This lesson plan discusses genetic mutations. The objectives are for students to learn about different types of mutations, explain the differences between them, and understand the importance of respecting those with genetic disorders. The lesson will involve identifying errors in chromosomes that represent different types of mutations like aneuploidy, discussing characteristics of genetic disorders like Down syndrome, and an assessment matching genetic concepts and conditions.

1. Semi-detailed Lesson Plan in Science II
I. Objectives
At the end of the 30-minute discussion, students should be able to:
 determine the different types of mutation;
 explain the differences among types of mutations; and
 speak out the importance of respecting persons with genetic disorders.
II. Subject Matter
Topic : Mutation
Reference : learngenetics.com
Materials : Powerpoint Presentation, Illustration Boards, Manila paper, markers
Value Infused : Respecting Persons With Genetic Disorders
III. Procedure
A. Routine Activities
1. Greetings
2. ClassroomManagement
3. Prayer
4. Food for Thought
5. Checking of Attendance
6. BioBits (Trivia of the Day)
B. Drill
Whose Comm. Is It?
The class will be divided into three (3) groups. Pictures of product
commercials will be flashed on the screen and the students should be able to
identify whose commercial is it. Answers will be written on the illustration
boards provided. The group with the highest score wins the game.
Commercial Answer
Surf

2. Ponds Men
Fita
Lucky Me
McDonald’s
C. Review
- What is DNA?
- What carries the DNA?
- How many chromosomes does a normal human have?
D. Motivation
Pictures of McDo’s commercial showing a person with Down syndrome will be
flashed on the screen, the students will be asked the following questions:
1. Are you familiar with his condition?
2. How does the brother treat his sibling with Down syndrome?
The teacher will then present the objectives for the day.

3. E. Lesson Proper
Task 1: The teacher will present the chart for the students to identify the errors
or mutations.
Mutation
What is mutation?
What is aneuploidy?
Task 2: After identifying the mutations, the teacher will ask the students to
describe the sets of chromosomes in comparison with the normal sets.
Types of Aneuploidy
What is nullisomy?
What is monosomy?
What is trisomy?
What is tetrasomy?

4. Task 3: Images will be flashed on the screen and the teacher will ask the
students some descriptions that they can easily note on the pictures.
Mutation in Humans
Down syndrome
What are the notable characteristics of a person with Down
syndrome?
How do they act? Do they act according to their age?
Edward’s syndrome
What can you observe from the organs of the babies?
Monosomy 7
If the patients are having blood transfusions and low platelet counts,
what do you think is the disease they suffer from?

5. Pallister-Killian syndrome
What can you observe from the foreheads of the two babies?
Special Question:
In humans, we have all types of aneuploidy except nullisomy,
why do you think is that so?
F. Generalization
- What is mutation?
- What is aneuploidy?
- What are the types of mutation according to chromosome number?
- Being familiarized on how hard it is for persons with genetic disorders as well as
the advancement of technology in which we can now be able to detect such
disorders, will you favor euthanasia or mercy killing on babies with detected
disorders for them not to suffer?
G. Application
Pass ‘N Roll
Mechanics: There will be a dice which will be drawn, the number will determine
who will answer the question and what will be the question. An illustration board will be
distributed among the groups, which will move according to the number on the dice drawn,
for the students to write their answers. The group with the highest point wins.
1. Any change in an organism’s DNA
2. Any change in the normal number of chromosomes
3. Presence of an extra pair of chromosomes
4.The most common human mutation
5. Characterized by bone marrow insufficiency
6. Characterized by high foreheads

6. IV. Evaluation
Direction: Match the items in column A with the items in column B. Write your answer on
the space provided before the number.
A
______1. Mutation
______2. Aneuploidy
______3. Nullisomy
______4. Trisomy
______5. Down syndrome
______6. Edward’s syndrome
______7. Patau syndrome
______8. Monosomy 7
______9.tetrasomy
______10.Pallister-Killian syndrome
B
a. tetrasomy 12
b. any variation in the number of
chromosomes
c. jaundice
d. deletion of the entire set of
chromosomes
e. trisomy 18
f. Trisomy 13
g. any alteration in the DNA
h. presence of an extra chromosome
i. bone marrow insufficiency
j. also known as trisomy 21
k. over replication of the entire set of
chromosomes
V. Assignment
Direction: On a one whole sheet of paper, write an essay of not less than 100 words on how
can humans prevent mutations from happening. Be resourceful and creative. Think critically.
Prepared by:
Jan del Rosario
3SED-SC