Matrix Effect

Characterization and Classification of Matrix Effects in Biological Samples Analysis 05 Feb 2010 Manish S. Yadav Bioanalytical Research, Veeda CR, Ahmedabad Dinesh Kumar & Amit Patel Bioanalytical Research, Veeda CR, Ahmedabad Presented by: Conceptualized by

ACKNOWLEDGEMENT All Bioscientists of Veeda

[object Object],[object Object],[object Object],[object Object],[object Object],Matrix Effect

[object Object],[object Object],Matrix Effect

[object Object],[object Object],[object Object],Ion Suppression

[object Object],[object Object],[object Object],[object Object],Types of Matrix Effect ,[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Matrix Effect Evaluation

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Reason for Matrix Effect in ESI

Reason for Matrix Effect in APCI ,[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],Approches – Our target…!!! To mininize Matrix Effect / Ion Suppression…

[object Object],[object Object],[object Object],[object Object],Terminology

Interference Materials in matrix Affect the MS Ionization Decrease Extraction During process MATRIX EFFECT EXTRACTION RECOVERY

Relationship: ,[object Object],[object Object],[object Object],[object Object]

If RE = -1  Evaluate Extraction Yield (EY) RE ≠ +1   ,[object Object],[object Object],[object Object],[object Object],[object Object],-1 PE ME ME ME RE RE RE RE RE RE -1 0 -1 -1 0 -1 -1 0 +1 0 -1 0 +1 +1 +1 0

Conclusion: ,[object Object],[object Object],[object Object],[object Object],[object Object]

Matrix Effect

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