The three main pairs of salivary glands are the parotid, submandibular, and sublingual glands. The parotid gland is the largest salivary gland located below the external ear. The submandibular gland is located below the mandible in the anterior digastric triangle. The sublingual gland is the smallest salivary gland located under the tongue.
This is a description on submandibular salivary gland. It is a large gland in tha floor of the mouth. It is clinically important and commonest site for stone formation. Imfection can produce pain. Submandibular duct opens on either side of frenulum
This is a description on submandibular salivary gland. It is a large gland in tha floor of the mouth. It is clinically important and commonest site for stone formation. Imfection can produce pain. Submandibular duct opens on either side of frenulum
The region on the lateral surface of the face that comprises the parotid gland & the structures immediately related to it
Largest of the salivary glands
Located subcutaneously, below and in front of the external auditory meatus
Occupies the deep hollow behind the ramus of the mandible
Wedge-shaped when viewed externally, with the base above & the apex behind the angle of the mandible
Detailed discussion on surgical anatomy of salivary glands with special focus on major glands. Relationship of facial nerve and its branhes to parotid gland is also discussed. Complications are also discussed. Surgical approaches are also discussed.
This is a description on parotid gland.
Gland on cheek.
Cause raised ear lobe
Can cause cheek pain if inflammed parotiditis
Pleomorphic adenoma
Salivary gland tumors
Malignancy is rare
Relations of parotid gland
The region on the lateral surface of the face that comprises the parotid gland & the structures immediately related to it
Largest of the salivary glands
Located subcutaneously, below and in front of the external auditory meatus
Occupies the deep hollow behind the ramus of the mandible
Wedge-shaped when viewed externally, with the base above & the apex behind the angle of the mandible
Detailed discussion on surgical anatomy of salivary glands with special focus on major glands. Relationship of facial nerve and its branhes to parotid gland is also discussed. Complications are also discussed. Surgical approaches are also discussed.
This is a description on parotid gland.
Gland on cheek.
Cause raised ear lobe
Can cause cheek pain if inflammed parotiditis
Pleomorphic adenoma
Salivary gland tumors
Malignancy is rare
Relations of parotid gland
Cerebrospinal fluid, CSF formation, circulation, absorption, function and clinical related to CSF,
HYDROCEPHALUS:
Communicating/ external,
non communicating/ internal
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
10. 4 surfaces:
1. Antero medial
2. Postero medial
3. Superficial/ lateral
4. Superior (base)
Apex of the gland is directed downwards
11. Apex
• Directed downwards
• Overlaps posterior belly of digastric
Structure passing through:
1. Cervical branch of facial nerve
2. Two divisions of the retromandibular vein
3. Formation of external jugular vein
12.
13. Superior surface/base
• Concave
• Concavity is related to external acoustic meatus & posterior part of
TMJ
Structure passing through:
1. Temporal branch of facial nerve
2. Superficial temporal vessels
3. Auriculotemporal nerve
14.
15. Superficial surface/ lateral
surface
• Largest of all the 4 surface
Covered by:
1. Skin
2. Superficial fascia
3. Deep fascia(parotid fascia, extension of
investing layer of deep cervical fascia)
4. Parotid lymph nodes
16. Antero medial surface
• Deeply grooved by the posterior border of ramus of mandible
Relations:
1. Post. Inferior part of masseter
2. Post. Border of ramus of mandible
3. Medial pterygoid muscle
4. Branches of facial nerve
17.
18.
19. Postero medial surface:
• Moulded to the mastoid & styloid process
Relation:
1. Mastoid process with sternocledomastoid & Posterior belly of
digastric
2. Styloid process with muscles attached to it
3. External carotid artery and branches of facial nerve enter
4. Deep to styloid: lies the internal carotid artery & internal jugular
vein
23. Posterior border:
• Separates the superficial
surface from the post.
Medial surface
• Overlaps the SCM
Relation:
1. post. Auricular branch
of facial nerve
2. Post. Auricular vessels
24. 3. Medial edge / pharyngeal border –
• separates the antero medial surface from the post. medial surface.
• It is related to the lateral wall of the pharynx.
25. Parotid duct/
Stenson's duct
• 5 cm long
• runs from the mid point
of anterior border
• Runs over the lateral
surface of masseter
• Pierces the buccinator
&
• Opens up at the upper
2nd molar vestibular
area
26. Branching of facial nerve
• Radiate like goose foot – Pes Anserinus
• Facial nerve emerges out from stylomastoid foramina
• Pierces post. medial surface
• Divides into
1. Temporal
2. Zygomatic
3. Buccal
4. Marginal mandibular
5. cervical
27. Structures passing through parotid
• Structures passing
through parotid
1. Facial nerve
2. Retromandibular
vein
3. External carotid
artery
29. SUBMANDIBULAR SALIVARY GLAND
• Large salivary gland
• situated in the anterior part of the digastric triangle.
• Enclosed between two layers of deep cervical fascia.
Superficial Part
It has three surfaces:
a. Inferior
b. Lateral
c. Medial surfaces.
30.
31. Relations:
The inferior surface is covered by:
a. Skin,
b. Platysma,
c. Cervical branch of the facial nerve
d. Deep fascia,
e. Facial vein
f. Submandibular lymph nodes
32. The lateral surface is related to
a. The submandibular fossa on the
mandible.
b. Insertion of the medial pterygoid
c. The facial artery
The medial surface is related to:
Mylohyoid, hyoglossus and
styloglossus muscles from before
backwards.
33. Deep Part
This part is small in size.
Relations
Present in between mylohyoid and
hyoglossus
Laterally – Mylohyoid
Medially – Hyoglossus
Above – Lingual nerve with
submandibular ganglion
Below – Hypoglossal nerve
34. Submandibular Duct/Wharton’s duct
• It is thin walled, and is about 5 cm long.
• At the anterior border of the hyoglossus, the duct is crossed by
the lingual nerve.
• It opens on the floor of the mouth, on the summit of the
sublingual papilla, at the side of the frenulum of the tongue.
35. Blood Supply and
Lymphatic Drainage
• The submandibular gland is
supplied by the facial artery.
• The veins drain into the
common facial or lingual vein.
• Lymph passes to
submandibular lymph nodes.
36.
37. SUBLINGUAL SALIVARY GLAND
This is smallest of the three salivary glands. It is almond-shaped
and weighs about 3 to 4 g.
Relations
Front – Meets opposite side gland
Behind–Comes in contact with deeper part of submandibular gland
Above – Mucous membrane of mouth
Below – Mylohyoid muscle
Lateral – Sublingual fossa
Medial – Genioglossus muscles
38. • About 15 ducts emerge from the gland. Most of them open
directly into the floor of the mouth on the summit of the
sublingual fold. A few of them join the submandibular duct