Lobun forte is a probiotic used for the reduction of uremic toxins in CKD patients. It is a combination of four probiotics, including Lactobacillus acidophilus, Bifidobacterium longum, Bacillus coagulans, and Streptococcus thermophilous. Read more about Lobun Forte https://medicaldialogues.in/partner/jbcpl/lobun-forte

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Probiotics for CKD, mechanism of action, uses and
more
medicaldialogues.in/partner/jbcpl/lobun-forte
, The Enteric uremic toxin reducer!
The gut has been identified as a Potential source of
inflammation in CKD patients , Probiotics have
promising effects by altering production and absorption
of uremic toxins and decreasing inflammation.
helps in
Rapid Reduction of Uremic Toxins in CKD patients
Delay the Progression of CKD from stage 3-4 to End
Stage Renal Disease
, The Enteric uremic toxin reducer!
capsule has
Probiotics NLT 45 Billion cells of a blend of Streptococcus thermophilus,
Lactobacillus acidophilus, Bifidobacterium longum, Bacillus coagulans.
1

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Formulated by the house of Probiotic originator of 50
+ yrs experience in manufacturing a variety of
proprietary Probiotic products which are stable
during shelf life, unaffected during Gastric transit and
reach intact the label claim microbial count for
colonization.
a blend of 4 Probiotics and each has a
significant function as shown below
Streptococcus thermophilus
High urea utilising microbe
Bacillus coagulans
After the permeability of gut for passing of toxins
Bifidobacterium longum
Helps in removal of putrefactive bacteria

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Lactobacillus acidophilus
Removes p-Cresol and indoxyl toxins
Does help like a dialyzer in CKD patients ?

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Enteric Toxin Reduction Technology uses probiotics to transform GUT into Dialyser
Superiority over similar other products
USPS CF 90 AUX 90
Additional
Strain
Bacillus coagulans alters
the permeability of gut for
passing toxins
Absent Absent
Storage No Cold Storage Strictly below
18 c
Strictly below 18 c
Probiotic
History
Brand from House of
Probiotics originator of 50
+ yrs experience
NA NA

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USPS CF 90 AUX 90
CFU:
Colony
Forming
Units
NLT 45 Billion CFU
reaches intact the target
site & multiplies for the
next 10 – 12 hrs with twice
daily dose helps to lower
circulating toxins in CKD
patients
Once a day
dose of 90
Billion may
not adequate
in lowering
toxin load
round the
clock as
microbial
count comes
down- after
some hours
Once a day dose of 90
Billion with Prebiotic
fructooligosaccharides(FOS).
Probiotics colonization does
not need any Prebiotic
support. Does not adequate
in lowering toxin load round
the clock as microbial count
declines after some hours.
LOBUN range available as
Each Capsule has Streptococcus thermophilus, Bacillus coagulans,
Bifidobacterium longum, Lactobacillus acidophilus to be taken twice
daily after meals

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Each Capsule has Streptococcus thermophilus, Bacillus coagulans,
Bifidobacterium longum, Lactobacillus acidophilus to be taken thrice
daily after meals
Outcomes
As evident from published clinical study of 45B CFU of Multispecies Probiotic
6 months clinical study in CKD 3 & 4 stage
2
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Urea hydrolysis in Large Intestine
hydrolysis
33% more Urea in 24 Hours
Acts at Ph > 7 and more potential than CF 90 strain

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Benefits of therapy in CKD patients
Lowers Urea, Uric acid and Creatinine
Reduces systemic circulation of DMA, NDMA, p-Cresol,
Indoles and Phosphate
Improves GFR & QOL
DMA : Dimethyl amine
NDMA : Nitroso dimethyl amine
GFR : Glomerular Filtration Rate
QOL : Quality of Life

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References:
1. Lau WL, Kalantar-Zadeh K, Vaziri ND. The Gut as a Source of Inflammation in Chronic
Kidney Disease. Nephron. 2015;130(2):92-8.
2. Adv Ther 2010 Sep;27(9):634-47.
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