Opioids are narcotic analgesics that bind to opioid receptors in the central and peripheral nervous systems to relieve pain. The major opioid receptors are mu, kappa, and sigma. Opioids produce analgesia by inhibiting neurotransmitter release presynaptically and by hyperpolarizing neurons postynaptically. Opioids are classified as agonist, agonist-antagonist, partial agonist, or antagonist depending on their receptor activity. Common opioids include morphine, codeine, hydromorphone, oxymorphone, pethidine, tramadol, methadone, fentanyl, remifentanil, buprenorphine, and naltrexone.
Neurohumoral transmission in CNS-
The term neurohumoral transmission designates the transfer of a nerve impulse from a presynaptic to a postsynaptic neuron by means of a humoral agent e.g. a biogenic amine, an amino acid or a peptide.
Neurohumoral transmission in CNS-
The term neurohumoral transmission designates the transfer of a nerve impulse from a presynaptic to a postsynaptic neuron by means of a humoral agent e.g. a biogenic amine, an amino acid or a peptide.
cholinergic receptors definetion and classifcation to 1-nicotinic and 2-muscarinic ...and their subtybes ..... then the sites and the mechanism ... and last the drugs effect
Neurohumoral transmission in CNS ,special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin and dopamine
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
This ppt provides the detailed about the bradykinin and their physiological and pharmacological actions and their generation and their mechanisms in detailed manner.
cholinergic receptors definetion and classifcation to 1-nicotinic and 2-muscarinic ...and their subtybes ..... then the sites and the mechanism ... and last the drugs effect
Neurohumoral transmission in CNS ,special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin and dopamine
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
This ppt provides the detailed about the bradykinin and their physiological and pharmacological actions and their generation and their mechanisms in detailed manner.
I am sharing this ppt on topic Narcotic Analgesia and it's antagonist. In that we include the Narcotic Receptors, Narcotic Analgesic introduction and mechanism of Action also i was explained about Narcotic Antagonist.
Some narcotic analgesics combine an opioid with aspirin, acetaminophen, or ibuprofen. Examples include: Percodan (chemical name: oxycodone and aspirin), Percocet and Roxicet (chemical name: oxycodone and acetaminophen), Vicodin, Lorcet, and Lortab (chemical name: hydrocodone and acetaminophen).
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Thesis Statement for students diagnonsed withADHD.ppt
Opioids analgesics medichem i
1. Opioids analgesics
Mrs. Asha Suryawanshi
Asst. Professor
M. Pharm(Pharmaceutical Chemistry)
SDDVCOP & RC New Panvel
2. Opioids are the narcotic analgesics that relieve pain by binding to opioid
receptors, which are present in the central and peripheral nervous system.
It can cause numbness and induce a state of unconsciousness
DEFINATION
3. Receptor CNS Location Response on
activation
µ Brain( laminae III & IV of the
cortex, thalamus) spinal cord
µi suprasipnal analgesics,
physical dependence .
µ2 Respiratory
depression,Miosis
sulphoria reduced
gastrointestinal motility
K Brain (hypothalamus,periqueuctal
gray, clustrum)
Spinal
analgesia,diuresis,dysph
oria, sedation, miosis,
depersonalization and
derealization
σ Brain (pontine nucleus olfactory
bulbs, deep cortex)
Analgeia ,may be
associated with mood
change
OPIOIDS RECEPTORS
4. MECHANISM OF ACTION
All opioid receptors are G-protein coupled
receptors and inhibit adenylate cyclase.
They are also involved in
Post synaptic µ receptor activation-
Increasing K+ Efflux .increases
hyperpolarization
Pre synaptic µ receptor activation- Reducing
pre synaptic Ca++ influx
Thus inhibit neuronal activity
7. MOA
Opioid drugs, typified by morphine, produce their pharmacological actions,
including analgesia, by acting on receptors located on neuronal cell membranes.
The presynaptic action of opioids to inhibit neurotransmitter release is considered to be their
major effect in the nervous system.
Uses :
1) This medication is used to treat severe pain.
2) Morphine belongs to a class of drugs known as opioid analgesics.
3)It works in the brain to change how your body feels and responds to pain.
10. MOA
Codeine is an opioid and an agonist of the mu opioid receptor.
It acts on the central nervous system to have an analgesic effect.
It is metabolized in the liver to produce morphine which is ten times more potent
against the µ receptor.
Uses
1) Codeine is used to treat mild to moderate pain and to relieve coughing.
2) It is also used to treat diarrhea and diarrhea-predominant irritable bowel syndrome.
3) It is a weak analgesic.
4) It is used in combination with paracetamol or with ibuprofen to relieve pain
12. MOA
It is an opioid agonist that binds to several opioid
receptors. Its analgesic characteristics are through its effect on the
mu-opioid receptors. It also
acts centrally at the level medulla,
depressing the respiratory drive and suppressing cough.
Uses
An opioid analgesic used to treat moderate to severe pain when the use
of an opioid is indicated.
13. Oxymorphone
MOA: An opioid analgesic with actions and uses similar to those
of morphine, apart from an absence of cough suppressant activity.
Uses:
It is used in the treatment of moderate to severe pain, including pain in
obstetrics.
15. MOA:
Pethidine is often employed in the treatment of
postanesthetic shivering. The pharmacologic mechanism of
this antishivering effect is not fully understood,but it may
involve the stimulation of κ-opioid receptors
Uses:
Pethidine is the most widely used opioid in labour and
deliverybut has fallen out of favour
Pethidine is the preferred painkiller for diverticulitis,
because it decreases intestinal intraluminal pressure
16. Tramodol
Tramadol induces analgesic effects through a variety of
different targets on the noradrenergic system, serotoninergic
system and opioid receptors system
17. MOA:
Tramadol is a centrally acting analgesic with a multimode of action. It acts on
serotonergic and noradrenergic nociception, while its metabolite
O-desmethyltramadol acts on the µ-opioid receptor.
Its analgesic potency is claimed to be about one tenth that of morphine.
Uses:
Tramadol (a schedule IV drug in the US) is used primarily to treat mild to
severe pain, both acute and chronic. There is moderate evidence for use
as a second-line treatment for fibromyalgia but is not FDA approved for
this use
19. MOA:
Methadone hydrochloride is a µ-agonist; a synthetic opioid analgesic with
multiple actions qualitatively similar to those of morphine, the most
prominent of which involves the central nervous system and organs
composed of smooth muscle
Uses:
The principal therapeutic uses for methadone are for analgesia and for
detoxification or maintenance in opioid addiction. The methadone
abstinence syndrome, although qualitatively similar to that of morphine,
differs in that the onset is slower, the course is more prolonged, and the
symptoms are less severe.
21. Uses:
Remifentanil is used as an opioid analgesic that has a rapid onset and
rapid recovery time. It has been used effectively during craniotomies ,
spinal surgery,cardiac surgery , and gastric bypass surgery .While
opiates function similarly, with respect to analgesia,
the pharmacokinetics of Remifentanil allows for quicker post-
operative recovery.
23. MOA:
It is a µ agonist. It has high lipophilic character and can
easily crosses blood brain barrier and enters central Nervous system
Uses
1) It is opioid analgesic. It is about 80 times more active than
Morphine.
2) It is given in combination with general analgesthetics to produce surgical analgesic
3) It helpful in maintaining the state of neuroleptanalgesia
25. Uses:
Pentazocine is used primarily to treat pain, although its analgesic effects
are subject to a ceiling effect.
It has been discontinued by its corporate sponsor in Australia, although
it may be available through the special access scheme
MOA:
It is believed to work by activating (agonizing)
κ-opioid receptors (KOR) and blocking (antagonizing) μ-
opioid receptors
27. Uses:
Buprenorphine is an opioid used to treat opioid use disorder, acute pain, and chronic
pain.
It can be used under the tongue (sublingual), in the cheek (buccal), by injection
(intravenous) as a skin patch (transversal), or as an implant.
MOA:
Buprenorphine is a partial agonist at the mu receptor, meaning that
it only partially activates opiate receptors.
It is also a weak kappa receptor antagonist and delta receptor
agonist. It is a potent analgesic that acts on the central nervous
system (CNS).
29. MOA:
Uses:
Naltrexone belongs to a class of drugs known as opiate antagonists.
It works in the brain to prevent opiate effects
(e.g., feelings of well-being, pain relief).
It also decreases the desire to take opiates. This medication is also
used to treat alcohol abuse.