The document reviews the medicinal properties of the neem tree (Azadirachta indica), highlighting its extensive use in traditional and modern medicine for treating various health conditions. Neem leaves exhibit numerous pharmacological activities, such as anti-inflammatory, antibacterial, and antioxidant effects, making them vital in treating ailments like ulcers and infections. Additionally, it discusses a patent controversy regarding neem products and emphasizes the historical significance of neem in Indian medicine.

1. NEEM RESEARCH N Natures E Eco Friendly E Economical M Miracle

2. By Dr Sanjeev Sood M.D. Ayurvedic Medicine Professor & Head Department of Panchakarma Dayanand Ayurvedic College Jalandhar India [email_address]

3. Medicinal properties of neem leaves: a review. Azadirachta indica, commonly known as neem, has attracted worldwide prominence in recent years, owing to its wide range of medicinal properties. Neem has been extensively used in Ayurveda, Unani and Homoeopathic medicine and has become a cynosure of modern medicine. Neem elaborates a vast array of biologically active compounds that are chemically diverse and structurally complex. More than 140 compounds have been isolated from different parts of neem. NEEM – RESEARCH NEEM – RESEARCH

4. All parts of the neem tree- leaves, flowers, seeds, fruits, roots and bark have been used traditionally for the treatment of inflammation, infections, fever, skin diseases and dental disorders . The medicinal utilities have been described especially for neem leaf. Neem leaf and its constituents have been demonstrated to exhibit immunomodulatory, anti-inflammatory, antihyperglycaemic, antiulcer, antimalarial, antifungal, antibacterial, antiviral, antioxidant, antimutagenic and anticarcinogenic properties . This review summarises the wide range of pharmacological activities of neem leaf. Subapriya R , Nagini S NEEM – RESEARCH

5. Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. The bark extract when taken at the dose of 30-60 mg twice daily for 10 weeks almost completely healed the duodenal ulcers monitored by barium meal X-ray or by endoscopy. One case of esophageal ulcer (gastroesophageal reflux disease) and one case of gastric ulcer also healed completely when treated at the dose of 30 mg twice daily for 6 weeks Bandyopadhyay U , Biswas K , Sengupta A , Moitra P , Dutta P , Sarkar D , Debnath P , Ganguly CK , Banerjee RK . NEEM – RESEARCH

6. Enhancement of immune responses to neem leaf extract (Azadirachta indica) correlates with antineoplastic activity in BALB/c-mice. Beuth J , Schneider H , Ko HL . A new shampoo based on neem (Azadirachta indica) is highly effective against head lice in vitro. Heukelbach J , Oliveira FA , Speare R . Chemomodulatory effects of Azadirachta indica on the hepatic status of skin tumor bearing mice. Koul A , Ghara AR , Gangar SC . NEEM – RESEARCH

7. Fractions of an antimalarial neem-leaf extract have activities superior to chloroquine, and are gametocytocidal. Udeinya IJ , Brown N , Shu EN , Udeinya FI , Quakeyie I Evaluation of antiplaque activity of Azadirachta indica leaf extract gel--a 6-week clinical study. The results of the study suggested that the dental gel containing neem extract has significantly (P<0.05) reduced the plaque index and bacterial count than that of the control group. Pai MR , Acharya LD , Udupa N . NEEM – RESEARCH

8. Effect of aqueous extract of Azadirachta Indica leaves on hepatotoxicity induced by antitubercular drugs in rats Kale BP, Kothekar MA, Tayade HP, Jaju JB, Mateenuddin M Other Important links http://www.neemfoundation.org/ http://www.nap.edu/books/0309046866/html/ International Neem Network (INN) India wins landmark patent battle NEEM – RESEARCH

9. Patent controversy In 1995 the European Patent Office (EPO) granted a patent on an anti-fungal product, derived from neem, to the US Department of Agriculture and multinational WR Grace. The Indian government challenged the patent when it was granted, claiming that the process for which the patent had been granted had actually been in use in India for over 2000 years. In 2000 the EPO ruled in India's favour but the US multinational mounted an appeal claiming that prior art about the product had never been published in a scientific journal. On 8 March 2005, that appeal was lost and the EPO revoked the Neem patent rights keeping the tree free of any patent restrictions. NEEM – RESEARCH

10. Medical properties of Neem have been known to Indians since time immemorial. The Neem tree brings joy and freedom from various diseases. It has proven beneficial or preventative for the following: NEEM – INDICATIONS

11. Abrasions Epilepsy Obesity Acne Eczema Piles AIDS Fungal Infections Peptic Ulcers Allergies Fever Prickly Heat Arrhythmia Food Poisoning Parasites Arthritis Genital Warts Pain Athletes Foot Gingivitis Plague Amenorrhoea Gonorrhea Periodontal Disease Bed Sores Gout Rashes Birth Control Gastritis Rheumatism Bleeding Gums Goitre Sore Throat Blood Purifier Gangrene Sprains Bronchitis Heart Disease Stomach Problems Bruises Hemorrhoids Stress Burns Hepatitis Syphilis Bad Breath Herpes Scabies Boils & Pimples High Blood Pressure Sinusitis Cavities Hives Snake Bite Chagas Disease Hypertension Sores Chicken Pox Hair Loss Smoking

12. Chlamydia Heart Burn Skin Ulcers Cholesterol Hangover Shingles Chronic Fatigue Headache Skin Problems Circulation (poor) Influenza Thrush Colds Insomnia Tuberculosis Cold Sores Immune System Toothache Cancer Indigestion Urinary Tract infection Conjunctivitis Intestinal Worms Urethra Infection Convulsions Infected Glands Ulcers Cough Inflammation Urinary Stones Cuts Joint Pains Viral Candida Kidney Problem Vaginal Disorders Dental Problems Lice Wounds Diabetes Leucoderma Warts Diaper Rash Leprosy Wrinkles Dry Skin Measles Yeast infections Dandruff Malaria Migraines Earache Encephalitis Nausea

13. Ayurvedic concept: TASTE RAS TIKATA (BITTER), KASHAY ( ASTRINGENT) PROPERTY GUNA LAGHU (LIGHT) POTENCY VEERYA SHEET (COLD) POST DIGESTIVE EFFECT VIPAKA KATU (PUNGENT) NEEM – RESEARCH

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