This document discusses the generation and propagation of action potentials in neurons. It notes that neurons respond to stimuli by producing either local, non-propagated potentials or propagated action potentials. Action potentials are generated when voltage-gated sodium channels open in response to depolarization, allowing sodium ions to rush in and briefly reverse the membrane potential. This wave of depolarization then propagates down the axon by electrotonic conduction. The document outlines the changes in membrane permeability and potential during an action potential and describes how action potentials conduct in either direction along the axon.
The document discusses synaptic transmission in the central nervous system. It describes the cellular organization of the brain including neurons and support cells. It then focuses on synapses, explaining that they allow chemical communication between neurons through neurotransmitters. There are two main types of synapses - electrical synapses which allow direct electrical coupling, and chemical synapses which use chemical messengers. Chemical synapses are more numerous and involve neurotransmitters being released into the synaptic cleft, binding to receptors and causing excitation or inhibition of the postsynaptic neuron. The properties of synaptic transmission include one-way conduction, synaptic delay, fatigue, convergence and divergence, summation, and facilitation.
This document provides an overview of the hypothalamus presented by Dr. Nilesh Kate. It begins with objectives and definitions of the hypothalamus. It then covers the physiological anatomy including external features, subdivisions, nuclei and connections. Major sections discuss the functions of the hypothalamus in areas like autonomic function, sleep/wake cycles, food intake regulation, endocrine function, temperature regulation and more. The final section covers applied aspects like lesions of the hypothalamus and associated clinical conditions such as diabetes insipidus and narcolepsy.
This document provides an overview of synapses, including their definition, structure, function, types of transmission (electrical vs. chemical), neurotransmitters, and various properties like synaptic delay, fatigue, summation, and more. It discusses excitatory and inhibitory neurotransmitters and how convergence and divergence allow signals to be dispersed or combined. Clinical implications are that problems with synaptic transmission can cause diseases like Parkinson's and Alzheimer's.
Nerve fibers are classified based on their structure, distribution, origin and function. They can be myelinated or unmyelinated. When injured, the distal portion undergoes Wallerian degeneration over 3 months as the axon and myelin sheath break down. The cell body shows chromatolysis. Regeneration is possible if the nerve ends are close together. New axonal growth occurs rapidly, entering the distal stump at 3-4mm/day. Myelination resumes over a year. Though anatomy recovers, full function returns slowly.
Otto Loewi discovered acetylcholine as the first neurotransmitter in 1936. Neurotransmitters are endogenous chemicals that transmit signals across synapses. They can be small molecules like acetylcholine, serotonin, histamine, catecholamines, amino acids, or large molecules like neuropeptides. Neurotransmitters are stored in vesicles and released by exocytosis. They act on receptors, which can be ligand-gated ion channels or G protein-coupled receptors. Reuptake and catabolism terminate neurotransmitter action. The major neurotransmitters, their locations, synthesis, release, receptors, and fate were described in detail.
This document discusses the generation and propagation of action potentials in neurons. It notes that neurons respond to stimuli by producing either local, non-propagated potentials or propagated action potentials. Action potentials are generated when voltage-gated sodium channels open in response to depolarization, allowing sodium ions to rush in and briefly reverse the membrane potential. This wave of depolarization then propagates down the axon by electrotonic conduction. The document outlines the changes in membrane permeability and potential during an action potential and describes how action potentials conduct in either direction along the axon.
The document discusses synaptic transmission in the central nervous system. It describes the cellular organization of the brain including neurons and support cells. It then focuses on synapses, explaining that they allow chemical communication between neurons through neurotransmitters. There are two main types of synapses - electrical synapses which allow direct electrical coupling, and chemical synapses which use chemical messengers. Chemical synapses are more numerous and involve neurotransmitters being released into the synaptic cleft, binding to receptors and causing excitation or inhibition of the postsynaptic neuron. The properties of synaptic transmission include one-way conduction, synaptic delay, fatigue, convergence and divergence, summation, and facilitation.
This document provides an overview of the hypothalamus presented by Dr. Nilesh Kate. It begins with objectives and definitions of the hypothalamus. It then covers the physiological anatomy including external features, subdivisions, nuclei and connections. Major sections discuss the functions of the hypothalamus in areas like autonomic function, sleep/wake cycles, food intake regulation, endocrine function, temperature regulation and more. The final section covers applied aspects like lesions of the hypothalamus and associated clinical conditions such as diabetes insipidus and narcolepsy.
This document provides an overview of synapses, including their definition, structure, function, types of transmission (electrical vs. chemical), neurotransmitters, and various properties like synaptic delay, fatigue, summation, and more. It discusses excitatory and inhibitory neurotransmitters and how convergence and divergence allow signals to be dispersed or combined. Clinical implications are that problems with synaptic transmission can cause diseases like Parkinson's and Alzheimer's.
Nerve fibers are classified based on their structure, distribution, origin and function. They can be myelinated or unmyelinated. When injured, the distal portion undergoes Wallerian degeneration over 3 months as the axon and myelin sheath break down. The cell body shows chromatolysis. Regeneration is possible if the nerve ends are close together. New axonal growth occurs rapidly, entering the distal stump at 3-4mm/day. Myelination resumes over a year. Though anatomy recovers, full function returns slowly.
Otto Loewi discovered acetylcholine as the first neurotransmitter in 1936. Neurotransmitters are endogenous chemicals that transmit signals across synapses. They can be small molecules like acetylcholine, serotonin, histamine, catecholamines, amino acids, or large molecules like neuropeptides. Neurotransmitters are stored in vesicles and released by exocytosis. They act on receptors, which can be ligand-gated ion channels or G protein-coupled receptors. Reuptake and catabolism terminate neurotransmitter action. The major neurotransmitters, their locations, synthesis, release, receptors, and fate were described in detail.
Neuromuscular transmission occurs at the neuromuscular junction, where motor neuron axon terminals synapse with skeletal muscle fibers. Acetylcholine is released from motor neuron terminals and binds to nicotinic acetylcholine receptors on the muscle fiber membrane, causing depolarization and muscle fiber excitation. Acetylcholine is rapidly broken down by acetylcholinesterase to terminate the signal. Diseases like myasthenia gravis can disrupt neuromuscular transmission.
Various neurotransmitters, mechanism of action and their physiological functions are explained and is useful for ug and pg students of medicine, neurology, psychiatry branches.
EPSP is an excitatory postsynaptic potential that occurs when a neurotransmitter like glutamate binds to receptors on the postsynaptic neuron, making its membrane permeable to sodium ions and depolarizing the neuron. IPSP is an inhibitory postsynaptic potential that occurs when GABA binds to receptors, making the membrane permeable to chloride ions and hyperpolarizing the neuron. EPSPs can summate and cause the neuron to generate an action potential, while IPSPs make action potential generation less likely. Together, the balance of EPSPs and IPSPs control whether a neuron will fire an action potential.
Nerve fibers can be classified based on their structure and distribution. There are two main types - myelinated and unmyelinated fibers. Nerve fibers also include somatic and autonomic fibers. Somatic fibers innervate skeletal muscles and the neurotransmitter is acetylcholine, leading to muscle excitation or central inhibition. Autonomic fibers innervate smooth, cardiac muscles and glands to maintain homeostasis, causing excitation or inhibition. Important properties of nerve fibers include excitability, conductivity, unfatigability, refractory periods, all-or-none response, summation, and accommodation.
Neurotransmitters are chemicals that transmit signals between neurons. The document discusses several key neurotransmitters like acetylcholine, norepinephrine, dopamine, GABA, glutamate, and serotonin. It describes their functions and roles in processes like memory, mood, movement, and sleep. The document also outlines the criteria for classifying a chemical as a neurotransmitter and how neurotransmitters are synthesized, released, bind to receptors, and degraded once their signaling work is complete.
Nerve fibers can be classified in six different ways: by structure, distribution, origin, function, neurotransmitter secretion, and diameter/impulse conduction. By structure, they are myelinated or non-myelinated. By distribution, they are somatic or autonomic. By origin, they are cranial or spinal. By function, they are sensory or motor. By neurotransmitter, they are adrenergic or cholinergic. By diameter/impulse conduction, Erlanger and Gasser classified them as type A, B, or C fibers with different speeds and functions.
The document summarizes the organization and function of the nervous system in three parts:
1) The central nervous system (CNS) consists of the brain and spinal cord. It receives sensory signals, determines responses, stores memory, and enables thought.
2) The peripheral nervous system (PNS) is outside the CNS and sends signals to the CNS, receives and transmits motor signals from the CNS, and stimulates effectors.
3) Within the PNS, the somatic nervous system controls voluntary movement via skeletal muscles, while the autonomic nervous system controls involuntary responses like digestion via organs and glands.
Neurotransmitters are chemicals that transmit signals between neurons. They are produced in neuron cell bodies, stored in vesicles, and released into the synapse upon receiving an action potential. Neurotransmitters can be excitatory or inhibitory, binding to receptors on the post-synaptic neuron to open or close ion channels. Common neurotransmitters include acetylcholine, amino acids like glutamate and GABA, biogenic amines, ATP, nitric oxide, and neuropeptides. Neurotransmitters are inactivated through diffusion, astrocyte reuptake, neuronal reuptake, or enzymatic degradation to terminate their signaling effects.
Structure, function and classification of neuronDr Sara Sadiq
The document summarizes the structure and classification of the nervous system. It discusses that the nervous system is divided into the central nervous system (CNS) and peripheral nervous system (PNS). The CNS contains the brain and spinal cord while the PNS contains all neural tissue outside the CNS. There are two main cell types - neurons which process and transmit information, and neuroglia which provide support. Neurons can be classified based on their number of poles (unipolar, bipolar, multipolar), length of axons, or their function (sensory, motor, interneurons). Myelin allows faster signal transmission along axons.
1) The document discusses the rhythmicity and automaticity of the heart, which refers to the heart's ability to beat regularly and generate impulses without external stimuli.
2) It originates from within the heart itself (myogenic, not neurogenic) and several factors can influence the heart rate such as the autonomic nervous system, temperature, drugs, blood gases, and inorganic ions.
3) The sinoatrial node acts as the pacemaker for the heart and has membrane properties that allow it to spontaneously depolarize, initiating the heartbeat via an action potential involving sodium, calcium, and potassium ion fluxes.
The document discusses the generation and propagation of action potentials in neurons. It begins by explaining the resting membrane potential, which arises from ion concentration gradients maintained by the sodium-potassium pump and potassium leakage channels. It then describes how an action potential is triggered when the membrane potential reaches a threshold, causing voltage-gated sodium channels to open and sodium ions to rush in, rapidly depolarizing the membrane. This wave of depolarization then propagates along the neuron as adjacent areas are triggered to reach threshold. The action potential involves sequential phases of depolarization, repolarization, and hyperpolarization.
The document discusses the structure and function of chemical synapses. It begins by defining a synapse as the junction between two nerve cells. It then describes the key anatomical components of a chemical synapse, including the presynaptic knob, synaptic cleft, and postsynaptic membrane. It explains the process of neurotransmission, including the release of neurotransmitters into the synaptic cleft, their binding to receptors on the postsynaptic membrane, and the resulting postsynaptic potentials. The document also discusses inhibition at synapses, the properties of synaptic transmission, and examples of neurotransmitters.
The cerebellum is located behind the brainstem and contains only 10% of the brain's volume. It receives input from muscles, joints, and the motor cortex, and provides corrective signals to the motor cortex to coordinate voluntary movement. The cerebellum evaluates and adjusts motor movements, integrating sensory information to ensure balance and motor learning. Damage to different parts of the cerebellum results in difficulties with coordination, posture, movement timing and sequencing.
Posterior Pituitary or Neurohypophysis composed mainly of glial-like cells called pituicytes.
The pituicytes do not secrete hormones.
They act simply as a supporting structure for large numbers
of terminal nerve fibers and terminal nerve endings from nerve tracts.
That originate in the supraoptic and paraventricular
nuclei of the hypothalamus.
about nerve fibers
It is the structural and the functional unit of nervous system.
The human nervous system contains approximate 1012 neurons.
A nerve fiber is a thread like extension of a nerve cell and consists of an axon and myelin sheath (if present) in the nervous system.
In peripheral nervous system it is formed by
schwann’s cell. While in case of central nervous system it is formed by oligodendroglia.
The places ,where myelin sheath is absent are called node of ranvier(2-3µm) and these are present once about 1-3 mm distance along the myelin sheath.
IT PREVENTS LEAKAGE OF IONS BY 5000 FOLDS.
IT INCREASES VELOCITY OF CONDUCTION BY 5-50 FOLDS DUE TO
SALTATORY CONDUCTION i.e. ABOUT 100 m/s IN CASE OF
MYELINATED NERVE FIBERS WHILE IN NONMYELINATED
IT IS ABOUT 0.25 m/s.
SALTATORY CONDUCTION CONSERVES ENERGY BECAUSE ONLY NODES OF RANVIER GET DEPOLARISED.
These are α type motor nerve fibers.
The neurotransmitter released at the neuron endings is acetylcholine(Ach).
It always leads to muscles excitation . Inhibition takes place centrally due to participation of interneurons.
they innervate smooth muscles , cardiac muscles and glands.
Their main work is to maintain homeostasis with the help of autonomic nervous system.
they can lead to either excitation or inhibition of effector organs
Erlanger and Grasser studied the action potential of mixed nerve trunk by means of cathode ray oscilloscope and they obtained the compounded spike. So they divided nerve fibers into 3 groups. They observed that the main cause of difference in nerve fibers is diameter
AS Diameter increases
Velocity of conduction increases.
Magnitude of electrical response increases.
Threshold of excitation decreases.
Duration of response decreases.
Refractory period decreases.
1. An action potential occurs when there is a rapid change in the membrane potential of a neuron from a negative resting potential to a positive potential and then back to a negative potential. This is driven by the movement of ions across the cell membrane through voltage-gated ion channels.
2. For an action potential to be initiated, the membrane potential must be depolarized beyond the threshold potential of around -65mV. This opens voltage-gated sodium channels, allowing sodium ions to enter the cell.
3. The influx of sodium ions causes further depolarization, followed by the opening of voltage-gated potassium channels which causes repolarization back to the resting potential and then hyperpolarization below the resting potential.
Nerve cells, Nervous communication & its link to the celllular signallingSabahat Ali
The document discusses the structure and function of neurons. It notes that neurons are specialized cells that communicate via electrical and chemical signals. They contain dendrites that receive signals, a cell body, and an axon that transmits signals. At synapses, chemical neurotransmitters transmit signals between neurons or to other cell types. Neurons form circuits that allow for complex coordinated responses. The action potential involves changes in ion channel permeability that propagate electrical signals rapidly along axons. Calcium acts as an important intracellular messenger in neurons and other cell types, often working through the calcium sensor protein calmodulin.
The document discusses neurotransmitters and their roles in the nervous system. It outlines the criteria for classifying a molecule as a neurotransmitter, identifies major types of neurotransmitters including amino acids, amines, and peptides. It describes the mechanism of neurotransmitter release and action, and discusses clinical disorders that can arise from disruptions in neurotransmitter metabolism such as Parkinson's disease, schizophrenia, and addiction.
The document discusses the hypothalamic factors and anterior pituitary hormones. It begins by describing the structure and functions of the anterior pituitary gland and its connection to the hypothalamus. It then summarizes the six main hormones secreted by the anterior pituitary - growth hormone, adrenocorticotropic hormone, thyroid-stimulating hormone, prolactin, follicle-stimulating hormone, and luteinizing hormone. It explains how these hormones control various target glands and metabolic functions throughout the body. Finally, it discusses how the hypothalamus controls pituitary secretion through releasing and inhibitory hormones, and provides examples of anterior pituitary hyperactivity and hypoactivity disorders.
Sensory receptors collect information from the environment and stimulate neurons to send impulses to the brain. There are specialized receptor cells that transform stimuli into electrical signals through transduction. Receptors act as detectors and transducers. The impulses travel along sensory pathways through the dorsal horn, dorsal columns or spinothalamic tract to the thalamus. They then project to the primary somatosensory cortex which has a somatotopic map of the body. The secondary somatosensory cortex integrates information from the primary cortex.
The document discusses neurohumoral transmission and the peripheral nervous system. It describes how the autonomic nervous system controls visceral functions through two neurons, while the somatic nervous system controls voluntary movement through a single neuron. The key types of neurotransmission are described, including the roles of neurotransmitters like acetylcholine and adrenaline. The processes of neurotransmission, including synthesis, storage, release and termination of neurotransmitters, are summarized.
Neurotransmitters are chemical messengers that transmit signals between neurons. The document discusses the history and criteria for classifying a substance as a neurotransmitter. Neurotransmitters are classified based on their chemical nature as amino acids, amines, or others. They are also classified based on their function as either excitatory or inhibitory. The document describes examples from each group and where they are secreted in the body. It further explains the processes of transport, release, inactivation, and reuptake of neurotransmitters at the synapse.
Neuromuscular transmission occurs at the neuromuscular junction, where motor neuron axon terminals synapse with skeletal muscle fibers. Acetylcholine is released from motor neuron terminals and binds to nicotinic acetylcholine receptors on the muscle fiber membrane, causing depolarization and muscle fiber excitation. Acetylcholine is rapidly broken down by acetylcholinesterase to terminate the signal. Diseases like myasthenia gravis can disrupt neuromuscular transmission.
Various neurotransmitters, mechanism of action and their physiological functions are explained and is useful for ug and pg students of medicine, neurology, psychiatry branches.
EPSP is an excitatory postsynaptic potential that occurs when a neurotransmitter like glutamate binds to receptors on the postsynaptic neuron, making its membrane permeable to sodium ions and depolarizing the neuron. IPSP is an inhibitory postsynaptic potential that occurs when GABA binds to receptors, making the membrane permeable to chloride ions and hyperpolarizing the neuron. EPSPs can summate and cause the neuron to generate an action potential, while IPSPs make action potential generation less likely. Together, the balance of EPSPs and IPSPs control whether a neuron will fire an action potential.
Nerve fibers can be classified based on their structure and distribution. There are two main types - myelinated and unmyelinated fibers. Nerve fibers also include somatic and autonomic fibers. Somatic fibers innervate skeletal muscles and the neurotransmitter is acetylcholine, leading to muscle excitation or central inhibition. Autonomic fibers innervate smooth, cardiac muscles and glands to maintain homeostasis, causing excitation or inhibition. Important properties of nerve fibers include excitability, conductivity, unfatigability, refractory periods, all-or-none response, summation, and accommodation.
Neurotransmitters are chemicals that transmit signals between neurons. The document discusses several key neurotransmitters like acetylcholine, norepinephrine, dopamine, GABA, glutamate, and serotonin. It describes their functions and roles in processes like memory, mood, movement, and sleep. The document also outlines the criteria for classifying a chemical as a neurotransmitter and how neurotransmitters are synthesized, released, bind to receptors, and degraded once their signaling work is complete.
Nerve fibers can be classified in six different ways: by structure, distribution, origin, function, neurotransmitter secretion, and diameter/impulse conduction. By structure, they are myelinated or non-myelinated. By distribution, they are somatic or autonomic. By origin, they are cranial or spinal. By function, they are sensory or motor. By neurotransmitter, they are adrenergic or cholinergic. By diameter/impulse conduction, Erlanger and Gasser classified them as type A, B, or C fibers with different speeds and functions.
The document summarizes the organization and function of the nervous system in three parts:
1) The central nervous system (CNS) consists of the brain and spinal cord. It receives sensory signals, determines responses, stores memory, and enables thought.
2) The peripheral nervous system (PNS) is outside the CNS and sends signals to the CNS, receives and transmits motor signals from the CNS, and stimulates effectors.
3) Within the PNS, the somatic nervous system controls voluntary movement via skeletal muscles, while the autonomic nervous system controls involuntary responses like digestion via organs and glands.
Neurotransmitters are chemicals that transmit signals between neurons. They are produced in neuron cell bodies, stored in vesicles, and released into the synapse upon receiving an action potential. Neurotransmitters can be excitatory or inhibitory, binding to receptors on the post-synaptic neuron to open or close ion channels. Common neurotransmitters include acetylcholine, amino acids like glutamate and GABA, biogenic amines, ATP, nitric oxide, and neuropeptides. Neurotransmitters are inactivated through diffusion, astrocyte reuptake, neuronal reuptake, or enzymatic degradation to terminate their signaling effects.
Structure, function and classification of neuronDr Sara Sadiq
The document summarizes the structure and classification of the nervous system. It discusses that the nervous system is divided into the central nervous system (CNS) and peripheral nervous system (PNS). The CNS contains the brain and spinal cord while the PNS contains all neural tissue outside the CNS. There are two main cell types - neurons which process and transmit information, and neuroglia which provide support. Neurons can be classified based on their number of poles (unipolar, bipolar, multipolar), length of axons, or their function (sensory, motor, interneurons). Myelin allows faster signal transmission along axons.
1) The document discusses the rhythmicity and automaticity of the heart, which refers to the heart's ability to beat regularly and generate impulses without external stimuli.
2) It originates from within the heart itself (myogenic, not neurogenic) and several factors can influence the heart rate such as the autonomic nervous system, temperature, drugs, blood gases, and inorganic ions.
3) The sinoatrial node acts as the pacemaker for the heart and has membrane properties that allow it to spontaneously depolarize, initiating the heartbeat via an action potential involving sodium, calcium, and potassium ion fluxes.
The document discusses the generation and propagation of action potentials in neurons. It begins by explaining the resting membrane potential, which arises from ion concentration gradients maintained by the sodium-potassium pump and potassium leakage channels. It then describes how an action potential is triggered when the membrane potential reaches a threshold, causing voltage-gated sodium channels to open and sodium ions to rush in, rapidly depolarizing the membrane. This wave of depolarization then propagates along the neuron as adjacent areas are triggered to reach threshold. The action potential involves sequential phases of depolarization, repolarization, and hyperpolarization.
The document discusses the structure and function of chemical synapses. It begins by defining a synapse as the junction between two nerve cells. It then describes the key anatomical components of a chemical synapse, including the presynaptic knob, synaptic cleft, and postsynaptic membrane. It explains the process of neurotransmission, including the release of neurotransmitters into the synaptic cleft, their binding to receptors on the postsynaptic membrane, and the resulting postsynaptic potentials. The document also discusses inhibition at synapses, the properties of synaptic transmission, and examples of neurotransmitters.
The cerebellum is located behind the brainstem and contains only 10% of the brain's volume. It receives input from muscles, joints, and the motor cortex, and provides corrective signals to the motor cortex to coordinate voluntary movement. The cerebellum evaluates and adjusts motor movements, integrating sensory information to ensure balance and motor learning. Damage to different parts of the cerebellum results in difficulties with coordination, posture, movement timing and sequencing.
Posterior Pituitary or Neurohypophysis composed mainly of glial-like cells called pituicytes.
The pituicytes do not secrete hormones.
They act simply as a supporting structure for large numbers
of terminal nerve fibers and terminal nerve endings from nerve tracts.
That originate in the supraoptic and paraventricular
nuclei of the hypothalamus.
about nerve fibers
It is the structural and the functional unit of nervous system.
The human nervous system contains approximate 1012 neurons.
A nerve fiber is a thread like extension of a nerve cell and consists of an axon and myelin sheath (if present) in the nervous system.
In peripheral nervous system it is formed by
schwann’s cell. While in case of central nervous system it is formed by oligodendroglia.
The places ,where myelin sheath is absent are called node of ranvier(2-3µm) and these are present once about 1-3 mm distance along the myelin sheath.
IT PREVENTS LEAKAGE OF IONS BY 5000 FOLDS.
IT INCREASES VELOCITY OF CONDUCTION BY 5-50 FOLDS DUE TO
SALTATORY CONDUCTION i.e. ABOUT 100 m/s IN CASE OF
MYELINATED NERVE FIBERS WHILE IN NONMYELINATED
IT IS ABOUT 0.25 m/s.
SALTATORY CONDUCTION CONSERVES ENERGY BECAUSE ONLY NODES OF RANVIER GET DEPOLARISED.
These are α type motor nerve fibers.
The neurotransmitter released at the neuron endings is acetylcholine(Ach).
It always leads to muscles excitation . Inhibition takes place centrally due to participation of interneurons.
they innervate smooth muscles , cardiac muscles and glands.
Their main work is to maintain homeostasis with the help of autonomic nervous system.
they can lead to either excitation or inhibition of effector organs
Erlanger and Grasser studied the action potential of mixed nerve trunk by means of cathode ray oscilloscope and they obtained the compounded spike. So they divided nerve fibers into 3 groups. They observed that the main cause of difference in nerve fibers is diameter
AS Diameter increases
Velocity of conduction increases.
Magnitude of electrical response increases.
Threshold of excitation decreases.
Duration of response decreases.
Refractory period decreases.
1. An action potential occurs when there is a rapid change in the membrane potential of a neuron from a negative resting potential to a positive potential and then back to a negative potential. This is driven by the movement of ions across the cell membrane through voltage-gated ion channels.
2. For an action potential to be initiated, the membrane potential must be depolarized beyond the threshold potential of around -65mV. This opens voltage-gated sodium channels, allowing sodium ions to enter the cell.
3. The influx of sodium ions causes further depolarization, followed by the opening of voltage-gated potassium channels which causes repolarization back to the resting potential and then hyperpolarization below the resting potential.
Nerve cells, Nervous communication & its link to the celllular signallingSabahat Ali
The document discusses the structure and function of neurons. It notes that neurons are specialized cells that communicate via electrical and chemical signals. They contain dendrites that receive signals, a cell body, and an axon that transmits signals. At synapses, chemical neurotransmitters transmit signals between neurons or to other cell types. Neurons form circuits that allow for complex coordinated responses. The action potential involves changes in ion channel permeability that propagate electrical signals rapidly along axons. Calcium acts as an important intracellular messenger in neurons and other cell types, often working through the calcium sensor protein calmodulin.
The document discusses neurotransmitters and their roles in the nervous system. It outlines the criteria for classifying a molecule as a neurotransmitter, identifies major types of neurotransmitters including amino acids, amines, and peptides. It describes the mechanism of neurotransmitter release and action, and discusses clinical disorders that can arise from disruptions in neurotransmitter metabolism such as Parkinson's disease, schizophrenia, and addiction.
The document discusses the hypothalamic factors and anterior pituitary hormones. It begins by describing the structure and functions of the anterior pituitary gland and its connection to the hypothalamus. It then summarizes the six main hormones secreted by the anterior pituitary - growth hormone, adrenocorticotropic hormone, thyroid-stimulating hormone, prolactin, follicle-stimulating hormone, and luteinizing hormone. It explains how these hormones control various target glands and metabolic functions throughout the body. Finally, it discusses how the hypothalamus controls pituitary secretion through releasing and inhibitory hormones, and provides examples of anterior pituitary hyperactivity and hypoactivity disorders.
Sensory receptors collect information from the environment and stimulate neurons to send impulses to the brain. There are specialized receptor cells that transform stimuli into electrical signals through transduction. Receptors act as detectors and transducers. The impulses travel along sensory pathways through the dorsal horn, dorsal columns or spinothalamic tract to the thalamus. They then project to the primary somatosensory cortex which has a somatotopic map of the body. The secondary somatosensory cortex integrates information from the primary cortex.
The document discusses neurohumoral transmission and the peripheral nervous system. It describes how the autonomic nervous system controls visceral functions through two neurons, while the somatic nervous system controls voluntary movement through a single neuron. The key types of neurotransmission are described, including the roles of neurotransmitters like acetylcholine and adrenaline. The processes of neurotransmission, including synthesis, storage, release and termination of neurotransmitters, are summarized.
Neurotransmitters are chemical messengers that transmit signals between neurons. The document discusses the history and criteria for classifying a substance as a neurotransmitter. Neurotransmitters are classified based on their chemical nature as amino acids, amines, or others. They are also classified based on their function as either excitatory or inhibitory. The document describes examples from each group and where they are secreted in the body. It further explains the processes of transport, release, inactivation, and reuptake of neurotransmitters at the synapse.
Neurotransmitters are chemical messengers that transmit signals between neurons. The document discusses the history and criteria for classifying a substance as a neurotransmitter. Neurotransmitters are classified based on their chemical nature as amino acids, amines, or others. They are also classified based on their function as either excitatory or inhibitory. The document provides examples of major neurotransmitters and where they are secreted in the body. It describes how neurotransmitters are transported, released, and taken back up at synapses. Finally, it discusses how neurotransmitters are inactivated after signal transmission.
The autonomic nervous system is divided into the sympathetic and parasympathetic nervous systems. The sympathetic system originates from the thoracic and lumbar spinal cord and generally increases heart rate and constricts blood vessels. The parasympathetic system originates from the brainstem and sacral spinal cord and generally decreases heart rate and dilates blood vessels. Both systems work in opposition to regulate organ functions through cholinergic and adrenergic receptors.
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This document outlines synaptic functions and neurotransmission. It discusses the basic functions of synapses, types of synapses including chemical and electrical synapses. The mechanisms of neurotransmission are explained including the roles of neurotransmitters, receptors, and ion channels. Over 50 known neurotransmitters are summarized including small molecule transmitters like acetylcholine, amines, amino acids and neuropeptides.
This document provides an overview of basic principles of drugs affecting the central nervous system (CNS). It discusses the cellular organization of the brain including neurons and supporting cells. It describes the blood-brain barrier and how it impacts drug delivery to the CNS. It also outlines neuronal excitability and ion channels, processes involved in synaptic signaling, and various central neurotransmitters including amino acids, acetylcholine, monoamines, peptides, purines, and neuromodulatory lipids.
The document provides an overview of the nervous system, including its organization and major components. It discusses the central nervous system (CNS), which includes the brain and spinal cord, and the peripheral nervous system (PNS). Key topics covered include the structure and function of neurons, types of neurons, nerve impulses, and synaptic transmission. The major divisions and structures of the brain are outlined. The role of the spinal cord and reflex arcs are also summarized.
The document provides an overview of autonomic neurotransmission. It discusses the anatomy and functions of the sympathetic and parasympathetic nervous systems. The key points are:
- The autonomic nervous system regulates involuntary functions and is composed of the sympathetic and parasympathetic divisions.
- The sympathetic division originates in the thoracic and lumbar spinal cord and is involved in the "fight or flight" response. The parasympathetic division originates in the cranial and sacral regions and is active during rest.
- Neurotransmission in the autonomic nervous system involves the release of acetylcholine or norepinephrine at neuroeffector junctions. These neurotransmitters are stored in vesicles and released via
Neurotransmitters are chemical messengers that are released by neurons to transmit signals between neurons or from neurons to effector cells. They are stored in synaptic vesicles and released into the synaptic cleft upon arrival of an action potential. Common neurotransmitters include acetylcholine, monoamines like dopamine and norepinephrine, amino acids, peptides, and gaseous transmitters. Neurotransmitters bind to receptors on the postsynaptic membrane, which can be ionotropic and directly open ion channels, or metabotropic and activate second messenger systems. Summation of excitatory and inhibitory postsynaptic potentials determines whether an action potential is initiated in the postsynaptic cell.
This document provides an overview of neuropharmacology and neurotransmission. It defines neuropharmacology and describes the two main branches. It explains what neurotransmission is and how it works, describing the role of neurons, neurotransmitters, and the mechanism of neurotransmission. It discusses different types of neurons, neurotransmitters like acetylcholine and dopamine, and conditions they are involved in like Alzheimer's and Parkinson's disease. The document also provides interesting facts about neurons and neurotransmitters. It concludes with a recent discovery about how endocannabinoids travel in the brain to reach receptors.
This document provides an overview of key topics related to the nervous system, including:
1. It introduces the organization of the nervous system and discusses nerve signal processing, sensory processing, motor control, consciousness, cognition, development, and recent advances.
2. It examines the structure and function of nerve cells, ion distribution and movement across cell membranes, giant nerve cells, resting membrane potential, and the action potential.
3. It explores the propagation of action potentials, saltatory conduction, the refractory period, electrical and chemical synapses, neurotransmitter release, postsynaptic receptors, and excitatory and inhibitory postsynaptic potentials.
Neurotransmitters are chemical messengers that help communicate between neurons or neurons and muscles. They are classified based on their composition into small molecule transmitters like acetylcholine, amines such as dopamine and serotonin, amino acids like glutamate and GABA, and peptide or gas transmitters. Receptors are also classified as ionotropic, which allow ion flow when activated by a neurotransmitter, or metabotropic, which initiate intracellular responses. Common excitatory neurotransmitters include glutamate and acetylcholine, while inhibitory ones include GABA and glycine. Together, neurotransmitters and receptors facilitate both excitation and inhibition in the nervous system to regulate functions like movement, mood, and learning.
This document discusses neurotransmitters and neuromodulators in the central nervous system. It describes how neurotransmitters transmit signals across synapses and provides examples of small molecule and large molecule transmitters. The major neurotransmitters discussed include amino acids like GABA, glycine, and glutamate, acetylcholine, and monoamines like dopamine, norepinephrine, epinephrine, histamine, and serotonin. It outlines the synthesis, storage, release, and termination of these neurotransmitters. Receptor types are also summarized.
This power point presentation deals with the different types of neurotransmitters in the CNS and and a breif information about histamine and antihistaminic drugs.
The document provides information on cholinergic drugs. It discusses that cholinergic drugs act similarly to acetylcholine by directly interacting with cholinergic receptors or increasing acetylcholine availability. It describes the two main cholinergic receptor types - muscarinic and nicotinic receptors. It also explains the mechanisms and effects of indirect-acting cholinergic drugs or anticholinesterases which inhibit the acetylcholinesterase enzyme and thereby increase acetylcholine levels. Specific drugs discussed are physostigmine and neostigmine, which reversibly inhibit acetylcholinesterase.
Introduction to the pharmacology of CNS drugsDomina Petric
The document provides an overview of central nervous system (CNS) pharmacology, covering ion channels, neurotransmitter receptors, synaptic transmission, and cellular organization of the brain. It describes two types of channels in nerve cell membranes: voltage-gated channels that respond to changes in membrane potential, and ligand-gated channels that open when neurotransmitters bind. Neurotransmitters can act on ionotropic receptors, directly opening channels, or metabotropic G protein-coupled receptors, which modulate voltage-gated channels via second messengers. Synaptic transmission involves the propagation of action potentials and release of neurotransmitters, producing excitatory or inhibitory postsynaptic potentials. The brain contains hierarchical systems with clearly delineated pathways, and
- The document discusses the physiology of synapses, neurotransmitters, and the neuromuscular junction. It describes the basic structure and function of chemical synapses between neurons.
- The key types of neurotransmitters are described, including acetylcholine, norepinephrine, dopamine, GABA, glycine, glutamate, serotonin, and histamine. Their receptors and effects on excitation or inhibition are summarized.
- The neuromuscular junction is discussed as a specialized chemical synapse, with acetylcholine as the neurotransmitter that binds to nicotinic receptors and causes muscle fiber depolarization.
Similar to Lect 2 receptor, synapse, neurotransmitters (20)
Common medication used for anesthesia, there action; dosage; adverse effect; duration of action.
They Include {inhalation + Induction + Muscle relaxant + Anticholinergic + Analgesic + Resuscitation}
Multiple endocrine neoplastic (MEN) syndromes are inherited disorders characterized by tumors in multiple endocrine glands. There are three main types: MEN1, MEN2a, and MEN2b. MEN1 is caused by mutations in the MEN1 gene and commonly involves the parathyroid, pancreas, and pituitary glands. MEN2a and MEN2b are caused by mutations in the RET proto-oncogene and involve the thyroid and adrenal glands. The tumors in MEN syndromes tend to be more aggressive and occur at a younger age than sporadic tumors. Genetic testing can diagnose MEN syndromes to guide screening and treatment of associated tumors.
1. Pheochromocytomas are rare tumors that originate from chromaffin cells in the adrenal medulla or extra-adrenal paraganglia. They secrete catecholamines and can cause hypertension.
2. Neuroblastoma is a common malignant tumor in children under 5 years old that originates from embryonic nerve cells, often in the adrenal medulla or chest. It commonly metastasizes and presents with abdominal issues or carcinoid syndrome.
3. Ganglioneuroma is a rare, benign tumor of the sympathetic nervous system in adults that produces symptoms due to its size and location. It is diagnosed using imaging and urine tests. Surgery is usually sufficient treatment.
This document discusses diseases of the adrenal cortex, including hyperadrenalism and hypoadrenalism. It describes three hyperadrenal clinical syndromes caused by excess production of cortisol, mineralocorticoids, or androgens. Cushing syndrome is discussed in depth, outlining its causes such as Cushing disease and ectopic ACTH secretion. Hyperaldosteronism and adrenogenital syndromes are also summarized. Hypoadrenalism includes primary and secondary causes, with Addison disease and acute adrenal crisis covered as examples of primary hypoadrenalism.
Lecture 7. diabetic mellitus & pancreatic tumourAyub Abdi
1. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia that affects over 29 million people in the US and 422 million worldwide.
2. There are several types of diabetes including type 1 caused by autoimmune destruction of beta cells, type 2 caused by insulin resistance and relative insulin deficiency, and gestational diabetes during pregnancy.
3. Chronic complications of diabetes include damage to blood vessels leading to heart disease, stroke, and kidney failure as well as nerve damage causing neuropathy. Rare forms include monogenic diabetes and pancreatic tumors such as insulinomas.
Primary hyperparathyroidism is usually caused by a parathyroid adenoma and results in hypercalcemia. It commonly affects those over 50 and can cause skeletal and renal problems. Parathyroid carcinoma is rare but can also cause hyperparathyroidism through local invasion and metastases. Secondary hyperparathyroidism is usually due to chronic kidney disease and leads to compensatory parathyroid gland hyperplasia in response to low calcium levels.
Lecture 5. nodular thyroditis & neoplasiaAyub Abdi
This document summarizes different types of thyroid diseases including thyroiditis, adenomas, and carcinomas. It describes the most common type of thyroiditis as resulting from diffuse and multinodular goiters caused by impaired thyroid hormone synthesis typically due to iodine deficiency. It also discusses the four main types of thyroid carcinomas - papillary, follicular, anaplastic, and medullary - providing details on their pathogenesis, morphology, clinical features, diagnosis and treatment.
1) Thyroiditis refers to inflammation of the thyroid gland and includes Hashimoto's thyroiditis, granulomatous thyroiditis, and subacute lymphocytic thyroiditis.
2) Hashimoto's thyroiditis is the most common cause of hypothyroidism in iodine-sufficient areas. It involves the gradual autoimmune destruction of the thyroid leading to thyroid failure.
3) Granulomatous thyroiditis causes acute neck pain and a tender thyroid mass. It can cause transient hyperthyroidism and is thought to be triggered by viral infections.
1) Hyperthyroidism is caused by elevated thyroid hormones due to hyperfunction of the thyroid gland. It causes a hypermetabolic state and common symptoms include weight loss, rapid heartbeat, nervousness, and goiter.
2) Hypothyroidism is a hypometabolic state caused by inadequate thyroid hormone production. Common symptoms include weight gain, fatigue, dry skin, constipation, and feeling cold.
3) Congenital hypothyroidism, known as cretinism, causes physical and mental retardation if not treated early in infancy. Screening programs help detect and treat this condition.
This document provides an overview of hypopituitarism, summarizing its key causes and clinical manifestations. It discusses several specific conditions associated with hypopituitarism, including panhypopituitarism, pituitary dwarfism, diabetes insipidus, pituitary apoplexy, Sheehan's syndrome, and Nelson's syndrome. The most common causes of panhypopituitarism are Sheehan's syndrome, empty sella syndrome, and non-secretory pituitary adenomas. Pituitary dwarfism results from growth hormone deficiency in children before growth is complete. Diabetes insipidus is caused by antidiuretic hormone deficiency.
This document provides an overview of hyperpituitarism, which is defined as excessive secretion of one or more pituitary hormones. The most common cause is a hormone-producing pituitary adenoma arising in the anterior lobe. Pituitary adenomas can be functional (hormone-producing) or nonfunctional and may cause hyperfunction of growth hormone (gigantism and acromegaly), prolactin, or ACTH (Cushing's syndrome). Other conditions like craniopharyngioma or metastatic carcinoma can also cause a mass effect by compressing surrounding structures. The document discusses various pituitary adenoma subtypes and hypersecretory syndromes in detail.
History taking & physical examination of lumpAyub Abdi
This document provides guidance for medical students on how to properly examine and document a patient's lump or mass. It outlines 12 key areas of inquiry: 1) the history of the lump, 2) examination of the lump, and 3) examination of surrounding structures. For the lump examination, it describes how to assess 13 characteristics including size, shape, surface, temperature, tenderness, edge, composition, and relations to surrounding tissues. Conducting a thorough examination and documentation of a patient's lump is important for accurately diagnosing its nature and cause.
in this presentation you will be learn the different drug form that all medical health workers prescribing the medication.
the medical student should have a good knowledge and keep in mind these drug forms based on medical administration the drugs are classified into invasive (injection and transdermal implantation) and non invasive (oral, inhalers, suppository)
Medical equipment and tools are crucial to saving a person's life or performing any procedure.
i presented here the most and commonly equipment used by medical student to improve their skills
This note paper is short notes of general physiology for medical students who which to understand the concept of the physiology, physiology is the mother of medicine.
This document provides information about a medical physiology MCQ book authored by Dr. Ayub Abdulkadir Abdi. It includes sections on the author's background, dedication, acknowledgements, reference materials, contents of the book, and images of bone structures. The document serves as a preface and introduction to the MCQ book, outlining its scope and providing context for the questions that follow.
A summary of skeletal muscle contraction and relaxationAyub Abdi
it consist for 4 pages and cover all the steps that occur during muscle contraction and relaxation, I does not take a time just 5 minute is enough to read. I hope it's interesting.
Hypovolemia is a deficiency of body fluid that results in a decrease in total fluid volume. It can be caused by fluid or sodium losses from the body through vomiting, diarrhea, burns, or hemorrhage. Symptoms include decreased blood pressure, increased heart rate, dry skin, nausea, and decreased urine output. Treatment involves oral or IV fluid replacement depending on the severity, with close monitoring to prevent fluid overload. Monitoring includes fluid balance charts, weight, and plasma biochemistry.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...rightmanforbloodline
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
3. • Receptors are sensory (afferent) nerve endings that
terminate in periphery as bare unmyelinated
endings or in the form of specialized capsulated
structures.
• receptors are often defined as the biological
transducers, which convert (transducer)
various forms of energy (stimuli) in the environment
into action potentials in nerve fiber.
• Generally, receptors are classified into two types:
A. Exteroceptors.
B. Interoceptors.
4. 1- EXTEROCEPTORS:
• Exteroceptors are the receptors, which give
response to stimuli arising from outside the
body.
• Exteroceptors are divided into three groups:
1. Cutaneous Receptors OR
Mechanoreceptors.
2. Chemoreceptors.
3. Telereceptors.
6. 2- INTEROCEPTORS:
• Interoceptors are the receptors, which give
response to stimuli arising from within the
body.
• Interoceptors are of two types which are as
follows:
1. Visceroceptors.
2. Proprioceptors.
7.
8. PROPERTIES OF RECEPTORS:
1. SPECIFICITY OF RESPONSE – MÜLLER LAW:
The response given by a particular type of receptor to
a specific sensation. For example, pain receptors
give response only to pain sensation.
2. ADAPTATION – SENSORY ADAPTATION:
Decline in discharge of sensory impulses when a
receptor is stimulated continuously with constant
strength.
a) Phasic receptors= Touch and pressure receptors
(adapted rapidly).
b) Tonic receptors= Muscle spindle, pain receptors
and cold receptors (adapted slowly).
9. 3. RESPONSE TO INCREASE IN STRENGTH OF
STIMULUS – WEBERFECHNER LAW:
During the stimulation of a receptor, if the response
given by the receptor is to be doubled, the strength
of stimulus must be increased 100 times.
4. SENSORY TRANSDUCTION:
is a process by which the energy (stimulus) in the
environment is converted into electrical impulses
(action potentials) in nerve fiber.
e.g. if pressure stimuli is applied to the nerve under
the skin, causes transmission of this stimuli as an
action potential inside the nerve fiber not as a
pressure.
10. 5. RECEPTOR POTENTIAL or generator potential:
a nonpropagated transmembrane potential
difference that develops when a receptor is
stimulated.
6. LAW OF PROJECTION:
When a sensory pathway
from receptor to cerebral
cortex is stimulated on any
particular site along its
course, the sensation
caused by stimulus is always
felt (referred) at the
location of receptor,
irrespective of site
stimulated.
11.
12. • Synapse is the junction between two neurons.
• Synapse is classifed by two methods:
A. Anatomical classifcation
B. Functional classifcation.
• ANATOMICAL CLASSIFICATION:
o Axoaxonic synapse.
o Axodendritic synapse.
o Axosomatic synapse.
14. • Neuron from which the axon arises is called the
presynaptic neuron and the neuron on which the
axon ends is called postsynaptic neuron.
• Axon of the presynaptic neuron divides into many
small branches before forming the synapse.
• These branches are known as presynaptic axon
terminals.
• Types of Axon Terminals:
1. Terminal knobs (excitatory function).
2. Terminal coils or free endings
(inhibitory function ).
15.
16. Structures in pre and post-synaptic:
• Presynaptic axon:
Mitochondria.
Synaptic vesicles.
Presynaptic membtane.
• Synaptic cleft:
cholinesterase,
which destroys acetylcholine.
• Postsynaptic neuron:
Postsynaptic membrane.
Receptor protein.
17. FUNCTIONS OF SYNAPSE:
• Main function of the synapse is to transmit the
impulses, i.e. action potential from one neuron to
another.
On the basis of functions, synapses are divided into
two types:
1. Excitatory synapses, which transmit the impulses
(excitatory function).
2. Inhibitory synapses, which inhibit the transmission
of impulses (inhibitory function).
EXCITATORY FUNCTION:
Excitatory Postsynaptic Potential
• Is the non-propagated electrical potential that develops
during the process of synaptic transmission.
20. INHIBITORY FUNCTION:
Inhibitory Postsynaptic Potential
• Inhibitory postsynaptic potential (IPSP) is the
electrical potential in the form of
hyperpolarization that develops during
postsynaptic inhibition.
• Types:
1. Postsynaptic or direct inhibition
2. Presynaptic or indirect inhibition
3. Negative feedback or Renshaw cell inhibition
4. Feedforward inhibition
5. Reciprocal inhibition.
21. 1. Postsynaptic or Direct Inhibition :
• Release of an inhibitory neurotransmitter from
presynaptic terminal instead of an excitatory
neurotransmitter substance.
• It is also called direct inhibition.
• Inhibitory neurotransmitters are
gammaaminobutyric acid (GABA), dopamine and
glycine.
27. PROPERTIES OF SYNAPSE:
A. ONE WAY CONDUCTION – BELL-MAGENDIE LAW.
B. SYNAPTIC DELAY (short delay, in which
neurotransmitter is released and cellular response
is done).
C. FATIGUE (depletion of neurotransmitter substance
either by destruction or not synthesized).
D. SUMMATION:
I- Spatial Summation.
II- Temporal Summation.
E. ELECTRICAL PROPERTY (EPSP and IPSP).
28.
29. CONVERGENCE AND DIVERGENCE:
• Convergence is the process by which many
presynaptic neurons terminate on a single
postsynaptic neuron.
• Divergence is the process by which one presynaptic
neuron terminates on many postsynaptic neurons.
31. • Neurotransmitter is a chemical substance that acts as a
mediator for the transmission of nerve impulse from one
neuron to another neuron through a synapse.
Properties of the neurotransmitters:
• Neurotransmitters must be present, produced, or
released by the neuron.
• Neurotransmitters must be act on target ells and
produced the response.
• Neurotransmitters must be inactivated after the
response.
• (amino acids, amines, others {nitric oxide,
Acetylcholine}).
• Excitatory or inhibitory neurotransmitters.
32. 1- ACETYLCHOLINE:
• Acetylcholine is a cholinergic neurotransmitter
• It possesses “excitatory function”.
• (acetyl CoA + choline).
• It is hydrolyzed into acetate and choline by the
enzyme acetylcholinesterase
• Muscarinic receptors and Nicotinic receptors.
• Nicotinic receptors are also present in the
neuromuscular junction on membrane of skeletal
muscle.
33.
34. 2- NORADRENALINE:
• Noradrenaline is the neurotransmitter in
adrenergic nerve fibers.
• Excitatory chemical mediator.
• Inhibition in few places.
• Involved in dreams,
arousal and elevation
of moods.
35. 3- DOPAMINE:
• Dopamine possesses inhibitory action.
• Prolactin inhibitory hormone secreted by
hypothalamus is considered to be dopamine.
36. 4- SEROTONIN:
• Serotonin is otherwise known as 5-
hydroxytryptamine (5-HT) .
• Large amount of serotonin (90%) is found in
enterochromatin cells of GI tract.
• Small amount is found in platelets and nervous
system.
• It is an inhibitory substance. It inhibits impulses of
pain sensation in posterior gray horn of spinal cord.
• It is supposed to cause depression of mood and
sleep.
37.
38. 5- HISTAMINE :
• is an excitatory neurotransmitter.
• Play an important role in arousal mechanism.
39. 6- GAMMAAMINOBUTYRIC ACID:
• Is an inhibitory neuro transmitter in synapses
particularly in CNS.
• Causes synaptic inhibition by opening potassium
channels and chloride channels.
40. 7- SUBSTANCE P:
• Substance P is secreted by the nerve endings
(first order neurons) of pain pathway in spinal cord.
• It mediates pain sensation.
• It is responsible for regulation of anxiety, stress,
mood disorders, neurotoxicity, nausea and vomiting.
41. 8- NITRIC OXIDE:
• Nitric oxide (NO) is a neurotransmitter in the
CNS.
• Dilator effect.
• Endothelial cells of blood vessels.
43. • Neuromodulator is the chemical messenger, which
modifies and regulates activities that take place
during the synaptic transmission.
• Not propagate nerve impulses like neurotransmitters.
• Action of neuromodulators:
Regulation of synthesis, breakdown or reuptake of
neurotransmitter.
Excitation or inhibition of membrane receptors by
acting independently or together with
neurotransmitter.
Control of gene expression.
Regulation of local blood flow.
a) NONOPIOID PEPTIDES.
b) OPIOID PEPTIDES.