This document summarizes intestinal infection by Entamoeba histolytica. It describes the life cycle of the parasite including ingestion of cysts, the luminal and tissue phases, and potential for extra-intestinal infection. It provides details on classification and treatment of intestinal and extra-intestinal amoebiasis with nitroimidazoles like metronidazole, tinidazole, and secnidazole. It also discusses other luminal and tissue amoebicides as well as treatments for related parasitic infections including giardiasis, trichomoniasis, trypanosomiasis, and toxoplasmosis.