The document discusses 5 major mass extinctions that have occurred in Earth's history. Mass extinctions refer to the extinction of a large number of species within a short period of time across the globe. The biggest mass extinction was the Permian-Triassic extinction about 252 million years ago, which killed off around 95% of all species. Causes of mass extinctions included climate change, asteroid impacts, volcanic eruptions, and changes in sea levels. The 6th mass extinction is currently underway due to human activity such as pollution, habitat destruction, and overexploitation of resources. Up to 50% of all species may go extinct by 2100 if human impacts are not addressed.