The male external genital organs include the penis, scrotum, testes, epididymides, and spermatic cords. The penis has two parts - the root and body. The body contains three cylinders that become engorged with blood during erection. The scrotum is a cutaneous sac that contains the testes and associated structures. Each testis produces and stores sperm and is surrounded by membranes. The epididymis is a highly coiled tube that acts as a reservoir for sperm. The spermatic cord connects the testes to the abdomen and contains vessels and nerves.
Anatomy of urinary bladder. surfaces, border of urinary bladder its relation , ligament support, peritoneal relation in male and females, pouches, blood supply of bladder, nerve supply of bladder, true and false ligament of urinary bladder,
Anatomy of urinary bladder. surfaces, border of urinary bladder its relation , ligament support, peritoneal relation in male and females, pouches, blood supply of bladder, nerve supply of bladder, true and false ligament of urinary bladder,
A brief slide presentation on inguinal region including both inguinal canal and ligament and applied anatomy. Just read the theory properly and follow the diagrams.
rectus sheath, the sheath covering rectus muscle of anterior abdominal wall, formation of the sheath, the muscles involved in ts formation, and the contents the sheath is covering
A brief slide presentation on inguinal region including both inguinal canal and ligament and applied anatomy. Just read the theory properly and follow the diagrams.
rectus sheath, the sheath covering rectus muscle of anterior abdominal wall, formation of the sheath, the muscles involved in ts formation, and the contents the sheath is covering
Most species have two sexes: male and female. Each sex has its own unique reproductive system. They are different in shape and structure, but both are specifically designed to produce, nourish, and transport either the egg or sperm.
Unlike the female, whose sex organs are located entirely within the pelvis, the male has reproductive organs, or genitals, that are both inside and outside the pelvis. The male genitals include:
the testicles
the duct system, which is made up of the epididymis and the vas deferens
the accessory glands, which include the seminal vesicles and prostate gland
the penis
The male reproductive system includes the penis, scrotum, testes, epididymis, vas deferens, prostate, and seminal vesicles. The penis and the urethra are part of the urinary and reproductive systems.
Cerebrospinal fluid, CSF formation, circulation, absorption, function and clinical related to CSF,
HYDROCEPHALUS:
Communicating/ external,
non communicating/ internal
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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3. 1. The penis
• The penis is the male organ of copulation.
• It is made up of:
(a)A root or attached portion,
(b)Body or free portion
4. Root of Penis
• Situated in the superficial perineal pouch.
• It is composed of three masses of erectile tissue,
namely the two crura and one bulb.
• Crus is attached to the margins of the pubic
arch, and is covered by the ischiocavernosus.
• The bulb is attached to the perineal membrane
in between the two crura. It is covered by the
bulbospongiosus.
• Its deep surface is pierced by the urethra to
reach the corpus spongiosum
• The part of the urethra within the bulb shows a
dilation in its floor – intra bulbar navicular fossa.
5. (a) Male genital organs; parts of the penis—(b) ventral view, and
(c) sagittal section
6. Body of Penis
1. Right and left corpora cavernosa
• continuation of the crus of the penis, do not reach the
end of the penis
• Surrounded by fibrous envelope: tunica albuginea
(superficial longitudinal & deep circular fibres)
2. Median corpus spongiosum
• forward continuation of the bulb of the penis. Its
terminal part is expanded to form a conical
enlargement, called the glans penis
• traversed by urethra
The penis has a:
• ventral surface : faces backwards and downwards,
dorsal surface : faces forwards and upwards
7. .
• The base of glans has a projecting margin: corona
glandis, which overhangs an obliquity grooved
constriction: the neck of the penis
• Within the glans, the urethra shows a dilation:
navicular fossa.
• The skin of the penis is very thin & dark. At neck
it is folded: prepuce/ foreskin
• On the undersurface of the glans, there is a
median fold of skin: frenulum
• The potential space between the glans & the
penis : preputial space
• on corona glandis & neck there are sebaceous
glands, which secrete : smegma
8. Superficial fascia of penis:
• consists of very loosely arranged arolar tissue
• completely devoid of fat
• contains superficial vein of the penis
Deep fascia of penis/ Buck’s fascia:
• it surrounds all the three masses of erectile tissue
• does not extend into the glans
• deep to it are:
a. Deep dorsal vein,
b. Dorsal arteries,
c. Dorsal nerves of the penis
9. supports of the body of penis
a. The fundiform ligament:
• it extends downwards from linea alba & splits
to enclose penis
• It lies superficial to the suspensory ligament
b. The suspensory ligament:
• It lies deep to the fundiform ligament
• extends from the pubic symphysis and blends
below with the fascia on each side of the
penis
10. Arteries of the Penis
The internal pudental artery gives 3 branches:
1. The deep artery of the penis
2. The dorsal artery of the penis
3. The artery of the bulb of the penis
The femoral artery gives:- superficial external
pudental artery
Veins of the penis
• The dorsal veins, superficial and deep, are
unpaired
11. Nerve Supply of the Penis
1. The sensory nerve supply derived from:
the dorsal nerve of the penis and
the ilioinguinal nerve
2. The autonomic nerves are derived from
the pelvic plexus via the prostatic plexus.
• The sympathetic nerves are vasoconstrictor,
• the parasympathetic nerves (S2–S4) are
vasodilator.
12. Lymphatic Drainage
• Lymphatics from the glans drain into the deep
inguinal nodes, also called gland of Cloquet.
• Lymphatics from the rest of the penis drain into the
superficial inguinal lymph nodes.
13. Mechanism of Erection of the Penis
1. Dilatation of the helicine arteries (deep
artery of the penis)
2. This enlargement presses the veins
3. Expansion of the corpora cavernosa,
4. Erection is controlled by parasympathetic
nerves (nervi erigentes, S2–S4).
14. 2. SCROTUM
The scrotum (Latin bag) is a cutaneous bag
containing the right and left testes,
the Epididymes and
the lower parts of the spermatic cords.
15. Layers of the Scrotum
1. Skin
2. Dartos muscle
3. The external spermatic fascia from external
oblique muscle.
4. The cremasteric muscle and fascia from
internal oblique muscle.
5. The internal spermatic fascia from fascia
transversalis
16. Blood Supply
1. Superficial external pudental
2. Deep external pudental
3. Scrotal branches of external pudental
4. Cremasteric branch of inferior epigastric
Nerve Supply
The anterior one-third:
by segment L1 through ilioinguinal nerve &
genitofemoral nerve
The posterior two-thirds:
segment S3
17. some common abnormalities of scrotal contents are:-
1. Tumors of the testis
2. Hydrocoele (accumulation of fluid)
3. Epididymitis (inflammation of epididymis)
4. Variocoele (enlargement of the veins within
the scrotum)
5. Spermatocoele (spermatic cysts)
18. 3. Testis
o The testis is the male gonad.
o It is homologous with the ovary of the female
o It is suspended in the scrotum by spermatic
cord
External Features
• 1. Two poles or ends: upper & lower
• 2. Two borders, anterior and posterior
• 3. Two surfaces, medial and lateral
19. (a) Testis epididymis, sinus of the epididymis, and (b) longitudinal
section of testis and epididymis
20. Coverings of the Testis
• The tunica vaginalis
• The tunica albuginea
• The tunica vasculosa
21. Structure of the Testis
• The glandular part of the testis consists of 200
to 300 lobules.
• Each lobule contains 2-3 seminiferous tubules.
• The seminiferous tubules join together at the
apices of the lobules to form 20 to 30 straight
tubules which enter the mediastinum. Here they
form a network of tubules, the rete testis. In its
turn, the rete testis gives rise to 12 to 30
efferent ductules which emerge near the upper
pole of the testis and enter the epididymis.
22. Arterial Supply
The testicular artery from abdominal aorta:
It descends on the posterior abdominal wall to reach the deep
inguinal ring where it enters the spermatic cord.
Venous Drainage
The veins emerging from the testis form the pampiniform
plexus
Right vein drains into inferior vena cava.
Left vein drains into left renal vein.
Lymphatic Drainage
The lymphatics from the testis ascend along the testicular
vessels and drain into the preaortic and para-aortic groups of
lymph nodes.
23. Nerve Supply
The testis is supplied by sympathetic nerves arising
from segment T10 of the spinal cord.
Clinical
Unilateral absence of testis: monorchism
bilateral absence of testis: anorchism
Undescended testis: cryptoorchidism
Ectopic testis: the testis may occupy an abnormal
position due to deviation
24. 4. Epididymis
• The epididymis is an organ made up of highly
coiled tube that act as reservoir of spermatozoa.
Parts
• efferent ductules
• head
• body
• the duct of the epididymis which continuous as
• ductus deferens
25. 6. Spermatic Cord
1. The ductus deferens.
2. The testicular and cremasteric arteries, and the artery of
the ductus deferens.
3. The pampiniform plexus of veins.
4. Lymph vessels from the testis
5. The genital branch of the genitofemoral nerve, and the
plexus of sympathetic nerves around the artery to the
ductus deferens and visceral afferent nerve fibres.
6. Remains of the processus vaginalis.