This document discusses the role of opioids and NSAIDs in pain management for physical medicine and rehabilitation (PMR). It begins by classifying opioids based on receptor occupation and describing their mechanisms of action and pharmacological effects. Specific opioids discussed include morphine, fentanyl, tramadol, and tapentadol. It then covers the classification of NSAIDs, their mechanisms of action, and specific drugs like aspirin, ibuprofen, diclofenac, and ketorolac. The document concludes by outlining the specific roles of opioids and NSAIDs in managing pain conditions commonly treated in PMR.
Ondansetron
Class
• Seratonin ( 5-HT3) antagonist.
Uses
1. The management of nausea and vomiting induced by chemotherapy and
radiotherapy .
2. In the prevention and treatment of PONV
Main action
• Antiemetic.
Introduction to Opioid analgesis, Terms, History, Classification, Morphine, Opioid receptors, Mechanism of action, Pharmacological actions of morphine, Pharmacokinetics, Adverse effects, Contraindications, Therapeutic uses
Presented by
B . Kranthi Kumar
Department of Pharmacology
Ondansetron
Class
• Seratonin ( 5-HT3) antagonist.
Uses
1. The management of nausea and vomiting induced by chemotherapy and
radiotherapy .
2. In the prevention and treatment of PONV
Main action
• Antiemetic.
Introduction to Opioid analgesis, Terms, History, Classification, Morphine, Opioid receptors, Mechanism of action, Pharmacological actions of morphine, Pharmacokinetics, Adverse effects, Contraindications, Therapeutic uses
Presented by
B . Kranthi Kumar
Department of Pharmacology
Intra-operative bronchospasm is a deadly complication during general anaesthesia especially immediately after intubation. This presentation is a guide to tackle such a situation.
This lecture is about what is the neostigmine and what are its medical uses, mechanism of action and side effects.
Neostigmine is a cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone.
Neostigmine is in the cholinergic family of medications. It works by blocking the action of acetylcholinesterase and therefore increases the levels of acetylcholine.
Neostigmine: Cholinesterase inhibitor = ↑ ACh
Neostigmine is an anticholinesterase inhibitor and inhibits the hydrolysis of acetylcholine by competing with acetylcholine for binding to acetylcholinesterase at the site of cholinergic transmission. By reducing the hydrolysis of acetylcholine, the transmission of nerve impulses is facilitated.
At the end of surgery, neostigmine has been given for the reversal of neuromuscular blocking agents with several adverse effects such as bradycardia and profuse secretion.
Atropine has been used to prevent those side effects of neostigmine.
Side effects titles as review:
.
Nausea, headache, insomnia, dry mouth, dizziness, vomiting, allergic reactions, skin rash, hot flashes, joint pain, stroke, weakness, muscle cramps, frequent urination
Neostigmine is rapidly absorbed after intramuscular injection (IM). Neostigmine binding to human serum albumin is approximately 15 to 25%.
Neostigmine is metabolized in the liver by microsomal enzymes. The apparent excretory half-life of neostigmine is between 24 and 113 minutes.
Presented by: Mohammadsaleh Moallem
opioid analgesics with detailed description of introduction, mechanism of action, adverse effect, uses and contraindication along with examples for under graduates.
Intra-operative bronchospasm is a deadly complication during general anaesthesia especially immediately after intubation. This presentation is a guide to tackle such a situation.
This lecture is about what is the neostigmine and what are its medical uses, mechanism of action and side effects.
Neostigmine is a cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone.
Neostigmine is in the cholinergic family of medications. It works by blocking the action of acetylcholinesterase and therefore increases the levels of acetylcholine.
Neostigmine: Cholinesterase inhibitor = ↑ ACh
Neostigmine is an anticholinesterase inhibitor and inhibits the hydrolysis of acetylcholine by competing with acetylcholine for binding to acetylcholinesterase at the site of cholinergic transmission. By reducing the hydrolysis of acetylcholine, the transmission of nerve impulses is facilitated.
At the end of surgery, neostigmine has been given for the reversal of neuromuscular blocking agents with several adverse effects such as bradycardia and profuse secretion.
Atropine has been used to prevent those side effects of neostigmine.
Side effects titles as review:
.
Nausea, headache, insomnia, dry mouth, dizziness, vomiting, allergic reactions, skin rash, hot flashes, joint pain, stroke, weakness, muscle cramps, frequent urination
Neostigmine is rapidly absorbed after intramuscular injection (IM). Neostigmine binding to human serum albumin is approximately 15 to 25%.
Neostigmine is metabolized in the liver by microsomal enzymes. The apparent excretory half-life of neostigmine is between 24 and 113 minutes.
Presented by: Mohammadsaleh Moallem
opioid analgesics with detailed description of introduction, mechanism of action, adverse effect, uses and contraindication along with examples for under graduates.
A comprehensive guide to peri-operative pain management and sedation for the general surgeon. With a focus on drug availability in the state healthcare sector South Africa
this is an important topic in palliative care. a form of care each of us may need when we suffer terminal illness and severe trauma at one point in our life time.
Osteoarthritis knee- introduction and approachJoe Antony
Osteoarthritis (OA) of the knee is a degenerative joint disorder characterized by structural changes like cartilage loss, synovial inflammation, and bone remodeling . Knee OA commonly affects daily activities due to symptoms like joint pain and stiffness, impacting functional abilities . Various factors contribute to knee OA development, including mechanical, enzymatic, and biological factors . In knee OA patients, proinflammatory cytokines like IL-6 and TNF-α have been found to correlate with functional impairment assessed by WOMAC scores, indicating a potential impact on knee joint function . Understanding the interplay between aging and knee OA is crucial, as aging processes can exacerbate the degenerative changes in the knee joint, leading to functional limitations . Evaluating patients' perspectives on knee OA management through instruments like the Knee Outcome Survey Activity Daily Living Scale (KOS-ADLS) is essential for assessing the success of interventions
Gait deviations in Transtibial prosthesis usersJoe Antony
Gait deviations in transtibial amputations involve altered biomechanics and asymmetries. Research highlights that spatiotemporal gait parameters are affected, with reduced propulsive force, knee extension moment, and increased knee abduction moment in the amputated leg. Additionally, individuals with transtibial amputations exhibit shorter stance times, longer swing times, and larger step lengths compared to able-bodied individuals. These deviations can lead to asymmetrical loads, potentially causing issues like osteoarthritis or lower back pain. Furthermore, gait asymmetry in transtibial amputees is associated with poor functional outcomes, impacting performance-based physical function tests like the Timed Up and Go, the 10-Meter Walk Test, and the 6-Minute Walk Test. Understanding these gait abnormalities is crucial for tailored interventions and prosthetic design to improve outcomes for individuals with transtibial amputations.
Basics of electro myo graphy study (EMG)Joe Antony
Electromyography (EMG) is a vital technique in the field of bioelectrical signal analysis. It involves capturing muscle activity through surface or needle electrodes for diagnostic purposes. EMG signals can be analyzed to detect various muscle conditions, such as myopathic or neuropathic lesions, using numerical parameters. The spatial frequency bandwidth of surface EMG signals is crucial for detailed muscle activity reconstruction, with appropriate inter-electrode distances being essential for accurate mapping. In the context of neuro-monitoring, EMG plays a role in intra-operative detection of adverse events and predicting postoperative outcomes, especially when used complementarily with other modalities like motor evoked potentials. Overall, EMG serves as a valuable tool for understanding muscle function, diagnosing muscle disorders, and enhancing neuro-monitoring practices
Principles of tendon transfer surgeries in rehabilitationJoe Antony
Tendon transfers, a fundamental aspect of reconstructive surgery, represent a sophisticated intervention in the domain of orthopedics and plastic surgery. This intricate procedure involves the repositioning or redirection of tendons to restore lost function, correct deformities, or alleviate debilitating conditions resulting from tendon injuries, neurological disorders, or musculoskeletal anomalies. By harnessing the body's inherent capacity for adaptation and regeneration, tendon transfers offer a transformative solution to patients grappling with impairments affecting mobility, dexterity, and overall quality of life.
Within the realm of medical science, tendon transfers stand as a testament to the innovative intersection of anatomy, biomechanics, and surgical expertise. Guided by meticulous anatomical knowledge and informed by patient-specific considerations, surgeons meticulously navigate the intricate network of tendinous structures to achieve optimal outcomes. This precise manipulation of tendons demands not only technical proficiency but also a profound understanding of functional anatomy, pathological processes, and the dynamic interplay between muscles and joints.
The rationale underlying tendon transfers rests upon the principle of functional restoration through strategic tendon re-routing. Whether addressing paralysis resulting from nerve injury or rectifying muscular imbalances precipitated by congenital anomalies, the overarching goal remains consistent: to enhance musculoskeletal function and foster meaningful improvements in patient well-being. By redistributing the forces exerted by muscles across joints, tendon transfers serve as a cornerstone in the rehabilitation arsenal, offering a pathway towards enhanced motor control, stability, and range of motion.
In this discourse, we embark on a comprehensive exploration of tendon transfers, delving into the intricacies of surgical technique, patient selection criteria, rehabilitative protocols, and outcomes assessment. Through a synthesis of clinical insights, scientific inquiry, and empirical evidence, we endeavor to illuminate the multifaceted dimensions of this therapeutic modality. By elucidating the underlying principles and practical applications of tendon transfers, we aspire to equip healthcare practitioners with the requisite knowledge and insights to navigate this dynamic landscape and empower patients with newfound avenues for functional restoration and renewed vitality.
International standards for neurological classification of spinal cordJoe Antony
The International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) or more commonly referred to as the ASIA Impairment Scale (AIS), was developed by the American Spinal Injury Association (ASIA) as a universal classification tool for Spinal Cord Injury based on a standardized sensory and motor assessment, with the most recent revised edition published in 2011. The impairment scale involves both a motor and sensory examination to determine the sensory and motor levels for the right and left side, the overall neurological level of the injury and completeness of the injury i.e. whether the injury is complete or incomplete.
Wheelchairs and seating systems allow individuals with mobility impairments to actively participate at home, work, school, and the community. The quality of life of an individual is reflective of the overall effectiveness of the wheelchair and seating system when considering activities of daily living (ADLs). Therefore it is imperative that the multidisciplinary team of rehabilitation professionals
considers not only the individual and the wheelchair but also the
activities, context, policies, and personal assistance associated with the technology. Historically, rehabilitation professionals have
focused on functional mobility at the time of implementation of
the wheelchair and seating system. Now, as a result of changes in the overall health care environment, driven by a need for increased value, rehabilitation professionals must integrate a more holistic
approach to manage costs while improving outcomes at the time
of implementation and throughout the life of the wheelchair and seating systems.To better understand the long-term effects of the wheelchair and seating system and to maximize the functional
outcomes of the individual, rehabilitation professionals across the multidisciplinary health care team must understand the advances in current technology as well as best practices in the service delivery.
process. The value of the wheelchair and seating system within
the context of health care now extends beyond the four walls of a
traditional clinic to the community in which the individual uses
the wheelchair and seating system.
Significant advances in management have resulted in an increase in survival after burn injury in regions of the world with access to current medical and surgical resources. As a consequence, burn survivors with access to up-to-date care and who tend to be young adults have long-term sequelae that impair function and limit
return to preinjury function, including work and community
reintegration. Up to 1 million burns require treatment annually in North America, and over 10 times as many burns occur worldwide. In low-income and middle-income countries, mortality is significantly greater than in high-income countries.The future
of burn care will be challenged by the expense and complexity of treatment, a predicted shortage of qualified burn care providers, and an aging population.
Physical medicine and rehabilitation (PM&R) is a relatively young specialty that developed during the 20th century, with signifi cant growth and development stimulated by
two World Wars and by increasingly severe epidemics of
paralytic poliomyelitis during the fi rst half of the 20th century
(1–4). During and after each of the World Wars, many soldiers returned with serious injuries and severe disabilities, and physicians and therapists were needed to treat and manage their chronic disabling conditions. This was particularly true after World War II, when the availability of antibiotics and improved surgical techniques allowed more injured soldiers to survive, albeit with significant
disabilities. Similarly, over the same time period, increasingly
severe epidemics of polio, frequent industrial accidents,
and escalating motor vehicle accidents as a result of
the increased availability of automobiles and higher-speed
roadways added greatly to the burden of impairment and
disability among the civilian population. Thus, events in the
fi rst half of the 20th century necessitated the development
of new restorative treatment programs incorporating new
physical and rehabilitative techniques, and the establishment
of training programs for physicians and therapists to
administer the treatments.
Nevertheless, with the exception of a relatively few scattered physical medicine physicians, it was not until the second half of the 20th century that specialists in rehabilitation medicine could profi tably direct their energies exclusively, or even preferentially, to rehabilitation outside of the unprecedented and unsustainable circumstances of wartime
military programs. Also largely missing until the second half
of the 20th century were separate departments in academic and nonacademic medical centers devoted to the specialty, established training programs in PM&R, a sufficient number of PM&R practitioners, separate dedicated facilities for
provision of rehabilitation services (e.g., dedicated wards in hospitals or separate rehabilitation centers), forums for the interchange of ideas (e.g., texts, journals, and professional societies), recognition by professional colleagues and the
public that rehabilitation medicine specialists provided a
needed service, and supportive legislation that would provide
fi nancial mechanisms to develop and provide such
resources
In lesions below the mid-pons, a state of flaccidity, termed spinal shock, ensues immediately after injury with loss of all reflexes caudal to the injury.
The resolution of spinal shock occurs gradually , taking weeks to months.
The recovery from spinal shock is poorly understood and likely results from multiple, simultaneous adaptations in spinal processing that allow motor neuron to function independently from supraspinal control.
Existence of spinal shock, followed by a gradual return of reflexes that eventually become hyperactive, suggests that spasticity is not just a result of a simple on/off switch triggered by an alteration in inhibitory and facilitative signals
Walking depends on the repeated performance by the lower limbs of a sequence of motions that simultaneously advances the body along the desired line of progression while also maintaining a stable weight-bearing posture. Effectiveness depends on free joint mobility and muscle action that is selective in both timing and intensity. Normal function is also optimally conservative of physiologic energy. Pathologic conditions alter the mode and efficiency of walking. The loss of some actions necessitates substitution of others if forward progression and stance stability are to be preserved. Through a detailed knowledge of normal function and the types of gait errors that the various pathologic conditions can introduce, the clinician becomes able to define the significant deficits and plan appropriate corrective measures
Tendo Achilles tenotomy as a part of Ponsetti techniqueJoe Antony
Most CTEV children will need the tenotomy, which is a minor procedure usually done
with local anaesthetic. Children need the tenotomy because their heel (Achilles) tendon is short and tight
and it pulls the heel up.If it is not corrected the child will walk on tiptoes. Some doctors use general anaesthetic for older patients. After the tenotomy a final POP cast is applied and left on for three weeks. During this time the tendon regenerates in the lengthened position and the foot
can be bent up easily towards the front of the leg (dorsiflexion). If your baby is unhappy after the tenotomy, it is fine to use some paracetamol
as you would after vaccinations
Prosthetic management of individuals with upper extremity
amputations presents all health professionals, including
prosthetists and therapists, with a set of unique challenges.
For those wearing an upper extremity prosthesis, the terminal
device (TD) of the prosthesis is not covered or obscured
by clothing in the same way that a lower extremity prosthesis
is “hidden” by pants, socks, and shoes. The person with
upper extremity amputation must cope with not only physical
appearance changes, but the loss of some of the most
complex movement patterns and functional activities of
the human body.
In addition, upper extremity limb loss deprives the patient
of an extensive and valuable system of tactile and proprioceptive
inputs that previously provided “feedback” to guide and
refine functional movement. Even the simplest tasks
related to grasp and release become challenging. The ability
to position the prosthetic limb segments in space, as well as
the ability to maintain advantageous postures needed to
manipulate objects, challenge the medical community to
continuously improve the functional and aesthetic outcomes
of prostheses for patients in this population.
Pelvic floor disorders include a wide-ranging group of potentially
disabling, embarrassing, and often painful conditions that can
greatly affect a person’s quality of life. The pelvic floor consists of
muscles, fascia, and ligaments that support the pelvic organs and
help to provide control for bodily functions. Pathology within the
musculoskeletal and neurologic structures of the deep pelvis can
lead to the development of pelvic pain, dyspareunia, voiding dysfunction
including urinary incontinence or urinary urgency, fecal
incontinence (FI), constipation, and pelvic organ prolapse (POP)
.
Both women and men can develop pelvic floor disorders,
although women are at increased risk compared with men because
of their unique anatomy and biomechanics. The female pelvis is
broader and shallower, requiring greater muscular and ligamentous
stiffness to provide support and stability. Women are also
more likely to incur injury to the pelvic floor as a result of pregnancy
and childbirth. As a result, abnormal biomechanics of the
pelvic floor muscles (PFMs) may lead to changes in contraction,
relaxation, muscle strength, and myofascial pain. In a 2014 study,
the prevalence of symptomatic pelvic floor disorders in the United
States was estimated to be approximately 25%. It is important
to note that this percentage does not consider women with pelvic
pain due to high-tone pelvic floor dysfunction.
People with pelvic floor disorders benefit from an interdisciplinary
rehabilitation approach to improve function and reduce pain.
Physiatrists with experience in acute and chronic pain, neurologic
and musculoskeletal conditions, and neurogenic bowel/bladder
management are well suited to direct such a patient’s care.In
addition to diagnosing and managing the patient’s pelvic floor
disorder medically, the physiatrist plays a key role in providing
a detailed prescription for physical therapy.
Ergonomic modification for a person with a desk jobJoe Antony
It was estimated that about 40.7 % of the global population was surfing the computers in the year 2012 as compared to 2006 of only 26.2%. [1]
Marshall et al study reveal that on average, six out of 10 employees used a chair at work and the number was expected to grow.[2]
Many researchers report that working 5.41 hours sitting at desk and 7 hour sleeping at night had a great impact on the physical and mental health.[2]
Sitting on a chair is one of the most common positions adopted by humans.
children and adults spend approx. 55% of their working hours or 7.7 hours/day in sitting postures.[2]
The ergonomic fit workstations have become a standard practice in various developed countries
A special HKAFO, which uses a mechanical linkage to couple flexion of one hip with extension of the other, which enables a reciprocal step-over-step gait.
Also allow swing through and swing to gaits
Prevent knee buckling without actually including knee in orthosis
Sense of freedom and more control over external devices
Light weight- 300gms
Cosmetically acceptable
Prevents pressure sore
Easy maintenance
Total contact cast is rigid or semi-rigid molded cast which extends from the patient’s foot to just below the knee, maintaining contact with the entire plantar surface of the foot and lower leg and immobilizing surrounding joints and soft tissue while allowing the patient to remain ambulatory.
Considered as gold standard of offloading techniques
Started in early 1930s as a treatment modality for post hansens neuropathic ulcer
Effective , Rapid and ambulatory
BOTOX dosage in Lower Limb Spasticity.pptxJoe Antony
Botox injections are noted primarily for the ability to reduce the appearance of facial wrinkles. They're also used to treat conditions such as neck spasms (cervical dystonia), excessive sweating (hyperhidrosis), an overactive bladder and lazy eye. Botox injections may also help prevent chronic migraines
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
1. ROLE OF OPIOIDS and NSAIDS IN
PMR
MODERATOR:
• Dr Sandeep Kumar Gupt
Assisstant prof
DEPT OF PMR
KGMU
PRESENTED BY:
• Dr Joe Antony
JR1
DEPT OF PMR
KGMU
2. Contents
• Opiods
– Classification
– Moa
– Pharmacological action
– Specific opiods
• Nsaids
– Classification
– Moa
– Pharmacological action
– Specific drugs
• Who pain ladder
3. OPIODS
⚫Opiod analgesics are one of the oldest remedies for
relief pain.
⚫Opium is
obtained
the dark brown
from the poppy
gummy
capsule
exudate
(papaver
somniferum)
⚫Opium has been in use since 4000BC.
5. MORPHINE
In CNS mu ( ),kappa( k)and delta( ) receptors
Stimulationof opioid receptors (Morphine)
Decrease the Intra cellular Calcium Level
Decrease the release of Neurotransmitter
It decreases the visceral Pain
6. Pharmacological action
⚫1.Analgesia:
Morphine is a potent analgesic and relieves pain without loss of
consciousness.in higher doses it relieves severe pain as that of biliary
colic.
⚫2.Euphoria ,sedation and hypnosis
Rapid IV inj of morphine produces a warm flushing of the
skin and an immensely pleasurable sensation.
It also produces drowsiness
7. 3.Respiration
Morphine produce respiratory depression. It
directlydepresses the respiratory center in the
brain stem
4.Cough center
Itdirectlydepress thecough center and thereby
suppress cough.opioids should be used as
antitussiveonly in the dry cough
8. 5.Nausea and emesis
Morphine directly stimulates the CTZ in the medula causing
nausea and vomitting.in higher doses it depress the
vomitting center and hence there is no vomitting in
poisoning .
6.pupil
Morphine produces miosis resulting in a characteristic
pinpoint pupil in high doses.
7.vagus
Morphine stimulates vagal center causing bradycardia.
9. 8.Heat regulation
Opioids shift the equlibirium point of heat regulating
center so that body temperature falls slightly.
9.Truncal rigidity
Higher dose of fentanyl found to enhance the tone of
the large trunk muscles by acting at supraspinal
levels.
10.Excitatory effect
In high doses opioids produce convulsion
10. • In therapeutic dose morphine produces
hypotension by;
• Direct peripheral vasodilatation.
• Inhibition of baroreceptor reflexes.
• In higher doses ,it causes depression of vasomotor
center and histamine release both contributing to a fall
in BP.
Cardiovascular system
11. • GIT
Opioids decrease the motility of the gut.
• Stomach
Gasric motility is decreased resulting in increased gastric empting time.gastric
acid secretion is reduced.
• Intestine :
Morphine diminises all secretions,delays digestion of food in the small
intestine.
• Other Smooth Muscles
Biliary tract – Morphine causes spasm of the sphincter of Oddi.Atrophine partially
antagonise this .
Urinary Bladder and Ureter – Opioids inhibit urinary voiding reflex, as a result of this
urinary retention occurs especially in the elderly males with Prostatic hypertrophy.
Bronchi –Morphine causes release of histamine from the mast cells leads to broncho
constriction.
13. Dosage
• 10-50mg
• 5 times daily
• No respiratory depression
until pain relief is there
Routes
• Oral
• Sc
• Intrathecal
• iv
14. TOLERANCE
• Tolerance is defined as the capacity of the body to
endure or become less responsive to a substance.
• Lethal dose of Morphine is 250 mg, addict can tolerate
morphine in gms .
15. DEPENDENCE
⚫Its ability to produce euphoria, makes it a drug of
addiction.
⚫Opioids produce both psychological and physical
dependence.
16. OTHER OPIOIDS
Heroin
It is converted to morphine in the
body.
It has higher lipid solubility.
It gives euphoric effects faster and
greater.
It is used as analgesics and banned in most
countries.
17. OTHER OPIOIDS
Codiene- It is Commonly used anti tussives. It is
also available with Paracetamol for analgesia.
Dexomethorphan -It acts centrally to elevate the
threshold forcoughing. It is effectiveas codeine.
18. Fentanyl
It is about 100 times more potent than morphine. It is
highly lipid solubleand fastacting.
Epidural fentanyl is used for postoperative and
obstetricanalgesia
Itcan also used in chronic pain .
-Routes – transdermal patches
ADVERSE EFFECT
Cough musclerigidity,
Nausea & Vomiting
Respiratory Depression
19. Tramadol
• Centrally acting atypical opiod
• it inhibits reuptake of NA and 5-HT, increases
5-HT release, and thus activates
monoaminergic spinal inhibition of pain
• i. v. I 00 mg tramadol is equianalgesic to IO mg
i.m. morphine.
20. • Oral bioavailability of
tramadol is good
• The t½ is 5-6 hours and
effects last for 4-6 hrs.
• Tramadol causes
insignificant respiratory
depression, sedation,
constipation or urinary
retention.
• nausea and dizziness may
be prominent.
• sleepiness, dry mouth,
sweating
• lowering of seizure
threshold, therefore
contraindicated in epileptics
• risk of 'serotonin syndrome‘
in patients on ssri
21. • Tramadol is indicated for mild-to-moderate
short-lasting pain
– due to diagnostic procedures, injury, surgery, etc,
as well as for chronic pain including cancer pain,
but is not effective in severe pain.
• Little tendency to dose escalation by chronic
users is seen and abuse potential is low.
• Dose: 50---100 mg oral/ i.m./slow i.v. infusion
(children I 2 mg/kg) 4 6 hourly.
22. • Roll in PMR
– Both nociceptive and neuropathic pain
– Chronic non malignant low back pain ( resistent to
nsaids)
– treating post herpetic neuralgia, phantom limb pain,
diabetic neuropathy, and polyneuropathy of various
etiologies
– American College of Rheumatology (ACR)
recommends tramadol for OA patients who failed to
achieve adequate benefit from nonnarcotic analgesic
medications
23. Tapentadol
• Newer atypical opiod
• Similar mechanism to tramadol
• useful alternative to tramadol for acute as well
as chronic pain of moderate severity. With less
nausea
• Dose· 50 I 100 mg 2-4 times/day.
24. Specific roll of opiods in PMR
• Post op analgesia- transdermal patches
• 2nd and 3rd line drugs for neuropathic pain
syndromes- phantom limb pain, diabetic
neuropathy
• Procedural pain
• Non productive cough suppression ( which
disturbs sleep)
• Diarrhoea treatment
25. NSAIDS
• Inflammation is the immediate response of our
body in response of harmful stimulus.
• The treatment of patients with inflammation
involves two primary goals
– Relief of symptoms and the maintenance of function:
usually the major continuing complaints of the patient;
– Slowing or arrest of the tissue-damaging process.
• Reduction of inflammation with NSAIDs often
results in relief of pain for significant periods
26. NSAID
• Aspirin, the original NSAID, has a number of adverse
effects.
• Many other NSAIDs have been developed in attempts
to improve upon aspirin’s efficacy and decrease its
toxicity.
• Although there are many differences in the kinetics of
NSAIDs, they have some general properties in common
• Most are well absorbed, and food does not
substantially change their bioavailability.
• Most are highly metabolized, some by
– Phase I followed by phase II mechanisms
– others by direct glucuronidation (phase II) alone
27. Pharmacokinetics
• NSAID metabolism proceeds, in large part, by way
of the CYP3A or CYP2C families of P450 enzymes
in the liver.
• While renal excretion is the most important
route for final elimination
• Nearly all undergo varying degrees of biliary
excretion and re-absorption
• Most of the NSAIDs are highly protein-bound
(∼ 98%), usually to albumin
• All NSAIDs can be found in synovial fluid after
repeated dosing
28. Pharmacodynamics
• Mediated chiefly through inhibition of prostaglandin
biosynthesis
• Various NSAIDs have additional possible mechanisms
of action
– inhibition of chemotaxis,
– down-regulation of interleukin-1 production,
– decreased production of free radicals and superoxide
– interference with calcium-mediated intracellular events
• NSAID’s may be either non-selective COX inhibitor or
preferentially/selective COX-2 inhibitor
31. Prefferential/selective COX-2
inhibitors
• Do not affect platelet function at their usual
doses.
• Efficacy of COX-2-selective drugs equals that
of the older NSAIDs, while GI safety may be
improved.
• Selective COX-2 inhibitors may increase the
incidence of edema and hypertension.
– Only celecoxib has FDA approval
32. Adverse Effect
• Central nervous system: Headaches, tinnitus, and dizziness.
• Cardiovascular: Fluid retention, hypertension, edema, and
rarely, myocardial infarction, and congestive heart failure.
• Gastrointestinal: Abdominal pain, dysplasia, nausea, vomiting, and
rarely, ulcers or bleeding.
– all NSAID are gastric irritants and can be associated with GI ulcers to
some extent
• Hematologic: Rare thrombocytopenia, neutropenia, or even
aplastic anemia.
• Hepatic: Abnormal liver function tests and rare liver failure.
• Pulmonary: Asthma.
• Skin: Rashes, all types, pruritus.
• Renal: Renal insufficiency, renal failure, hyperkalemia, and
proteinuria
33. Aspirin
• Rarely used as an anti-
inflammatory
medication
• But it has proved to be
beneficial for CVS
patient in terms of its
anti-platelet effects
34. Other uses of Salicylates
• Salicylates are used to treat:
– rheumatoid arthritis
– juvenile arthritis
– osteoarthritis
– other inflammatory disorders
• 5-Amino salicylates (mesalamine, sulfasalazine):
Crohn's disease.
• Salicylic acid is used topically to treat:
– plantar warts
– fungal infections
– Corns
35. Adverse Effect
• Common side effects listed earlier
• Adverse effects at antithrombotic doses are
gastric upset (intolerance) and gastric and
duodenal ulcers
• Hepatotoxicity, asthma, rashes, GI bleeding,
and renal toxicity rarely if ever occur
at antithrombotic doses.
• Contraindicates its use by patients with
hemophilia
36. Adverse effects
• The use of aspirin and
other salicylates to
control fever during viral
infections in children and
adolescents is totally
contraindicated
• Is associated with an
increased incidence of
Reye's syndrome,
characterized by
– vomiting,
– hepatic disturbances,
– Encephalopathy that has a
35% mortality rate.
37. PROPIONIC ACID DERIVATIVES -
Ibuprofen
• Better tolerated alternative to aspirin
• All have similar pharmacodynamic properties
• But differ considerably in potency and to some extent
in duration of action.
• The analgesic, antipyretic and anti-inflammatory
efficacy is rated somewhat lower than high dose of
aspirin
• All inhibit PG synthesis: Naproxen being the most
potent
• Inhibition of platelet aggregation is short-lasting with
ibuprofen, but longer lasting with naproxen.
38. Clinical Use: Ibuprofen
• Available as an 'over-the-counter’ drug as 200
mg, 400 mg, 600 mg
• Used as a simple analgesic and antipyretic
• Effective in dysmenorrhoea
• Ibuprofen and its congeners are widely used in
rheumatoid arthritis, osteoarthritis and other
mucoskeletal disorder
• indicated in soft tissue injuries, fracture, tooth
extraction and to relieve post- partum pain
39. Clinical Use: Ibuprofen
• oral and intravenous routes are
equally effective
• Topical cream preparation appears
to be absorbed into fascia and
muscle;
– Relieve joint pain in osteoarthritis
• A liquid gel preparation 400 mg,
provides prompt relief and good
overall efficacy in postsurgical
mucosal pain.
40. Adverse Effect
• Common adverse effects are already listed
• Contraindicated in individuals with nasal polyps,
angioedema, and bronchospastic reactivity to
aspirin
• Aseptic meningitis (particularly in patients with
systemic lupus erythematosus), and
fluid retention have been reported
• Concomitant administration of ibuprofen
and aspirin
– Antagonistic effect
41. Diclofenac
• Phenylacetic acid derivative
that is relatively non-
selective as a COX inhibitor.
• Its available as diclofenac
sodium salt.
• Antiplatelet action is short
lasting.
• T1/2 : 2 hrs
• Good tissue penetrability
42. Diclofenac – Clinical Use
• Most extensively used NSAID
• Combination of diclofenac and omeprazole: effective
with respect to the prevention of recurrent bleeding
– but renal adverse effects were common in high-risk
patients.
– Dosage above 150 mg/d: impair renal blood flow and
glomerular filtration rate
• Other combination includes ibuprofen+diclofenac:
excellent pain management
43. Diclofenac – Clinical Use
• Can be used after intraocular lens implantation
and strabismus surgery.
• Rectal suppository form can be considered for
preemptive analgesia and postoperative nausea
• Also available as an oral mouthwash and for
intramuscular administration
• osteoarthritis, bursitis, ankylosing spondylitis,
toothache, dysmenorrhoea - quick relief of pain
• Td patches- 1/3% diclofenac epolamine- used
for minor soft tissue injuries
44. KETOROLAC
• Novel NSAID with potent
analgesic and moderate
anti-inflammatory effect.
• In post operative pain it
has equivalent efficacy of
morphine
– But it does not interact
with opoid receptors and
is free of opioid side effect
45. KETOROLAC
• Rapidly absorbed after oral and i.m. administration.
• T1/2 5-7 hrs, highly plasma bound and 60% excreted
unchanged.
• Metabolic pathway is glucuronidation conjugation
• Clinical use
– frequently used in postoperative pain management: dental
• and acute musculoskeletal pain
– When used with an opioid, it may decrease the opioid
requirement by 25–50%.
• inflammatory conditions.
46. KETOROLAC – Clinical Use
• renal colic and pain due to bony metastasis
• Orally it is used in a dose of 10-20mg
• Rated superior to aspirin, paracetamol (600
mg) and equivalent to ibuprofen (400 mg)
• Continuous use for more than 5 day is not
recommended - renal toxicity
47. Paracetamol
• Acetaminophen: de-ethylated active
metabolite of phenacetin
• Central analgesic action of paracetamol is like
aspirin, i.e. it raises pain threshold
• It is a poor inhibitor of PG synthesis in
peripheral tissues, but more active on COX in
the brain.
• Its a good and promptly acting antipyretic, but
negligible anti-inflammatory action
48. Pharmacology
• Analgesic action of aspirin and paracetamol is
additive.
• Well tolerated orally, but only about 1/4th is
protein bound
• It is uniformly distributed in the body
• Metabolism occurs mainly by conjugation of
glucuronic acid and sulfate
• Plasma t1/2 2-3 hrs, effects after an oral dose last
for 3-5 hours
50. Clinical Use
• One of the most commonly OTC drug for
analgesic: headache, migraine,
musculoskeletal pain, dysmenorrhea
• But is relatively ineffective when inlflamation
is prominent.
• First choice analgesic for osteoarthritis
• Drug of choice: as antipyretic, especially in
children (no risk of Reye's syndrome)
51. Clinical Use
• Equally efficacious as aspirin for non-
inflammatory conditions, without its side
effect
– Insignificant gastric irritation, mucosal erosion and
bleeding
– Occurs rarely in overdose.
– does not affect platelet function, clotting factors
– Used in combination with opiods
– Decrease dose requirement of both
52. Adverse Effect
• Safe and well tolerated
• Nausea and rashes occur occasionally and other side
effects are similar to other NSAID
• Analgesic nephropathy: after years of heavy use
– Personality defect.
– Pathological lesions like necrosis, tubular atrophy followed
by renal fibrosis
• Acute paracetamol poisoning: especially in small
children who have low hepatic glucuronide conjugating
ability.
• If a large dose > 150 mg/kg or > 10 g in an adult: serious toxicities
• Fatality is common > 250 mg/kg.
53. Celecoxib
• selective COX-2 inhibitor—about 10–20 times
more selective for COX-2 than for COX-1
• associated with fewer GI ulcers than most other
NSAIDs
• Probably because it is a sulfonamide, celecoxib may
cause rashes
• does not affect platelet aggregation at usual
doses.
• It interacts occasionally with warfarin
• Adverse effects are the common toxicities listed above.
• Use – in patients with concomitant use of other
anticoagulants, before spinal or intra articular
injections