This document discusses evaluating the normality of data distributions. It covers probability, normal distributions, z-scores, empirical rules, and tests for skewness and kurtosis. Normal distributions are symmetric and bell-shaped. The normality of data can be determined using z-scores and empirical rules. Skewness measures asymmetry in a distribution, while kurtosis measures tail weight. Normality tests like Shapiro-Wilk can determine if a dataset comes from a normal distribution.
Range, quartiles, and interquartile rangeswarna sudha
The IQR describes the middle 50% of values when ordered from lowest to highest. To find the interquartile range (IQR), first find the median (middle value) of the lower and upper half of the data. These values are quartile 1 (Q1) and quartile 3 (Q3). The IQR is the difference between Q3 and Q1.
Range, quartiles, and interquartile rangeswarna sudha
The IQR describes the middle 50% of values when ordered from lowest to highest. To find the interquartile range (IQR), first find the median (middle value) of the lower and upper half of the data. These values are quartile 1 (Q1) and quartile 3 (Q3). The IQR is the difference between Q3 and Q1.
Parametric vs Nonparametric Tests: When to use whichGönenç Dalgıç
There are several statistical tests which can be categorized as parametric and nonparametric. This presentation will help the readers to identify which type of tests can be appropriate regarding particular data features.
Lecture on Introduction to Descriptive Statistics - Part 1 and Part 2. These slides were presented during a lecture at the Colombo Institute of Research and Psychology.
Parametric vs Nonparametric Tests: When to use whichGönenç Dalgıç
There are several statistical tests which can be categorized as parametric and nonparametric. This presentation will help the readers to identify which type of tests can be appropriate regarding particular data features.
Lecture on Introduction to Descriptive Statistics - Part 1 and Part 2. These slides were presented during a lecture at the Colombo Institute of Research and Psychology.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
3. Probability
• The set of all possible distinct outcomes to an experiment.
No. of ways event can occur/ No. of outcomes
Probability range
0 To 1
0 percent to 100 percent
Yes or No
4. Example of a dice
Value of probability
is always equal to or
less than 1
6. NORMAL PROBABILITY DISTRIBUTION OF
DATA
• Normal probability distribution, also called Gaussian
distribution refers to a family of distributions that are bell
shaped.
• These are symmetric in nature and peak at the mean, with
the probability distribution decreasing away before and
after.
• Define by two parameters ‘ its MEAN value and S.D.
8. CHARACTERISTICS OF NORMALLY
DISTRIBUTED DATA
• Symmetry
Mean = Median = Mode
• Normally distributed value can be large in both positive and negative
direction
• Probability of any specific value will be zero
• Unimodal
• Defined by its Mean an S.D completely
9. METHODS TO DETERMINE PROBABILITY
FROM NORMAL DISTRIBUTION OF DATA
• Z- score based
• (Z-Distribution)
10.
11.
12. How to calculate Z – Score???
• U= Mean
• Sigma = S.D
• X = Data at a point
13. • Exercise:
• Question: For a process with a mean of 100, a standard deviation of 10 and
an upper specification of 120, what is the probability that a randomly
selected item is defective (or beyond the upper specification limit)?
14. • Answer:
• The Z-score is equal to = (120 –100) / 10 = 2.
• This means that the upper specification limit is 2standard
deviations above the mean.
• Now that we have the Z-score, we can use the Z-table to
find the probability.
• From the Z-table (the complementary cumulative table),
the area under the curve for a Z-value of 2 = 0.9772
• Now (1 – 0.9772 = 0.02275 or 2.275%).
• •This means that there is a chance of 2.275%for any
randomly selected item to be defective.
15. METHODS TO DETERMINE PROBABILITY
FROM NORMAL DISTRIBUTION OF DATA
• Empirical Rule
17. SKEWED DATA
• Skewness in statistics represents an imbalance and an
asymmetry from the mean of a data distribution. In a
normal data distribution with a symmetrical bell
curve, the mean and median are the same. In a
skewed data distribution, the median and the mean
are different values. Normal value = 0
19. TEST OF SKEWNESS
• In order to ascertain whether a distribution is skewed or not the following tests may be
applied. Skewness is present if:
• The values of mean, median and mode do not coincide.
• When the data are plotted on a graph they do not give the normal bell shaped form i.e.
when cut along a vertical line through the centre the two halves are not equal.
• The sum of the positive deviations from the median is not equal to the sum of the
negative deviations.
• Quartiles are not equidistant from the median.
• Frequencies are not equally distributed at points of equal deviation from the mode.
20. MEASURE OF SKEWNESS
The measures of skewness are:
• Karl Pearson's Coefficient of skewness
• Bowley’s Coefficient of skewness
• Kelly’s Coefficient of skewness
21. Karl Pearson's Coefficient of skewness
• The formula for measuring skewness as given by Karl Pearson is as follows
• Where, SKP = Karl Pearson's Coefficient of skewness, σ = standard deviation
22. • In case the mode is indeterminate, the coefficient of skewness is
• The value of coefficient of skewness is zero, when the distribution is
• symmetrical.
• Normally, this coefficient of skewness lies between +1.96 to -1.96.
• If the mean is greater than the mode, then the coefficient of skewness will be
positive, otherwise negative.
23. Excercise
Mean = 70.5.
Median = 80.
Mode = 85.
Standard deviation = 19.33
Measure skweness ?
Answer
Pearson’s Coefficient of Skewness
Step 1: Subtract the mode from the mean: 70.5 – 85 = -
14.5.
Step 2: Divide by the standard deviation: -14.5 / 19.33 = -
0.75.
so data is positively skewed
24. Kurtosis
• Kurtosis is a measure of whether the data are heavy-tailed or light-tailed
relative to a normal distribution. Normal value= 3
• Kurtosis represents the attribute of flatness
• Or peakedness of a distribution
27. When do we do normality test?
A lot of statistical tests (e.g. t-test) require that
our data are normally distributed and therefore
we should always check if this assumption is
violated.
28. Example Scenario on SPSS
Given a set of data, we would like to check if its distribution is normal.
In this example, the null hypothesis is that the data is normally distributed and the
alternative hypothesis is that the data is not normally distributed.
31. Step 2
From the list on the left,
select the variable "Data"
to the "Dependent List".
• Click "Plots" on the right. A
new window pops out.
Check "None" for boxplot,
uncheck everything for
descriptive and make sure
the box "Normality plots
with tests" is checked.
33. The test statistics are shown in the third table.
Here two tests for normality are run. For data-
set small than 2000 elements, we use the
Shapiro-Wilk test, otherwise, the Kolmogorov-
Smirnov test is used. In our case, since we have
only 20 elements, the Shapiro-Wilk test is used.
From A, the p-value is 0.316. We can reject the
alternative hypothesis and conclude that the
data comes from a normal distribution.