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MITOSIS & MEIOSIS
Why can’t a cell keep on increasing
              in size?




Cells MUST divide when their SA:V becomes small.
Cells divide :
        1.For growth



  2. To produce
gametes or spores
                                     3.To replace
                                     damaged cells



             Salmon gametes mixing
Mucor
The nucleus contains thread-
   like structures called:
A nucleus can contain:
TWO types of cells in the body
  Non-reproductive              Gametes
   or somatic cells            (sex cells)

  diploid number             haploid number
  of chromosomes




                                  sperms
phagocyte       Nerve cell
types of cell division


produces body cells




  produces sex cells
takes place in any part of a plant or animal
 which is producing new cells for growth or
 replacement
e.g.
bone marrow producing new blood cells
e.g.
bone marrow producing new blood
 cells
e.g.
skin cell production
growth of a muscle
Mitosis in
                 buds




 Mitosis in
shoot & root
    tips
occurs in reproductive organs and results
 in the formation of sex cells




                         Meiosis forms the
                         ovum and sperms
                            in animals.
Key           Haploid gametes (23)
   Haploid                                       Where does
                                 Egg (23)
  Diploid                                       meiosis occur
                                               in a male and a
                                               female human?
                        Sperm (23)
        MEIOSIS                   FERTILISATION



Ovary                       Testis
                                               Diploid
                                               zygote
                                                (46)


                                 Mitosis and
                                                         Testes in
                                 development              males &
         Multicellular diploid                           ovaries in
         adults (46)
                                                          females
MALE     FEMALE
Sex organs   Testes   Ovaries

Gametes      Sperm    Ovum / egg
MALE            FEMALE
Sex organs   Anthers         Ovaries


Gametes      Inside pollen   Egg cell
             grains
Mark with an ‘X’ where meiosis occurs.
is called a REDUCTION-DIVISION.
            Why?

as it causes the chromosome number to
 halve




  How is it possible to produce 4
        cells by meiosis?
Mitosis or meiosis?
Which process restores the diploid
   number of chromosomes?
Meiosis reduces the chromosome number;
Fertilisation restores the diploid number.



                23         23
46                                       46
      meiosis   egg
                           23

                23              fertilisation
46
                sperm
Both occur in plants and animals.

Both produce new cells as they
 are types of cell division.
TWO daughter cells
First
                      division




                        Second
                        division



FOUR daughter cells
Genetic
  variation is
almost infinite
 as a result of
   meiosis
First
 division



 Second
division


            NEW COMBINATIONS
1. exchange of genetic material during
  meiosis
2. random fertilisation
Random Fertilisation
 = even more variation
 A human ovum plus a human sperm
     - 1 of 8 million combinations possible for
       each ovum and sperm

      - 223 x 223 = over 70 trillion combinations

  Any 2 parents will produce a
   zygote with over 70 trillion
   possible combinations without
  considering crossing over
                                                UNIQUE!!
Mitosis                    Meiosis
1) Two cells are produced   Four cells are produced

2) Cells have the diploid Cells have the haploid
 number of chromosomes number of chromosomes

3) One division occurs      Two divisions occur

4) Cells are genetically    Cells are genetically
identical (CLONES)
           CLONES           different

5) Produces somatic cells   Produces sex cells
46


   Write the
                23        23
 numbers of
chromosomes
 found in the
 cells shown.        46



                     46
are thread-like structures found in the nucleus


they only show up clearly at cell division as
 they shorten and thicken
Number of Chromosomes



Fruit Flies: 8    Carrots: 20
                                     Dog: 48




 Shrimp: 254     Adders tongue
                 (Fern): 1260
                 Largest number of
                 chromosomes
Fig. 4 Homologous
chromosomes of a fruit fly.
46
        chromosomes
          in humans




44 autosomes
                 2 sex chromosomes
Down’s Syndrome children have
      47 chromosomes
The chance of having a Down syndrome child
        goes up with maternal age
A "good" egg from a
Egg is in center of picture   32 year old woman.
This is a low quality, egg
from a woman 41 years old.
Egg is irregularly shaped
and dark.
A chromosome consists of DNA
    packed around proteins
The total extended length of DNA in a
      human cell is nearly 2m.




           Cheek cells
Carry information
 to make an
 individual
consists of two parallel strands linked
 together by weak hydrogen bonds

it is twisted into a spiral
is a DOUBLE HELIX (a helix is any spiral-
 shaped object)
four different bases:
   A: adenine;
   T: thymine;
   C: cytosine;
   G: guanine
A always pairs with T
C with G


this is called
 complementary base
 pairing
is the basic unit
     of DNA
The diagram shows
   part of a DNA
     molecule.
   Complete the
diagram by labelling
     the bases.


                           T
                       G
                           G
                       A
is a series of chemical structures called
 bases along the length of a chromosome


provides ‘instructions’ to the cell, e.g. to
 make pepsin or the skin colour
is a spontaneous change in a gene or a
 chromosome which may produce a change in
 the characteristic under its control


a mutation can be:
 harmful
 lethal
 beneficial (mutations in bacteria often
 produce resistance to drugs)
Naturally
 when chemicals on the DNA change position
  during nuclear division


Artificially
 by means of mutagens
 an agent that causes a change in
  genetic composition
X-rays
UV-rays
cigarette smoke
asbestos
formaldehyde
pesticides
Question: MAY, 2004 (pg 78)

It is not advisable for pregnant females to take X-
rays because these can cause mutations in the
developing foetus. The X-rays can in fact act as a
mutagen (or mutagenic agent).
ii)Explain the term mutation by referring to the
DNA molecule. (2)
A spontaneous change in the structure of DNA.
A change in the sequence of bases occurs.
Question: pg 78
ii) Name one human disease or condition which
    results from a mutation. (1)
Haemophilia / Down’s syndrome



iii)Name one mutagen other than X-rays. (1)
UV rays
the
 information
 to build
 proteins
What are the building blocks of
       proteins called?
Name the bond between amino
           acids.
Fig.9 Protein synthesis inside a cell.
Fig.9 Protein synthesis inside a cell.
THE END

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Mitosis & meiosis

  • 2. Why can’t a cell keep on increasing in size? Cells MUST divide when their SA:V becomes small.
  • 3. Cells divide : 1.For growth 2. To produce gametes or spores 3.To replace damaged cells Salmon gametes mixing Mucor
  • 4. The nucleus contains thread- like structures called:
  • 5. A nucleus can contain:
  • 6. TWO types of cells in the body Non-reproductive Gametes or somatic cells (sex cells) diploid number haploid number of chromosomes sperms phagocyte Nerve cell
  • 7. types of cell division produces body cells produces sex cells
  • 8. takes place in any part of a plant or animal which is producing new cells for growth or replacement e.g. bone marrow producing new blood cells
  • 11. Mitosis in buds Mitosis in shoot & root tips
  • 12.
  • 13.
  • 14. occurs in reproductive organs and results in the formation of sex cells Meiosis forms the ovum and sperms in animals.
  • 15. Key Haploid gametes (23) Haploid Where does Egg (23) Diploid meiosis occur in a male and a female human? Sperm (23) MEIOSIS FERTILISATION Ovary Testis Diploid zygote (46) Mitosis and Testes in development males & Multicellular diploid ovaries in adults (46) females
  • 16. MALE FEMALE Sex organs Testes Ovaries Gametes Sperm Ovum / egg
  • 17. MALE FEMALE Sex organs Anthers Ovaries Gametes Inside pollen Egg cell grains
  • 18. Mark with an ‘X’ where meiosis occurs.
  • 19.
  • 20. is called a REDUCTION-DIVISION. Why? as it causes the chromosome number to halve How is it possible to produce 4 cells by meiosis?
  • 21.
  • 23. Which process restores the diploid number of chromosomes?
  • 24. Meiosis reduces the chromosome number; Fertilisation restores the diploid number. 23 23 46 46 meiosis egg 23 23 fertilisation 46 sperm
  • 25. Both occur in plants and animals. Both produce new cells as they are types of cell division.
  • 26.
  • 28.
  • 29.
  • 30. First division Second division FOUR daughter cells
  • 31. Genetic variation is almost infinite as a result of meiosis
  • 32.
  • 33. First division Second division NEW COMBINATIONS
  • 34. 1. exchange of genetic material during meiosis 2. random fertilisation
  • 35. Random Fertilisation = even more variation  A human ovum plus a human sperm - 1 of 8 million combinations possible for each ovum and sperm - 223 x 223 = over 70 trillion combinations  Any 2 parents will produce a zygote with over 70 trillion possible combinations without considering crossing over UNIQUE!!
  • 36. Mitosis Meiosis 1) Two cells are produced Four cells are produced 2) Cells have the diploid Cells have the haploid number of chromosomes number of chromosomes 3) One division occurs Two divisions occur 4) Cells are genetically Cells are genetically identical (CLONES) CLONES different 5) Produces somatic cells Produces sex cells
  • 37. 46 Write the 23 23 numbers of chromosomes found in the cells shown. 46 46
  • 38. are thread-like structures found in the nucleus they only show up clearly at cell division as they shorten and thicken
  • 39. Number of Chromosomes Fruit Flies: 8 Carrots: 20 Dog: 48 Shrimp: 254 Adders tongue (Fern): 1260 Largest number of chromosomes
  • 40. Fig. 4 Homologous chromosomes of a fruit fly.
  • 41. 46 chromosomes in humans 44 autosomes 2 sex chromosomes
  • 42.
  • 43. Down’s Syndrome children have 47 chromosomes
  • 44. The chance of having a Down syndrome child goes up with maternal age
  • 45. A "good" egg from a Egg is in center of picture 32 year old woman. This is a low quality, egg from a woman 41 years old. Egg is irregularly shaped and dark.
  • 46. A chromosome consists of DNA packed around proteins
  • 47. The total extended length of DNA in a human cell is nearly 2m. Cheek cells
  • 48. Carry information to make an individual
  • 49.
  • 50. consists of two parallel strands linked together by weak hydrogen bonds it is twisted into a spiral
  • 51. is a DOUBLE HELIX (a helix is any spiral- shaped object)
  • 52. four different bases: A: adenine; T: thymine; C: cytosine; G: guanine
  • 53. A always pairs with T C with G this is called complementary base pairing
  • 54. is the basic unit of DNA
  • 55. The diagram shows part of a DNA molecule. Complete the diagram by labelling the bases. T G G A
  • 56. is a series of chemical structures called bases along the length of a chromosome provides ‘instructions’ to the cell, e.g. to make pepsin or the skin colour
  • 57. is a spontaneous change in a gene or a chromosome which may produce a change in the characteristic under its control a mutation can be:  harmful  lethal  beneficial (mutations in bacteria often produce resistance to drugs)
  • 58. Naturally  when chemicals on the DNA change position during nuclear division Artificially  by means of mutagens
  • 59.  an agent that causes a change in genetic composition
  • 63. Question: MAY, 2004 (pg 78) It is not advisable for pregnant females to take X- rays because these can cause mutations in the developing foetus. The X-rays can in fact act as a mutagen (or mutagenic agent). ii)Explain the term mutation by referring to the DNA molecule. (2) A spontaneous change in the structure of DNA. A change in the sequence of bases occurs.
  • 64. Question: pg 78 ii) Name one human disease or condition which results from a mutation. (1) Haemophilia / Down’s syndrome iii)Name one mutagen other than X-rays. (1) UV rays
  • 65. the information to build proteins
  • 66. What are the building blocks of proteins called?
  • 67. Name the bond between amino acids.
  • 68. Fig.9 Protein synthesis inside a cell.
  • 69. Fig.9 Protein synthesis inside a cell.

Editor's Notes

  1. Figure 13.5 The human life cycle
  2. http://i.pbase.com/u9/dannysmythe/large/4319077.Carrot.jpg http://www.news.wisc.edu/newsphotos/images/fruit_fly_research03_6801.JPG