1) The document discusses six major mass extinctions that have occurred throughout Earth's history. These extinctions were likely caused by a combination of large asteroid impacts, flood basalt eruptions, climate change, and other environmental upheavals.
2) The most severe extinction was at the end of the Permian period about 250 million years ago, wiping out over 90% of species. This was possibly triggered by intense volcanic activity.
3) We are currently in the midst of the Holocene or Anthropocene extinction caused primarily by human activities like habitat destruction, pollution, overexploitation of resources, and invasive species. If trends continue, half of existing animal and plant species may be extinct by 2100.