This document provides an overview of multiple sclerosis (MS). It defines MS as an immune-mediated progressive demyelinating disease of the central nervous system. The causes include autoimmune activity and genetic predisposition. In MS, sensitized T cells cross the blood-brain barrier and remain in the central nervous system, promoting damage. Clinical manifestations include fatigue, weakness, numbness, vision problems, and pain. Diagnosis involves MRI, cerebrospinal fluid analysis, and other tests. Treatment includes medications like corticosteroids, mitoxantrone, and amantadine to manage symptoms and slow progression. Nursing care focuses on assessing neurological function and managing issues like incontinence, speech and swallowing difficulties.