formation of the drugs .
Ex:- PVP, PEG, and Cyclodextrin
A high HLB surfactant, particularly anionic surfactants (e.g., Tween 20,
60, 80, long chain anionic surfactants such as SLS)
Plasticizers:-
Permeability of membranes can be increased by adding plasticizer,
which increases the water diffusion coefficient.
Ex:-PEG , phthalates, benzoates, etc.. 13
14. WICKING AGENTS:-
It helps to draw water to surfaces inside the core of the tablet, thereby
creating channels or a network of increased surface area.
Ex:-SLS, PVP, bentonite etc..
COATING SOLVENTS:-
Used for manufacturing the walls of the osmotic device.
Ex:-acetone and methanol 80:20,
acetone and water 90:10
14
15. CLASSIFICATION OF OSMOTIC PUMP
They are generally classified onto two types:-
Implantable osmotic drug delivery system
Rose nelson pump
Higuchi leeper osmotic pump
Higuchi theeuwes osmotic pump
Oral osmotic drug delivery system
Elementary osmotic pump
Multi chamber osmotic pump
.expandable
.non expandable
Push pull osmotic pump
Sandwiched osmotic pump
Controlled porosity osmotic pump
Multi particulate delayed release
Mono lithic osmotic system 15
16. ROSE NELSON PUMP:-
The first osmotic pump developed in 1955 for the delivery of drugs to the sheep
and cattle gut
It composed of three chambers water, salt and drug chambers.
The difference in osmotic pressure across the membrane moves water from the
water chamber in to the salt chamber.
The volume of chamber increases because of this water flow, which distends the
latex diaphragm separating the salt and drug chambers, thereby pumping drug
out of the device.
16
17. Higuchi leeper osmotic pump
It has no water chamber, and the activation of the device occurs after
imbibition of the water from surrounding environment.
Widely employed for veterinary use. It is either swallowed or implanted in
body of an animal for delivery of antibiotics or growth hormones to animal.
Porous Membrane Support MgSO4 Movable Separator Drug Chamber Rigid
Housing Satd. Sol. Of MgSO4. Solid MgSO4 Semi-permeable Membrane.
17
18. Higuchi theeuwes osmotic pump:-
When this pump is exposed to water, the core imbibes water osmotically at a
controlled rate, determined by the membrane permeability to water and by the
osmotic pressure of the core formulation.
As the membrane is non expandable, the increase in volume caused by the
imbibition of water leads to the development of hydrostatic pressure inside the
tablet.
This pressure is relieved by the flow of saturated solution out of the device
through the delivery orifice.
18
19. Elementary osmotic pump
• It is fabricated as a tablet coated with semi permeable membrane, usually
cellulose acetate
• When this coated tablet is exposed to an aqueous environment, the osmotic
pressure of the soluble drug inside the tablet draws water through the
semipermeable coating and a saturated aqueous solution of drug is formed
the device. The membrane is non- extensible and the increase in volume due to
inhibition of water raises the hydrostatic pressure inside the tablet, eventually
leading to flow of saturated solution of active agent out of the device through a
small orifice.
19
20. PUSH PULL OSMOTIC PUMP
It is a modification of EOP, it can delivered both poorly water soluble and highly water
soluble drugs at a constant rate.
When the system is placed in aqueous environment, water is attracted into the tablet by
an osmotic agent in both the layers. The osmotic attraction in the drug layer pulls water
into the compartment to form in situ a suspension of drug.
The osmotic agent in the nondrug layer simultaneously attracts water into that
compartment, causing it to expand volumetrically, and the expansion of nondrug layer
pushes the drug suspension out of the delivery orifice .
20
21. SANDWICHED OSMOTIC PUMP
It is composed of polymeric push layer sandwiched between two drug layers with two
delivery orifices.
When placed in the aqueous environment, the middle push layer containing the swelling
agents' swells and the drug is released from the two orifices situated on opposite sides of
the tablet
21
22. CONTROLLED POROSITY OSMOTIC PUMP:-
It is an osmotic tablet wherein the delivery orifices (holes) are formed in situ through
leaching of water soluble pore-forming agents incorporated in semipermeable membrane
(SPM)
Drug release rate from CPOP depends on various factors like coating thickness,
solubility of drug in tablet core, level of leachable pore-forming agent(s) and the osmotic
pressure difference across the membrane.
22
23. MARKETED PRODUCTS OF OSMOTIC DRUG DELIVERY SYSTEM
Products Incorporating ALZA's OROS® Technology
A. Cardura® XL (doxazosin mesylate) sold in Germany for the treatment of
hypertension.
B. B. Covera-HS® (verapamil) a Controlled Release system for the
of hypertension and angina pectoris.
C. C. Sudafed® (pseudoephedrine) for 24-hour relief of cold and other
respiratory allergies.
D. D. Procardia XL® (nifedipine) extended-release tablet for the treatment of
angina and hypertension.
Products Incorporating ALZA's DUROS® Implant Technology
A. Viadur® (leuprolide acetate implant) delivers leuprolide continuously for 12
months.
23
24. ENZYME ACTIVATED DRUG DELIVERY SYSTEM
This type of biochemical system depends on the enzymatic process to activate
release of drug.
Drug reservoir is either physically entrapped in microspheres or chemically
bound to polymer chains from biopolymers (albumins or polypeptides).
The release of drug is activated by enzymatic hydrolysis of biopolymers
(albumins or polypeptides) by specific enzyme in target tissue.
Ex. Albumin microspheres release 5-fluorouracil in a controlled manner by
protease – activated biodegradation.
24