The document discusses the global consensus sequence development and analysis of conserved domains in the NS3 protein of dengue virus. It describes how over 125 sequences of the NS3 protein from the four dengue virus serotypes were aligned and analyzed. Key conserved domains that encode the serine protease and helicase functions were identified. The phylogenetic tree analysis grouped the sequences by serotype. Suggestions for potential antiviral peptides targeting conserved motifs in these domains to disrupt protein functions and reduce viral replication are provided.