The document summarizes the normal menstrual cycle, which typically occurs over 4 phases in a 28 day cycle. It is regulated by the hypothalamus, pituitary gland, and ovaries. The follicular phase begins with menstruation and involves follicle development and estrogen rise. Ovulation occurs around day 14 when an egg is released. In the luteal phase, the corpus luteum forms and secretes progesterone to thicken the uterine lining. If implantation does not occur, progesterone drops and menstruation begins, restarting the cycle.
The female reproductive system is made up of the internal and external sex organs that function in reproduction of new offspring. In humans, the female reproductive system is immature at birth and develops to maturity at puberty to be able to produce gametes, and to carry a fetes to full term.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
Series of events that takes place in the genital organ in an effort to expel the viable products of conception out of the womb through the vagina into the outer world is called labour.
there are four stages of labour.
The female reproductive system is made up of the internal and external sex organs that function in reproduction of new offspring. In humans, the female reproductive system is immature at birth and develops to maturity at puberty to be able to produce gametes, and to carry a fetes to full term.
DEVELOPMENT OF PLACENTA,PLACENTA AT TERM , DECIDUA,PLACENTAL MEMBRANE , PLACENTAL CICULATION,PLACENTAL ENDOCRINE SYNTHESIS,ABNORMAL PLACENTA,FUNCTIONS.
Series of events that takes place in the genital organ in an effort to expel the viable products of conception out of the womb through the vagina into the outer world is called labour.
there are four stages of labour.
Physiology Of Menstruation
By: Nur Afiqah Binti Jasmi (11-2013-031) & Luqman Hakim Bin Mohd Jais (11-2013-170)
Dokter Pembimbing: Dr. Harianto Wijaya Sp.OG
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The developmental anatomy of reproductive systemSahar Hafeez
This lecture encompasses the pertinent structural details of the sequence of embryological development of the male and female reproductive tracts. Focusing over the detail of differentiation of gonadal ridges into male & female gonads and development of the duct systems in both sexes during the first few weeks intrauterine life.
Gynecological signs and symptoms that may require medical attention. Gynecology is a branch of medicine that specializes in the treatment of women - specifically, the treatment of diseases and problems.
Ovary: Structure and hormonal regulationN K Agarwal
Slides describe the structure of ovary, folliculogenesis, hormonal control of female reproductive cycle, mechanism of ovulation, female sex hormones and their function.
Female reproductive functions can be divided into two major phases:
preparation of the female body for conception and pregnancy and
(2) the period of pregnancy itself.
This lecture is concerned with preparation of the female body for pregnancy, and presents the physiology of pregnancy and childbirth
Ovarian cycle (the guyton and hall physiology)Maryam Fida
Ovarian cycle
The germ cells that migrate into the ovaries during early embryonic development multiply, so that by about 5 months of gestation (prenatal life) the ovaries contain approximately 6 million to 7 million oogonia.
Most of these oogonia die prenatally through a process of apoptosis.
The production of new oogonia stops at this point and never resumes again.
The oogonia begin meiosis toward the end of gestation, at which time they are called primary oocytes.
Like spermatogenesis in the prenatal male, oogenesis is arrested at prophase I of the first meiotic division.
The primary oocytes are thus still diploidPrimary oocytes decrease in number throughout a woman’s life.
The ovaries of a newborn girl contain about 2 million Primary oocytes—all she will ever have.
Each Primary oocyte is contained within its own hollow ball of single layer of granulosa cells, the Primordial follicle.
By the time a girl reaches puberty, the number of Primary oocytes and follicles has been reduced to 400,000.
Only about 400 of these Primary oocytes will ovulate during the woman’s reproductive years, and the rest will die by apoptosis.
Oogenesis ceases entirely at menopause
Definition:
“Monthly rhythmical changes in the secretion of the female hormones and corresponding physical changes in the ovaries and other sexual organs”.
Duration: The duration of the cycle averages 28 days. It may be as short as 20 days ar as long as 45 days.
PHASES
Follicular Phase (Proliferative Phase) (1-14 Day)
Menstrual Phase (Day 1-5)
Preovulatory Phase. (Day 6-14)
Ovulation (Day 14)
Post Ovulatory Phase (Secretory Phase). (15-28 Day)
Leuteal Phase (Day 15-26)
Premenstrual phase. (Last 2 Day)
Concept of Hypothalamic-Pituitary-ovarian Axis
Overall, the most advanced follicle reduces the FSH supply to other follicles while at the same time it makes itself more sensitive to the FSH that remains.
The less developed, less sensitive follicles undergo atresia, while the most developed follicle attains a diameter of up to 2.5 cm. This follicle, called a mature (graafian) follicle, protrudes from the surface of the ovary like a blister.
As the follicle matures, the primary oocyte completes meiosis I and becomes a secondary oocyte.
This cell begins meiosis II but stops at metaphase II. It is now ready for ovulation.
FSH and estrogen also stimulate the maturing follicle to produce LH receptors, which are important to the next phase of the cycle
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. NORMAL MENSTRUAL CYCLE
mean duration of the MC
Mean 28 days (only 15% of )
Range 21-35
average duration of menses
3-8 days
normal estimated blood loss
Approximately 30 ml
ovulation occur
Usually day 14
36 hrs after the onset of mid-cycle LH surge
3. NORMAL MENSTRUAL CYCLE
the phases of the MC & ovulation regulates by:
Interaction between hypothalamus, pituitary & ovaries
mean age of menarche & menopause are:
Menarche 12.7
Menopause 51.4
4. The Cycle
• Strongly linked to the endocrine system
(hormone based and paracrine based)
• Typically takes 28 days to cycle through 4
phases
– Follicular
– Ovulation
– Luteal
– Menstruation
• Hormones raise and fall
6. Follicular
• Begins when estrogen levels are low
• Anterior pituitary secretes FSH and LH,
stimulation follicle to develop
• Cells around egg enlarge, releasing
estrogen
• This causes this uterine lining to thicken
7. Ovulation
• LH and FSH still being released, for
another 3-4 days
• Follicle ruptures, releasing ova into the
Fallopian tubes
8. Luteal
• Now empty follicle changes to a yellow
colour, becomes corpus luteum
• Continues to secrete estrogen, but now
beings to release progesterone
• Progesterone further develops uterine
lining
• If pregnant, embryo will release hormones
to preserve corpus luteum
9. Menstruation
• Menstruation
• If no embryo, the corpus luteum begins to
disintegrate
• Progesterone levels drop, uterine lining
detaches, menstruation can begin
• Tissue, blood, unfertilized egg all
discharged
• Can take from 3-7 days
14. PHYSIOLOGYOF THE MENSTRUAL
CYCLE
Ovulation divides the MC into two phases:
1-FOLLICULAR PHASE
-Begins with menses on day 1 of the menstrual
cycle
& ends with ovulation
RECRUITMENT
FSH maturation of a cohort of ovarian
follicles “recruitment”
only one reaches maturity
15. FOLLICULAR PHASE
MATURATION OF THE FOLLICLE (FOLLICULOGENESIS)
FSH primordial follicle
(oocyte arrested in the diplotene stage of the 1st meiotic
division surrounded by a single layer of granulosa cells)
Primary follicle
(oocyte surrounded by a single layer of granulosa cells
basement membrane & thica cells)
Secondary follicle or preantral follicle
(oocyte surrounded by zona pellucida , several layers of
granulosa cells & theca cells)
16. FOLLICULOGENESIS (2)
tertiary or antral follicle
secondary follicle accumulate fluid in a cavity
“antrum”
oocyte is in eccentric position
surrounded by granulosa cells “cumulous
oophorus”
17. FOLLICULOGENESIS (2)
SELECTION
Selection of the dominant follicle occurs day 5-7
It depends on
- the intrinsic capacity of the follicle to
synthesize estrogen
-highest/and ratio in the follicular fluid
As the follicle mature estrogen FSH
“-ve feed back on the pituitary” the follicle
with the highest no: of FSH receptors will
continue to thrive
The other follicles “that were recruited” will
become atretic
20. FOLLICULOGENESIS (3)
OTHER FACTORS THAT PLAY A ROLE IN FOLLICULOGENISIS
-INHIBIN
• Local peptide in the follicular fluid
• -ve feed back on pituitary FSH secreation
• Locally enhances LH-induced androstenedione production
-ACTIVIN
• Found in follicular fluid
• Stimulates FSH induced estrogen production
• gonadotropin receptors
• androgen
• No real stimulation of FSH secretion in vivo (bound to protein in
serum)
21. PREOVULATORY PERIOD
NEGATIVE FEEDBACK ON THE PIUITARY
- estradiol & inhibin -ve feed back on pituitary FSH
-This mechanism operating since childhood
POSITIVE FEEDBACK ON THE PITUITARY
• estradiol (reaching a threshold concentration) +ve feed back
on the pituitary (facilitated by low levels of progestrone) LH
surge secretion of progestrone
• Operates after puberty
• +ve feed back on pituitary FSH
22. PREOVULATORY PERIOD
LH SURGE
• Lasts for 48 hrs
• Ovulation occurs after 36 hrs
• Accompanied by rapid fall in estradiol level
• Triggers the resumption of meiosis
• Affects follicular wall follicular rupture
• Granulosa cells lutenization progestrone
synthesis
23. OVULATION
• The dominant follicle protrudes from the ovarian cortex
• Gentle release of the oocyte surrounded by the cumulus
granulosa cells
• Mechanism of follicular rupture
1- Follicular pressure
Changes in composition of the antral fluid colloid
osmotic pressure
2-Enzymatic rupture of the follicular wall
LH & FSH granulosa cells production of plasminogen
activator
plasmin fibrinolytic activity breake down of F. wall
LH prostglandin E plasminogen activator
PG F2α lysosomes under follicular wall
24. LUTEAL PHASE
LASTS 14 days
FORMATION OF THE CORPUS LUTEUM
• After ovulation the point of rupture in the follicular
wall seals
• Vascular capillaries cross the basement
membrane & grow into the granulosa cells
availability of LDL-cholestrole
LH LDL binding to receptors
3α OH steroid dehydrogenase activity
progestrone
25. LUTEAL PHASE
• Marked in progestrone secretion
• Progestrone actions:
-suppress follicular maturation on the
ipsilateral ovary
-thermogenic activity basal body
temp
-endometrial maturation
• Progestrone peak 8 days after ovulation (D22 MC)
• Corpus luteum is sustained by LH
• It looses its sensitivity to gonadotropins
luteolysis
estrogen & progestrone level desquamation of
the endometrium “menses”
26. LUTEAL PHASE
• estrogen & progestrone FSH &LH
• The new cycle stars with the beginning of menses
• If pregnancy occurs hCG secreation maintain the
corpus luteum
27. ENDOMETRIAL CHANGES DURING THE
MENSTRUAL CYCLE
1-Basal layer of the endometrium
-Adjacent to the myometrium
-Unresponsive to hormonal stimulation
-Remains intact throughout the menstrual cycle
2-Functional layer of the endometrium
Composed of two layers:
-zona compacta superficial
-Spongiosum layer
28. ENDOMETRIAL CHANGES DURING THE MENSTRUAL
CYCLE
1-Follicular /proliferative phase
Estrogen mitotic activity in the glands & stroma
enometrial thickness from 2 to 8 mm
(from basalis to opposed basalis layer)
2-Luteal /secretory phase
Progestrone - Mitotic activity is severely restricted
-Endometrial glands produce then secrete
glycogen rich vacoules
-Stromal edema
-Stromal cells enlargement
-Spiral arterioles develop, lengthen & coil
29. MENSTRUATION
• Periodic desquamation of the endometrium
• The external hallmark of the menstrual cycle
• Just before menses the endometrium is infiltrated with
leucocytes
• Prostaglandins are maximal in the endometrium just
before menses
• Prostaglandins constriction of the spiral arterioles
ischemia & desquamation
Followed by arteriolar relaxation, bleeding & tissue
breakdown
30. HYPOTHALAMIC ROLE IN THE MENSTRUAL
CYCLE
• The hypothalamus secretes GnRH in a pulsatile fashion
• GnRH activity is first evident at puberty
• Follicular phase GnRH pulses occur hourly
• Luteal phase GnRH pulses occur every 90 minutes
• Loss of pulsatility down regulation of pituitary receptors
secretion of gonadotropins
• Release of GnRH is modulated by –ve feedback by:
steroids
gonadotropins
• Release of GnRH is modulated by external neural signals
31. THANKYOU
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an empty mind with an open one”
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