CARDIAC TAMPONADE ( Cardiac emergency) • Cardiac Tamponade is a life threatening complication caused by excessive accumulation of fluid in the pericardium. Or • Compression of all cardiac chambers due to excessive accumulation of pericardial fluid leading to compromised cardiac out put.
Mitral valve replacement is a procedure whereby the diseased mitral valve of a patients heart is replaced by either a mechanical or tissue(bioprosthetic )valve.’
CARDIAC TAMPONADE ( Cardiac emergency) • Cardiac Tamponade is a life threatening complication caused by excessive accumulation of fluid in the pericardium. Or • Compression of all cardiac chambers due to excessive accumulation of pericardial fluid leading to compromised cardiac out put.
Mitral valve replacement is a procedure whereby the diseased mitral valve of a patients heart is replaced by either a mechanical or tissue(bioprosthetic )valve.’
complication of myocardial infarction,There are some complications in myocardial infarction , a disease resulting from complications of myocardial infarction can be very dangerous because it can lead to cardiogenic shock
Valvular heart disease is any cardiovascular disease process involving one or more of the four valves of the heart (the aortic and mitral valves on the left side of heart and the pulmonic and tricuspid valves on the right side of heart).
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Nursing Care of Clients with Valvular Disorders
1. Maria Carmela L. Domocmat, RN, MSN
Instructor, School of Nursing
Northern Luzon Adventist College
2. valves of the heart control the flow of blood
through the heart into the pulmonary artery
and aorta
by opening and closing in response to the BP
changes as the heart contracts and relaxes.
atrioventricular valves and semilunar valves
8/23/2012 Maria Carmela L. Domocmat
3. separate the atria from the ventricles
tricuspid valve
separates the right atrium from the right ventricle
has three leaflets
mitral valve
separates the left atrium from the left ventricle
has Two leaflets
both valves have chordae tendineae that anchor
the valve leaflets to the papillary muscles and
ventricular wall.
8/23/2012 Maria Carmela L. Domocmat
5. located between the ventricles and their
corresponding arteries.
pulmonic valve
lies between right ventricle and pulmonary artery;
aortic valve
Lies between the left ventricle and the aorta
8/23/2012 Maria Carmela L. Domocmat
8. Annulus: a (fibrous) ringlike structure, or any
body part that is shaped like a ring
Commissure: a site of union of corresponding
parts; specifically, the sites of junction
between adjacent cusps of the heart valves.
http://medical-dictionary.thefreedictionary.com/commissure
8/23/2012 Maria Carmela L. Domocmat
9. Chordae tendineae: thread-like bands of
fibrous tissue that attach on one end to the
edges of the tricuspid and mitral valves of the
heart and on the other end to the papillary
muscles.
Papillary muscles: small muscle within the
heart that anchors the heart valves.
http://medical-dictionary.thefreedictionary.com/commissure
8/23/2012 Maria Carmela L. Domocmat
10. 1 Heart Valves, ana phy.flv
8/23/2012 Maria Carmela L. Domocmat
11. DISORDERS OF THE MITRAL DISORDERS OF THE AORTIC
VALVE VALVE
mitral valve prolapse aortic regurgitation
mitral regurgitation aortic stenosis
mitral stenosis
Tricuspid and pulmonic valve disorders
usually with fewer symptoms and
complications.
8/23/2012 Maria Carmela L. Domocmat
12. lead to various symptoms that, depending on
their severity, may require surgical repair or
replacement of the valve to correct the
problem
Regurgitation and stenosis may occur at the
same time in the same or different valves.
8/23/2012 Maria Carmela L. Domocmat
14. Valvular stenosis
Valvular insufficiency
8/23/2012 Maria Carmela L. Domocmat
15. Valvular stenosis
impedance of blood flow
the tissues forming the valve leaflets become
stiffer, narrowing the valve opening and reducing
the amount of blood that can flow through it. If
the narrowing is mild, the overall functioning of
the heart may not be reduced
8/23/2012 Maria Carmela L. Domocmat
16. Valvular insufficiency
Aka: regurgitation, incompetence, "leaky valve"
occurs when the leaflets do not close completely,
letting blood leak backward across the valve.
This backward flow is referred to as “regurgitant
flow.”
8/23/2012 Maria Carmela L. Domocmat
18. Mitral Valve Prolapse
Mitral Regurgitation
Mitral Valve Stenosis
Aortic Regurgitation
Aortic Stenosis
Tricuspid Regurgitation
8/23/2012 Maria Carmela L. Domocmat
19. Mitral stenosis
Progressive thickening and contracture of valve
cusps wit narrowing of the orifice and progressive
obstruction to blood flow
Aortic stenosis
Narrowing of orifice between LV and aorta
Tricuspid stenosis
Narrowing of tricuspid valve orifice due to
commissual fusion and fibrosis
8/23/2012 Maria Carmela L. Domocmat
20. Mitral insufficiency (regurgitation)
Incomplete closure of the mitral valve during
systole, allowing blood to flow back into LA
Aortic insufficiency (regurgitation)
Valve flaps fail to completely seal the aortic orifice
during diastole and thus permit backflow of blood
from aorta into LV
Tricuspid insufficiency (regurgitation)
Allows regurgitation of blood from RV into the RA
during systole
8/23/2012 Maria Carmela L. Domocmat
25. most common cause
rheumatic valvulitis
rheumatic endocarditis
other causes
malignant carcinoid, SLE, RA
8/23/2012 Maria Carmela L. Domocmat
26. causes
progressively thickens the mitral valve
leaflets and chordae tendineae.
The leaflets often fuse (glued) together.
Eventually, the mitral valve orifice narrows
and progressively obstructs blood flow into
the ventricle.
8/23/2012 Maria Carmela L. Domocmat
27. Normally, the mitral valve opening is as wide as the
diameter of three fingers.
In cases of marked stenosis, the opening narrows to the
width of a pencil.
LA - great difficulty moving blood into the ventricle
Bcoz of increased resistance of the narrowed orifice;
it dilates (stretches) and hypertrophies (thickens) bcoz of
increased blood volume it holds
no valve to protect the pulmonary veins from the
backward flow of blood from the atrium, the pulmonary
circulation becomes congested.
RV - must contract against abnormally high pulmonary
arterial pressure (PAP) and is subjected to excessive strain.
right ventricle fails
8/23/2012 Maria Carmela L. Domocmat
28. Rheumatic Fever or infective
Endocarditis
Inflammation of valve leaflets
Fibrosis and retraction of
leaflets
Shortening of chordae tendinae
Narrowing of valvular orifice
(n=4-
(n=4-6 cm2)
Mild stenosis-2 cm2
stenosis-
Severe stenosis-1 cm2
stenosis-
8/23/2012 Maria Carmela L. Domocmat
29. Decrease blood flow from left atrium to
left ventricle
Rupture of
small Stagnation
Increase LA pressure of blood in
bronchial
vessels the left
atrium
Left atrial enlargement
Hemoptysis
Thrombus
Increase pulmonary venous pressure
Embolism
Impinges on Increase right ventricular pressure
left recurrent
laryngeal
nerve Right ventricular Enlargement Pulmonary
edema
Hoarseness Orthopnea
Right Ventricular Failure
PND
8/23/2012 Edema Carmela L. Domocmat Anorexia
Maria Ascites Fatigue NVE
30. HF s/s
Dyspnea on exertion
▪ first symptom
▪ due to pulmonary venous hypertension
progressive fatigue
▪ as a result of low CO
Hemoptysis
cough
repeated respiratory infections
8/23/2012 Maria Carmela L. Domocmat
31. pulse - weak , irregular
Increase intensity of S1 Listen
diastolic rumble/ diastolic murmur
low-pitched, rumbling, heard at the apex
Opening snap after S2- apex
heart murmurs heard during diastole.
start at or after S2 and end before or at S1.
result of the increased blood volume and pressure,
the atrium dilates, hypertrophies, and becomes
electrically unstable
atrial dysrhythmias
8/23/2012 Maria Carmela L. Domocmat
32. Echocardiography
used to diagnose mitral stenosis
used to determine the severity
Electrocardiography (ECG)
cardiac catheterization with angiography
8/23/2012 Maria Carmela L. Domocmat
33. Antibiotic prophylaxis therapy
to prevent recurrence of infections
Treat CHF
Anticoagulants
to decrease the risk developing atrial thrombus
Treat anemia
8/23/2012 Maria Carmela L. Domocmat
34. Valvuloplasty
Closed Mitral commissurotomy or valvotomy
Open mitral commissurotomy or valvotomy
▪ to open or rupture the fused commissures of the mitral
valve.
Percutaneous transluminal valvuloplasty /
Balloon valvuloplasty
Mitral valve replacement
8/23/2012 Maria Carmela L. Domocmat
36. involves blood flowing back from the left
ventricle into the left atrium during systole.
Often, the margins of the mitral valve cannot
close during systole.
8/23/2012 Maria Carmela L. Domocmat
37. may be caused by problems with
one or more of the leaflets : shorten or tear
chordae tendineae : elongate, shorten, or tear
Annulus : stretched by heart enlargement or
deformed by calcification
8/23/2012 Maria Carmela L. Domocmat
38. may be caused by problems with
papillary muscles: rupture, stretch, or be pulled
out of position by changes in the ventricular wall
(e.g., scar from a myocardial infarction or
ventricular dilation). papillary muscle may be
unable to contract because of ischemia.
8/23/2012 Maria Carmela L. Domocmat
39. Regardless of the cause
blood regurgitates back into the atrium during systole.
With each beat of LV , some of blood is forced back into
LA
Because this blood is added to the blood that is beginning
to flow in from the lungs, LA must stretch. It eventually
hypertrophies and dilates.
The backward flow of blood from the ventricle diminishes
the volume of blood flowing into the atrium from the
lungs.
As a result, the lungs become congested, eventually
adding extra strain on the right ventricle.
Mitral regurgitation ultimately involves the lungs and RV
8/23/2012 Maria Carmela L. Domocmat
40. Due to myxomatous degeneration, which
cuases stretching of the leaflets and chordae
tendineae
Chronic RHD
CAD
Infective endocarditis
Meds and penetrating and nonpenetrating
trauma
8/23/2012 Maria Carmela L. Domocmat
42. Pathophysiology
Increase left ventricular
pressure
Systole Small amount to
blood pump to
Increase backflow of aorta
blood to left ventricle
through incompetent
MV Increase LV work
load to pump more
blood
LAH
LVH
Inc. LA pressure
RVH RVF
LVH
Inc. pulmonary
pressure Ascites /edema
8/23/2012 Maria Carmela L. Domocmat Orthopnea PND Dyspnea
43. Chronic mitral regurgitation - often
asymptomatic
Acute mitral regurgitation (e.g., that resulting
from a myocardial infarction)
manifests as severe CHF
Dyspnea, fatigue, and weakness
Palpitations, SOBon exertion, and cough from
pulmonary congestion also occur.
8/23/2012 Maria Carmela L. Domocmat
44. Holosystolic or pansystolic murmur 5 Holosystolic Murmur.flv
a high-pitched, blowing sound at the apex.
heard best at the apex and radiates to the axilla and
usually accompanied by a thrill
a heart murmur occurring throughout systole.
Pulse - regular and of good volume, or it may
be irregular as a result of extrasystolic beats or
atrial fibrillation.
8/23/2012 Maria Carmela L. Domocmat
45. Echocardiography
used to diagnose
monitor the progression
8/23/2012 Maria Carmela L. Domocmat
51. congenital leaflet malformations
abnormal number of leaflets (i.e., one or two
rather than three)
rheumatic endocarditis
RF
cusp calcification of unknown cause
8/23/2012 Maria Carmela L. Domocmat
52. progressive narrowing of the valve orifice,
usually over a period of several years to several decades.
LV overcomes the obstruction to circulation by
contracting more slowly but with greater energy than
normal, forcibly squeezing the blood through the very
small orifice.
obstruction to LV outflow increases pressure on the
left ventricle, which results in thickening of the muscle
wall.
heart muscle hypertrophies.
When these compensatory mechanisms of the heart
begin to fail, clinical signs and symptoms develop.
8/23/2012 Maria Carmela L. Domocmat
54. Pathophysiology
Narrowed aortic orifice
Decreased
Increased back flow of blood flow to
blood to left ventricle aorta
during systole
Decrease CO
Increased LV pressure
Syncope
Decreased
LVH coronary
blood flow
Increased LA pressure
Angina
LAH
8/23/2012 Maria Carmela L. Domocmat
56. Many asymptomatic
exertional dyspnea
caused by LVF
Other signs are dizziness and syncope because of reduced blood
flow to the brain.
Angina pectoris
a frequent symptom
results from the increased oxygen demands of the
hypertrophied left ventricle, the decreased time in diastole for
myocardial perfusion, and the decreased blood flow into the
coronary arteries.
BP - can be low but usually normal
low pulse pressure (30 mm Hg or less)
because of diminished blood flow
8/23/2012 Maria Carmela L. Domocmat
57. systolic murmur
loud, rough systolic murmur
low-pitched, rough, rasping, and vibrating
heard over the aortic area (R upper sternal border)
may radiate into the carotid arteries and to the
apex of LV
8/23/2012 Maria Carmela L. Domocmat
58. Thrill/ Vibration
Palpated over base of heart/ 2nd RICS
caused by turbulent blood flow across the
narrowed valve orifice.
Gallavardin phenomenon
murmur also reflected to mitral area which may give a
false impression of a mitral regurgitation
8/23/2012 Maria Carmela L. Domocmat
59. 12-leadECG and echocardiogram
Evidence of LV hypertrophy may be seen
Echocardiography (2D echo)
used to diagnose and monitor the progression of
aortic stenosis.
left-sided heart catheterization
measure the severity of the aortic stenosis and
evaluate the coronary arteries.
Pressure tracings are taken from LV and base of aorta.
systolic pressure in LV is considerably higher than that
in the aorta during systole.
8/23/2012 Maria Carmela L. Domocmat
61. is the flow of blood back into the left ventricle
from the aorta during diastole.
may be caused by inflammatory lesions that
deform the leaflets of the aortic valve,
preventing them from completely closing the
aortic valve orifice.
8/23/2012 Maria Carmela L. Domocmat
62. endocarditis
rheumatic heart disease (RHD)
congenital abnormalities (e.g., marfan
syndrome)
Syphilis - may produce aortitis
dissecting aneurysm
causes dilation or tearing of the ascending aorta
deterioration of an aortic valve replacement
8/23/2012 Maria Carmela L. Domocmat
63. blood from the aorta returns to the LV during diastole
in addition to the blood normally delivered by the LA
LV dilates
trying to accommodate the increased volume of blood.
LV hypertrophies
trying to increase muscle strength to expel more blood
with above normal force—raising systolic BP.
reflex vasodilation
arteries attempt to compensate for the higher pressures
peripheral arterioles relax
reducing peripheral resistance and diastolic BP.
8/23/2012 Maria Carmela L. Domocmat
67. Pathophysiology
Etiologic factors
Incompetent aortic valve
Regurgitation of blood from systemic
circulation + blood form LA increases
LV pressure
LVH
LVF
RVF
8/23/2012 Maria Carmela L. Domocmat
68. Usually asymptomatic
Progressive s/s of LVF
Exertional dyspnea and fatigue
breathing difficulties (e.g., orthopnea, PND)
8/23/2012 Maria Carmela L. Domocmat
69. Diastolic murmur
Austin flint murmur
Watson's water hammer pulse
Corrigan’s pulse
Widened pulse pressure
Hill’s sign
8/23/2012 Maria Carmela L. Domocmat
70. Diastolic murmur 3 Austin Flint Murmur.avi.flv
high-pitched, blowing sound at the third or 4th ICS L
sternal border
sitting up and leaning forward
Austin flint murmur
low pitched diastolic rumble similar to mitral stenosis;
indicates moderate to severe insufficiency
a mid-diastolic or presystolic murmur low-pitched
rumbling murmur which is best heard at the cardiac apex.
A murmur due to aortic regurgitation, originating at the
mitral valve when blood enters simultaneously from both
the aorta and the left atrium.
8/23/2012 Maria Carmela L. Domocmat
71. Watson's water hammer pulse
AKA: collapsing pulse, cannonball pulse
is the medical sign which describes a pulse that is
bounding and forceful, as if it were the hitting of a
water hammer that was causing the pulse.
PA: radial pulse of a supine patient with arm at
side is firmly palpated with slight pressure until
the pulse is obscured. The arm is then raised over
the patient's head, with the arm perpendicular to
the supine patient.
http://depts.washington.edu/physdx/heart/physical.html
8/23/2012 Maria Carmela L. Domocmat
72. Corrigan’s pulse
marked arterial pulsations
forceful heartbeat visible or palpable at the carotid or
temporal arteries.
result of the increased force and volume of the blood
ejected from the hypertrophied LV.
De Musset’s sign
Rhythmic nodding or bobbing of the head in synchrony
with the heart beat
Increased pulse pressure
Refers to the difference between the systolic pressure and
the diastolic pressure.
Normal - 50-60.
http://depts.washington.edu/physdx/heart/physical.html
8/23/2012 Maria Carmela L. Domocmat
73. Hill’s sign
systolic blood pressure is higher in the legs than in
the arms(> 20mmHg) .
Pistol shot femoral pulse (Traube's sign)
short, loud, snapping sounds with each pulse with
auscultation over the femoral, brachial, or radial
pulse.
a pulse that sounds like a pistol shot
8/23/2012 Maria Carmela L. Domocmat
74. Duroziez’s sign
to-and-fro murmur over the lightly compressed
femoral arteries
a double murmur over the femoral or other large
peripheral artery; due to aortic insufficiency.
8/23/2012 Maria Carmela L. Domocmat
75. Quincke’s pulse
systolic blushing and diastolic blanching of the
nail bed when gentle pressure is place on the nail
alternate blanching and flushing of the nail bed
due to pulsation of subpapillary arteriolar and
venous plexuses;
QUINCKE'S PULSE.wmv
4 Quincke's pulse.avi.flv
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76. Diagnosis may be confirmed
Echocardiogram
radionuclide imaging
ECG
Magnetic resonance imaging
cardiac catheterization
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77. antibiotic prophylaxis
Before the patient undergoes invasive or dental
procedures
to prevent endocarditis
Treat HF and dysrhythmias
8/23/2012 Maria Carmela L. Domocmat
78. Aortic Valve Replacement.mp4
Aortic valve replacement
treatment of choice Aortic Valve replacement- OR.flv
One- or two-balloon percutaneous aortic
valvuloplasty
For symptomatic and not surgical candidates
Note: surgery is recommended for any
patient with left ventricular hypertrophy,
regardless of the presence or absence of
symptoms.
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80. a disorder in which the heart's tricuspid valve
does not close properly, causing blood to flow
backward (leak) into the right upper heart
chamber (atrium) when the right lower heart
chamber (ventricle) contracts.
http://www.ncbi.nlm.nih.gov/pubmedhealth/P
MH0001222/
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81. Infective endocarditis- drug abusers
RVF/LVF
Rheumatic Heart disease
RV infarction
Ebstein's anomaly
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82. Ebstein's anomaly
rare heart defect in which parts of the tricuspid valve
are abnormal.
leaflets are unusually deep in the RV ; often larger
than normal.
Congenital defect
exact cause is unknown
although the use of certain drugs (such as lithium or
benzodiazepines) during pregnancy may play a role.
condition is rare
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83. Holosystolic / Pansystolic murmur in tricuspid area
High-pitched
increases with inspiration
At parasternal region at 4th ICS
s/s RHF
Hepatic congestion, RUQ pain, jaundice
Pulsatile liver
Right ventricular lift
Jugular venous pulsation
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85. Tricuspid regurgitation is a disorder involving backflow of blood from RV to RA during
contraction of RV . The most common cause of tricuspid regurgitation is not damage to
the valve itself but enlargement of the RV, which may be a complication of any disorder
that causes RVHF.
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86. ECG- RV and RA enlargement
CXR- RV enlargement with obliteration of the
retrosternal space on lateral view
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88. Narrowing of tricuspid valve orifice due to
commissual fusion and fibrosis
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89. Usually follows RF
Commonly assoc with diseases of mitral valve
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90. Rumbling or blowing mid-diastolic murmur
along L sternal border
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91. Treat left sided HF
Valvuloplasty
Valve replacement
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92.
93. Educate about
Diagnosis
progressive nature of valvular heart disease
treatment plan
report any new symptoms or changes in
symptoms
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94. Emphasize need for prophylactic antibiotic
therapy before any invasive procedure that may
introduce infectious agents to the patient’s
bloodstream.
(e.g., dental work, genitourinary or
gastrointestinal procedure)
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95. Teach that infectious agent (usually a
bacterium) is able to adhere to the diseased
heart valve more readily than to a normal
valve. Once attached to the valve, the
infectious agent multiplies, resulting in
endocarditis and further damage to the
valve.
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96. Collaborate with patient
develop a meds schedule
teach about name, dosage, actions, side effects,
and any drug-drug or drug-food interactions of
the prescribed meds for HF , dysrhythmias,
angina pectoris, or other symptoms
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97. Teach to weigh daily
report weight gain of 2 pounds in 1 day or 5
pounds in 1 week
assist patient with planning activity and rest
periods to achieve a lifestyle acceptable to
the patient.
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98. VS : HR, BP RR measured and compared with
previous data for any changes.
Auscultate heart and lung sounds
Palpate peripheral pulses
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99. Assess s/s HF
fatigue, dyspnea with exertion, increase in
coughing, hemoptysis, multiple respiratory
infections, orthopnea, or PND
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100. Assess dysrhythmias
by palpating the patient’s pulse for strength and
rhythm (ie, regular or irregular) and asks if the
patient has experienced palpitations or felt
forceful heartbeats
Assess for dizziness, syncope, increased
weakness, or angina pectoris
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101. Peiop care - surgical valve replacement or
valvuloplasty
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105. Repair of a cardiac valve
Types
Commissurotomy
Annuloplasty
Chordoplasty
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106. depends on the cause and type of valve
dysfunction.
Commissurotomy
Repair to commissures between leaflets
Annuloplasty
Repair to annulus of the valve by
Leaflet repair
Chordoplasty
Repair to the chordae
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107. Most require
general anesthesia
cardiopulmonary bypass
Some can be performed in the cath lab
Percutaneous partial cardiopulmonary bypass
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108. CCU - first 24 to 72 hrs post op
PACU/ CCU care
focus hemodynamic stabilization & recovery from
anesthesia
VS q 5 to 15 min and as needed until recovers from
anesthesia or sedation
▪ then q 2 to 4 hrs and as needed
IV meds
▪ blood pressure; dysrhythmias
Patient assessments
▪ q 1 to 4 hrs and PRN
▪ Esp neuro, respi, cardio
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109. Patient transferred to a telemetry or surgical unit
after recovery fr anes & sedation
hemodynamically stable without IV meds
assessments are stable
Surgical area care
wound care
patient teaching regarding diet, activity, medications, and self-
care.
Patients are discharged from the hospital in 1 to 7 days.
In general, valves that have undergone valvuloplasty function longer
than replacement valves, and the patients do not require continuous
anticoagulation.
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110. most common valvuloplasty
the procedure performed to separate the
fused leaflets.
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111. Commissurotomy is a special form of valvuloplasty. Commissurotomy is used when the
leaflets of the valve become stiff and actually fuse together at the base, which is the ring
portion (or annulus) of the valve. Sometimes a scalpel is used to cut the fused leaflets
(commissures) near the ring, which may help them open and close better. In other cases,
a balloon catheter, similar to a catheter used during angioplasty, is inserted into the valve.
The balloon is inflated, splitting the commissures and freeing the leaflets to open and
shut fully.
8/23/2012 http://www.heart-valve-surgery.com/heart-valve-repair-valvuloplasty-annuloplasty.php
Maria Carmela L. Domocmat
112. each valve has leaflets;
the site where the leaflets meet is called the
commissure.
The leaflets may adhere to one another and
close the commissure (i.e., stenosis).
leaflets fuse in such a way that, in addition to
stenosis, the leaflets are also prevented from
closing completely, resulting in a backward flow
of blood (i.e., regurgitation).
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113. CLOSED COMMISSUROTOMY
Balloon Valvuloplasty
OPEN COMMISSUROTOMY
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115. do not require cardiopulmonary bypass
The valve is not directly visualized.
general anesthetic
midsternal incision
a small hole is cut into the heart
surgeon’s finger or a dilator is used to break
open the commissure.
for mitral, aortic, tricuspid, and pulmonary
valve disease.
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116. Another type of closed commissurotomy
Indications
For mitral and aortic valve stenosis
younger patients
for aortic valve stenosis in elderly patients
patients with complex medical conditions that
place them at high risk for the complications of
more extensive surgical procedures.
also has been used for tricuspid and pulmonic
valve stenosis
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117. in cath lab
local anesthetic
remain in hospital 24 to 48 hours postop
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118. C/I
Left atrial or ventricular thrombus
severe aortic root dilation
Significant mitral valve regurgitation
thoracolumbar scoliosis,
Rotation of the great vessels
and other cardiac conditions that require open
heart surgery
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119. Types
Mitral balloon valvuloplasty
Aortic balloon valvuloplasty
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122. A balloon-tipped catheter is percutaneously
inserted, threaded to affected valve, and
positioned across narrowed orifice
Balloon is inflated and deflated, causing a
crack of the calcified commissures and
enlargement of the valve orifice
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123. Complications
some degree of mitral regurgitation
bleeding from catheter insertion sites
emboli resulting in complications such as strokes
left-to-right atrial shunts through an atrial septal
defect caused by the procedure.
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124. introduce catheter thru aorta, across AV, and
into LV .
The one-balloon or the two-balloon
technique can be used for treating aortic
stenosis.
not as effective as procedure for mitral valve,
rate of restenosis - nearly 50% in first 12 to 15
mos post op
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125. complications
aortic regurgitation Let’s
emboli watch
baby
ventricular perforation sophie
rupture of the aortic valve annulus
Ventricular dysrhythmias
mitral valve damage
bleeding from the catheter insertion sites
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126. CLOSED COMMISSUROTOMY
Balloon Valvuloplasty
OPEN COMMISSUROTOMY
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127. performed with direct visualization of valve
general anesthesia
Median sternotomy or left thoracic incision
Cardiopulmonary bypass
incision is made into the heart
A finger, scalpel, balloon, or dilator may be used
to open the commissures
direct visualization of valve
Advantages: thrombus ID and removed, calcifications
can be seen, and if valve has chordae or papillary
muscles, they may be surgically repaired
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128. Repair of a cardiac valve
Types
Commissurotomy
Annuloplasty
Chordoplasty
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129. repair of the valve annulus (i.e., junction of
the valve leaflets and the muscular heart wall)
Or retailoring of the valve ring
narrows the diameter of the valve’s orifice
and is useful for the treatment of valvular
regurgitation.
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130. General anesthesia & cardiopulmonary bypass
2 techniques
(1) use annuloplasty ring
The leaflets of the valve are sutured to a ring, creating an
annulus of the desired size. When the ring is in place, the
tension created by the moving blood and contracting
heart is borne by ring rather than by valve or a suture line,
and progressive regurgitation is prevented by the repair.
(2) tacking the valve leaflets to atrium with sutures or
taking tucks to tighten the annulus.
may degenerate more quickly than with the annuloplasty
ring technique
▪ Because valve’s leaflets and suture lines are subjected to the direct
forces of the blood and heart muscle movement,
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135. Damage to cardiac valve leaflets may result
from stretching, shortening, or tearing.
Types:
removal of the extra tissue
tucked
leaflet plication
leaflet resection
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136. Leaflet repair for elongated, ballooning, or
other excess tissue leaflets is removal of the
extra tissue.
The elongated tissue may be folded over
onto itself (i.e., tucked) and sutured (i.e.,
leaflet plication).
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137. Image of the aortic leaflets after correction of the prolapse using free edge plication
with prolene 6/0 sutures.
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138. leaflet resection
A wedge of tissue cut from middle of leaflet and gap
sutured closed
Short leaflets are most often repaired by
chordoplasty.
After the short chordae are released, the leaflets
often unfurl and can resume their normal
function of closing the valve during systole. A
piece of pericardium may also be sutured to
extend the leaflet.
A pericardial patch may be used to repair holes
in the leaflets.
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139. Repair of a cardiac valve
Types
Commissurotomy
Annuloplasty
Chordoplasty
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140. is the repair of the chordae tendineae.
mitral valve is involved with chordoplasty
(because it has the chordae tendineae);
seldom is chordoplasty required for the
tricuspid valve.
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141. Regurgitation may be caused by stretched,
torn, or shortened chordae tendineae.
Stretched chordae tendineae can be
shortened, torn ones can be reattached to
the leaflet, and shortened ones can be
elongated. Regurgitation may also be caused
by stretched papillary muscles, which can be
shortened.
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142. Artificial chordoplasty. A, residual prolapse of A2 is
evident on saline testing. B, a Gore-Tex suture is passed
through the fibrous tip of the papillary muscle and the
margin of the prolapsing segment. C, optimal artificial
chordae height is determined by intermittently testing
valve competency by injecting saline into the ventricle. D,
http://www.mitralvalverepair.org/content/view/67/
a final saline test confirms correction of prolapse.*
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144. Prosthetic valve replacement
annulus or leaflets of the valve are
immobilized by calcifications, valve
replacement is performed.
General anesthesia and cardiopulmonary
bypass
median sternotomy or right thoracotomy
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145. valve is visualized
leaflets and other valve structures, such as the chordae and
papillary muscles, are removed
Some surgeons leave the posterior mitral valve leaflet, its
chordae, and papillary muscles in place to help maintain the shape
and function of the left ventricle after mitral valve replacement.
Sutures are placed around the annulus and then into the valve
prosthesis.
replacement valve is slid down the suture into position and tied
into place
incision is closed, and surgeon evaluates the function of the heart
and the quality of the prosthetic repair.
patient is weaned from cardiopulmonary bypass, and surgery is
completed.
Heart valve surgery - operation for replacement heart valves.flv
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146. Complications
unique to valve replacement are related to the sudden changes in
intracardiac blood pressures.
All prosthetic valve replacements create a degree of stenosis when
they are implanted in the heart. Usually, the stenosis is mild and does
not effect heart function. If valve replacement was for a stenotic
valve,blood flow through the heart is often improved.
The signs and symptoms of the backward heart failure resolve in a few
hours or days. If valve replacement was for a regurgitant valve, it may
take months for the chamber into which blood had been regurgitat
ing to achieve its optimal postoperative function. The signs and
symptoms of heart failure resolve gradually as the heart function
improves. The patient is at risk for many postoperative complications,
such as bleeding, thromboembolism, infection, congestive heart
failure, hypertension, dysrhythmias, hemolysis, and mechanical
obstruction of the valve.
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147. Two types of valve prostheses may be used:
mechanical valves
Tissue (i.e., biologic) valves
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148. Designs: ball-and-cage or disk
thought to be more durable than tissue
prosthetic valves
Indications:
younger patients
if the patient has renal failure, hypercalcemia,
endocarditis, or sepsis and requires valve
replacement.
do not deteriorate or become infected as easily as the
tissue valves used for patients with these conditions.
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152. long-term anticoagulation with warfarin is
required
Thromboemboli are significant complications
associated with mechanical valves
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153. three types: xenografts, homografts, and
autografts.
less likely to generate thromboemboli, and
long-term nticoagulation is not required.
are not as durable as mechanical valves and
require replacement more frequently.
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154. are tissue valves (eg, bioprostheses,
heterografts);
most are from pigs (porcine), but valves from
cows (bovine) may also be used.
Durability - 7 to 10 yrs
don’t require anticoagulation therapy
do not generate thrombi
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155. Indications
for women of childbearing age
because the potential complications of long-term
anticoagulation associated with menses, placental
transfer to a fetus, and delivery of a child do not exist
patients older than 70 years of age
patients with a history of peptic ulcer disease
and others who cannot tolerate long-term
anticoagulation.
for all tricuspid valve replacements
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156. or allografts (i.e., human valves)
obtained from cadaver tissue donations.
The aortic valve and a portion of the aorta or the
pulmonic valve and a portion of the pulmonary artery
are harvested and stored cryogenically.
limited availability
not always available and are very expensive.
last for about 10 to 15 years
don’t require anticoagulation
not thrombogenic and are resistant to subacute bacterial
endocarditis.
used for aortic and pulmonic valve replacement.
excellent hemodynamic flow pattern
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157. autologous valves are obtained by excising
the patient’s own pulmonic valve and a
portion of the pulmonary artery for use as the
aortic valve.
Anticoagulation is unnecessary
because the valve is the patient’s own tissue and is
not thrombogenic.
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158. Indications:
alternative for children (it may grow as the child
grows),
women of childbearing age
young adults
patients with a history of peptic ulcer disease
those who cannot tolerate anticoagulation.
Aortic valve autografts have remained viable
for more than 20 years.
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159. Most aortic valve autograft procedures -
double valve replacement procedures
because a homograft also is performed for
pulmonic valve replacement.
If pulmonary vascular pressures are normal, some
surgeons elect not to replace the pulmonic valve.
The patient can recover without a valve between
the right ventricle and the pulmonary artery.
8/23/2012 Maria Carmela L. Domocmat
160. MARBLE-IN-A-CAGE (Starr-Edwards ball-and-cage valve)
developed by Miles "Lowell" Edwards and cardiothoracic surgeon Albert Starr
first used in 1960.
When resting against the ring, the caged ball prevents backward blood flow into the heart.
When the heart beats, the outflow of blood pushes the ball forward and the blood can flow
around the ball. However, the ball slows blood flow to below a normal rate, and people with
these valves could not perform strenuous activity.
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161. • The marble-in-a-cage
valve took up a lot of
space, pressing on other
body parts, so valve-
makers sought a flatter
design.
• invented in 1977
• still in use today, rely on
a disc that flips open
"like a toilet seat,"
• When open, it also
allows more blood
through than the ball
design did. http://www.scientificamerican.com/article.cfm?id=artificial-heart-valves
8/23/2012 Maria Carmela L. Domocmat
162. The most common mechanical
valve in use today is this double-
door design
first implanted in the 1970s,
made of carbon-based material
with two flaps that open and
close with the pumping of
blood.
Mechanical valves are durable
and long-lasting, but because
they can cause dangerous blood
clots to form, patients must take
blood thinners such as warfarin
for the rest of their lives. That, in
turn, increases the risk of stroke.
http://www.scientificamerican.com/article.cfm?id=artificial-heart-valves
8/23/2012 Maria Carmela L. Domocmat
163. To avoid the risk of blood
clots, Parisian doctor
Alain Carpentier
developed pig valves,
first implanted in 1965.
Valve-makers use the
chemical
glutaraldehyde, a
common tissue stabilizer
used in laboratories and
embalming, to sterilize
and inactivate the tissue
so the patient's immune
system won't attack it. http://www.scientificamerican.com/article.cfm?id=artificial-heart-valves
8/23/2012 Maria Carmela L. Domocmat
164. Today, many valves are
made from cows, with
tissue mounted in a wire
frame covered with Dacron
fabric, a design around
since the 1980s. Cutting
leaflets out of the sac that
surrounds a cow's heart,
valve-makers can make
any required shape or size;
they can also use chemicals
to make the tissue less
likely to attract the calcium
that can harden a valve.
http://www.scientificamerican.com/article.cfm?id=artificial-heart-valves
8/23/2012 Maria Carmela L. Domocmat
165. Open-heart surgery is not an
option for many patients of
fragile health, so researchers
designed this collapsible
valve—available since 2007 in
Europe, but not yet approved
in the U.S.—that can be
slipped into an artery without
cutting open the chest.
It scrunches down to pencil-
width so a surgeon can thread
it from a blood vessel in the
leg up to the heart, then use a
balloon to inflate it, pushing
the old valve out of the way.
Fluoroscopy and TAVI Procedure.flv
http://www.scientificamerican.com/article.cfm?id=artificial-heart-valves
8/23/2012 Maria Carmela L. Domocmat
166. Sometimes a whole new
valve is unnecessary, and a
surgeon can use a ring like
this to restructure the faulty
valve. "Repair is definitely a
lot better," Yoganathan says.
"You still maintain a lot of the
natural function." According
to the Mayo Clinic, the
original valve better resists
infection, does not require
blood thinners and generally
means a longer life
expectancy. Yoganathan
predicts more repair devices
will be available in the future. http://www.scientificamerican.com/article.cfm?id=artificial-heart-valves
8/23/2012 Maria Carmela L. Domocmat
170. TRICUSPID REGURGITATION TRICUSPID STENOSIS
Holosystolic / Pansystolic Rumbling or blowing mid-
murmur in tricuspid area diastolic murmur along L
sternal border
s/s RHF