This document outlines 3 possible scenarios for the future course of the COVID-19 pandemic over the next 18-24 months according to medical experts: 1) alternating smaller peaks and valleys gradually diminishing over time, 2) a large second wave in fall/winter followed by smaller waves in 2021 similar to the 1918 flu, or 3) a "slow burn" of ongoing low-level transmission. The worst case scenario is a massive second wave exceeding the initial outbreak, overwhelming healthcare systems. Ongoing social distancing measures may be needed intermittently into 2022. Lifting lockdowns does not mean the end of COVID-19, which could remain for months or years until a vaccine is developed.
INTRODUCTION OF COVID-19, ORIGIN OF COVID-19, STRUCTURE OF COVID-19, CAUSES OF CORON VIRUS, SYMPTOMS OF COVID-19, TYPICAL SYMPTOMS OF COVID-19, MODE OF TRANSMISSION, PEOPLE WHI ARE AT HIGHER RISK, WHY COVID-19 IS SAID T BE AS THE PANDEMIC BY WHO?, PREVENTION, WHAT TO DO, WHAT NOT TO DO, MYTHS AND FACTS OF COVID-19 SPREADING, SOME OTHER CONSEQUENCES OF COVID-19, MOST IMPORTANT POINTS OF COVID-19, COVID-19 VACCINES INTRODUCTION, TYPES OF VACCINES , COVAXIN, COVISHIELD, COVID VACCINE REGISTERATION, WHO CAN REGISTER, WHO SHOULDNT TAKE VACCINE SHOTS, STEP BY STEP GUIDE FOR REGISTERATION, COMPARISON BETWEEN COVAXIN AND COVISHIELD,
corona is a pandemic disease in the world so many people are died because of this disease, it's not coming in a particular structure. it's having a different type of structure . how to prevent this disease maintain social distance, maintain hand hygiene, wear masks .nowady vaccines are available covishield ,covaxin, Pfizer, sputnik vaccine etc...this mainly helpful to prevent the corona
INTRODUCTION OF COVID-19, ORIGIN OF COVID-19, STRUCTURE OF COVID-19, CAUSES OF CORON VIRUS, SYMPTOMS OF COVID-19, TYPICAL SYMPTOMS OF COVID-19, MODE OF TRANSMISSION, PEOPLE WHI ARE AT HIGHER RISK, WHY COVID-19 IS SAID T BE AS THE PANDEMIC BY WHO?, PREVENTION, WHAT TO DO, WHAT NOT TO DO, MYTHS AND FACTS OF COVID-19 SPREADING, SOME OTHER CONSEQUENCES OF COVID-19, MOST IMPORTANT POINTS OF COVID-19, COVID-19 VACCINES INTRODUCTION, TYPES OF VACCINES , COVAXIN, COVISHIELD, COVID VACCINE REGISTERATION, WHO CAN REGISTER, WHO SHOULDNT TAKE VACCINE SHOTS, STEP BY STEP GUIDE FOR REGISTERATION, COMPARISON BETWEEN COVAXIN AND COVISHIELD,
corona is a pandemic disease in the world so many people are died because of this disease, it's not coming in a particular structure. it's having a different type of structure . how to prevent this disease maintain social distance, maintain hand hygiene, wear masks .nowady vaccines are available covishield ,covaxin, Pfizer, sputnik vaccine etc...this mainly helpful to prevent the corona
COVID-19 - Treatment Using Vitamin C (Ascorbic Acid)ALLAN CURA
A summary of the paradigm-shift in protocol - from respiratory to vascular - highlighting the effectiveness of using Ascorbic Acid as Treatment on COVID-19
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.
Most people who fall sick with COVID-19 will experience mild to moderate symptoms and recover without special treatment.
This is a presentation for all the people who are unaware about COVID-19.
COVID-19 = Corona Virus Disease 2019. Please like and share my presentation.
Presentation by:-
C. S. Nelson
VI - E
D.A.V Boys Senior Secondary School.
D.A.V Group of School.
A review on COVID-19, enlist all the details and information that i know about the current pandemic. i hope you found it informative. i am B.pharm student and currently searching for good job in Pharma Sector. if you want more presentation on any topic then i will deliver it to you, just take a step ahead and make a call on my phone number or you can whatsapp me. I always here to help.
Contact No. 8279242736
E.mail i'd : jain.gaurav402@gmail.com
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.
Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment.
Elderly people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness.
WHO clearly stated that the COVID-19 virus spreads primarily through droplets of saliva or discharge from the nose when an infected person coughs or sneezes.
guidelines of WHO on Coronavirus, structure of coronavirus, prevention and ongoing researches for COVID-19, what does pandemic mean, role of immune system for coronavirus and how to improve general immunity, how COVID-19 got its name, about SARS-CoV-2, when and how to use mask and dispose it off, myths related to coronavirus, studies going on in Oxford University for vaccine of COVID-19 from chimpanzee called as ChAdOx1 nCoV-19
this ppt is on corona virus. in this ppt u will read about that what is corona from where does it started and where it ended, what are the symptoms and precautions of corona virus, and abt vaccines also.
This is a kind of seminar presentation that covers the basic information about COVID 19 including virus origin, the molecular structure of the virus. It also presents adequate information on the outbreak happened all over the world and the mathematical model for prediction of what will happen later. The other part of the presentation contains a cellular mechanism of how the virus invades our body. Finally, treatment strategies are clarified.
COVID-19: Truths, Myths & Possible Consequences.Dito Bukia
This presentation provides all the necessary information about COVID-19: general facts about coronavirus, how it spreads, how it affects the human, how to prevent infection and what are the possible pandemic scenarios.
Forecasts for the end of the new coronavirus pandemic in brazil and the worldFernando Alcoforado
This article aims to present the predictions for the end of the Coronavirus pandemic in Brazil and worldwide made by the University of Technology and Design of Singapore and the University of Minnesota in the United States.
COVID-19 - Treatment Using Vitamin C (Ascorbic Acid)ALLAN CURA
A summary of the paradigm-shift in protocol - from respiratory to vascular - highlighting the effectiveness of using Ascorbic Acid as Treatment on COVID-19
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.
Most people who fall sick with COVID-19 will experience mild to moderate symptoms and recover without special treatment.
This is a presentation for all the people who are unaware about COVID-19.
COVID-19 = Corona Virus Disease 2019. Please like and share my presentation.
Presentation by:-
C. S. Nelson
VI - E
D.A.V Boys Senior Secondary School.
D.A.V Group of School.
A review on COVID-19, enlist all the details and information that i know about the current pandemic. i hope you found it informative. i am B.pharm student and currently searching for good job in Pharma Sector. if you want more presentation on any topic then i will deliver it to you, just take a step ahead and make a call on my phone number or you can whatsapp me. I always here to help.
Contact No. 8279242736
E.mail i'd : jain.gaurav402@gmail.com
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.
Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment.
Elderly people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness.
WHO clearly stated that the COVID-19 virus spreads primarily through droplets of saliva or discharge from the nose when an infected person coughs or sneezes.
guidelines of WHO on Coronavirus, structure of coronavirus, prevention and ongoing researches for COVID-19, what does pandemic mean, role of immune system for coronavirus and how to improve general immunity, how COVID-19 got its name, about SARS-CoV-2, when and how to use mask and dispose it off, myths related to coronavirus, studies going on in Oxford University for vaccine of COVID-19 from chimpanzee called as ChAdOx1 nCoV-19
this ppt is on corona virus. in this ppt u will read about that what is corona from where does it started and where it ended, what are the symptoms and precautions of corona virus, and abt vaccines also.
This is a kind of seminar presentation that covers the basic information about COVID 19 including virus origin, the molecular structure of the virus. It also presents adequate information on the outbreak happened all over the world and the mathematical model for prediction of what will happen later. The other part of the presentation contains a cellular mechanism of how the virus invades our body. Finally, treatment strategies are clarified.
COVID-19: Truths, Myths & Possible Consequences.Dito Bukia
This presentation provides all the necessary information about COVID-19: general facts about coronavirus, how it spreads, how it affects the human, how to prevent infection and what are the possible pandemic scenarios.
Forecasts for the end of the new coronavirus pandemic in brazil and the worldFernando Alcoforado
This article aims to present the predictions for the end of the Coronavirus pandemic in Brazil and worldwide made by the University of Technology and Design of Singapore and the University of Minnesota in the United States.
Contemplating Covid 19 Economic Recovery and a Market Performance Comparison ...Niraj Singhvi
Maple Growth Partners is of the opinion that the economic recovery will likely be W-shaped, however, it all depends on the stricter/ longer government interventions during the course of the virus outbreak. We looked at the market performance during the prior outbreaks to understand the length of the virus impact on to the economy. Interestingly, all the previous major virus outbreaks occurred when the world was already dealing with some political/ economic adversities. We provided a gist of typical leading/lagging economic indicators to be cognizant of the ongoing market impact driven by Covid 19 outbreak. Lastly,
we also analyzed gold prices to see if there’s any shift in demand for this safe haven asset during periods of pandemic uncertainties.
The pandemic continues to expand. More than 175 countries and territories have reported cases of COVID-19, the disease caused by the coronavirus (SARS-CoV-2). Case growth has accelerated to more than 735,000 cases and 35,000 deaths as
of March 30. Some geographies have a handful of cases, others with early community transmission have a few hundred, and those with uncontrolled, widespread transmission have tens of thousands. Governments have launched unprecedented public- health and economic responses. The situation evolves by the day.
Emergency management 11
Emergency Management
Abstract:
In the month of December, 2019 there was outbreak of pneumonia with unknown reason in Wuhan, China. Wuhan is the center of attention because of the respiratory disorder cause by a virus called Corona and also known as Novel COVID – 19. Validate the existence of this virus was also diagnosed in Wuhan. Then it start spreading all over the world due to the social gatherings. It ultimately take thousands of people towards death. Then after its huge destruction a final step of lockdown is taken up by the government of each country. The animal-to-human transmission was presumed as the main mechanism. It was concluded that the virus could also be transmitted from human-to-human, and symptomatic people are the most frequent source of COVID-19 spread. The virus-host interaction and the evolution of the epidemic, with specific reference to the times when the epidemic will reach its peak.
Introduction:
There is scanty knowledge on the actual pandemic potential of this new SARS-like virus. It might be speculated that SARS-CoV-2 epidemic is grossly underdiagnosed and that the infection is silently spreading across the globe. There are no comparable analogies to corona virus. This virus is not like any of the other epidemiological threats that have emerged in recent decades; it is less fatal but much more contagious.
Distribution of cases by the following:
· Time: The outbreak of 2019 novel coronavirus disease (COVID-19) was first reported on December 31, 2019.
· Place: the epidemiology of 2019 novel coronavirus disease (COVID-19) in a remote region of China, far from Wuhan, we analyzed the epidemiology of COVID-19 in Gansu Province
Explanation of the research topic (corona virus):
As the outbreak of coronavirus disease 2019 (COVID-19) is rapidly expanding in China and beyond, with the potential to become a world-wide pandemic, real-time analyses of epidemiological data are needed to increase situational awareness and inform interventions. The current most likely hypothesis is that an intermediary host animal has played a role in the transmission. Identifying the animal source of the 2019-nCoV would help to ensure that there will be no further future similar outbreaks with the same virus and will also help understanding the initial spread of the disease.
Numerator (cases of corona virus):
Deaths divided the total of deaths plus recoveries. In early days because of the exponential increase new cases significantly outpace recoveries. You’re dividing by new cases but the numerator hasn’t had a chance to catch up to the death toll yet to be associated with those cases. If you look at COVID 19 on Feb 17, you get the 2% number only if dividing by total cases. If you look vs recovered cases, it’s 13%.
The WHO’s fatality percentage, announced March 17, 2020, is based simply on the number of deaths g.
Review of Recent COVID-19 Science ~ Denis G. Rancourt, PhDPandataAnalytics
Measures do not prevent deaths, transmission is not by contact, masks provide no benefit, vaccines are inherently dangerous: Review update of recent science relevant to COVID-19 policy.
After months of deliberation, the World Health Organization has
declared COVID-19 a pandemic. As it seemed clear for quite some time, the virus will likely spread to most (if not all) countries on the globe. However, actions can still limit its impact.
Advertising in the time of a plague - Part 1 (ENG)DDB Warszawa
Communication Strategies in the face of the coronavirus pandemic
The pandemic is a time of dynamic changes and constant challenges for the brands, that is why we publish strategic reports as a part of the “Advertising in the time of plague” series. Their aim is to help calibrate communication and actions during this difficult time.
The first report is called “Communication strategies in the face of the coronavirus pandemic”. Published soon after restrictions were introduced, it advises how to communicate during this time. The second one, “100 predictions. What the future holds” seeks to answer the questions of what is ahead of us and how we can get ready for this frequently mentioned “New Normal”.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
4. ◼ I believe that the COVID-19 pandemic is the most serious global public
health threat humanity faced since the 1918/19 influenza pandemic.
◼ People around the world are now asking what will be the future for
the COVID-19 pandemic.
5.
6. ◼ How our lives will look in the short- to medium-term future is uncertain,
but what does seem clear is we won’t return to a pre-COVID-19 life any
time soon.
◼ What seems clear is that the end of 2020 won’t be the end of COVID-
19, and that we are likely to be dealing with it for at least the next
18-24 months.
7. ▪ How will the COVID-19 pandemic end?
Experts predict 3 possible scenarios based on key lessons from past influenza
pandemics.
▪ Epidemiologists for the University of Minnesota Center for Infectious Disease
Research and Policy (CIDRAP) have laid out three possible scenarios for what
the next 18 to 24 months might look like. (May 08, 2020)
8. ◼ The medical experts warn that “we must be prepared for at least another
18 to 24 months of significant COVID-19 activity.”
◼ The current pandemic is likely to last 18 to 24 months, or until about
60% to 70% of the population reaches immunity.
9. Up to two-thirds of a population needs immunity,
via infection or vaccines, to stop COVID-19
15. The first scenario shows an initial wave of cases — the
current one — followed by “peaks and valleys” that
shrink over time.
16. Scenario 1: Peaks and valleys
◼ The current initial wave of cases is followed by alternating mini-waves of
much smaller outbreaks every few months with only a few (but never
zero) cases in between.
◼ The location of the outbreaks may depend on regional variations in the
sort of mitigation measures that are in place .
17. ◼ In this scenario, the current wave of COVID-19 cases is followed by a
series of smaller waves, or "peaks and valleys," that occur consistently
over a one- to two-year period, but gradually diminish in 2021.
18. In scenario 2, a larger “fall peak,” or possibly a winter
peak, and subsequent smaller waves come after the
current one. This is similar to what happened during
the 1918 Spanish influenza pandemic
19. Scenario 2: Fall Peak
◼ The worst-case scenario, and the most likely outcome we need to prepare
for it., is one in which the first wave is followed by a larger wave in the fall
or winter of 2020, and one or more smaller subsequent waves in 2021.
◼ This mirrors what happened during the 1918 Spanish influenza pandemic
and the 2009 H1N1 flu.
20. ◼ The current outbreak will be followed by a massive second wave in the
fall or winter, that is twice as large and long-lasting. Subsequently, one
or more smaller waves could occur in 2021.
◼ This is exactly what happened with the 1918 Spanish flu pandemic; a
moderate wave in March 1918 was followed by an explosion in cases
that September, followed by smaller peaks until early 1919.
21.
22.
23. The third possibility shows an strong spring peak that
turns into a “slow burn,” with smaller ups and downs.
24. Scenario 3: A 'slow burn' of ongoing transmission
◼ The final scenario suggests that the current wave of coronavirus infections
is the biggest we'd see.
◼ Then in the coming months, the COVID-19 pandemic would shift into a
"slow burn" of ongoing transmission and new cases .
25. ◼ A “slow burn” of the pandemic would look like a sustained continuation
of cases over a long period of time with “no clear wave pattern.”
◼ "While this third pattern was not seen with past influenza pandemics, it
remains a possibility for COVID-19,"
26. ◼ “This third scenario likely would not require the reinstitution of mitigation
measures, although cases and deaths will continue to occur .
◼ Scenario 3 is a “slow burn” of ongoing transmission until we reach herd
immunity (60-70% of people infected).
27.
28. ◼ The only thing that will prevent all of these potential scenarios is the
development of a vaccine.
◼ If one doesn’t become available, then we are likely to have continued
outbreaks until at least half of the world has been infected – only 10%
of the world is estimated to have been infected so far.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44. ◼ Scenario 2 is the worst-case scenario, and the most likely outcome
we need to prepare for it.
◼ A second wave of infections with an even higher peak would require
countries to reinstitute mitigation measures like lockdowns.
45. ◼ The second scenario is possibly the most frightening because in many
countries health systems are only just about coping right now.
◼ If later this year we have a second outbreak of COVID-19 that dwarfs this
one, most health systems – especially fragile ones in low- and middle-
income countries – could buckle under the strain and collapse, causing
extremely high death rates.
46. ◼ The second wave, “would absolutely take the health care system down.”
Avoiding that was the whole point of efforts to “flatten the curve” to
prevent an imminent or actual crash of the health care system, similar
to what northern Italy experienced in March,Health authorities should
plan for the worst-case scenario.
47.
48. ◼ Flattening the curve: slowing the spread of Covid-19 enough to keep
the number of patients needing hospitalization, intensive care, or a
ventilator no greater than the health system’s capacity. Flattening
the curve did not mean zero cases and deaths .
◼ “If we also had a bad flu season, it would be really difficult for hospitals
to cope.
55. The best defence is preparation
◼ The researchers strongly recommend that governments and local
authorities prepare as best they can for future outbreaks –and for
a potential worst-case scenario, where no vaccine is found to be
effective, and where herd immunity cannot be achieved.
56. ◼ Regardless of which scenario unfolds, "we must be prepared for at least
another 18 to 24 months of significant COVID-19 activity, with hot spots
popping up periodically in diverse geographic areas.
◼ During new "waves" of cases, areas may need to periodically reinstate and
relax mitigation measures, such as social distancing, to prevent the health
care system from being overwhelmed with cases.
57.
58.
59.
60.
61. ◼ While one-time social distancing may suppress critical cases to within
hospital capacity, infections will resurge once these measures are lifted
◼ This will overwhelm hospitals to the extent that social distancing may need
to be maintained intermittently into 2022
62.
63. ◼ A single round of social distancing will probably not be sufficient in the long
term.
◼ Instead, researchers say, we should be prepared for occasional restrictions
and lockdowns over the next few years, until there’s widespread immunity or
an effective vaccine.
64. ◼ Until there is a vaccine, there is no way other than social Distancing to
stop the spread of the virus.
◼ Social Distancing Might Stop. And Start. And Stop. And Start. Until We
Have A Vaccine. (on and off social distancing).
65.
66. ◼ “We want to re-emphasize that easing restrictions is not the end of the
epidemic in any country,” Lifting lockdowns does not signal the end of
COVID-19.
◼ It’s becoming clear that the coronavirus is not going to simply vanish
after restrictions are lifted,Instead, it’s going to be with us for a while —
certainly for months, and possibly years.