D Rise (Vitamin D )

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D Rise contains Cholecalciferol, a fat-soluble vitamin that helps regulate serum calcium and phosphorous concentrations by enhancing the efficiency of the small intestine in absorbing these minerals from the diet. Read more about D-rise (https://d-rise.in/)

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Azmarda has sacubitril and valsartan which is the first approved agent in a new class of drug called angiotensin receptor neprilysin inhibitor (ARNI)3. Azmarda containing Sacubitril/ Valsartan is indicated in adults with long-term heart failure who have symptoms of the disease to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.Azmarda containing Sacubitril/ Valsartan exhibits the novel mechanism of action of an angiotensin receptor neprilysin inhibitor (ARNI) by simultaneously inhibiting neprilysin (neutral endopeptidase; NEP) via sacubitril, the active metabolite of the prodrug sacubitril, and by blocking the angiotensin II type-1 (AT1) receptor via valsartan. The complementary cardiovascular benefits and renal effects of Azmarda in heart failure patients are attributed to the enhancement of peptides that are degraded by neprilysin, such as natriuretic peptides (NP), by sacubitril and the simultaneous inhibition of the deleterious effects of angiotensin II by valsartan. Sustained activation of the renin-angiotensin-aldosterone system results in vasoconstriction, renal sodium and fluid retention, activation of cellular growth and proliferation, and subsequent maladaptive cardiovascular remodeling. Valsartan inhibits detrimental cardiovascular and renal effects of angiotensin II by selectively blocking the AT1 receptor and also inhibits angiotensin II-dependent aldosterone release Read more about Azmarda https://medicaldialogues.in/partner/jbcpl/azmarda-sacubitril-valsartan

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