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Non selective beta blockers
This document discusses non-selective beta-blockers, which block the action of catecholamines mediated through beta receptors. It describes their pharmacological actions on the heart, respiratory tract, eyes, and other effects. Specific non-selective beta-blockers discussed include sotalol, nadolol, pindolol, oxprenolol, and penbutalol. The advantages of cardio-selective beta-blockers over non-selective ones are also summarized. Finally, it briefly discusses third generation beta-blockers such as carvedilol and cartelol that have additional vasodilatory properties.
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Non selective beta blockers
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- 2. WHAT ARE BETABLOCKERS ?? BETA BLOCKERS ARE THE DRUGS THAT BLOCK THE ACTION OF CATECHOLAMINES MEDIATED THROUGH β RECEPTORS ALL β BLOCKERS ARE COMPETATIVE ANTAGONISTS
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- 4. PHARMACOLOGICAL ACTIONS HEART– beta blockers decreases HR, FORCE OF CONTRACTION, CARDIAC OUTPUT BP FALLS AV CONDUCTION IS DELAYED DUE TO BLOCKADE OF BETA RECEPORS IN AV NODE ,THUS MYOCARDIAL OXYGEN REQUIREMENT IS REDUCED DUE TO REDUCED CARDIAC WORK. BETA-BLOCKERS PREVENTS EXERCISE –INDUCED IN HR & FORCE OF CONTRACTION
- 5. PHARMACOLOGICAL ACTION RESPIRATORYTRACT- BLOCKADE OF β2 RECEPTORS IN BRONCHIAL SMOOTH MUSCLE CAUSES AN INCREASES IN AIRWAY RESISTANCE MAY PRECIPITATE ACCUTE ATTACK IN ASTHMATICS. EYE- MANY BETA BLOCKERS REDUCES IOP BY DECREASED SECRETION OF AQUEOUS HUMOUR OTHER EFFECTS- MANY BETA BLOCKERS IN HIGHER DOSES SODIUM CHANNELS AND HAVE A LOCAL ANAESTHETIC EFFECT- MEMBRANE STABLISING EFFECT
- 6. NON SELECIVE BETABLOCKERS SOTALOL-NON SELECTIVE ,HAS ADDITIONAL POTASSIUM CHANNEL BLOCKING PROPERTY. NADOLOL- LONG ACTING BETA BLOCKER ,USED IN HYPERTENSION,ANGINA ,OESOPHAGEAL VARICES,MIGRANE PROPHYLAXIS AND IN TREMORS.
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- 11. PINDOLOL OXPRENOLOL &PENBUTALOL NON SELECTIVE, PARTIAL AGONISTS ACT BETA 1 & BETA 2 RECEPTORS . PENBUTOLOL IN ADDITION HAS WEAK INTRINSIC SYMPATHOMIMETIC ACTIVITY. ADVANTAGES MILDER BRADYCARDIA MILDER MYOCARDIAL DEPRESSION BETTER TOLERATED IN ASTHMATICS MILDER EFFECT ON LIPID PROFILE LESS CHANCES OF REBOUND HYPERTENSION ON WITHDRAWAL.
- 12. DIS ADVANTAGE NOTSUITABLE FOR PROPHYLAXIS OF MIGRANE AND MYOCARDIAL INFARCTION DOSES PINDOLOL-10-30 mg OXPRENOLOL -40-80mg PENBUTALOL-20-80mg LEVATOL 20,40mg
- 13. ADVANTAGES OF CARDIOSELECTIVEβ BLOCKERS OVER NON SELECTIVE β BLOCKERS I. SAFER IN ASTHMATICS II. SAFER IN DIABETES III. PERIPHERAL VASCULAR DISEASES IV. LESS DELETERIOUS EFFECTS ON LIPID PROFILE V. LESS LIABLE TO IMPAIR EXERCISE CAPACITY
- 14. Third generation betablockers THESE INCLUDES ,CARVEDILOL,CARTELOL,LAVETALOL,BUCINDALOL THESE ARE BETA BLOCKERS WITH ADDITIONAL VASODIALATORY PROPERTIES CARTELOL- NON SELECTIVE BETA BLOCKER WITH PARTIAL AGONISTIC ACTIVITY AT β1 RECEPTORS AND THUS CAUSES BRADYCARDIA CARVEDILOL- BLOCKS β1,β2 & α1 RECEPTORS IT ALSO HAS MEMBRANE STABILIZING AND ANTI INFLAMMATORY PROPERTIES.