This document discusses several species of lungworms (genus Dictyocaulus) that infect various livestock animals such as cattle, sheep, horses, and donkeys. It provides details on the life cycle, hosts, clinical signs, diagnosis, and treatment for each species. The major species described are D. viviparus which causes bronchitis in cattle; D. filaria which infects sheep and goats; and D. arnfieldi found in horses, donkeys, and mules. Lungworm infections can lead to bronchitis, pneumonia, and respiratory distress if not properly treated.
Canine parvovirus (CPV) is a highly contagious and relatively common cause of acute, infectious GI illness in young dogs. Although its exact origin is unknown, it is believed to have arisen from feline panleukopenia virus or a related parvovirus of nondomestic animals
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Canine parvovirus (CPV) is a highly contagious and relatively common cause of acute, infectious GI illness in young dogs. Although its exact origin is unknown, it is believed to have arisen from feline panleukopenia virus or a related parvovirus of nondomestic animals
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Study of parasites Hymenolepis nana, Taenia Echinococcus(), & Pneumocystis carinii
Treatment
Morphology
Life cycle
Pathogenesis
Laboratory diagnosis
Parasites
Hymenolepis nana – Cestode (Dwarf Tapeworm)
Taenia Echinococcus – Cestode (Dog Tapeworm)
Pneumocystis carinii - Sporozoan parasite
Hymenolepis nana
Geographical Distribution
Habitat
Morphology of Hymenolepis nana
Adult Worm
Eggs
Larva
Life cycle of Hymenolepis nana
Direct Cycle
Indirect Cycle
Hymenolepis nana - Life cycle
Life cycle of Hymenolepis nana
Pathogenesis of Hymenolepis nana
Laboratory diagnosis of Hymenolepis nana
Treatment of Hymenolepis nana
Prevention (Prophylaxis) of H. nana
Taenia Echinococcus
Echinococcus Genus: Tapeworm with carnivorous and herbivorous hosts.
Morphology of Taenia Echinococcus
Life Cycle of Taenia Echinococcus
Infectious laryngotracheitis (ILT) is an economically important respiratory disease of poultry. This highly contagious disease is caused by Gallid alpha herpesvirus type 1 (GaHV-1), commonly known as infectious laryngotracheitis virus (ILTV). The virus can be easily transmitted by infected birds and fomites. Lax biosecurity, transportation of infected birds, and spread of contaminated litter facilitates spread of the virus. Clinical signs of respiratory disease are not pathognomonic. Diagnosis is by real-time PCR and histopathology . Implementation of biosecurity is necessary for prevention, but vaccination is commonly used for control of the disease in endemic regions worldwide.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. Dictyocaulus
This genus living in the bronchi of cattle, sheep,
horses and donkeys is the major cause of
parasitic bronchitis in these hosts.
Hosts
Ruminants, horses and donkeys
Site
Trachea and bronchi
4. Identification
• The adults are thread like worms up to 8.0
cm in length.
• Their location in the trachea and bronchi
and their size are diagnostic.
• D. viviparus is the most pathogenic of the
three species
5. Dictyocaulus viviparus
D. viviparus is the cause of parasitic bronchitis in
cattle, also known as
• husk
• hoose
• verminous pneumonia
• dictyocaulosis.
• This disease is characterized by bronchitis and
pneumonia.
• The disease is prevalent in temperate areas with
high rain fall.
6. Dictyocaulus viviparus
Cattle lung worm
Definitive Host Spectrum
• Cattle, buffalo, camel
Intermediate Host
None
Geographic Distribution
Worldwide, especially moist temperate regions
7. Morphology
– Adults - males 4-5.5 cm, females 6-8 cm, threadlike,
white
– Eggs - larvated, 82-88 x 33-38 microns (seldom
seen in feces)
– Larvae - 300-360 microns (present in feces)
8.
9.
10. Life cycle
• Larvated eggs are laid by females, may hatch in
the lungs but usually are coughed up, swallowed
and hatch in the alimentary tract.
• L 1 are usually found in feces and reach the
infective L 3 stage in 6 days or more when they
are dispersed with the feces and move up onto
the forage.
• Larvae (L 3 ) are ingested, penetrate the
intestinal wall and are carried via the lymphatic
vessels to the mesenteric lymph glands.
11. Life cycle
• A molt takes place in these lymph glands,
then the larvae migrate via the lymph and
blood vessels to the lungs
• Larvae (L4) become arrested in the
capillaries and break into the air passages,
where they mature to L5 and adult
• Prepatent period - 22 days
12. Pathogenesis
Site of Infection
• Lumen of trachea, bronchi, bronchioles
Pathogenesis/Clinical Signs
• Blockage of bronchioles with an eosinophilic
exudate
• Atelectasis and emphysema
• Severe damage to the epithelium of the
trachea and bronchi may be caused by
inflammation with neutrophils, macrophages,
and eosinophils
13. Pathogenesis
• Eosinophils secrete major basic protein
(MBP) which damages parasite membranes
and is toxic to normal tissue
• Pulmonary edema and 2nd bacterial infection
• Clinical signs - coughing, dyspnea, polypnea,
rapid loss of condition
• Once exposed, protective immunity is
established for the following year, but requires
consistent exposure for immunity to persist
16. Diagnosis
• Eggs and larvae in nasal discharge
• Finding L 1 in feces using Baermann
technique can confirm an active infection but
may miss a light infection
• specific ELISA which demonstrates exposure
17. Treatment
• Albendazole
• Fenbendazole
• Ivermectin, doramectin, eprinomectin approved
@ 200 mcg/kg
• Improvement should be observed after
approximately 24 hours
18. Other Control Measures
• Immunization with x-irradiated L 3 is
commercially available and used in Europe
• Effective in highly endemic areas, doesn’t
work well where there is a low year-round
infectivity
• Shelf life of irradiated larvae is 3-6 months
Public Health Significance
• None
19. Dictyocaulus arnfieldi
(LUNGWORM)
Definitive Host Spectrum
– Horse, mule, donkey, zebra
– Donkey is usually the source of infections in
horses and is the natural DH
Intermediate Host
– None
Geographic Distribution
– Worldwide
21. Life Cycle (Stages)
– Larvated eggs are coughed up, swallowed, passed
in feces, hatch within a few hours
– L 3 are the infective stage and are ingested
– Migration to the bronchi is via the lymph vessels
– Prepatent period
– 12 to 14 weeks in donkeys
– 6 to 8 weeks in horses
22. Pathogenesis
Site of Infection
– Bronchi, bronchioles
Pathogenesis/Clinical Signs
– Generally nonpathogenic in donkeys, even with
heavy infections
– Clinical signs in horses, appearing during the
prepatent period, include coughing, polypnea, nasal
discharge
23. Diagnosis
– For patent infections, eggs or L 1 in feces
– For horses with clinical signs described
above, co-grazing with donkeys is suggestive
of dictyocauliasis
24. Treatment & control
Treatment
– Moxidectin (Quest)
– Fenbendazole, 5mg/kg (single dose)
– Ivermectin @ 200 mcg/kg
Other Control Measures
– Graze donkeys and horses separately
Public Health Significance
– None
25. (Dictyocaulus filarial( THREAD
LUNGWORM OF SHEEP
Definitive Host Spectrum
– Sheep, goats, some wild ruminants
Intermediate Host
– None
Geographical Distribution
– Worldwide, especially important in eastern
Europe and India
26. Morphology
– Adults –thread like, males 3-8 cm, females 5-10 cm
long and fairly mobile
– Eggs - larvated, 112-138 x 69-90 microns
– Larvae - 550-580 microns long, with a cuticular
knob at the anterior end, contains dark food
granules
27. Life Cycle (Stages)
– Larvated eggs are laid by females, may hatch
in the lungs but usually are coughed up,
swallowed and hatch in the alimentary tract
– L 1 are usually found in feces and reach the
infective L 3 stage in 6 days or more when
they are dispersed with the feces and move
up onto the forage
– Larvae (L 3 ) are ingested, penetrate the
intestinal wall and are carried via the
lymphatic vessels to the mesenteric lymph
glands
28. Life Cycle
– A molt takes place in these lymph glands,
then the larvae migrate via the lymph and
blood vessels to the lungs
– Larvae (L4) become arrested in the capillaries
and break into the air passages, where they
mature to L5 and adult
– Prepatent period - about 4 weeks
29. Pathogenesis
Site of Infection
– Mucosa of trachea, bronchi, bronchioles
Pathogenesis/Clinical Signs
– Catarrhal bronchitis, with exudate passing
back into the alveoli, causing atelectasis or
pneumonia
– 2nd bacterial infections and more extensive
areas of pneumonia
– Clinical signs - dyspnea, polypnea, cough,
mucous exudate from the nostrils, abnormal
lung sounds on auscultation
30. Diagnosis & Treatment
Diagnosis
– Usually by finding larvae (L 1 ) in feces by use
of Baermann technique
– Eggs may be found in nasal discharge or
sputum, but their absence is insignificant
Treatment
– Levamisole, 7.5 mg/kg parenterally
– Ivermectin - approved as a drench,
eprinomectin
– benzimidazoles