The document describes the process of renal transplantation recipient surgery. It discusses:
- The moderators and their roles
- Preparing the allograft kidney by inspecting and dissecting vessels and ligating branches
- Preparing the recipient with anesthesia and positioning
- Exposing the iliac vessels through an incision and developing the retroperitoneal space
- Performing the anastomoses of the renal vessels to the iliac vessels and reperfusion
- Constructing the ureteroneocystostomy
- Closing with catheters, drains, and stents
This document discusses urinary extravasation, which is when urine leaks out of the urinary tract into other body cavities. It defines two types - superficial and deep extravasation. Superficial extravasation occurs above the perineal membrane and is usually caused by injuries to the penile urethra during instrumentation. Deep extravasation occurs below the perineal membrane due to injuries of the membranous urethra or extraperitoneal bladder from pelvic trauma. Management involves pain relief, antibiotics, suprapubic catheterization, and sometimes surgical exploration and drainage of collections.
This document describes 10 cases of urinary system imaging findings. Case 1 describes x-ray and CT findings of xanthogranulomatous pyelonephritis and staghorn calculus in an elderly female. Case 2 describes CT findings of transitional cell carcinoma of the renal pelvis in a 68-year-old woman. Case 3 describes CT findings of renal infarction in a patient with rheumatic heart disease and flank pain. The remaining cases describe various urinary system conditions and imaging findings including percutaneous nephrostomy (Case 4), bladder stone (Case 5), retrograde pyelogram (Case 6), neurogenic bladder (Case 7), papillary necrosis (Case 8), pheochromocytoma
This document provides information about an X-ray KUB (kidneys, ureters, bladder) exam performed by the Department of Urology at Govt Royapettah Hospital and Kilpauk Medical College in Chennai, India. It lists the moderators and their qualifications. It then discusses the history of X-rays, how they are produced, standard views, and how to systematically read an X-ray KUB. It describes how to assess technical quality and what to look for, including renal calcifications which are most commonly due to kidney stones. It also discusses mimics of urinary calcifications like gallstones.
This document discusses urinary obstruction, including its pathophysiology, causes, effects on renal physiology and function, histological changes, clinical impact, and renal recovery after relief of obstruction. It provides an overview of how urinary obstruction can lead to permanent kidney damage depending on the severity, chronicity, and baseline kidney condition. Both unilateral and bilateral obstruction are examined, along with the triphasic response and changes in renal blood flow, filtration, and tubular transport that occur.
This document describes a voiding cystourethrogram (VCUG) conducted by the Department of Urology at GRH and KMC in Chennai, India. It lists the professors and assistant professors moderating the VCUG. The document provides details on the indications, techniques, and pediatric applications of VCUGs, focusing on evaluating conditions like vesicoureteral reflux, posterior urethral valves, bladder diverticula, and ectopic ureters. It compares VCUG to nuclear cystography and voiding sonography as diagnostic tools.
This document provides information about intravenous urography (IVU), including its definition, history, indications, contraindications, technique, phases, and what is evaluated. Some key points:
- IVU involves injecting iodine contrast intravenously and taking x-ray images as it passes through the kidneys, ureters, and bladder. It was introduced in 1929 by American urologist Moses Swick.
- Indications include evaluating for ureteral obstruction, trauma, congenital anomalies, hematuria, infection, or uncontrolled hypertension. Contraindications include contrast allergy and renal impairment.
- The technique involves injecting contrast as a rapid bolus,
The document describes the process of renal transplantation recipient surgery. It discusses:
- The moderators and their roles
- Preparing the allograft kidney by inspecting and dissecting vessels and ligating branches
- Preparing the recipient with anesthesia and positioning
- Exposing the iliac vessels through an incision and developing the retroperitoneal space
- Performing the anastomoses of the renal vessels to the iliac vessels and reperfusion
- Constructing the ureteroneocystostomy
- Closing with catheters, drains, and stents
This document discusses urinary extravasation, which is when urine leaks out of the urinary tract into other body cavities. It defines two types - superficial and deep extravasation. Superficial extravasation occurs above the perineal membrane and is usually caused by injuries to the penile urethra during instrumentation. Deep extravasation occurs below the perineal membrane due to injuries of the membranous urethra or extraperitoneal bladder from pelvic trauma. Management involves pain relief, antibiotics, suprapubic catheterization, and sometimes surgical exploration and drainage of collections.
This document describes 10 cases of urinary system imaging findings. Case 1 describes x-ray and CT findings of xanthogranulomatous pyelonephritis and staghorn calculus in an elderly female. Case 2 describes CT findings of transitional cell carcinoma of the renal pelvis in a 68-year-old woman. Case 3 describes CT findings of renal infarction in a patient with rheumatic heart disease and flank pain. The remaining cases describe various urinary system conditions and imaging findings including percutaneous nephrostomy (Case 4), bladder stone (Case 5), retrograde pyelogram (Case 6), neurogenic bladder (Case 7), papillary necrosis (Case 8), pheochromocytoma
This document provides information about an X-ray KUB (kidneys, ureters, bladder) exam performed by the Department of Urology at Govt Royapettah Hospital and Kilpauk Medical College in Chennai, India. It lists the moderators and their qualifications. It then discusses the history of X-rays, how they are produced, standard views, and how to systematically read an X-ray KUB. It describes how to assess technical quality and what to look for, including renal calcifications which are most commonly due to kidney stones. It also discusses mimics of urinary calcifications like gallstones.
This document discusses urinary obstruction, including its pathophysiology, causes, effects on renal physiology and function, histological changes, clinical impact, and renal recovery after relief of obstruction. It provides an overview of how urinary obstruction can lead to permanent kidney damage depending on the severity, chronicity, and baseline kidney condition. Both unilateral and bilateral obstruction are examined, along with the triphasic response and changes in renal blood flow, filtration, and tubular transport that occur.
This document describes a voiding cystourethrogram (VCUG) conducted by the Department of Urology at GRH and KMC in Chennai, India. It lists the professors and assistant professors moderating the VCUG. The document provides details on the indications, techniques, and pediatric applications of VCUGs, focusing on evaluating conditions like vesicoureteral reflux, posterior urethral valves, bladder diverticula, and ectopic ureters. It compares VCUG to nuclear cystography and voiding sonography as diagnostic tools.
This document provides information about intravenous urography (IVU), including its definition, history, indications, contraindications, technique, phases, and what is evaluated. Some key points:
- IVU involves injecting iodine contrast intravenously and taking x-ray images as it passes through the kidneys, ureters, and bladder. It was introduced in 1929 by American urologist Moses Swick.
- Indications include evaluating for ureteral obstruction, trauma, congenital anomalies, hematuria, infection, or uncontrolled hypertension. Contraindications include contrast allergy and renal impairment.
- The technique involves injecting contrast as a rapid bolus,
This document provides information about a KUB (kidney, ureter, bladder) x-ray performed at the Department of Urology, Government Royapettah Hospital and Kilpauk Medical College in Chennai. It lists the professors and assistant professors in the department and provides details on the history, physics, techniques, anatomical landmarks, disorders, and interpretations of renal calculi, ureter, bladder, and other findings that can be seen on a KUB x-ray.
This document discusses the artificial urinary sphincter (AUS), a device used to treat urinary incontinence. It provides details on the device components and procedure for implantation. Key points include:
- The AUS consists of a fluid-filled cuff placed around the bladder neck, a control pump in the scrotum, and a pressure-regulating balloon.
- During implantation, the cuff is placed around the bladder neck or bulbar urethra after dissection. The pump is placed in a scrotal pouch and the balloon is placed preperitoneally or intraperitoneally.
- Complications include urinary retention, infection at a rate of 1
This document provides an overview of the anatomy of the genitourinary tract. It describes the anatomy of the kidneys, ureters, bladder, and genital organs in males and females. Key details include the location and relations of the kidneys, course of the ureters through the abdomen and pelvis, structures surrounding and entering the bladder, and the internal and external anatomy of the penis and urethra in males and urethra in females. Multiple images are provided to illustrate structures like blood vessels, fascial layers and relations to surrounding organs.
This document discusses ureteroceles, which are cystic dilations of the terminal ureter. It describes classifications of ureteroceles and their embryology. Diagnosis can be made through prenatal ultrasound or MRI showing hydronephrosis and the intravesical cyst. Evaluation involves ultrasound, intravenous pyelography, voiding cystourethrography, and nuclear scans. Management is individualized and may include prenatal decompression or postnatal surgical procedures to preserve renal function, eliminate infection/obstruction/reflux, and maintain continence. Treatment aims to minimize morbidity while meeting these goals.
The document provides information about urodynamics testing performed at the Department of Urology, Government Royapettah Hospital and Kilpauk Medical College in Chennai. It discusses the professors and assistant professors who moderate the tests. It then describes the purpose and components of urodynamics testing, which involves a series of tests to evaluate urine storage and evacuation. The key components reviewed include uroflowmetry, measurement of post-void residual urine, cystometrogram, pressure flow studies, and videourodynamics. The document provides details on performing each test and interpreting the results.
This document provides information about intravenous urography (IVU), including:
- IVU involves injecting contrast media intravenously and imaging the kidneys, ureters, and bladder.
- It has indications like evaluating suspected obstruction, assessing integrity after trauma, and investigating hematuria or infection.
- Contraindications include contrast allergy and renal failure. Advantages include clearly outlining the urinary system, while disadvantages include need for contrast and radiation exposure.
- The document describes the IVU technique, expected timing of images, and what should be evaluated on the images.
- It also covers normal anatomy, types of contrast media, and abnormal findings that could be
This document discusses transitional urology, which involves the planned movement of adolescents and young adults with chronic urological conditions from pediatric to adult-centered care. It provides an overview of common urological conditions seen in transitional urology, including spina bifida, bladder exstrophy, hypospadias, posterior urethral valves, vesicoureteral reflux, and pediatric genitourinary cancers. It also discusses specific issues in transitional urology like urinary tract infections in neurogenic/reconstructed bladders, troubleshooting continent catheterizable channels, risks of malignancy with augmentation cystoplasty, and presentation of BPH and pelvic organ prolapse in patients with neurogenic
This document provides information about urinary catheters including their history, types, uses, sizes and materials. It discusses the evolution of catheters from ancient times to modern developments like the Foley catheter. Key points covered include the different types of catheters based on retention mechanism (e.g. Foley), materials (e.g. latex, silicone), uses (diagnostic, therapeutic), sizes and coatings/impregnations (e.g. hydrogel, silver alloy). Trials comparing outcomes of different catheter materials are also summarized.
This document describes uroflowmetry - a noninvasive test used to evaluate urine flow. It discusses the normal and abnormal flow patterns seen in uroflowmetry and their clinical significance. Uroflowmetry provides parameters like maximum flow rate, average flow rate and voided volume. It can detect bladder outlet obstruction, detrusor underactivity or overactivity. However, pressure-flow studies are needed to precisely define lower urinary tract function. Uroflowmetry is useful for screening and monitoring treatment response, though invasive therapy should not be based on uroflowmetry alone per AUA guidelines.
This document provides information about percutaneous nephrolithotomy (PNL) from the Department of Urology at Govt Royapettah Hospital and Kilpauk Medical College in Chennai. It discusses the moderators of the department, indications and contraindications for PNL, preoperative investigations and consent, renal anatomy considerations, PNL technique, intrarenal access points, and patient positioning for the procedure. The document emphasizes accessing the renal collecting system through a posterior calyx rather than the pelvis or infundibulum. It also highlights important anatomical structures like Brodel's plane to aid safe access during PNL.
This document provides an overview of MRI in urology, with a focus on MRI of the prostate. It discusses the moderators and professors of the department of urology. It then covers the basic principles of MRI, including magnetic field strength, radiofrequency pulses, T1/T2 weighting, and contrast agents. Applications of MRI for prostate imaging and prostate cancer detection are described, including T2-weighted imaging, diffusion-weighted imaging, and magnetic resonance spectroscopy. The PIRADS scoring system and assessment of extracapsular extension on MRI are also summarized.
This document describes the renogram procedure. It provides details on:
- The radiopharmaceuticals used, including 99mTc-DTPA, 99mTc-MAG3, and 99mTc-DMSA
- How the procedure is performed, including patient preparation, image acquisition, and time-activity curve analysis
- The roles of the radiopharmaceuticals in evaluating renal blood flow, glomerular filtration rate, and renal handling and excretion
- Factors that can affect the procedure such as hydration, medications, and kidney positioning
This document discusses the anatomy and physiology of the vesicoureteral junction (VUJ) and vesicoureteral reflux (VUR). It provides details on:
- The anatomy of the intravesical and intramural portions of the ureter and factors that allow antegrade urine flow and prevent reflux under normal conditions.
- Grading systems used to classify the degree of reflux seen on voiding cystourethrogram.
- Evaluation methods for VUR including ultrasound, voiding cystourethrogram, radionuclide cystogram, and renal scintigraphy.
- Factors that can cause primary or secondary reflux such as congenital defects or increased
This document describes procedures for anatrophic nephrolithotomy, pyelolithotomy, and managing residual stones. It provides details on: preoperative planning and preparation including imaging and antibiotics; surgical techniques for accessing the kidney/pelvis, making incisions, removing stones, and closing; managing complications; and using coagulum to fill the pelvis to detect residual fragments. It is a technical reference for open stone surgery techniques from the Department of Urology at Govt Royapettah Hospital and Kilpauk Medical College in Chennai, India.
This document provides information about retrocaval ureter, including its etiology, diagnosis, and management. Retrocaval ureter is a rare congenital anomaly where the ureter passes behind the inferior vena cava. It occurs due to persistence of the subcardinal veins during embryonic development. Clinical presentations include flank pain, hematuria, urinary tract infections, and urolithiasis. Diagnosis involves imaging tests like intravenous urogram, CT urography, and renography. Surgical management includes open or laparoscopic pyeloplasty to reposition the ureter anterior to the inferior vena cava. Preserving the retrocaval ureter segment may be
In this presentation nuclear medicine application in nephrology is explained in detail based on UPTODATE evidence based recommendations.
Different examples were given.
The document discusses emphysematous pyelonephritis (EPN), a severe necrotizing infection of the renal parenchyma that causes gas accumulation. EPN most often occurs in persons with uncontrolled diabetes, especially women. It requires prompt diagnosis using CT scan and treatment with IV antibiotics and percutaneous drainage to drain abscesses. Factors like altered mental status, thrombocytopenia and elevated creatinine indicate higher risk cases that may require emergency nephrectomy. With aggressive treatment, reported mortality has improved but remains at 20-25%.
This document discusses the etiopathogenesis, clinical features, and diagnosis of ureteropelvic junction (UPJ) obstruction. It begins by defining UPJ obstruction as a restriction of urine flow from the renal pelvis to the ureter. UPJ obstruction can be caused by intrinsic factors like anatomical abnormalities or extrinsic factors like crossing vessels. Clinically, it can present at any age as flank pain, hematuria, or hypertension. Diagnosis involves imaging like renal ultrasound, CT urogram, diuretic renogram, and voiding cystourethrogram to evaluate obstruction and identify associated issues like vesicoureteral reflux. Surgical correction may be needed to repair the obstruction and preserve
This study evaluated percutaneous nephrolithotomy (PCNL) using a modified supine position for treating staghorn stones. The study included 37 patients with staghorn stones who underwent PCNL. Using a flank-free modified supine position, the mean operative time was 110.7 minutes. A single tract was used in 32 patients (86.4%), while 5 patients (13.5%) required a second tract. At 24 hours post-op, 24 patients (64.8%) were stone-free, and by discharge 29 patients (78.3%) were stone-free. The mean hemoglobin and transfusion rates showed the procedure was well-tolerated. The study concluded the flank-
This document discusses congenital pelvi-ureteric junction obstruction (PUJO). It covers the etiology, pathogenesis, pathological changes, and clinical presentation of PUJO. The main causes of PUJO are believed to be intrinsic abnormalities at the pelvi-ureteric junction that cause an aperistaltic segment and prevent normal urine flow. This can result from developmental arrest or incomplete recanalization. PUJO can also be caused by external compression from aberrant vessels. Longstanding obstruction leads to hydronephrosis, tubular dilation, interstitial fibrosis and loss of renal function over time. Clinically, PUJO usually presents with hydronephrosis in infants and children.
This document describes a universal shaking machine produced by Technocracy Pvt. Ltd. The shaking machine is compact and heavy-duty, with adjustable speeds between 10 to 350 RPM. It can accommodate a variety of vessels and trays for flasks. An orbital platform accepts optional trays for staining, destaining, and developing electrophoresis gels and filter assay media. A timer allows automatic shut-off between 3 to 120 minutes.
Since 2001, we Krishna Scientific Suppliers are recognized as a coveted Manufacturer, Supplier, Exporter & Service Provider of Industrial Fermenter, Autoclave, Sterilizer & Machines, Incubator, Laminar Cabinets and laboratory instruments. The range offered by us encompasses rotary shaker, BOD incubator, fume hood, and plant growth chamber. Additionally, we offer our clients a wide assortment of hot plate, magnetic stirrers, Moisture Meter, pH Meter, Microscope, Distilled Water Still (Wall Mounted), BOD Incubator, and many more laboratory instruments.
This document provides information about a KUB (kidney, ureter, bladder) x-ray performed at the Department of Urology, Government Royapettah Hospital and Kilpauk Medical College in Chennai. It lists the professors and assistant professors in the department and provides details on the history, physics, techniques, anatomical landmarks, disorders, and interpretations of renal calculi, ureter, bladder, and other findings that can be seen on a KUB x-ray.
This document discusses the artificial urinary sphincter (AUS), a device used to treat urinary incontinence. It provides details on the device components and procedure for implantation. Key points include:
- The AUS consists of a fluid-filled cuff placed around the bladder neck, a control pump in the scrotum, and a pressure-regulating balloon.
- During implantation, the cuff is placed around the bladder neck or bulbar urethra after dissection. The pump is placed in a scrotal pouch and the balloon is placed preperitoneally or intraperitoneally.
- Complications include urinary retention, infection at a rate of 1
This document provides an overview of the anatomy of the genitourinary tract. It describes the anatomy of the kidneys, ureters, bladder, and genital organs in males and females. Key details include the location and relations of the kidneys, course of the ureters through the abdomen and pelvis, structures surrounding and entering the bladder, and the internal and external anatomy of the penis and urethra in males and urethra in females. Multiple images are provided to illustrate structures like blood vessels, fascial layers and relations to surrounding organs.
This document discusses ureteroceles, which are cystic dilations of the terminal ureter. It describes classifications of ureteroceles and their embryology. Diagnosis can be made through prenatal ultrasound or MRI showing hydronephrosis and the intravesical cyst. Evaluation involves ultrasound, intravenous pyelography, voiding cystourethrography, and nuclear scans. Management is individualized and may include prenatal decompression or postnatal surgical procedures to preserve renal function, eliminate infection/obstruction/reflux, and maintain continence. Treatment aims to minimize morbidity while meeting these goals.
The document provides information about urodynamics testing performed at the Department of Urology, Government Royapettah Hospital and Kilpauk Medical College in Chennai. It discusses the professors and assistant professors who moderate the tests. It then describes the purpose and components of urodynamics testing, which involves a series of tests to evaluate urine storage and evacuation. The key components reviewed include uroflowmetry, measurement of post-void residual urine, cystometrogram, pressure flow studies, and videourodynamics. The document provides details on performing each test and interpreting the results.
This document provides information about intravenous urography (IVU), including:
- IVU involves injecting contrast media intravenously and imaging the kidneys, ureters, and bladder.
- It has indications like evaluating suspected obstruction, assessing integrity after trauma, and investigating hematuria or infection.
- Contraindications include contrast allergy and renal failure. Advantages include clearly outlining the urinary system, while disadvantages include need for contrast and radiation exposure.
- The document describes the IVU technique, expected timing of images, and what should be evaluated on the images.
- It also covers normal anatomy, types of contrast media, and abnormal findings that could be
This document discusses transitional urology, which involves the planned movement of adolescents and young adults with chronic urological conditions from pediatric to adult-centered care. It provides an overview of common urological conditions seen in transitional urology, including spina bifida, bladder exstrophy, hypospadias, posterior urethral valves, vesicoureteral reflux, and pediatric genitourinary cancers. It also discusses specific issues in transitional urology like urinary tract infections in neurogenic/reconstructed bladders, troubleshooting continent catheterizable channels, risks of malignancy with augmentation cystoplasty, and presentation of BPH and pelvic organ prolapse in patients with neurogenic
This document provides information about urinary catheters including their history, types, uses, sizes and materials. It discusses the evolution of catheters from ancient times to modern developments like the Foley catheter. Key points covered include the different types of catheters based on retention mechanism (e.g. Foley), materials (e.g. latex, silicone), uses (diagnostic, therapeutic), sizes and coatings/impregnations (e.g. hydrogel, silver alloy). Trials comparing outcomes of different catheter materials are also summarized.
This document describes uroflowmetry - a noninvasive test used to evaluate urine flow. It discusses the normal and abnormal flow patterns seen in uroflowmetry and their clinical significance. Uroflowmetry provides parameters like maximum flow rate, average flow rate and voided volume. It can detect bladder outlet obstruction, detrusor underactivity or overactivity. However, pressure-flow studies are needed to precisely define lower urinary tract function. Uroflowmetry is useful for screening and monitoring treatment response, though invasive therapy should not be based on uroflowmetry alone per AUA guidelines.
This document provides information about percutaneous nephrolithotomy (PNL) from the Department of Urology at Govt Royapettah Hospital and Kilpauk Medical College in Chennai. It discusses the moderators of the department, indications and contraindications for PNL, preoperative investigations and consent, renal anatomy considerations, PNL technique, intrarenal access points, and patient positioning for the procedure. The document emphasizes accessing the renal collecting system through a posterior calyx rather than the pelvis or infundibulum. It also highlights important anatomical structures like Brodel's plane to aid safe access during PNL.
This document provides an overview of MRI in urology, with a focus on MRI of the prostate. It discusses the moderators and professors of the department of urology. It then covers the basic principles of MRI, including magnetic field strength, radiofrequency pulses, T1/T2 weighting, and contrast agents. Applications of MRI for prostate imaging and prostate cancer detection are described, including T2-weighted imaging, diffusion-weighted imaging, and magnetic resonance spectroscopy. The PIRADS scoring system and assessment of extracapsular extension on MRI are also summarized.
This document describes the renogram procedure. It provides details on:
- The radiopharmaceuticals used, including 99mTc-DTPA, 99mTc-MAG3, and 99mTc-DMSA
- How the procedure is performed, including patient preparation, image acquisition, and time-activity curve analysis
- The roles of the radiopharmaceuticals in evaluating renal blood flow, glomerular filtration rate, and renal handling and excretion
- Factors that can affect the procedure such as hydration, medications, and kidney positioning
This document discusses the anatomy and physiology of the vesicoureteral junction (VUJ) and vesicoureteral reflux (VUR). It provides details on:
- The anatomy of the intravesical and intramural portions of the ureter and factors that allow antegrade urine flow and prevent reflux under normal conditions.
- Grading systems used to classify the degree of reflux seen on voiding cystourethrogram.
- Evaluation methods for VUR including ultrasound, voiding cystourethrogram, radionuclide cystogram, and renal scintigraphy.
- Factors that can cause primary or secondary reflux such as congenital defects or increased
This document describes procedures for anatrophic nephrolithotomy, pyelolithotomy, and managing residual stones. It provides details on: preoperative planning and preparation including imaging and antibiotics; surgical techniques for accessing the kidney/pelvis, making incisions, removing stones, and closing; managing complications; and using coagulum to fill the pelvis to detect residual fragments. It is a technical reference for open stone surgery techniques from the Department of Urology at Govt Royapettah Hospital and Kilpauk Medical College in Chennai, India.
This document provides information about retrocaval ureter, including its etiology, diagnosis, and management. Retrocaval ureter is a rare congenital anomaly where the ureter passes behind the inferior vena cava. It occurs due to persistence of the subcardinal veins during embryonic development. Clinical presentations include flank pain, hematuria, urinary tract infections, and urolithiasis. Diagnosis involves imaging tests like intravenous urogram, CT urography, and renography. Surgical management includes open or laparoscopic pyeloplasty to reposition the ureter anterior to the inferior vena cava. Preserving the retrocaval ureter segment may be
In this presentation nuclear medicine application in nephrology is explained in detail based on UPTODATE evidence based recommendations.
Different examples were given.
The document discusses emphysematous pyelonephritis (EPN), a severe necrotizing infection of the renal parenchyma that causes gas accumulation. EPN most often occurs in persons with uncontrolled diabetes, especially women. It requires prompt diagnosis using CT scan and treatment with IV antibiotics and percutaneous drainage to drain abscesses. Factors like altered mental status, thrombocytopenia and elevated creatinine indicate higher risk cases that may require emergency nephrectomy. With aggressive treatment, reported mortality has improved but remains at 20-25%.
This document discusses the etiopathogenesis, clinical features, and diagnosis of ureteropelvic junction (UPJ) obstruction. It begins by defining UPJ obstruction as a restriction of urine flow from the renal pelvis to the ureter. UPJ obstruction can be caused by intrinsic factors like anatomical abnormalities or extrinsic factors like crossing vessels. Clinically, it can present at any age as flank pain, hematuria, or hypertension. Diagnosis involves imaging like renal ultrasound, CT urogram, diuretic renogram, and voiding cystourethrogram to evaluate obstruction and identify associated issues like vesicoureteral reflux. Surgical correction may be needed to repair the obstruction and preserve
This study evaluated percutaneous nephrolithotomy (PCNL) using a modified supine position for treating staghorn stones. The study included 37 patients with staghorn stones who underwent PCNL. Using a flank-free modified supine position, the mean operative time was 110.7 minutes. A single tract was used in 32 patients (86.4%), while 5 patients (13.5%) required a second tract. At 24 hours post-op, 24 patients (64.8%) were stone-free, and by discharge 29 patients (78.3%) were stone-free. The mean hemoglobin and transfusion rates showed the procedure was well-tolerated. The study concluded the flank-
This document discusses congenital pelvi-ureteric junction obstruction (PUJO). It covers the etiology, pathogenesis, pathological changes, and clinical presentation of PUJO. The main causes of PUJO are believed to be intrinsic abnormalities at the pelvi-ureteric junction that cause an aperistaltic segment and prevent normal urine flow. This can result from developmental arrest or incomplete recanalization. PUJO can also be caused by external compression from aberrant vessels. Longstanding obstruction leads to hydronephrosis, tubular dilation, interstitial fibrosis and loss of renal function over time. Clinically, PUJO usually presents with hydronephrosis in infants and children.
This document describes a universal shaking machine produced by Technocracy Pvt. Ltd. The shaking machine is compact and heavy-duty, with adjustable speeds between 10 to 350 RPM. It can accommodate a variety of vessels and trays for flasks. An orbital platform accepts optional trays for staining, destaining, and developing electrophoresis gels and filter assay media. A timer allows automatic shut-off between 3 to 120 minutes.
Since 2001, we Krishna Scientific Suppliers are recognized as a coveted Manufacturer, Supplier, Exporter & Service Provider of Industrial Fermenter, Autoclave, Sterilizer & Machines, Incubator, Laminar Cabinets and laboratory instruments. The range offered by us encompasses rotary shaker, BOD incubator, fume hood, and plant growth chamber. Additionally, we offer our clients a wide assortment of hot plate, magnetic stirrers, Moisture Meter, pH Meter, Microscope, Distilled Water Still (Wall Mounted), BOD Incubator, and many more laboratory instruments.
There are several factors to consider when choosing a laboratory mixing device. First, the requirements of the specific lab must be determined, including power supply, sample volumes, consistency of materials, and torque needs. The type of mixing device, such as a mechanical shaker or rocker, must then match the sample requirements. Key features include variable speed control, compatibility with cold storage, easy cleaning, and durability. Understanding the specific needs of the lab and materials being mixed is essential for selecting the appropriate mixing equipment.
This document provides guidance on evaluating and screening potential renal transplant recipients. It discusses:
1. General concepts to consider include referring all end-stage renal disease patients for transplant evaluation once renal replacement therapy is needed within 12 months, and encouraging preemptive kidney transplantation when feasible.
2. The evaluation process involves assessing medical history and conditions, performing initial screening tests, and evaluating any cardiovascular, infectious, or other systemic diseases to identify any absolute contraindications to transplantation or conditions requiring further treatment and monitoring.
3. Cardiovascular disease is a major cause of death for transplant recipients, so candidates undergo cardiac screening and testing based on risk factors to clear them for surgery or identify any need for pre-operative cardiac
The document summarizes the evaluation of an adult kidney transplant recipient. It discusses timing transplantation based on GFR levels, screening for contraindications like infections and cardiovascular disease, evaluating immunological factors like PRA and HLA typing, and special considerations for populations like diabetics, children, and those on dialysis. The goal of the evaluation is to minimize risks and maximize outcomes for the recipient and longevity of the transplanted kidney.
Automated analyzers have advanced diagnostic testing by increasing efficiency and accuracy while reducing human error. There are four basic approaches to automated analyzers: continuous flow analyzers, centrifugal analyzers, discrete auto analyzers, and dry chemical analyzers. Each type has its own principles and advantages such as processing multiple samples simultaneously, using small sample volumes, and eliminating manual steps. Automated analyzers have improved healthcare by providing faster, higher quality, and more standardized test results.
1. The document discusses the management of various types of urinary tract injuries including renal, ureteric, bladder and urethral injuries.
2. It provides clinical scenarios for each type and discusses their relevant anatomy, epidemiology, signs and symptoms, investigations and treatment approaches.
3. Management depends on the grade of injury and may involve conservative approaches, surgical exploration or repair, with the goal of preserving renal function and maintaining hemodynamic stability in trauma patients.
1. Abdominal trauma is commonly encountered in emergency departments and can be life-threatening. Blunt and penetrating injuries can cause damage to solid organs like the spleen, liver, and pancreas.
2. A thorough primary and secondary survey is essential to identify injuries. Diagnostic tools like FAST ultrasound, CT scans, and laparoscopy help evaluate injuries. Conservative management is appropriate for many mild organ injuries.
3. Splenic injuries require close monitoring or surgery depending on grade. Liver injuries often stop bleeding spontaneously but may require packing or resection. Pancreatic injuries are difficult to diagnose and usually repaired surgically. Proper identification and treatment of abdominal injuries is critical for patient outcomes.
The document provides information on abdominal injuries, including:
1. The abdomen can be injured through penetrating or blunt trauma, involving the abdominal wall, solid organs, hollow viscus, or vasculature.
2. Assessment of abdominal injury focuses on recognizing conditions requiring immediate surgery and avoiding delayed intervention. Investigations include physical exam, paracentesis, diagnostic peritoneal lavage, FAST scan, and imaging.
3. Management depends on injury mechanism and patient stability. Penetrating injuries may require laparotomy for bleeding control or foreign body removal. Indications for laparotomy include bleeding control, injury identification, and contamination protection. Specific organ repairs include splenectomy, tractotomy, and primary suturing
The document discusses liver trauma, providing details on the anatomy and physiology of the liver, classifications of traumatic liver injuries, clinical presentations, diagnostic imaging approaches including CT scans and angiography, and treatments. Key points covered include: the liver is the second most commonly injured abdominal organ from trauma but most common cause of death; injuries are often from blunt force such as motor vehicle accidents; CT scans are the diagnostic standard and can classify injuries on a scale of I-VI based on features like hematomas and lacerations; angiography can identify active bleeding for potential embolization treatment.
1) Abdominal trauma is commonly encountered and can be life-threatening. Identification of serious intra-abdominal injuries can be challenging.
2) Motor vehicle accidents account for 60% of abdominal trauma, with blunt trauma more common than penetrating injuries.
3) Injuries to solid organs like the spleen, liver, and kidneys require careful assessment and may be graded based on severity. Conservative management is often attempted initially if the patient is stable.
4) Diagnostic tools like FAST ultrasound, CT scans, and laparoscopy can help identify injuries, but repeated examinations are often necessary. Management may involve surgery or conservative approaches depending on injury severity and patient stability.
The document discusses various imaging modalities used in trauma patients, including their applications and benefits. It recommends that initially for major trauma patients, lateral cervical spine and chest X-rays be performed to assess for fractures and pneumothorax. Abdominal ultrasound should also be done to check for hemorrhage. Computed tomography can further assess brain, vascular and solid organ injuries if available in the emergency department. Common imaging findings of injuries to vital organs like the liver, spleen and kidneys are also outlined.
(1) Perform a primary survey and assess for ABCDE issues.
(2) Consider a seatbelt sign and evaluate for abdominal tenderness or rigidity which suggest occult injury.
(3) Perform a FAST exam to check for hemoperitoneum which, if positive, indicates need for surgical consultation given the mechanism of injury.
(4) If the patient is stable, further evaluation with CT scan would be most accurate to diagnose potential solid organ or retroperitoneal injuries from the handlebar impact.
This document provides an overview of abdominal trauma, including blunt and penetrating injuries. It discusses the anatomy, mechanisms of injury, assessment techniques like the FAST scan and CT scan, management principles, and specific injuries to the liver, spleen, diaphragm, and pelvis. Treatment may involve resuscitation, laparotomy, interventional radiology, or observation depending on the stability of the patient and findings on imaging and examination. Unrecognized abdominal injuries can be preventable causes of death, so early recognition and management of intra-abdominal injuries is important for saving lives.
A 43 year old male patient was transferred with an ambulance in the emergency department of the hospital with bleeding from right thigh after a motorcycle accident. He had become a trapped under the motorcycle.
Discuss the medical, surgical and anesthetic management of this patient.
1) The document discusses the diagnosis and treatment of intra-abdominal injuries, including the external anatomy of the abdomen, classification of injuries as blunt, penetrating, or iatrogenic, signs and symptoms of potential abdominal injury, and priorities for diagnosis and management.
2) Key diagnostic tests discussed are physical exam, plain films, FAST ultrasound, CT scan, diagnostic peritoneal lavage, and exploratory laparotomy. Indications, advantages, limitations, and sensitivities of each test are provided.
3) Treatment priorities and approaches are outlined, including resuscitation, damage control resuscitation, identifying the source of bleeding, and surgical procedures for exploratory laparotomy and repair of specific organ injuries
This document discusses imaging in abdominal trauma. It begins by outlining the mechanisms and types of abdominal injuries from blunt and penetrating trauma. It then describes the FAST (Focused Assessment with Sonography for Trauma) exam and its role in the initial assessment of hemodynamically unstable patients. For stable patients, CT is typically used to further evaluate injuries suggested on clinical exam or FAST. The document outlines key CT findings for various intra-abdominal injuries and hemorrhage.
1. The document discusses the triage and assessment of abdominal trauma. It outlines the principles of trauma management including treating the greatest threat to life first.
2. The primary and secondary surveys are described in detail, covering the assessment of the airway, breathing, circulation, disability, and exposure. Specific injuries to the abdomen like liver and spleen injuries are also discussed.
3. Investigations for abdominal trauma including focused assessment with sonography, diagnostic peritoneal lavage, CT scans, and grades of injuries are provided. The management of positive findings is also summarized.
- A 32-year-old male motorcyclist was in a high-speed collision where he was thrown from his bike after hitting a vehicle.
- On examination, he has right-sided chest, abdominal, and pelvic tenderness. Vital signs have stabilized with IV fluids.
- Given the mechanism of injury and physical exam findings, the patient has likely sustained injuries to intra-abdominal organs and/or pelvic structures on the right side from the high-speed impact. Further evaluation with tests like FAST ultrasound, CT scan, and possible diagnostic peritoneal lavage or laparoscopy may be needed to identify specific injuries.
This document discusses various types of vascular injuries. It covers the basic principles of vascular injury including anatomy, type of injury, mechanisms, clinical manifestations, investigations and management. It describes different types of vascular injuries like laceration, transection, dissection, crush and thrombosis. It discusses evaluation and investigations like Doppler, duplex ultrasound, angiography, CT angiography and MRI. It covers management of vascular injuries in different body regions like neck, chest, abdomen and extremities. It provides guidelines on treatment approaches including operative versus endovascular management.
This document discusses approaches to managing abdominal trauma in the emergency department. It begins by outlining learning objectives which include identifying abdominal trauma, learning assessment approaches, and trauma management. It then discusses the primary and secondary surveys as well as indications of shock. Specific injuries like solid organ injuries, hollow visceral injuries, retroperitoneal injuries, and diaphragmatic injuries are examined. Mechanisms of injury, physical exam findings, ultrasound, and management are also reviewed to provide emergency physicians with guidance on evaluating and treating abdominal trauma.
1) Liver abscesses can be either pyogenic (caused by bacteria) or amoebic (caused by the parasite Entamoeba histolytica).
2) Pyogenic liver abscesses are more common in western countries and are usually caused by E. coli or Klebsiella pneumoniae, while amoebic liver abscesses are more common in Asia and Africa.
3) The most common causes of pyogenic liver abscesses are infections that spread from the biliary tract, while amoebic liver abscesses usually originate from ingesting cysts of E. histolytica through contaminated food or water.
This document provides guidance on the initial assessment and management of abdominal trauma. It discusses:
- Recognizing abdominal injuries through physical exam, ultrasound, CT, and diagnostic tools.
- Managing hemorrhage from abdominal injuries through damage control resuscitation including permissive hypotension, blood product transfusion, and early surgery to control bleeding.
- Evaluating different areas of the abdomen that could be injured, including the intraperitoneal cavity, retroperitoneum, thorax, heart, and diaphragm.
Blunt abdominal trauma can cause serious internal injuries that may not be apparent initially. Over one-third of patients considered asymptomatic based on initial exams were found to have abdominal organ injuries. A high index of suspicion is needed to properly evaluate patients for potential internal injuries. Evaluation involves thorough history and physical exam, along with diagnostic tools like ultrasound, CT scans, and possible exploratory surgery to identify injuries requiring treatment.
Resuscitation and management of abdominal trauma patients involves a primary and secondary survey approach. During primary survey, airway, breathing, circulation, disability, and exposure are assessed and stabilized concurrently with resuscitation to address the lethal triad of coagulopathy, hypothermia and acidosis. Fluid resuscitation is aimed at restoring normal vital signs and urine output while assessing response. Secondary survey involves full history, exam, and investigation including FAST scan, CT scan if stable, to diagnose injuries which may often be managed conservatively but sometimes require surgery. Common injuries include spleen, liver and kidney injuries.
Abdominal trauma can result from blunt or penetrating injuries and is a leading cause of death worldwide, especially in young people. Assessment involves a primary survey to evaluate life threats and ongoing resuscitation, followed by a secondary survey and investigation of potential injuries. Common abdominal injuries include injuries to the spleen, liver, hollow organs, and retroperitoneal structures. Treatment depends on the severity and location of injuries, with many solid organ injuries now managed conservatively through observation rather than surgery, provided the patient is stable. CT scan is useful for diagnosis, while laparotomy may be needed for severe or uncertain injuries or ongoing bleeding.
Similar to Modlin kidney transplant techniques presentation (20)
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
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2. Charles Modlin, M.D., MBA
•
College: Northwestern
•
Medical School:
•
Internship/Residency:
•
Fellowship
Renovascular Surgery/
Renal Transplant:
University
Northwestern University
New York University
Cleveland Clinic
•
Staff: Cleveland Clinic
32. Renal Trauma
•
•
•
•
19 y/o AA male
Admitted with 2 Gun Shot Wounds: ER
Physical Exam:
- Vitals BP 90/50, Pulse 150 regular, RR labored
breathing, no breath-sounds left lung semiconscious, uncooperative, pain, abdomen distended
and tender +rebound, rigidity, bullet entry posterior
left chest, exit site right anterior abdominal wall,
another entry site left gluteus
- Stat Hematocrit 18%, ABG 7.28 pH,pCO2 60,pO2 68
- Bladder Catheterized: Urine Clear (NO Hematuria)
WHAT WOULD YOU DO????
33. Immediate Resuscitation
•
•
•
•
•
•
•
•
•
•
Femoral Venous Lines/ Large Bore IVs
Normal Saline Hydration
Albumin
Blood
FFP
(PT/PTT coagulopathic)
CXR: Pneumothorax: Chest Tube Insertion
Hypoventilation/ Acidotic /Intubation
Serial Hematocrits; Hct Stable/ BP stable
What would you do????
34. What would you do???
•
•
•
Admit to the ICU and Observe.
Obtain a CT scan.
Prepare the O.R. for Immediate Surgical
Exploration.
35. Surgical Exploration
•
•
•
•
•
Midline-abdominal Incision made
Trauma to Gallbladder, L Kidney, Tail of
Pancreas
Retroperitoneal Hematoma Bilaterally
Gallbladder removed
Retroperitoneal Hematoma Non-Expanding
- Kidney Partially Visualized (trauma to
lower pole)
- Retroperitoneal hematoma
- Drains Placed, Patient Closed
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52. Surgical Exploration
•
•
What type of incision?
- Left Flank Incision
- Left Thoraco-Abdominal
- Abdominal Midline
- Chevron
Why? Hint: What is the most important
thing you must do upon entering the
patients body?
53. Renal Trauma Grading
•
Renal injuries are graded by the American
Association for the Surgery of Trauma
(AAST)
- on the basis of the depth of injury and
the involvement of vessels or the
collecting system as follows (Moore,
1989).
54. Grading
Classified according to the Organ Injury Scaling (OIS)
Committee Scale
•
Minor
•
Contusion Microscopic or gross haematuria, Urological studies
normalHaematomaSubcapsular, nonexapnding without
parenchymal laceration.
I
II
•
•
Haematoma Nonexapnding perirenal haematoma confined to renal
retroperitoneum. Laceration<1cm parenchymal depth of renal
cortex without urinary extravasation.
Major
III
•
Laceration>1cm depth of renal cortex, without collecting system
rupture or urinary extravasation
IV
•
LacerationParenchymal laceration extending through the renal
cortex, medulla and collecting system.VascularMain renal artery or
vein injury with contained haemorrhage.
V
•
Laceration Completely shattered kidney. Vascular Avulsion of
renal hilum which devascularizes kidney.