Monkeypox is a rare disease caused by infection with monkeypox virus. It was first discovered in 1958 when outbreaks occurred in monkey colonies. The first human case was in 1970 in the DRC. Symptoms are similar to but milder than smallpox and include fever, headache, muscle aches and a rash that often begins on the face then spreads to other parts of the body. It can spread through contact with infected animals, humans or contaminated materials and from mother to fetus. Differential diagnoses include varicella, smallpox and vaccinia virus infection.
Monkeypox is a rare zoonosis caused by monkeypox virus. This disease is similar to smallpox disease but with lesser severity. This disease is common among Africans. It can be prevented by avoiding contact with contaminated animal and human fluids as well as respiratory droplets. It require a multidisciplinary approach to achieve cure and prevention.
Video presentation - https://www.youtube.com/watch?v=45CjKnJaIC0
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Here is a comprehensive and updated presentation on the Monkeypox by noted infectious diseases expert Dr ISHWAR GILADA, Consultant in HIV/STDs, Unison Medicare & Research Centre, and Secretary General, Organised Medicine Academic Guild-OMAG;
President, AIDS Society of India (ASI) &
Governing Council Member, International AIDS Society (IAS)
E-mail: gilada@usa.net, drisgilada@gmail.com
Just a short update to bring awareness to health care professionals of the monkeypox virus dilemma in 2022,and to inform professionals in Nigeria to be alert as to make diagnosis and inform appropriate authorities. Also, to alert of some of the impediments we face in the undeveloped world in measures against viral infections.
Just one bite of a mosquito can take us closer to death. Don't let that happen to anyone. Happy World Malaria Day. The only way to celebrate the occasion of World Malaria Day is by joining hands against this disease.
Arthropods form a major group of disease vectors with mosquitoes, flies, sand flies, lice, fleas, ticks and mites transmitting a huge number of diseases.
Monkeypox is a rare zoonosis caused by monkeypox virus. This disease is similar to smallpox disease but with lesser severity. This disease is common among Africans. It can be prevented by avoiding contact with contaminated animal and human fluids as well as respiratory droplets. It require a multidisciplinary approach to achieve cure and prevention.
Video presentation - https://www.youtube.com/watch?v=45CjKnJaIC0
Learn Community Medicine along with me : https://t.me/drvkspm
Be my friend by connecting with me through:
Instagram : https://www.instagram.com/drvenkateshkarthikeyan/
Facebook : https://www.facebook.com/drvenkateshkarthikeyan/
Twitter : https://twitter.com/dr_venkatesh_k
Website : www.drvenkateshkarthikeyan.com
LinkedIn : https://in.linkedin.com/in/dr-venkatesh-karthikeyan-8b1234ab
Learn Community Medicine along with me : https://t.me/drvkspm
Here is a comprehensive and updated presentation on the Monkeypox by noted infectious diseases expert Dr ISHWAR GILADA, Consultant in HIV/STDs, Unison Medicare & Research Centre, and Secretary General, Organised Medicine Academic Guild-OMAG;
President, AIDS Society of India (ASI) &
Governing Council Member, International AIDS Society (IAS)
E-mail: gilada@usa.net, drisgilada@gmail.com
Just a short update to bring awareness to health care professionals of the monkeypox virus dilemma in 2022,and to inform professionals in Nigeria to be alert as to make diagnosis and inform appropriate authorities. Also, to alert of some of the impediments we face in the undeveloped world in measures against viral infections.
Just one bite of a mosquito can take us closer to death. Don't let that happen to anyone. Happy World Malaria Day. The only way to celebrate the occasion of World Malaria Day is by joining hands against this disease.
Arthropods form a major group of disease vectors with mosquitoes, flies, sand flies, lice, fleas, ticks and mites transmitting a huge number of diseases.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
4. Monkeypox is a rare disease that is caused by infection with
monkeypox virus. Monkeypox virus belongs to the Orthopoxvirus
genus in the family Poxviridae.
The Orthopoxvirus genus also includes variola virus (which causes
smallpox), vaccinia virus (used in the smallpox vaccine), and
cowpox virus.
5. • Monkeypox was first discovered in 1958 when two outbreaks
of a pox-like disease occurred in colonies of monkeys kept
for research, hence the name ‘monkeypox.’
• The first human case of monkeypox was recorded in 1970
in the Democratic Republic of Congo during a period of
intensified effort to eliminate smallpox.
• Since then monkeypox has been reported in humans in other
central and western African countries.
6. Signs and Symptoms
• In humans, the symptoms of monkeypox are similar to but milder
than the symptoms of smallpox.
• Monkeypox begins with fever, headache, muscle aches, and
exhaustion.
• The main difference between symptoms of smallpox and monkeypox
is that monkeypox causes lymph nodes to swell (lymphadenopathy)
while smallpox does not.
• The incubation period (time from infection to symptoms) for
monkeypox is usually 7−14 days but can range from 5−21 days.
7. • The illness begins with:
• Fever ,Headache ,Muscle aches ,Backache ,Swollen lymph nodes ,Chills ,
Exhaustion.
• Within 1 to 3 days (sometimes longer) after the appearance of fever, the
patient develops a rash, often beginning on the face then spreading to other
parts of the body.
• Lesions progress through the following stages before falling off:
• Macules
• Papules
• Vesicles
• Pustules
• Scabs
• The illness typically lasts for 2−4 weeks.
• In Africa, monkeypox has been shown to cause death in as many as 1 in 10
persons who contract the disease.
12. Differential Diagnosis of monkypox
• 1-Varicella
• The fever, malaise, and headache of varicella are usually less severe than
monkeypox infection.
• Lesions in varicella are superficial, heterogeneous and have a
centripital(rash first appears on the chest, back, and face. Then it spreads over the entire
body) distribution,
• in contrast to the homogeneous, centrifugal rash of monkeypox. ( Rash
often begins on the face and then spreads to other parts of the body.
• Involvement of the palms and soles is rare in varicella, but common in
monkeypox.
• Lymphadenopathy is another important feature for differentiating
monkeypox from varicella, since it is a prominent feature in monkeypox but
is not present in varicella
13.
14. • 2 -Smallpox
• Smallpox is caused by the variola virus, which is a member
of the genus Orthopoxvirus, family Poxviridae.
• The lesions of smallpox usually start on the face, then spread
to other areas of the body with a centrifugal distribution.
• Palmar and plantar lesions occur in most patients.
• Lesions on one area of the body are all in the same stage of
development, unlike chickenpox.
• The fever and headache in smallpox infection tend to be
more severe compared to monkeypox
• Lymphadenopathy is a prominent, distinguishing feature that is
common in monkeypox infection, but absent in smallpox .
•
15. • 3-vaccinia virus
• The vaccinia virus is a member of the Orthopoxvirus genus and is used
for smallpox vaccination.
• Typically, patients develop an erythematous papule at the site of
vaccination 3-5 days after receiving the vaccine.
• The papule progresses to a vesicular lesion, then forms a pustule and
enlarges.
• As the pustule dries, a crust forms over the lesion, which then resolves 2
to 3 weeks after the vaccination, resulting in scar formation.
• This typical reaction pattern signifies that the individual has responded
successfully to the vaccination. Patients may also experience symptoms
such as fatigue, headache, fever, myalgias, regional lymphadenopathy, and
satellite lesions.
•
16. • The lesions of vaccinia may appear similar to smallpox, but they
lack the centrifugal distribution usually seen in smallpox infection.
• Other diseases that should be considered in the differential diagnosis
of monkeypox include herpes zoster, herpes simples, molluscum
contagiosum, erythema multiforme, acne, drug reactions,
impetigo, allergic dermatitis, scabies, and syphilis
18. Transmission
• contact with the virus from an infected animal, infected
person, or materials contaminated with the virus.
• The virus can also cross the placenta from the mother to her
fetus.
• Monkeypox virus may spread from animals to people
through the bite or scratch of an infected animal, by handling
wild game, or through the use of products made from
infected animals.
• direct contact with body fluids or sores on an infected
person or with materials that have touched body fluids or
sores, such as clothing or linens.
19. • Monkeypox spreads between people primarily through
direct contact with infectious sores, scabs, or body fluids.
It also can be spread by respiratory secretions during
prolonged, face-to-face contact.
• Monkeypox can spread during intimate contact between
people, including during sex, as well as activities like kissing,
cuddling, or touching parts of the body with monkeypox
sores.
• At this time, it is not known if monkeypox can spread
through semen or vaginal fluids.
• Page last reviewed: May 29, 2022
•
20. Prevention
• Avoid contact with animals that could harbor the virus
(including animals that are sick or that have been found dead in
areas where monkeypox occurs).
• Avoid contact with any materials, such as bedding,()الفرش that
has been in contact with a sick animal.
• Isolate infected patients from others who could be at risk for
infection.
• Practice good hand hygiene after contact with infected animals
or humans. For example, washing your hands with soap and
water or using an alcohol-based hand sanitizer.
• Use personal protective equipment (PPE) when caring for
patients
21. Vaccination
• JYNNEOSTM (also known as Imvamune or Imvanex)
• is an attenuated live virus vaccine which has been approved
by the U.S.
• The Advisory Committee on Immunization Practices (ACIP)
is currently evaluating JYNNEOSTM for the protection of
people at risk of occupational exposure to orthopoxviruses
such as smallpox and monkeypox in a pre-event setting
22. Clinical Guidance for the Treatment of Monkeypox
• Many individuals infected with monkeypox virus have a mild,
self-limiting disease course in the absence of specific
therapy.
• Persons who should be considered for treatment following
consultation with CDC might include:
• Persons with severe disease (e.g., hemorrhagic disease, confluent
lesions, sepsis, encephalitis.
• Immunocompromised.
• Pediatric populations, particularly patients younger than 8 years of
age2
• Pregnant or breastfeeding women
23. Medical Countermeasures Available for the Treatment of Monkeypox
• Tecovirimat (also known as TPOXX) is an antiviral
medication that is approved for the treatment of human
smallpox disease in adults and pediatric patients weighing at
least 3 kg
• Tecovirimat is available as oral (200 mg capsule) and
injection for intravenous formulations.
• CDC allows for the use of Tecovirimat for the treatment of
non-variola orthopoxviruses (including monkeypox) in an
outbreak.
24. • Cidofovir (also known as Vistide) is an antiviral medication
that is approved by the FDA pdf icon[PDF – 6 pages]external
icon for the treatment of cytomegalovirus (CMV) retinitis
in patients with Acquired Immunodeficiency Syndrome
(AIDS).
• CDC allows for the use of Cidofovir for the treatment of
orthopoxviruses (including monkeypox) in an outbreak.
25. • Brincidofovir (also known as Tembexa) is an antiviral
medication that was on June 4, 2021 for the treatment of
human smallpox disease in adult and pediatric patients,
including neonates.
26. • Vaccinia Immune Globulin Intravenous (VIGIV)
is licensed by FDAexternal icon for the treatment of
complications due to vaccinia vaccination including eczema
vaccinatum, progressive vaccinia, severe generalized
vaccinia, vaccinia infections in individuals who have skin
conditions, and aberrant infections induced by vaccinia virus
(except in cases of isolated keratitis).
• CDC holds and EA-IND that allows the use of VIGIV for the
treatment of orthopoxviruses (including monkeypox) in an
outbreak.