This presentation is made to act as a guide and a short reminder to clinicians and medical students on Volkmann's Ischaemic Contracture, which is a medical condition that can lead to activities limitation and public participation restriction. This presentation explore aspects of the condition such as what it is, causes, how it can be diagnosed, how it can be managed and others.
This presentation is made to act as a guide and a short reminder to clinicians and medical students on Volkmann's Ischaemic Contracture, which is a medical condition that can lead to activities limitation and public participation restriction. This presentation explore aspects of the condition such as what it is, causes, how it can be diagnosed, how it can be managed and others.
Oswestry Disability Index or Oswestry low back pain disability questionnaire is a self-administered questionnaire divided into ten sections designed to assess limitations of various activities of daily living.
Each section is scored on a 0 – 5 scale, 5 representing the greatest disability. The index is calculated by dividing the summed score by the total possible score, which is then multiplied by 100 and expressed as a percentage.
Oswestry low back pain disability questionnaire has questions about: Pain Intensity, Standing, Personal Care, Sleeping, Lifting, Sex Life, Walking, social life, Sitting and Traveling.
Neck Disability Index (NDI) is a 10 item questions that measures a patient's neck pain related disability, it was first published in 1991 by Dr. Howard Vernon and was based on the Oswestry Low Back Pain Disability Questionnaire.
The 10 Questions of NDI include activities of daily living, such as: personal care, lifting, reading, work, driving, sleeping, recreational activities, pain intensity, concentration and headache.
The items are scored in descending order with the top statement = 0 and the bottom statement = 5
All subsections are added together for a cumulative score. The higher the score, the greater the disability.
Thomas Test is used to evaluate hip flexion contracture and psoas syndrome (Iliopsoas Tightness), which is more common in runners, dancers, and gymnasts with symptoms of hip “stiffness” and “clicking” feeling when flexing at the waist.
Thomas Test is used to evaluate hip flexion contracture and psoas syndrome (Iliopsoas Tightness), which is more common in runners, dancers, and gymnasts with symptoms of hip “stiffness” and “clicking” feeling when flexing at the waist.
Homan's Sign is a screening test used to check for deep vein thrombosis (DVT) of the calf. It’s sometimes called dorsiflexion sign.
It was first describes by John Homans in 1941 who was an American surgeon.
Read More: https://orthofixar.com/special-test/homans-sign/
A variety of hip muscles surround the hip joint, and act to accelerate, decelerate, and stabilize the hip joint. About 21 muscles cross the hip, providing both tri-planar movement and stability between the femur and the acetabulum.
https://orthofixar.com/anatomy/hip-muscles-anatomy/
Thomas Test (or as it called Hugh Owen Thomas well leg raising test) is used to measure the flexibility of the hip flexor muscles. It’s used to test for hip flexion contracture and psoas syndrome, which is more common in runners, dancers, and gymnasts with symptoms of hip “stiffness” and “clicking” feeling when flexing at the waist.
For more, See:
https://www.orthofixar.com/special-test/thomas-test/
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
1. Mortons Neuroma
Mortons Neuroma is a compressive neuropathy of the interdigital nerve, usually between the third and
fourth metatarsals.
Interdigital neuroma was first described in 1845 by Durlacher, and, in 1876, Morton expanded the
clinical description and gave the condition its eponym, Morton Neuroma.
Females are affected more commonly than males 8:1 (most likely from wearing high heels and
shoes with narrow toe boxes).
The condition is usually unilateral
Pathophysiology
The pathophysiology of this condition is still poorly understood. Theories include:
1. Compression/tension around the intermetatarsal ligament,
2. Repetitive microtrauma,
3. Vascular changes,
4. Excessive bursal tissue,
5. Endoneural edema,
6. Eventual neural fibrosis.
Mortons Neuroma
Mortons Neuroma Symptoms
The diagnosis usually is made by careful history and physical examination, although various diagnostic
studies may be helpful in selected cases.
1. Patients will frequently report pain and burning on the plantar aspect of the web space, with
over 60% of patients noting pain radiating into the toe distally.
2. Numbness is reported in only 40% of patients.
These symptoms are exacerbated by footwear with narrow toe boxes and high heels.
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq
2. Patients often note that they feel better in their bare feet and get quick relief with removal of their
shoes.
Physical examination includes:
Palpation between and just distal to the metatarsal heads elicits plantar tenderness.
Tenderness in the web space is believed to be the most common finding in interdigital neuroma.
Palpating the web spaces with the patient standing sometimes is helpful in differentiating a second
web space neuroma from a plantar plate lesion at the second metatarsophalangeal joint. If the
tenderness is mostly in the web space and not in the plantar aspect of the base of the proximal phalanx
or the dorsolateral aspect of the second metatarsophalangeal joint, a neuroma is likely.
Compressing the medial and lateral aspect of the forefoot while palpating the web space structures
can provoke symptoms and occasionally a bursal“click” (Mortons Neuroma Test): This click is best
appreciated when the patient lies prone, and the examiner places the thumb dorsally and the index
finger plantarward over the appropriate web space (usually the third) and gently rocks the hand back
and forth.
Injection of the involved web space with local anesthetic is diagnostic if the neuritic symptoms are
relieved temporally.
Metatarsalgia and MTP synovitis often present similarly and should be ruled out.
See Also: Mortons Neuroma Test
Mortons Neuroma Test
Radiology Evaluation
Plain films should be performed to rule out bony masses or deformity.
Ultrasound has been reported to be 85% accurate in diagnosing of Mortons Neuroma.
MRI can be used to identify other pathologies, but not required for diagnosis.
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq
3. Mortons Neuroma MRI
Pathological Findings
The following list summarizes reported pathological findings of Mortons Neuroma:
1. Perineural fibrosis.
2. Increased number of intrafascicular arterioles with thickened and hyalinized walls caused by
multiple layers of basement membranes.
3. Demyelinization and degeneration of nerve fibers with a decrease in the number of axis
cylinders.
4. Endoneural edema.
5. Absence of inflammatory changes.
6. Frequent presence of bursal tissue accompanying the specimen.
Interdigital nerve is greatly thickened by perineural fibrous tissue (hematoxylin and eosin stain)
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq
4. Vessels in
region often show degenerative changes such as fraying and duplication of internal elastic lamina
(Verhoeff-van Gieson stain)
Some axons are missing, and others show degenerative changes (Bielschowsky stain)
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq
5. Small bursa
may be found in region (hematoxylin and eosin stain)
Mortons Neuroma Treatment
The mainstay of Mortons Neuroma treatment is surgery by neuroma excision, but nonoperative
treatment is successful often enough to warrant at least a trial period.
Nonoperative treatment:
Nonoperative treatment of Morton's Neuroma include:
1. Shoewear modification (avoiding high heels and narrow toe boxes) is the most important and
effective intervention.
2. Metatarsal pads placed proximal to the focus of pain can prevent direct pressure and widen the
intermetatarsal space during weight bearing, thereby indirectly decompressing the nerve.
3. Corticosteroid injections into the affected web space can have moderate effectiveness (
≈50%
of patients report positive response).
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq
6. Morton's
neuroma metatarsal pads
Operative treatment:
Detailed preoperative examination and careful patient selection for surgery is recommended. In
addition, the patient must be informed before surgery that some symptoms may remain after surgery
(caused by other causes of metatarsalgia that might coexist in a patient with an interdigital neuroma).
Mortons Neuroma is treated surgically by Excision via dorsal or volar approach:
1. Dorsal approach:
The most common used approach.
Incise the transverse intermetatarsal ligament, identify the common digital nerve and its
branches, and resect the nerve 2 to 3 cm proximal to the intermetatarsal ligament (proximal to
the small plantar branches), which allows the proximal stump to retract.
This minimizes formation of stump neuroma, the most common complication of neuroma
excision.
Difficult visualization results in a 4% rate of failure to excise the neuroma.
Overall success rates approach 80%.
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq
7. 2. Plantar
approach:
Decreases the rate of missed neuroma excision.
Does not require incision of the transverse intermetatarsal ligament.
Increased risk (5%) of painful plantar scar.
Typically used for revision neuroma resection.
For a recurrent interdigital neuroma, a plantar approach is recommended because the exposure
is excellent.
A Randomized Controlled Trial by Christian Akermark
1 of plantar versus dorsal incisions for
operative treatment of primary Morton's neuroma, he demonstrated 87% (plantar) and 83% (dorsal)
clinically good outcomes and no significant differences between the procedures in regard to pain,
restrictions in daily activities, and scar tenderness.
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq
8. Another prospective 2-year follow-up study2 of plantar incisions in the treatment of primary
intermetatarsal neuromas (Morton's neuroma), it shows that surgery with a plantar incision seems to
be a reliable and safe intervention of primary Morton's neuromas, with only limited number of minor
complications and a subjective satisfactory outcome, well in accordance with other studies, using
different, surgical approaches.
Notes
In a strict sense, the term neuroma is incorrect because the haphazard proliferation of axons
seen in a traumatic
neuroma is not found and the deposition of hyaline and collagenous material accounts for the
enlargement.
The term interdigital neuritis, rather than interdigital neuroma, has been suggested.
The pathological process probably is degenerative, rather than proliferative, with repetitive
trauma against the deep transverse intermetatarsal ligament being the most likely cause, but
even this is uncertain.
If symptoms occur after midfoot or forefoot trauma, surgical excision should only be
cautiously considered because it may require several months for tissue homeostasis to return
and symptoms to decrease or resolve.
References
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq
9. 1. Akermark C, Crone H, Skoog A, Weidenhielm L. A prospective randomized controlled trial
of plantar versus dorsal incisions for operative treatment of primary Morton's neuroma. Foot
Ankle Int. 2013 Sep;34(9):1198-204. doi: 10.1177/1071100713484300. Epub 2013 Apr 5.
PMID: 23564425.
2. Akermark C, Saartok T, Zuber Z. A prospective 2-year follow-up study of plantar incisions in
the treatment of primary intermetatarsal neuromas (Morton's neuroma). Foot Ankle Surg.
2008;14(2):67-73. doi: 10.1016/j.fas.2007.10.004. Epub 2008 Feb 21. PMID: 19083618.
3. Campbel's Operative Orthopaedics 12th edition Book.
4. Millers Review of Orthopaedics -7th Edition Book.
For more see: Morton's Neuroma ORTHOFIXAR | By Dr.MhmadFarooq