The document discusses the key factors to consider when selecting materials for pharmaceutical plant construction. Material selection depends on chemical factors like potential for contamination or corrosion, physical factors like strength and thermal properties, and economic factors. A wide range of materials may be used, and the choice is based on expert advice, experience, and testing given pharmaceuticals can have varying chemical properties and manufacturing requires withstanding various temperatures, pressures, and stresses. Proper material selection is important for product quality and plant success.
SUBJECT:-Pharmaceutical engineering 1
CONTENTS
-general study of composition
-properties
factors affecting the selection of material of pharmaceutical plant
-construction with special reference to S.S and glass
Complexation and Protein Binding [Part-2](Method of analysis, Complexation a...Ms. Pooja Bhandare
Method of Analysis: Methods of continuous variation / JOB’S method of continuous variation.
pH titration method.
Distribution method.
Solubility method.
Spectroscopy and charge transfer complexation.
Miscellaneous method
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
SUBJECT:-Pharmaceutical engineering 1
CONTENTS
-general study of composition
-properties
factors affecting the selection of material of pharmaceutical plant
-construction with special reference to S.S and glass
Complexation and Protein Binding [Part-2](Method of analysis, Complexation a...Ms. Pooja Bhandare
Method of Analysis: Methods of continuous variation / JOB’S method of continuous variation.
pH titration method.
Distribution method.
Solubility method.
Spectroscopy and charge transfer complexation.
Miscellaneous method
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
Sanjo College of Pharmaceutical Studies, Physical Pharmaceutics I , 3rd semester B.Pharm, Complexation & protein binding, Classification in detail, determination methods, application of complexes in pharmacy.
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
Description of Construction, Working and Application of Pharmaceutical Machin...Makrani Shaharukh
Description of Construction, Working and Application of Pharmaceutical Machinery Such as Rotary Tablet Machine, Fluidized Bed Coater, Fluid Energy Mill and Humidifier.
Quantitative approach to the to the factor influcing solubility of drug; (Sol...Ms. Pooja Bhandare
Quantitative approach to the to the factor influcing solubility of drugs, Temperature,Nature of solvent, The boiling point of the liquids and the melting point of solids,Crystal properties:
Particle size (surface area ) of drug particles: The influence of substituent’s in molecular structures, Molecular size:
. pH :
Sanjo College of Pharmaceutical Studies, Physical Pharmaceutics I , 3rd semester B.Pharm, Complexation & protein binding, Classification in detail, determination methods, application of complexes in pharmacy.
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
Definition of drying
Importance of drying
Difference between drying and evaporation
Drying is defined as removal of the liquid from a material by application of heat & is accomplished by transfer of a liquid from the surface into an unsaturated vapor phase .
Drying is the final removal of water from material (usually by heat)
Drying is commonly the last stage in a manufacture process
Non-thermal drying
1- As Squeezing wetted sponge
2- Adsorption by desiccant (desiccation)
3- Extraction.
Preservation of drug products
Preparation of bulk drugs
Improved handling
Improved characteristics
Equipments
Drying is necessary in order to avoid deterioration. A few examples are…
--blood products, tissues… undergo microbial growth
--effervescent tablets, synthetic & semi synthetic drugs undergo…. chemical decomposition.
Description of Construction, Working and Application of Pharmaceutical Machin...Makrani Shaharukh
Description of Construction, Working and Application of Pharmaceutical Machinery Such as Rotary Tablet Machine, Fluidized Bed Coater, Fluid Energy Mill and Humidifier.
Unit-5 Materials for plant construction (Metals and Nonmetals ).pptxpakhichakraborty1
Pharmaceutical engineering notes By CVS shubhramanyam UNIT-V
topics covered: Material used for plant construction, Basic material handing system for solids, conveyors, types of conveyors, storage of solids.
All the pharmaceutical packaging related pin point covered in this powerpoint presentation, like Definition of packaging and types of packaging. Also there is evaluation parameters of packaging and main body of the presentation is to involve the types of packaging material used to package the different pharmaceutical products like Glass, Plastic, Metals, Rubbers etc. And there's Frequently asked questions in the end of the slides.
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Packaging of pharmaceuticals, glass, plastic, rubber , metal as a container, ...RajkumarKumawat11
Packaging of pharmaceuticals, glass, plastic, rubber , metal as a container, aerosol and aerosol packaging, pharmaceutics, pharmaceutical packaging, Packaging chapter for pharma students, rajkumar kumawat
SELECTION AND EVALUATION OF PHARMACEUTICAL PACKAGING TECHNIQUE.pdfShankar Maind Patil
Many pharmaceutical products are sell out in the market from its site to customer site covering miles of distance but .
Its necessary for them to keep their inner content intact throughout their use period .
That's how Packing involved in it.
Different materials like
Glass
Metal
Rubber
Plastic
Have been used for it .
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2. MATERIALS OF PHARMACEUTICAL
PLANT CONSTRUCTION
• A wide variety of materials are used for
manufacturing, processing and packaging of
products.
• Some products are highly acidic while some are
highly alkaline. so design of equipment ,material
selection and fabrication techniques need to be
considered carefully.
• These factors affect the success or failure of a
new chemical plant.
3. MATERIALS OF PHARMACEUTICAL
PLANT CONSTRUCTION
• if container is not compaitable with the
material then there are chances of
contamination.
• The proper choice of material is important
• The choice is based on expert advice,
previous experience and laboratory tests
4. MATERIALS OF PHARMACEUTICAL
PLANT CONSTRUCTION
• FACTORS AFFECTING DURING MATERIALS
SELECTED FOR PHARMACEUTICAL PLANT
CONSTRUCTION
• Chemical factors
• Physical factors
• Economic factors
5. CHEMICAL FACTORS
• Each time a chemical placed in the container
or equipment is exposed to the construction
material of the same.
• so construction material can contaminate the
product or the product can destroy the
construction.
6. CONTAMINATION OF THE PRODUCT
• Iron contamination can change the color of
products such as gelatin capsules.
• It catalyzes some reactions that can increase
the decomposition rate of the product.
• The leaching of glass makes the aqueous
product alkaline. This alkaline medium can
catalyze the decomposition of the product
e.g. lead inactivate penicillin
7. CORROSION OF MATERIAL OF
CONSTRUCTION
• The product can be corrosive in nature. They
can react with the material and can destroy it.
This shortens the life span of the equipment.
• Extreme PH, strong acids, strong alkalis,
powerful oxidizing agents, tannins etc react
with the materials and adversely affect them.
8. PHYSICAL FACTORS
1. STRENGTH:
• The materials must have sufficient physical
strength to withstand the pressure and stress
required
• Iron and steel have sufficient physical strength
• The tablet punching machine, the die, and the
upper and lower punches – made of stainless
steel(withstand high pressure)
9. PHYSICAL FACTORS
• 1. STRENGTH:
• The aerosol container must withstand high
pressure .so tin containers covered with some
polymers are used
• Plastic materials are weak-used for packaging
materials such as blister packs
10. MASS
• For transportation, light weight materials are
used.
• Plastic, aluminum, and paper packaging
materials are used for the packaging of the
pharmaceutical products.
11. WEAR PROPERTIES
• When there is friction occurs between two
surfaces, the softer surface disappears and
these materials contaminate the products.
E.g. during milling and grinding operations
grinding surfaces can wear out and
contaminate the powder.
• For handling pharmaceutical products
ceramics or iron are not used
12. THERMAL CONDUCTIVITY
• The materials should possess good thermal
conductivity
• Equipments such as dryers, evaporators, heat
exchangers-iron ,copper or graphite tubes are
used
13. THERMAL EXPANSION
• If the material has a very high coefficient of
thermal expansion, as the temperature
increases the shape of the equipment
changes. This produces unequal stresses
cause fracture.
• The materials that are capable of maintain
the shape and dimension of the equipments
at the working temperature should be used.
14. EASE OF FABRICATION
• Glass and plastic can be easily molded in to
containers of different shapes and size
15. CLEANING:
• Smooth and polished surfaces facilitate ease
in cleaning
• The surfaces of glass and stainless steel can be
smooth and polished
16. STERILIZATION
• In the production of parenterals, ophthalmic
and bulk drugs all equipment must be
sterilized.
• This is usually done by introducing high
pressure steam.
• The materials must withstand high
temperature(121° c) and pressure 15 pounds
per square inch
17. TRANSPARENCY
• In the reactors and fermentors observation
window provided to observe the progress of
the process.
18. ECONOMIC FACTORS
• The initial cost of the equipment depends on
the material used
• The materials that require a lower
maintenance cost are used because in the
long term it is economical.