This document summarizes key aspects of lipid biochemistry. Lipids include fats, oils, steroids, and waxes and share properties of insolubility in water but solubility in non-polar solvents. They serve important functions like energy storage, insulation, cell signaling, and transporting other lipids in the blood. Lipids are classified as simple or complex, with simple lipids including fats and oils, and complex lipids including phospholipids, glycolipids, and lipoproteins. Fatty acids are the building blocks of lipids and can be saturated or unsaturated. Triacylglycerols are the main form for storing fatty acids. Steroids like cholesterol are precursors for important compounds and serve structural and
Lipids may be regarded as organic substances which is insoluble in water, soluble in organic solvents (alcohol , ether etc.), Triacylglycerols (formerly triglycerides) are the esters of glycerol with fatty acids.
biological macromolecules large cellular components abundantly obtained naturally and are responsible for varieties of essential functions for the growth and survival of living organisms.
Lipids may be regarded as organic substances which is insoluble in water, soluble in organic solvents (alcohol , ether etc.), Triacylglycerols (formerly triglycerides) are the esters of glycerol with fatty acids.
biological macromolecules large cellular components abundantly obtained naturally and are responsible for varieties of essential functions for the growth and survival of living organisms.
Lipids-Introduction, properties and functions.
Classification-Simple lipids, complex lipids and derived lipids.
Lipids contain fatty acid and alcohol.
Saturated and Unsaturated fatty acids. Nomenclature of fatty acids, Cis-trans isomerism, essential fatty acids
Simple lipids-Fats, waxes
Compound lipids-Structure, function with examples of Phospholipids, Glycolipids, sulpholipids and lipoproteins.
Derived lipids: Structure, types, and functions of steroids, terpenes and carotenoids.
Lipoproteins-classified into chylomicrons, very low-density lipoproteins (VLDL), low density lipoproteins (LDL) and high-density lipoproteins (HDL) and their function.
Eicosanoids-prostanoids, leukotrienes (LTs), and lipoxins (LXs).
Functions of Eicosanoids
Lipids, micelles and liposomes.
Lipids, classification, digestion and absorptionHu--da
Introduction of lipids
Sources of lipids
Classification of lipids
Trans fat
Alteration of dietary fats during food processing
Digestion, absorption of lipids
Absorption of cholesterol
Lipid transport
Lipid metabolism
Biosynthesis of fatty acids
Essential fatty acids
Oxidation of fatty acids
Impact of diet on fatty acids synthesis
Cholesterol synthesis and excretion
This presentation intends to offer a bird's eye view of bio-molecules in general and lipids in particular along with its beneficial and harmful attributes.
Lipids-Introduction, properties and functions.
Classification-Simple lipids, complex lipids and derived lipids.
Lipids contain fatty acid and alcohol.
Saturated and Unsaturated fatty acids. Nomenclature of fatty acids, Cis-trans isomerism, essential fatty acids
Simple lipids-Fats, waxes
Compound lipids-Structure, function with examples of Phospholipids, Glycolipids, sulpholipids and lipoproteins.
Derived lipids: Structure, types, and functions of steroids, terpenes and carotenoids.
Lipoproteins-classified into chylomicrons, very low-density lipoproteins (VLDL), low density lipoproteins (LDL) and high-density lipoproteins (HDL) and their function.
Eicosanoids-prostanoids, leukotrienes (LTs), and lipoxins (LXs).
Functions of Eicosanoids
Lipids, micelles and liposomes.
Lipids, classification, digestion and absorptionHu--da
Introduction of lipids
Sources of lipids
Classification of lipids
Trans fat
Alteration of dietary fats during food processing
Digestion, absorption of lipids
Absorption of cholesterol
Lipid transport
Lipid metabolism
Biosynthesis of fatty acids
Essential fatty acids
Oxidation of fatty acids
Impact of diet on fatty acids synthesis
Cholesterol synthesis and excretion
This presentation intends to offer a bird's eye view of bio-molecules in general and lipids in particular along with its beneficial and harmful attributes.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
This slide is special for master students (MIBS & MIFB) in UUM. Also useful for readers who are interested in the topic of contemporary Islamic banking.
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
2. BIOMEDICAL IMPORTANCE
The lipids are a heterogeneous group of
compounds, including fats, oils, steroids, waxes
They have the common property of being:
Relatively insoluble in water and
Soluble in non-polar solvents such as ether and
chloroform.
3. Importance :
1. They are important dietary constituents because of:
a. Their high energy value
b. The fat-soluble vitamins and the essential fatty acids
contained in the fat of natural foods
.2. Fat is stored in adipose tissue, where it also serves as a
thermal insulator in the subcutaneous tissues and around
certain organs
.3. Non-polar lipids act as electrical insulators, allowing rapid
propagation of depolarization waves along myelinated nerves.
4. 4.Combinations of lipid and protein (lipoproteins) are important
cellular constituent, occurring both in the cell membrane and in
the mitochondria, and serving also as the means of
Transporting lipids in the blood
5 Knowledge of lipid biochemistry is necessary in understanding
many important biomedical areas, eg, obesity, diabetes
mellitus, atherosclerosis, and the role of various
polyunsaturated fatty acids in nutrition and health.
6. LIPIDS ARE CLASSIFIED AS:
SIMPLE OR COMPLEX
Simple lipids: Esters of fatty acids with various alcohols.
Fats: Esters of fatty acids with glycerol.
Oils and Waxes:
Complex lipids: Esters of fatty acids containing groups in addition
to an alcohol and a fatty acid.
I. Phospholipids: Lipids containing, in addition to fatty
acids and an alcohol, a phosphoric acid residue. eg, in
glycerophospholipids the alcohol is glycerol and in
sphingophospholipids the alcohol is sphingosine.
7. II. Glycolipids (glycosphingolipids):
Lipids containing a fatty acid, sphingosine, and carbohydrate.
Other complex lipids:
Lipids such as sulfolipids and aminolipids. Lipoproteins may
also be placed in this category.
8. Fatty acids
Fatty acids are building block of most lipids,
Having one polar carboxyl group (head) and a non-polar
hydrocarbon chain (tail).
Fatty acids occur mainly as esters in natural fats and oils
but do occur in the un -esterified form as free fatty acids, a
transport form found in the plasma.
Fatty acids that occur in natural fats has even number of
carbon atoms.
The chain may be saturated (no double bonds) or
unsaturated ( one or more double bonds).
9. Thus, Saturated acids end in -anoic, eg, octanoic acid,
and Unsaturated acids with double bonds end in -enoic,
eg, octadecenoic acid (oleic acid).
Carbon atoms are numbered from the carboxyl carbon (carbon
No. 1). the terminal methyl carbon is known as the ω or n-carbon.
10. Various conventions use Δ for indicating the number
and position of the double bonds .
e.g. Δ9 indicates a double bond between carbons 9
and 10 of the fatty acid;
ω9 indicates a double bond on the ninth carbon
counting from the ω- carbon.
In animals, additional double bonds are introduced
only between the existing double bond (e.g., ω9, ω6, or
ω3)
11. Unsaturated Fatty Acids Contain One or More
Double Bonds
Fatty acids may be further subdivided as follows:
Monounsaturated containing one double bond.
Polyunsaturated containing two or more double bonds.
Eicosanoid: (20-carbon) polyenoic fatty acids, comprise
the Prostanoids, leukotrienes (LTs), lipoxins (LXs).
Prostanoids include prostaglandins (PGs), prostacyclins
(PGIs), and thromboxanes (TXs).
12.
13. Most Naturally Occurring Have cis Double Bonds.
If on the same side of the bond, it is cis-, as in oleic acid
if on opposite sides, it is trans-, as in “elaidic acid,”
the trans isomer of oleic acid.
Geometric isomerism of Δ9, 18:1
fatty acids (oleic and Elaidic
acids).
14. TRIACYLGLYCEROLS (TRIGLYCERIDES)*
===Are the main storage forms of fatty acids
The triacylglycerols are esters of glycerol &fatty acids.
Mono- and diacylglycerol wherein one or two fatty
acids are esterified with glycerol are also found in the
tissues.
To number the carbon atoms of glycerol
unambiguously, the -sn- (stereochemical numbering)
system is used
15. Enzymes readily distinguish between them and are
nearly always specific for one or the other carbon;
e.g., Glycerol is always phosphorylated on sn-3 by
Glycerol kinase to give glycerol 3-phosphate and
not glycerol-1-phosphate .
16. STEROIDS PLAY MANY PHYSIOLOGICALLY IMPORTANT ROLES
Cholesterol is probably the best known steroid because of
its association with atherosclerosis.
However, biochemically it is also of significance because it
is the precursor of a large number of equally important
steroids that include
=Bile acids,
=Adrenocortical hormones,
=Sex hormones,
=D vitamins, cardiac glycosides, sitosterols of the plant
kingdom, and some alkaloids.
17. All of the steroids have a similar cyclic nucleus
resembling phenanthrene (rings A, B, and C) to
which a cyclopentane ring (D) is attached.
The carbon positions on the steroid nucleus are
numbered as shown in Figure
18. Cholesterol Is a Significant Constituent of Many Tissues
Cholesterol is widely distributed in all cells of the body but
particularly in nervous tissue.
It is a major constituent of the plasma membrane and of
plasma lipoproteins.
It is often found as cholesteryl ester, where the hydroxyl
group on position 3 is esterified with a long-chain fatty acid.
It occurs in animals but not in plants.
HO
19. For the synthesis of bile salts that are important in
lipid digestion and absorption.
For the synthesis of steroid hormones that are
biologically important like the sex hormones estrogen
and progesterone.
For the synthesis of vitamin D3
As a structural material in biological membranes.
As a component of lipoproteins as transport forms of
lipid based energy.
Cholesterol is important in many ways: