This document provides information on various organic chemistry reactions including:
1. Sandmeyer and Gatterman reactions which introduce halides into benzene rings using diazonium salts.
2. Finkelstein, Swarts, and Wurtz reactions which involve halogen exchange or formation of hydrocarbons.
3. Friedel-Crafts reactions which alkylate or acylate benzene rings using alkyl/acyl halides and Lewis acids.
Dakin reaction- organic and Heterocyclic chemistry- As per PCI syllabusAkhil Nagar
The Dakin reaction involves the replacement of an aldehyde group on ortho and para hydroxy and ortho amino-benzaldehyde (or ketone) compounds with a hydroxyl group when reacted with alkaline hydrogen peroxide. The mechanism involves the aldehyde group being oxidized by hydrogen peroxide to a carboxyl group, which then undergoes base hydrolysis to form the hydroxyl substituted product.
The document summarizes the Gattermann reaction, which is a chemical reaction that formylates aromatic compounds. Specifically, it involves treating benzene or its derivatives with hydrogen cyanide and hydrogen chloride in the presence of aluminum chloride. This leads to the formation of an electrophile that attacks the benzene ring. After hydrolysis, it produces benzaldehyde or substituted benzaldehydes. The reaction is named after German chemist Ludwig Gattermann and provides a method for obtaining chlorobenzene or bromobenzene.
The document summarizes Friedel-Crafts reactions, which involve attaching substituents to aromatic rings using Lewis acid catalysts. It describes two main types - alkylation and acylation reactions. The alkylation involves reacting an alkyl halide with an aromatic compound, forming a cation that undergoes electrophilic aromatic substitution. Acylation involves reacting an acyl chloride with an aromatic compound to form a ketone. Both proceed by generation of a carbocation which is attacked by the aromatic ring. Dealkylation can also occur in the reverse using protons or Lewis acids to remove alkyl groups.
Stereochemistry of biaryls and ansa compoundsAnzar Sk
This document discusses the stereochemistry of biaryls. It introduces biaryl structures and describes their substituents and relative orientations. Charts and diagrams are used to illustrate biaryl configurations and interplanar angles. The R-S nomenclature system for assigning stereochemistry is also introduced, using diagrams to show how substituents are positioned around a central chiral plane or atom.
Industrial chemistry lecture on sulfuric acid (ji&rb)Lisa Pluis
Sulfuric acid has strong acidic properties, is colorless and oily, and is produced industrially via the contact process. It is widely used in applications like lead-acid batteries, fertilizer production, metal pickling, and manufacture of other acids due to its dehydrating ability. Exposure can cause severe burns and its atmospheric emissions contribute to acid rain.
A presentation covering the various methods of prevention of corrosion. Material selection, design of structures, alteration of materials, alteration of environment, cathodic & anodic protection, and coatings are the different methods used. These are briefly described.
1. The Wacker process oxidizes ethylene to acetaldehyde using a palladium and copper chloride catalyst. Ethylene coordinates to Pd which inserts an oxygen atom and isomerizes to acetaldehyde. CuCl2 helps reoxidize Pd to continue the catalytic cycle.
2. Metal-oxo complexes catalyze many oxidation reactions including allylic oxidation, olefin metathesis, aromatic oxidation, water oxidation, alkene dihydroxylation, and epoxidation of alkenes. These complexes form reactive M=O bonds.
3. Phase-transfer catalysis improves reactions of anionic oxo complexes by using large organic cations to transfer the oxo anion
Dakin reaction- organic and Heterocyclic chemistry- As per PCI syllabusAkhil Nagar
The Dakin reaction involves the replacement of an aldehyde group on ortho and para hydroxy and ortho amino-benzaldehyde (or ketone) compounds with a hydroxyl group when reacted with alkaline hydrogen peroxide. The mechanism involves the aldehyde group being oxidized by hydrogen peroxide to a carboxyl group, which then undergoes base hydrolysis to form the hydroxyl substituted product.
The document summarizes the Gattermann reaction, which is a chemical reaction that formylates aromatic compounds. Specifically, it involves treating benzene or its derivatives with hydrogen cyanide and hydrogen chloride in the presence of aluminum chloride. This leads to the formation of an electrophile that attacks the benzene ring. After hydrolysis, it produces benzaldehyde or substituted benzaldehydes. The reaction is named after German chemist Ludwig Gattermann and provides a method for obtaining chlorobenzene or bromobenzene.
The document summarizes Friedel-Crafts reactions, which involve attaching substituents to aromatic rings using Lewis acid catalysts. It describes two main types - alkylation and acylation reactions. The alkylation involves reacting an alkyl halide with an aromatic compound, forming a cation that undergoes electrophilic aromatic substitution. Acylation involves reacting an acyl chloride with an aromatic compound to form a ketone. Both proceed by generation of a carbocation which is attacked by the aromatic ring. Dealkylation can also occur in the reverse using protons or Lewis acids to remove alkyl groups.
Stereochemistry of biaryls and ansa compoundsAnzar Sk
This document discusses the stereochemistry of biaryls. It introduces biaryl structures and describes their substituents and relative orientations. Charts and diagrams are used to illustrate biaryl configurations and interplanar angles. The R-S nomenclature system for assigning stereochemistry is also introduced, using diagrams to show how substituents are positioned around a central chiral plane or atom.
Industrial chemistry lecture on sulfuric acid (ji&rb)Lisa Pluis
Sulfuric acid has strong acidic properties, is colorless and oily, and is produced industrially via the contact process. It is widely used in applications like lead-acid batteries, fertilizer production, metal pickling, and manufacture of other acids due to its dehydrating ability. Exposure can cause severe burns and its atmospheric emissions contribute to acid rain.
A presentation covering the various methods of prevention of corrosion. Material selection, design of structures, alteration of materials, alteration of environment, cathodic & anodic protection, and coatings are the different methods used. These are briefly described.
1. The Wacker process oxidizes ethylene to acetaldehyde using a palladium and copper chloride catalyst. Ethylene coordinates to Pd which inserts an oxygen atom and isomerizes to acetaldehyde. CuCl2 helps reoxidize Pd to continue the catalytic cycle.
2. Metal-oxo complexes catalyze many oxidation reactions including allylic oxidation, olefin metathesis, aromatic oxidation, water oxidation, alkene dihydroxylation, and epoxidation of alkenes. These complexes form reactive M=O bonds.
3. Phase-transfer catalysis improves reactions of anionic oxo complexes by using large organic cations to transfer the oxo anion
Quinoline is a colorless liquid with a strong odor that is slightly soluble in water. It has various industrial uses including in the manufacture of dyes, as a precursor to hydroxyquinoline and cyanine dyes, and in the production of herbicides and pesticides. Quinoline undergoes electrophilic substitution on the benzene ring and can be synthesized through the Skraup reaction involving aniline, glycerol, and an oxidizing agent. It is also produced commercially via the Combes quinoline synthesis which condenses anilines with β-diketones.
The Gattermann-Koch reaction is a chemical reaction discovered in 1897 by German chemists Ludwig Gattermann and Julius Arnold Koch. It involves the formylation (addition of an aldehyde group) of aromatic compounds using a mixture of carbon monoxide, hydrogen chloride, and anhydrous aluminum chloride catalyst. The unstable formyl chloride intermediate reacts to add the formyl group to the aromatic ring, producing an aromatic aldehyde such as benzaldehyde from benzene.
IMPORTANT NAMED REACTIONS in Organic synthesis with Introduction, General Mechanism, and their synthetic application covering more than 20 named reactions in it.
There are two main types of corrosion: dry corrosion which occurs in the absence of moisture, and wet corrosion which occurs in the presence of a conducting medium. Some common forms of corrosion include uniform corrosion, localized corrosion such as pitting and crevice corrosion, intergranular corrosion, stress corrosion cracking, and galvanic corrosion. Methods to prevent corrosion include proper metal selection, equipment design considerations, coatings and linings, altering the environment, using corrosion inhibitors, and cathodic protection methods like sacrificial anodes or impressed current systems.
Organic Chemistry Name Reaction with mechanisms 140TusharRanjanNath
140 name reactions in brief. Its mechanisms and advantages and disadvantages. All structures were made by individuals without pasting from other sources.
Application of emf measurements for pH Determination by S E Bhandarkarsubodhbhandarkar1
This document discusses indicator and reference electrodes used in electrochemistry. It describes the construction and working of hydrogen, quinhydrone, and glass indicator electrodes, as well as the calomel reference electrode. It also shows how to determine pH using each of these indicator electrodes by measuring the cell potential (Ecell) and relating it to pH through the Nernst equation. The key points are that the electrode with the higher oxidation potential is placed on the left side, and pH can be calculated from the cell potential and other known values.
Surface chemistry ppt CLASS 12 CBSE CHAPTER 5ritik
- Adsorption is the accumulation of molecular species at the surface of a solid or liquid rather than in the bulk. The substance that accumulates is called the adsorbate and the surface it accumulates on is the adsorbent.
- Examples of adsorption include gases accumulating on charcoal surfaces, dye molecules accumulating on charcoal when added to solutions, and aqueous sugar solutions becoming colorless when passed over beds of charcoal.
- There are two main types of adsorption - physical adsorption (physisorption) due to weak van der Waals forces, and chemical adsorption (chemisorption) due to chemical bonding between adsorbate and adsorbent.
A 1,3-dipolar cycloaddition is a fascinating and diverse reaction that can be used in stepwise syntheses of large molecules, such as masked aldol reactions, and has potential biological applications. While it is an incredibly useful reactions, is also has a simple mechanism.
Contributed by: Created by Alexandra Kent and Judy Zhu (Undergraduates)Edited by Margaret Hilton
Honors Organic Chemistry
University of Utah
Protection and deprotection of Functional group in synthethis of new compounds.Pragati Shah
These slides are about Protection and de protection of Functional group in synthesis of new compounds. Protecting group in synthesis of molecules play an important role.
The document discusses the concept of umpolung in organic chemistry, which is the reversal of polarity of a functional group through chemical modification. Specifically, it describes strategies for temporarily modifying carbonyl groups so that the carbon behaves as a nucleophile rather than an electrophile. Several methods are presented for generating equivalents of formyl and acyl anions, including using derivatives of 1,3-dithianes, nitroalkanes, cyanohydrins, enolethers, and lithium acetylides, which allow the "umpolung" of carbonyl reactivity and new disconnection pathways in retrosynthesis. An example of using a dithiane approach in the synthesis of the antibiotic vermic
The Schmidt reaction involves reacting an azide with a carbonyl compound like an aldehyde, ketone, or carboxylic acid under acidic conditions. This results in the formation of an amine or amide with the expulsion of nitrogen. The reaction was first reported in 1924 by Karl Friedrich Schmidt and involves the migration of a carbonyl substituent to the nitrogen atom of the azide. The Schmidt reaction is useful for synthesizing natural products and can be made enantioselective. Problems include site selectivity and potential tetrazole side product formation, though reaction conditions can be adjusted to control these issues.
The Schmidt reaction involves reacting an azide with a carbonyl compound like an aldehyde, ketone, or carboxylic acid under acidic conditions. This results in the formation of an amine or amide with the expulsion of nitrogen. The reaction was first reported in 1924 by Karl Friedrich Schmidt and involves the migration of a carbonyl substituent to the nitrogen atom of the azide. The Schmidt reaction is useful for synthesizing amines, amides, nitriles, and lactams and has been applied to natural product synthesis. It can proceed intramolecularly and variants have been developed to achieve enantioselectivity.
Corrosion is the degradation or destruction of a metal due to a reaction with its environment. It occurs via either a chemical or electrochemical process. There are four requirements for electrochemical corrosion to occur: an anode, cathode, electrically conductive medium, and a metallic path connecting the anode and cathode. Corrosion can cause economic losses through damage to structures and equipment, reduce safety, and waste limited metal resources. It is important to study corrosion to prevent failures and catastrophic accidents while extending equipment lifetime in a cost-effective manner.
Favorskki and benzillic acid rearrangementushaSanmugaraj
The document discusses molecular rearrangements, specifically the Favorskii and benzylic acid rearrangements. It explains that rearrangements involve the migration of a group from one atom to an adjacent atom. The Favorskii rearrangement involves the base-catalyzed rearrangement of α-haloketones to form carboxylic acids or derivatives. The benzylic acid rearrangement involves the rearrangement of α-diketones to form α-hydroxy acids when treated with strong bases through migration of an aryl group. Both rearrangements proceed through carbon-carbon bond formation between the migrating group and an adjacent carbon atom.
The document discusses several carbon-carbon bond forming reactions:
1. Aldol condensation allows aldehydes and ketones to undergo self-condensation in the presence of a base to form β-hydroxy carbonyl compounds.
2. The Perkin reaction uses an acid anhydride to form α,β-unsaturated aromatic acids from aromatic aldehydes.
3. The Wittig reaction converts a carbonyl group to an alkene using a phosphonium ylide.
Corrosion is the deterioration of materials due to chemical or electrochemical reaction with the environment. It is an inevitable process that leads to significant economic losses. Corrosion engineering studies corrosion mechanisms and works to prevent or control corrosion economically and safely. Common types of corrosion include galvanic, erosion, crevice, pitting, and microbiologically influenced corrosion. Factors that influence corrosion include the metal properties, environmental conditions like temperature, pH, and presence of ions. Protection methods include material selection, cathodic protection, modifying the environment, metallic coatings, inorganic coatings, and organic coatings.
The Simmons-Smith reaction involves the addition of dichloromethylzinc to an alkene to form a cyclopropane ring. The reaction proceeds through a carbene intermediate that inserts into the carbon-carbon double bond of the alkene in a stereospecific manner, with trans-alkenes yielding trans-cyclopropanes and cis-alkenes yielding cis-cyclopropanes. Examples of the reaction forming cyclopropane rings are shown, along with unstable cyclic intermediates that can form from beta-ketoesters or gamma-ketoesters.
1) The document discusses various reactions of carbonyl compounds including aldehydes and ketones.
2) It describes reactions with nucleophiles like hydride ions, amines, alcohols and Grignard reagents that add to the carbonyl group.
3) It also discusses reactions where the alpha-hydrogen of carbonyl compounds is removed, making the alpha-carbon nucleophilic and able to react with electrophiles via substitutions and additions. Important reactions covered include halogenation, alkylation and aldol additions.
Quinoline is a colorless liquid with a strong odor that is slightly soluble in water. It has various industrial uses including in the manufacture of dyes, as a precursor to hydroxyquinoline and cyanine dyes, and in the production of herbicides and pesticides. Quinoline undergoes electrophilic substitution on the benzene ring and can be synthesized through the Skraup reaction involving aniline, glycerol, and an oxidizing agent. It is also produced commercially via the Combes quinoline synthesis which condenses anilines with β-diketones.
The Gattermann-Koch reaction is a chemical reaction discovered in 1897 by German chemists Ludwig Gattermann and Julius Arnold Koch. It involves the formylation (addition of an aldehyde group) of aromatic compounds using a mixture of carbon monoxide, hydrogen chloride, and anhydrous aluminum chloride catalyst. The unstable formyl chloride intermediate reacts to add the formyl group to the aromatic ring, producing an aromatic aldehyde such as benzaldehyde from benzene.
IMPORTANT NAMED REACTIONS in Organic synthesis with Introduction, General Mechanism, and their synthetic application covering more than 20 named reactions in it.
There are two main types of corrosion: dry corrosion which occurs in the absence of moisture, and wet corrosion which occurs in the presence of a conducting medium. Some common forms of corrosion include uniform corrosion, localized corrosion such as pitting and crevice corrosion, intergranular corrosion, stress corrosion cracking, and galvanic corrosion. Methods to prevent corrosion include proper metal selection, equipment design considerations, coatings and linings, altering the environment, using corrosion inhibitors, and cathodic protection methods like sacrificial anodes or impressed current systems.
Organic Chemistry Name Reaction with mechanisms 140TusharRanjanNath
140 name reactions in brief. Its mechanisms and advantages and disadvantages. All structures were made by individuals without pasting from other sources.
Application of emf measurements for pH Determination by S E Bhandarkarsubodhbhandarkar1
This document discusses indicator and reference electrodes used in electrochemistry. It describes the construction and working of hydrogen, quinhydrone, and glass indicator electrodes, as well as the calomel reference electrode. It also shows how to determine pH using each of these indicator electrodes by measuring the cell potential (Ecell) and relating it to pH through the Nernst equation. The key points are that the electrode with the higher oxidation potential is placed on the left side, and pH can be calculated from the cell potential and other known values.
Surface chemistry ppt CLASS 12 CBSE CHAPTER 5ritik
- Adsorption is the accumulation of molecular species at the surface of a solid or liquid rather than in the bulk. The substance that accumulates is called the adsorbate and the surface it accumulates on is the adsorbent.
- Examples of adsorption include gases accumulating on charcoal surfaces, dye molecules accumulating on charcoal when added to solutions, and aqueous sugar solutions becoming colorless when passed over beds of charcoal.
- There are two main types of adsorption - physical adsorption (physisorption) due to weak van der Waals forces, and chemical adsorption (chemisorption) due to chemical bonding between adsorbate and adsorbent.
A 1,3-dipolar cycloaddition is a fascinating and diverse reaction that can be used in stepwise syntheses of large molecules, such as masked aldol reactions, and has potential biological applications. While it is an incredibly useful reactions, is also has a simple mechanism.
Contributed by: Created by Alexandra Kent and Judy Zhu (Undergraduates)Edited by Margaret Hilton
Honors Organic Chemistry
University of Utah
Protection and deprotection of Functional group in synthethis of new compounds.Pragati Shah
These slides are about Protection and de protection of Functional group in synthesis of new compounds. Protecting group in synthesis of molecules play an important role.
The document discusses the concept of umpolung in organic chemistry, which is the reversal of polarity of a functional group through chemical modification. Specifically, it describes strategies for temporarily modifying carbonyl groups so that the carbon behaves as a nucleophile rather than an electrophile. Several methods are presented for generating equivalents of formyl and acyl anions, including using derivatives of 1,3-dithianes, nitroalkanes, cyanohydrins, enolethers, and lithium acetylides, which allow the "umpolung" of carbonyl reactivity and new disconnection pathways in retrosynthesis. An example of using a dithiane approach in the synthesis of the antibiotic vermic
The Schmidt reaction involves reacting an azide with a carbonyl compound like an aldehyde, ketone, or carboxylic acid under acidic conditions. This results in the formation of an amine or amide with the expulsion of nitrogen. The reaction was first reported in 1924 by Karl Friedrich Schmidt and involves the migration of a carbonyl substituent to the nitrogen atom of the azide. The Schmidt reaction is useful for synthesizing natural products and can be made enantioselective. Problems include site selectivity and potential tetrazole side product formation, though reaction conditions can be adjusted to control these issues.
The Schmidt reaction involves reacting an azide with a carbonyl compound like an aldehyde, ketone, or carboxylic acid under acidic conditions. This results in the formation of an amine or amide with the expulsion of nitrogen. The reaction was first reported in 1924 by Karl Friedrich Schmidt and involves the migration of a carbonyl substituent to the nitrogen atom of the azide. The Schmidt reaction is useful for synthesizing amines, amides, nitriles, and lactams and has been applied to natural product synthesis. It can proceed intramolecularly and variants have been developed to achieve enantioselectivity.
Corrosion is the degradation or destruction of a metal due to a reaction with its environment. It occurs via either a chemical or electrochemical process. There are four requirements for electrochemical corrosion to occur: an anode, cathode, electrically conductive medium, and a metallic path connecting the anode and cathode. Corrosion can cause economic losses through damage to structures and equipment, reduce safety, and waste limited metal resources. It is important to study corrosion to prevent failures and catastrophic accidents while extending equipment lifetime in a cost-effective manner.
Favorskki and benzillic acid rearrangementushaSanmugaraj
The document discusses molecular rearrangements, specifically the Favorskii and benzylic acid rearrangements. It explains that rearrangements involve the migration of a group from one atom to an adjacent atom. The Favorskii rearrangement involves the base-catalyzed rearrangement of α-haloketones to form carboxylic acids or derivatives. The benzylic acid rearrangement involves the rearrangement of α-diketones to form α-hydroxy acids when treated with strong bases through migration of an aryl group. Both rearrangements proceed through carbon-carbon bond formation between the migrating group and an adjacent carbon atom.
The document discusses several carbon-carbon bond forming reactions:
1. Aldol condensation allows aldehydes and ketones to undergo self-condensation in the presence of a base to form β-hydroxy carbonyl compounds.
2. The Perkin reaction uses an acid anhydride to form α,β-unsaturated aromatic acids from aromatic aldehydes.
3. The Wittig reaction converts a carbonyl group to an alkene using a phosphonium ylide.
Corrosion is the deterioration of materials due to chemical or electrochemical reaction with the environment. It is an inevitable process that leads to significant economic losses. Corrosion engineering studies corrosion mechanisms and works to prevent or control corrosion economically and safely. Common types of corrosion include galvanic, erosion, crevice, pitting, and microbiologically influenced corrosion. Factors that influence corrosion include the metal properties, environmental conditions like temperature, pH, and presence of ions. Protection methods include material selection, cathodic protection, modifying the environment, metallic coatings, inorganic coatings, and organic coatings.
The Simmons-Smith reaction involves the addition of dichloromethylzinc to an alkene to form a cyclopropane ring. The reaction proceeds through a carbene intermediate that inserts into the carbon-carbon double bond of the alkene in a stereospecific manner, with trans-alkenes yielding trans-cyclopropanes and cis-alkenes yielding cis-cyclopropanes. Examples of the reaction forming cyclopropane rings are shown, along with unstable cyclic intermediates that can form from beta-ketoesters or gamma-ketoesters.
1) The document discusses various reactions of carbonyl compounds including aldehydes and ketones.
2) It describes reactions with nucleophiles like hydride ions, amines, alcohols and Grignard reagents that add to the carbonyl group.
3) It also discusses reactions where the alpha-hydrogen of carbonyl compounds is removed, making the alpha-carbon nucleophilic and able to react with electrophiles via substitutions and additions. Important reactions covered include halogenation, alkylation and aldol additions.
Haloalkanes and Haloarenes Topic 2 Class XII By Kailash BhattKailashBhatt21
This document describes several methods for preparing haloalkanes and haloarenes. Haloalkanes can be prepared from alcohols by replacing the hydroxyl group with a halogen, from alkenes by addition of hydrogen halides or halogens, or by halide exchange reactions like the Finkelstein or Swarts reactions. Haloarenes can be prepared through electrophilic substitution of arenes with halogens, from diazonium salts using the Sandmeyer reaction, or by halogenation of aromatic hydrocarbons.
The document summarizes various reactions of aldehydes and ketones. It describes how aldehydes and ketones undergo nucleophilic addition reactions, with the nucleophile attacking the carbonyl carbon. This forms an alkoxide intermediate which gives an alcohol upon protonation. It also discusses the relative reactivities of aldehydes and ketones, hydrate and cyanohydrin formation, imine formation, oxidation and reductions of carbonyl compounds, acetal formation, and the Wittig reaction.
Aldehydes and ketones contain a carbonyl group (>C=O) and can undergo numerous reactions. In aldehydes, the carbonyl is bonded to one alkyl group and one hydrogen. In ketones, it is bonded to two alkyl groups. Common reactions include reduction to alcohols using LiAlH4 or NaBH4, addition of Grignard reagents, and reactions involving the acidic alpha-hydrogens like benzoin condensation, Cannizzaro reaction, and Clemmenson reduction. Other important reactions are the Wittig reaction, Knoevenagel condensation, Wolf-Kishner reduction, and Baeyer-Villiger oxidation.
Amides are named by replacing the suffix -oic acid in the carboxylic acid name with -amide. Nitriles are named by adding the suffix -nitrile to the alkane name. The nitrile carbon is assigned position 1. α-Hydrogen atoms of carbonyl compounds are acidic due to stabilization of the resulting enolate anion. This allows for halogenation and reactions involving enolate intermediates, such as aldol condensations.
This document discusses various aldol condensation reactions and their mechanisms. It introduces crossed aldol condensation which produces up to four products from two different carbonyl compounds. Self-aldol condensation uses a single aldehyde or ketone. Intramolecular aldol condensation occurs when a molecule contains two carbonyl groups. Several industrial reactions are also summarized, including the Aldox process, Perkin reaction, and Meerwein-Ponndorf-Verley reaction. In conclusion, these reactions are reversible and complete conversion can be achieved through excess alcohol or acetone removal.
Aldehydes and ketones are the carbonyl compounds with general formula CnH2nO. Aldehydes have at least one hydrogen atom bonded to the carbonyl group and other group is either hydrogen or an alkyl or aryl group (i.e. Aldehyde has one alkyl or aryl group and one of the hydrogen bonded to the carbonyl carbon) with characteristics functional group -CHO.
CBSE Class 12 Chemistry Chapter 10 (Haloalkanes and Haloarenes) | Homi InstituteHomi Institute
Haloalkanes and haloarenes are formed by the replacement of hydrogen atoms in hydrocarbons by halogen atoms. Haloalkanes contain halogen atoms attached to sp3 hybridized carbon atoms of an alkyl group, while haloarenes contain halogen atoms attached to sp2 hybridized carbon atoms of an aryl group. These compounds find wide applications in industry and medicine as solvents, starting materials for synthesis, and components of drugs like chloroquine and halothane. They can be prepared from alcohols, hydrocarbons, and other precursors using various reactions.
This document summarizes information about haloalkanes and haloarenes. It discusses the formation, classification, properties and reactions of alkyl halides and aryl halides.
Key points include:
1) Haloalkanes are formed by replacing a hydrogen atom in an alkane with a halogen atom. Haloarenes are formed similarly by replacing hydrogen in an aromatic hydrocarbon.
2) Alkyl halides and aryl halides can be classified based on the number of halogen substituents as well as their position on the carbon chain or ring.
3) The physical properties of haloalkanes and haloarenes, such as melting point and boiling point, depend on factors like the
Alkenes are unsaturated hydrocarbons that contain at least one carbon-carbon double bond. They have the general formula CnH2n. Some key properties of alkenes include being less dense than alkanes and having boiling points that increase with molecular weight. Alkenes undergo addition reactions, such as adding halogens, hydrogen halides, hydrogen, and water across the double bond. The addition occurs according to Markovnikov's rule, where the negative part of the additive joins to the carbon with fewer hydrogen atoms. Alkenes can be prepared from alkynes, alkyl halides, and alcohols through reactions like reduction, dehydrohalogenation, and dehydration.
Alkenes and their preparation-HYDROCARBONS PART 2ritik
Alkenes can be prepared through various methods including reduction of alkynes, dehydrohalogenation of alkyl halides, dehydration of alcohols, and heating vicinal dihalogen derivatives with zinc dust. Addition reactions of alkenes follow Markovnikov's rule or anti-Markovnikov's rule in the presence of peroxides. Alkenes undergo addition reactions with halogens, hydrogen halides, water, sulfuric acid and undergo oxidation, ozonolysis, and polymerization.
aldehyde, any of a class of organic compounds in which a carbon atom shares a double bond with an oxygen atom, a single bond with a hydrogen atom, and a single bond with another atom or group of atoms (designated R in general chemical formulas and structure diagrams).
ORGANIC CHEMISTRY 3
CARBONYL COMPOUND
These are organ compounds with Carbonyl group as functional group
If the carbonyl compound is directly bonded to two alkyl groups two aryl groups or one group and one aryl group, the resulting carbonyl compound known as KETONE.
I.e. General structure of kenton can be represented as ( )where R and R' can be alkyl or aryl group
This document provides an overview of 10 common chemical oxidation reactions that can convert alcohols to aldehydes and ketones. It describes the reagents, reaction mechanisms, advantages/disadvantages, and examples for each reaction, including Jones oxidation, PCC oxidation, Swern oxidation, Dess-Martin periodinane oxidation, MnO2 oxidation, Babler oxidation, Corey-Kim oxidation, Parikh-Doering oxidation, Fetizon oxidation, and Oppenauer oxidation.
In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C=O. It is common to several classes of organic compounds, as part of many larger functional groups.
Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
Gender and Mental Health - Counselling and Family Therapy Applications and In...PsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
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You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
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Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
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LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
1. Grade 12
Organic Chemistry – Specific Name Reactions
Class XII
Sandmeyer Reaction
The Cl , Br and CN nucleophiles can easily be introduced in the benzene ring of benzene diazonium salt in the
presence of Cu(I) ion. This reaction is called Sandmeyer reaction.
Gatterman Reaction
Chlorine or bromine can be introduced in the benzene ring by treating the benzene diazonium salt solution with
corresponding halogen acid in the presence of copper powder. This is referred as Gatterman reaction.
Note: The yield in Sandmeyer reaction is found to be better than Gattermann reaction.
Balz-Schiemann Reaction
When arenediazonium chloride is treated with fluoroboric acid, arene diazonium fluoroborate is precipitated
which on heating decomposes to yield aryl fluoride.
Finkelstein Reaction
Alkyl iodides are often prepared by the reaction of alkyl chlorides/ bromides with NaI in dry acetone. This
reaction is known as Finkelstein reaction.
Note: This reaction in forward direction can be favoured by precipitating NaX formed in dry acetone (according
to Le Chatelier’s principle).
2. Grade 12
Swarts Reaction
Heating an alkyl chloride/bromide in the presence of a metallic fluoride such as AgF, Hg2F2, CoF2 or SbF3 gives
alkyl fluorides. The reaction is termed as Swarts reaction.
Note: Finkelstein Reaction and Swarts Reaction are known as halogen exchange reaction.
Wurtz Reaction
Alkyl halides react with sodium in dry ether to give hydrocarbons containing double the number of carbon atoms
present in the halide. This reaction is known as Wurtz reaction.
Wurtz-Fittig Reaction
A mixture of an alkyl halide and aryl halide gives an alkylarene when treated with sodium in dry ether and is
called Wurtz-Fittig reaction.
Fittig Reaction
Aryl halides also give analogous compounds when treated with sodium in dry ether, in which two aryl groups are
joined together. It is called Fittig reaction.
Friedel-Crafts alkylation Reaction
When benzene is treated with an alkyl halide in the presence of anhydrous aluminium chloride, alkylbenene is
formed.
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Note: Aromatic carboxylic acids do not undergo Friedel-Crafts reaction because the carboxyl group is
deactivating and the catalyst aluminium chloride (Lewis acid) gets bonded to the carboxyl group.
Friedel-Crafts acylation reaction
The reaction of benzene with an acyl halide or acid anhydride in the presence of Lewis acids (AlCl3) yields acyl
benzene.
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Reimer-Tiemann Reaction
On treating phenol with chloroform in the presence of sodium hydroxide, a –CHO group is introduced at ortho
position of benzene ring resulting salicylaldehyde. This reaction is known as Reimer - Tiemann reaction.
Kolbe’s Reaction
Phenol with sodium hydroxide gives sodium phenoxide ion which with carbon dioxide in acidic medium results
hydroxybenzoic acid (salicylic acid). This is known as Kolbe’s reaction.
Rosenmund Reduction
Acyl chloride (acid chloride) is hydrogenated over catalyst, palladium on barium sulphate. This reaction is called
Rosenmund reduction.
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Stephen reaction
Nitriles are reduced to corresponding imine with stannous chloride in the presence of hydrochloric acid, which
on hydrolysis give corresponding aldehyde. This reaction is called Stephen reaction.
Etard reaction
Chromyl chloride oxidizes methyl group to a chromium complex, which on hydrolysis gives corresponding
benzaldehyde. This reaction is called Etard reaction.
Gatterman – Koch reaction
When benzene or its derivative is treated with carbon monoxide and hydrogen chloride in the presence of
anhydrous aluminium chloride or cuprous chloride, it gives benzaldehyde or substituted benzaldehyde. This
reaction is known as Gatterman-Koch reaction.
Clemmensen Reduction
The carbonyl group of aldehydes and ketones is reduced to CH2 group on treatment with zinc-
amalgam and concentrated hydrochloric acid. This is known as Clemmensen reduction.
Wolff Kishner Reduction
The carbonyl group of aldehydes and ketones is reduced to CH2 group on treatment with hydrazine followed by
heating with sodium or potassium hydroxide in high boiling solvent such as ethylene glycol. This is known
Wolff Kishner reduction.
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Tollens’ test
On warming an aldehyde with freshly prepared ammoniacal silver nitrate solution (Tollens’ reagent), a bright
silver mirror is produced due to the formation of silver metal. The aldehydes are oxidised to corresponding
carboxylate anion. The reaction occurs in alkaline medium.
Fehling’s test
Fehling reagent comprises of two solutions, Fehling solution A and Fehling solution B. Fehling solution A is
aqueous copper sulphate and Fehling solution B is alkaline sodium potassium tartarate (Rochelle salt). These two
solutions are mixed in equal amounts before test. On heating an aldehyde with Fehling’s reagent, a reddish
brown precipitate is obtained. Aldehydes are oxidised to corresponding carboxylate anion. Aromatic aldehydes
do not respond to this test.
Aldol reaction
Aldehydes and ketones having at least one α-hydrogen undergo a reaction in the presence of dilute alkali as
catalyst to form β-hydroxy aldehydes (aldol) or β-hydroxy ketones (ketol), respectively. This is known as Aldol
reaction. The name aldol is derived from the names of the two functional groups, aldehyde and alcohol, present
in the products.
Aldol condensation.
The aldol and ketol readily lose water to give α,β-unsaturated carbonyl compounds which are aldol condensation
products and the reaction is called Aldol condensation.
Cross aldol condensation:
When aldol condensation is carried out between two different aldehydes and / or ketones, it is called cross aldol
condensation. If both of them contain α-hydrogen atoms, it gives a mixture of four products.
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Cannizzaro reaction:
Aldehydes which do not have an α-hydrogen atom, undergo self oxidation and reduction (disproportionation)
reaction on treatment with concentrated alkali. In this reaction, one molecule of the aldehyde is reduced to
alcohol while another is oxidised to carboxylic acid salt.
Kolbe electrolysis
An aqueous solution of sodium or potassium salt of a carboxylic acid on electrolysis gives alkane containing
even number of carbon atoms.It is decarboxylation reaction. The reaction is known as Kolbe electrolysis.
Hell-Volhard-Zelinsky (HVZ )reaction.
Carboxylic acids having an α-hydrogen are halogenated at the α-position on treatment with chlorine or bromine
in the presence of small amount of red phosphorus to give α-halocarboxylic acids. The reaction is known as
Hell-Volhard-Zelinsky reaction.
Gabriel phthalimide synthesis
Gabriel synthesis is used for the preparation of pure primary amines.
Phthalimide on treatment with ethanolic potassium hydroxide forms potassium salt of phthalimide which on
heating with alkyl halide followed by alkaline hydrolysis produces the corresponding primary amine.
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Note: Aromatic primary amines cannot be prepared by this method because aryl halides do not undergo
nucleophilic substitution with the anion formed by phthalimide.
Hoffmann bromamide degradation reaction
An amide with bromine in an aqueous or ethanolic solution of sodium hydroxide gives primary amines.
In this degradation reaction, migration of an alkyl or aryl group takes place from carbonyl carbon of the amide to
the nitrogen atom. The amine so formed contains one carbon less than that present in the amide.
Carbylamine reaction
Aliphatic and aromatic primary amines on heating with chloroform and ethanolic potassium hydroxide form
isocyanides or carbylamines which are foul smelling substances. This reaction is known as carbylamines
reaction or isocyanide test.
Note: Secondary and tertiary amines do not show this reaction and is used as a test for primary amines.
Hinsberg’s Test
Benzenesulphonyl chloride (C6H5SO2Cl), which is also known as Hinsberg’s reagent, reacts with primary and
secondary amines to form sulphonamides.
(a) The reaction of benzenesulphonyl chloride with primary amine yields N-ethylbenzenesulphonyl amide. The
hydrogen attached to nitrogen in sulphonamide is strongly acidic due to the presence of strong electron
withdrawing sulphonyl group. Hence, it is soluble in alkali.
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(b) In the reaction with secondary amine, N,N-diethyl- benzenesulphonamide is formed. Since N, N-
diethylbenzene sulphonamide does not contain any hydrogen atom attached to nitrogen atom, it is not acidic and
hence insoluble in alkali.
(c) Tertiary amines do not react with benzenesulphonyl chloride.
Note: This test is used for the distinction of primary, secondary and tertiary amines and also for the separation of
a mixture of amines. However, these days benzenesulphonyl chloride is replaced by p-toluenesulphonyl chloride.
Coupling Reactions:
Benzene diazonium chloride reacts with phenol in which the phenol molecule at its para position is
coupled with the diazonium salt to form p-hydroxyazobenzene. This type of reaction is known as coupling
reaction.
Similarly the reaction of diazonium salt with aniline yields p-aminoazobenzene.