Dr. Richard Cote of Sylvester Comprehensive Cancer Center presented "New Technologies That Will Have an Impact on Cancer" at the 2011 WellBeingWell Conference in Miami.
Electronics and computational techniques are increasingly being used to analyze biological cells to diagnose diseases and develop methodologies to cure diseases inside the body. One such technology is ‘Nanotechnology’. The paper emphasizes on the best and effective utilization of Nanotechnology in the treatment of cancer. The design of nano device is based on the constant study of cancer cells and nanotechnology.
The nano device is injected to the patient which can travel through blood vessel, identify and destroy cancer cells. The system is fully automated whereby the device manages to move to the affected cells through certain algebraic calculations automatically wherever it might be placed. This would be loaded into a simple microprocessor like 8085 and can be embedded along with the nano device for automatic discovery of cancer cells. Manual guidance and monitoring is done to control the device explicitly, further more command signals are activated automatically or manually to destroy the affected cells through RF signals. The theme is based on the fact that the cancer cells get destroyed on exposure to RF signals, due to high heat generation.
In our paper we design a device that contains sensors, transceivers, motors and a processor which are made up of biodegradable compound. No more destruction of healthy cells due to harmful toxins and radiations generated through chemotherapy and radiation therapy. Electronics and computational techniques are increasingly being used to analyze biological cells to diagnose diseases, and develop methodologies to cure the diseases inside the human body.
The main aim of this paper deals with the eradication of cancer cells by providing a steady, possible method of destroying and curing the cancer in an efficient and safe way so that healthy cells are not affected in any manner. This technology also focuses on a main idea that the patient is not affected by cancer again. The purpose of using the RF signal is to save normal cells.
This presentation is related to cancer treatment and involvement of the nanotechnology in cancer research. This has different nanotechnology-related delivery information.
Electronics and computational techniques are increasingly being used to analyze biological cells to diagnose diseases and develop methodologies to cure diseases inside the body. One such technology is ‘Nanotechnology’. The paper emphasizes on the best and effective utilization of Nanotechnology in the treatment of cancer. The design of nano device is based on the constant study of cancer cells and nanotechnology.
The nano device is injected to the patient which can travel through blood vessel, identify and destroy cancer cells. The system is fully automated whereby the device manages to move to the affected cells through certain algebraic calculations automatically wherever it might be placed. This would be loaded into a simple microprocessor like 8085 and can be embedded along with the nano device for automatic discovery of cancer cells. Manual guidance and monitoring is done to control the device explicitly, further more command signals are activated automatically or manually to destroy the affected cells through RF signals. The theme is based on the fact that the cancer cells get destroyed on exposure to RF signals, due to high heat generation.
In our paper we design a device that contains sensors, transceivers, motors and a processor which are made up of biodegradable compound. No more destruction of healthy cells due to harmful toxins and radiations generated through chemotherapy and radiation therapy. Electronics and computational techniques are increasingly being used to analyze biological cells to diagnose diseases, and develop methodologies to cure the diseases inside the human body.
The main aim of this paper deals with the eradication of cancer cells by providing a steady, possible method of destroying and curing the cancer in an efficient and safe way so that healthy cells are not affected in any manner. This technology also focuses on a main idea that the patient is not affected by cancer again. The purpose of using the RF signal is to save normal cells.
This presentation is related to cancer treatment and involvement of the nanotechnology in cancer research. This has different nanotechnology-related delivery information.
Regular cancer treatment focuses on killing the cancer cells through large doses of medicine, but it also kills other cells in the body and causes significant side effects and potential long-term effects. UCalgary researcher David Cramb – who looks at using nanoparticles to deliver the drugs solely to the tumor in much smaller, more effective quantities shares the potential breakthroughs that can be made possible through nanomedicine both in the treatment and diagnosis of cancer. Watch the full webinar recording: http://www.ucalgary.ca/explore/nanomedicine-new-way-detect-and-treat-cancer
14th International Conference and Exhibition on Nanomedicine and Pharmaceutic...Evelyn Smith
Conference Series Ltd organizes highly notable pharmaceutical conferences throughout the world. Currently we are bringing forth “14th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology” (NanoMed 2018) scheduled to be held during April 09-11, 2018 at Amsterdam, Netherlands. The conference gathers all the participants across the globe to attend and share their insights and convey recent developments in the field of Pharmaceutical Nanotechnology and Drug delivery. The main theme of the conference is “Emerging Importance of Nanomedicine & Nanotechnology to Drive the Pharma Industry”.
NanoPharma 2018 aims to bring together leading academic scientists, researchers, research scholars, fellow key decision makers and experts all-around the Academic Institutions, Healthcare Institutes, Pharmaceutical, Biotech, Biomedical, Formulation scientists and researchers making the congress a perfect platform to share experience, foster collaborations through the research talks & presentations to put forward many thought provoking strategies. It's a perfect stage to brainstorm, discover new ideas, search for new skills and a platform to show your capabilities and discoveries to the world. It also provides a premier interdisciplinary platform for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions opted in the fields of Nanotechnology and Nanomedicine.
Conference Highlights:
Nanomedicines and Biomedical Applications | Drug Discovery and Designing | Pharmaceutical Nanotechnology | Regenerative Medicine and Tissue Engineering | Drug Delivery Research | Novel Drug Delivery Systems | Nano Pharmaceuticals | Nanobiotechnology | Graphene Medicine | Personalized Nanomedicine | Nanomedicine & Cancer | Pharmaceutical Companies and Markets | Business Opportunities in Nanotechnology
For more details Visit: http://nanotechnology.pharmaceuticalconferences.com/
Antitumor applications of nano-traditional Chinese medicineLucyPi1
An article by Deng et al. [1] that was first published in ACS Nano in 2019 revealed that nanoparticles extracted from cuttlefish ink (CINPs) could inhibit tumor growth by synergizing immunotherapy and photothermal therapy. The researchers found that these CINPs, which had significant antitumor efficacy, could effectively reprogram tumor-associated macrophages (TAMs) from the immune-suppressive M2-like phenotype to the antitumor M1-like phenotype.
Uses of Nanotechnology:
1- Diagnosis and treatment of cancer
According to the US National Cancer Institute (OTIR, 2006) “Nanotechnology will
change the very foundations of cancer diagnosis, treatment, and prevention”. We have
already seen how nanotechnology, an extremely wide and versatile field, can affect many
of its composing disciplines in amazingly innovative and unpredictable ways.
Q- what is cancer ?
Cancer is a disease caused by normal cells changing them so that they grow in an uncontrolled way.
The uncontrolled growth can cause problems in one or more of the following ways:
-spreading into normal tissues nearby.
-causing pressure on other body structure.
-spreading to other parts of the body through the lymphatic system or blood stream.
The word cancer was first applied to the disease by Hippocrates (460–370 B.C.), the
Greek philosopher, who used the words carcinos and carcinoma to refer to non-ulcer
forming and ulcer forming tumors. The words refer to a crab, probably due to the
external appearance of cancerous tumors, which have branch-like projections that
resemble the claws of a crab.
Regular cancer treatment focuses on killing the cancer cells through large doses of medicine, but it also kills other cells in the body and causes significant side effects and potential long-term effects. UCalgary researcher David Cramb – who looks at using nanoparticles to deliver the drugs solely to the tumor in much smaller, more effective quantities shares the potential breakthroughs that can be made possible through nanomedicine both in the treatment and diagnosis of cancer. Watch the full webinar recording: http://www.ucalgary.ca/explore/nanomedicine-new-way-detect-and-treat-cancer
14th International Conference and Exhibition on Nanomedicine and Pharmaceutic...Evelyn Smith
Conference Series Ltd organizes highly notable pharmaceutical conferences throughout the world. Currently we are bringing forth “14th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology” (NanoMed 2018) scheduled to be held during April 09-11, 2018 at Amsterdam, Netherlands. The conference gathers all the participants across the globe to attend and share their insights and convey recent developments in the field of Pharmaceutical Nanotechnology and Drug delivery. The main theme of the conference is “Emerging Importance of Nanomedicine & Nanotechnology to Drive the Pharma Industry”.
NanoPharma 2018 aims to bring together leading academic scientists, researchers, research scholars, fellow key decision makers and experts all-around the Academic Institutions, Healthcare Institutes, Pharmaceutical, Biotech, Biomedical, Formulation scientists and researchers making the congress a perfect platform to share experience, foster collaborations through the research talks & presentations to put forward many thought provoking strategies. It's a perfect stage to brainstorm, discover new ideas, search for new skills and a platform to show your capabilities and discoveries to the world. It also provides a premier interdisciplinary platform for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions opted in the fields of Nanotechnology and Nanomedicine.
Conference Highlights:
Nanomedicines and Biomedical Applications | Drug Discovery and Designing | Pharmaceutical Nanotechnology | Regenerative Medicine and Tissue Engineering | Drug Delivery Research | Novel Drug Delivery Systems | Nano Pharmaceuticals | Nanobiotechnology | Graphene Medicine | Personalized Nanomedicine | Nanomedicine & Cancer | Pharmaceutical Companies and Markets | Business Opportunities in Nanotechnology
For more details Visit: http://nanotechnology.pharmaceuticalconferences.com/
Antitumor applications of nano-traditional Chinese medicineLucyPi1
An article by Deng et al. [1] that was first published in ACS Nano in 2019 revealed that nanoparticles extracted from cuttlefish ink (CINPs) could inhibit tumor growth by synergizing immunotherapy and photothermal therapy. The researchers found that these CINPs, which had significant antitumor efficacy, could effectively reprogram tumor-associated macrophages (TAMs) from the immune-suppressive M2-like phenotype to the antitumor M1-like phenotype.
Uses of Nanotechnology:
1- Diagnosis and treatment of cancer
According to the US National Cancer Institute (OTIR, 2006) “Nanotechnology will
change the very foundations of cancer diagnosis, treatment, and prevention”. We have
already seen how nanotechnology, an extremely wide and versatile field, can affect many
of its composing disciplines in amazingly innovative and unpredictable ways.
Q- what is cancer ?
Cancer is a disease caused by normal cells changing them so that they grow in an uncontrolled way.
The uncontrolled growth can cause problems in one or more of the following ways:
-spreading into normal tissues nearby.
-causing pressure on other body structure.
-spreading to other parts of the body through the lymphatic system or blood stream.
The word cancer was first applied to the disease by Hippocrates (460–370 B.C.), the
Greek philosopher, who used the words carcinos and carcinoma to refer to non-ulcer
forming and ulcer forming tumors. The words refer to a crab, probably due to the
external appearance of cancerous tumors, which have branch-like projections that
resemble the claws of a crab.
Nanotechnology and potential in Cancer therapy and treatmentladen12
this presentation focuses on new nanotechnology and it possible use in detection and therapy with cancer. it was prepared by final year biochemistry student at NCU.
The Acoustic Technology for Ctcs Isolation in Blood: Low-Cost Devices_Crimson...CrimsonpublishersCancer
Blood samples can be used as a liquid biopsy in cancer diagnosis and chemotherapy monitoring. This label- free method offers benefits over traditional tissue invasive biopsy. It is possible to separate rare cells from blood samples by Ultrasounds on the basis of their physical properties in a biocompatible manner. A successful separation of cultured cancer cells from WBCs with acoustic-based methods is being demonstrated during the last years through different technological approaches. The concept of plate acoustic waves (PAW) applied to acoustophoresis was recently introduced to perform acoustic flow-through separation of rare cells in blood samples. It lies in the geometrical chip design, different to other micro separators (BAW and SAW). This new strategy allows soft materials of extremely reduced volume and low-cost fabrication and opens a door to printing manufacturing processes.
(December 2, 2021) The Bench to Bedside Series: Preclinical Cancer Research w...Scintica Instrumentation
Overview:
The goal of this webinar will be to provide a high-level overview of the various stages of preclinical cancer research and discuss the role that innovative instrumentation can play in moving science forward.
To better understand how to treat and control cancer, researchers start by investigating the basics – the cells, molecules, and genes that make up the human body. This type of study, which is often referred to as basic or discovery research, aims to understand the underlying mechanisms contributing to cancer growth and spread. This knowledge is an essential starting point for developing future diagnostic tests and treatment strategies.
After finding an innovative idea that works in cells, researchers need to take their studies to the next level by employing animal models that have similar biology to humans. Animal models have helped scientists make some of the most important cancer discoveries over the years. Furthermore, preclinical imaging technologies allow researchers to perform longitudinal animal studies that are noninvasive leaving the underlying biology intact so that one can track changes throughout the entire disease process.
It was previously thought that the journey from bench to bedside was unidirectional, starting with discovery research and moving towards clinical trials. However, in the last decade, it has become crucial for basic scientists and clinicians to work together towards finding innovative solutions that will positively impact patient care.
After attending this webinar, we hope you will have a better understanding of the preclinical workflow needed to push an idea from bench to bedside as well as some of the key equipment that is needed along the way.
This webinar series will be hosted by Drs. Katie Parkins and Tyler Lalonde, both of which have extensive experience in translational research areas including oncology, neuroscience, molecular imaging, and drug development.
In this webinar we will discuss the following topics:
• Introduction To Cancer Research
• What does “Bench to Bedside” mean?
• In vitro characterization
• Rapid throughput screening
• Quantitative tools
• Moving towards translation
Identification of Rare and Novel Alleles in FFPE Tumor Samples | ESHG 2015 Po...Thermo Fisher Scientific
Tumors are becoming recognized as genetically heterogeneous masses of cells with different clonal histories. Identifying the mutations present in these heterogeneous masses can lead to important insights into the future behavior of the tumor and possible intervention mechanisms. However, the rarity of pathogenic mutations in small subsets of cells can make identification of such alleles difficult. In this study, we demonstrate a complete workflow that facilitates the identification of rare and novel alleles from FFPE tumor sections. We collected small regions with different cellular morphologies from lung tumor samples using laser capture microdissection, extracted both DNA and RNA from these regions, and characterized mutations present and transcript abundances by using Ion AmpliSeq™ targeted sequencing. We show that LCM facilitates the detection of alleles that are not detectable in macrodissected tissue scrapes. We also show that different regions of a tumor have very different patterns of alleles detectable and have a great deal of genetic diversity. Finally, we show that RNA expression patterns are also clearly different in the different regions. Interestingly, dissected regions with similar gross tissue morphologies display differences in alleles present and RNA expression patterns. These results suggest how we may in the future use this method to analyze mutations present in a tumor is to microdissect different subregions of the tumor, and using Ion AmpliSeq™ panels to identify the alleles present in those subregions.
Peter Hamilton on Next generation Imaging and Computer Vision in Pathology: p...Cirdan
Automated image analysis has had a long history but continues to grow with massive improvements in algorithms, speed, performance, and with emerging opportunities for high throughput tissue biomarker analysis and automated decision support for primary diagnostics. Of particular importance is the development of computer vision and image analysis for H&E stained samples. This talk will outline recent advances in automated tissue analysis for biomarker discovery and diagnostics and how adoption of digital pathology will drive the demand for quantitative imaging and decision support.
As an example, PathXL have developed TissueMark for the automated identification and analysis of tumour in lung, colon, breast and prostate cancer digital H&E slides. The conventional pathological estimation of % tumour nuclei in H&E samples shows gross variation between pathologists, undermining the quality of next generation sequencing, molecular testing and patient therapy and potential of false negative diagnoses. TissueMark uses a combination of pattern recognition, glandular analysis and nuclear segmentation to identify premaligant and invasive cancer patterns in H&E stained tissues and use this to assess tumour cell numbers and annotate samples for nucleic acid extraction and molecular profiling. Benchmark data was generated to validate TissueMark technology and showed concordance of automated data with manual counts, accelerating tumour markup and improving sample quality assessment. This represents an example of how automated imaging of tissue samples can be of immense value in quantitative tumour analysis for molecular diagnostics, thereby improving reliability in discovery and diagnostics.
This together with other examples in pathology research and practice will demonstrate that next generation tissue imaging technology in digital pathology could radically change how pathology is practiced.
Dr. Thomas Yankeelov: Integrating Advanced Imaging and Biophysical Models to...Dawn Yankeelov
This is a talk from the Technology Association of Louisville Kentucky. Dawn Yankeelov is co-chair of TALK, and Dr. Thomas Yankeelov is the director for the Institute of Imaging Science at Vanderbilt University. He presented his latest research in June 2013, "Integrating Advanced Imaging and Biophysical Models to Predict Tumor Growth."
Molecular characterization of a patient’s tumor to guide treatment decisions is increasingly being
applied in clinical care and can have a significant impact on disease outcome. These molecular analyses,
including mutation characterization, are typically performed on tissue acquired through a biopsy at diagnosis.
However, tumors are highly heterogeneous and sampling in its entirety is challenging. Furthermore, tumors
evolve over time and can alter their molecular genotype, making clinical decisions based on historical biopsy
data suboptimal. Personalized medicine for cancer patients aims to tailor the best treatment options for the
individual at diagnosis and during treatment. To fully enable personalized medicine it is desirable to have an
easily accessible, minimally invasive way to determine and follow the molecular makeup of a patient’s tumor
longitudinally. One such approach is through a liquid biopsy, where the genetic makeup of the tumor can be
assessed through a bio fluid sample. Liquid biopsies have the potential to help clinicians screen for disease,
stratify patients to the best treatment and monitor treatment response and resistance mechanisms in the tumor. A liquid biopsy can be used for molecular characterization of the tumor and its non-invasive nature
allows repeat sampling to monitor genetic changes over time without the need for a tissue biopsy. This review will summarize three approaches in the liquid biopsy field: circulating tumor cells (CTCs), cell free DNA (cfDNA) and exosomes. We also outline some of the analytical challenges encountered using liquid biopsy techniques to detect rare mutations in a background of wild-type sequences.
Dr. Marc Lippman of Sylvester Comprehensive Cancer Center presented "Why Clinical Trials Are Important to Everyone" at the 2011 WellBeingWell Conference in Miami.
Dr. Mark Stoutenberg of University of Miami Health System discussed the importance of physical activity and exercise at the 2011 WellBeingWell Conference.
Dr. Michael Antoni of Sylvester Comprehensive Cancer Center discussed stress management for cancer patients at the 2011 WellBeingWell Conference in Miami.
Dr. Ashwin Mehta of University of Miami Health System presented "Integrative Approaches to Optimum Sleep" at the 2011 WellBeingWell Conference in Miami.
Dr. Eugene Ahn of Sylvester Comprehensive Cancer Center discussed mind-body approaches to cancer healing at the 2011 WellBeingWell Conference in Miami.
Dr. Janet Konefal of UHealth - University of Miami Health System discussed ways to live a healthy lifestyle at the 2011 WellBeingWell Conference in Miami.
"Facing the Mirror With Cancer" is a book designed to help cancer patients learn how to use makeup and other beauty tricks to improve their self-confidence and appearance. Lori Ovitz presented this during the 2011 WellBeingWell Conference hosted by Sylvester Comprehensive Cancer Center in Miami.
Dr. Jerry Goodwin, chief medical officer of Sylvester Comprehensive Cancer Center/UMHC, presented "Can Cancer Be Prevented?" at the 2011 WellBeingWell Conference in Miami.
More from Sylvester Comprehensive Cancer Center (18)
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
1. New Technologies That Will Have an Impact on Cancer Sylvester Comprehensive Cancer Center Well-Being Session, April 26, 2011 Richard J. Cote, MD, FRCPath Chair, Pathology Director, Biomedical Nanoscience Institute University of Miami
2. Length Scales FITC IgG DNA Diameter GFP Virus Colloidal gold Bacterium Animal Cell Plant Cell 0.5nm 5nm 2nm 1nm 50nm 100nm 1 m 10 m 100 m Nanoworld Microworld
8. Challenge in Building and Using Nanosensor Devices: Need microfluidics 24 Sensor Array for Coupling with Microfluidic Delivery + = A sensor array chip with 3 rows of 8 devices is overlaid with a matching PDMS microflidic system . Indium Oxide Nanowires are grown chemically to lie across electrical ‘ source ’ and ‘ drain ’ to create a ‘ device ’. An FET array contains 3 rows of 8 devices to form a Sensor Array Chip.
14. Mean (and range) of sizes of normal cellular components of blood, and certain cancer cell lines. Universal Platform for Cell Capture Based on Size Normal blood components Cancer cell lines 0 5 10 15 20 25 30 Platelets RBC Basophils Lymphocytes Neutrophils Eosinophils Monocytes NCI-H522 J82 RT4 HCC-70 MDA-MB-231 HT1080 T24 SK-Br-3 HCC-38 LnCaP NCI-1395 Cell size ( μ m)
15. Microfilter Based Cell Separation Assembled Filter Device Parylene Filter Membrane SEM of Cell Captured on filter Syringe 1 PDMS Chamber Parylene Membrane Filter Trapped Tumor Cell RBC’s in the flow through MNCs 100µm A B C 100µm
16. Multiplexed Imaging On-Chip Multiplex PCR Her2/neu FISH analysis on microfilter CK PSA CK PSA DAPI
17.
18.
19. Serial CTC counts predict survival in prostate cancer Moreno et al Proc Am Soc Clin Oncol 2007;25:239s. DeBono et al, CCR , 2008, MSKCC, CCF, U Mich Kaplan–Meier plot for overall survival of CTC counts categories conversion at any time point following the early or late cycle of treatment. Survival times were calculated from the date of baseline (BL) CTC blood draw. Multivariate analysis was carried out using a Cox regression model with a time-dependant co-variable. 1 2 3 4 Curve Logrank Comparison p-Value* 1 vs. 2 0.1528 1 vs. 3 <0.0001 1 vs. 4 <0.0001 2 vs. 3 <0.0001 2 vs. 4 <0.0001 3 vs. 4 0.5013 %Probability of Survival Time from Baseline Blood Draw (Months) 0 2 4 6 8 10 12 14 16 18 22 24 26 28 30 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% 20 *p-values not adjusted for multiple hypothesis tests Grp Description N (%) Median OS in months (95% CI) 1 <5 CTC at all draws 88 (38%) >26 (21.4 to -----) 2 > 5 CTC at BL & <5 CTC at last draw 45 (20%) 21.3 (18.4 to ----) 3 <5 CTC at Early Draw & > 5 CTC at Last Draw 26 (11%) 9.3 (8.2 to 11.3) 4 > 5 CTC at All Draws 71 (31%) 6.8 (5.8 to 10.3)
20.
21. Nanoparticles can serve as imaging contrast agents Magnetized nanoparticles can be used to image sentinel lymph nodes Example: SentiMag technology by Endomagnetics Johnson L et al, Discov Med. 2010 Apr;9(47):374-9. QD800- based imaging agents tested in vivo are stable up to several days Yang et al, Oral Oncology, 46, 864-868, 2010
22. Cote et al J Clin Oncol. 1991 Recurrence Rates Based on Tumor Burden in the Bone Marrow
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24. Nanosensor Platforms Team Nanosensor Collaborators Dr. Mark Thompson, USC Dr. Chong wu Zhou, USC Dr. Thomas Thundat, ORNL Dr. Ram Datar, UM Dr. Marco Curreli, USC Dr. Fumi Ishikawa, USC Dr. Henry Lin, ORNL Dr. Arun Majumdar
25. Dr. Yu Chong Tai, Caltech Dr. Ram Datar, UM Dr. Marija Balic, Austria Dr. Siyang Zheng , PennState Dr. Henry Lin, ORNL Anthony Williams, UM CTC Microfilter Team CTC Microfilter Collaborators