The human body consists of 11 major organ systems that work together to keep the body functioning properly. The key organ systems include the integumentary, skeletal, muscular, nervous, endocrine, cardiovascular, lymphatic, digestive, respiratory, urinary, and reproductive systems. Each system is made up of various organs that work in coordination to carry out important tasks like protection, support, movement, coordination, regulation, transport, absorption, excretion, and reproduction.