This document discusses several topics related to radioactivity and radiation, including:
1) Why elements are radioactive - unstable nuclei have excess energy and emit radiation to reach stability.
2) Discoveries of radioactivity and X-rays - Antoine Becquerel discovered radioactivity from uranium in 1896, while Wilhelm Roentgen discovered X-rays in 1895.
3) Types of radiation include alpha particles, beta particles, photons, and their interactions with matter. Ionizing radiation can remove electrons while non-ionizing cannot.
X-ray imaging is still one of the most important diagnostic methods used in medicine. It provides mainly morphological (anatomical) information - but may also provide some physiological (functional) information.
X-rays are used in medicine for medical analysis. Dentists use them to find complications, cavities and impacted teeth. Soft body tissue are transparent to the waves. Bones also block the rays.
X-ray imaging is still one of the most important diagnostic methods used in medicine. It provides mainly morphological (anatomical) information - but may also provide some physiological (functional) information.
X-rays are used in medicine for medical analysis. Dentists use them to find complications, cavities and impacted teeth. Soft body tissue are transparent to the waves. Bones also block the rays.
Production of X rays, Different X ray diffraction methods, Bragg‘s law, Rotating crystal technique, X ray powder technique, Types of crystals and applications of X-ray Diffraction
Gamma Rays (γ)
(noun) penetrating electromagnetic radiation of a kind arising from the radioactive decay of atomic nuclei.
Gamma rays ( often denoted by the Greek letter gamma, γ) is an energetic form of electromagnetic radiation produced by radioactivity or nuclear or subatomic processes such as electron-positron destruction
Production of X rays, Different X ray diffraction methods, Bragg‘s law, Rotating crystal technique, X ray powder technique, Types of crystals and applications of X-ray Diffraction
Gamma Rays (γ)
(noun) penetrating electromagnetic radiation of a kind arising from the radioactive decay of atomic nuclei.
Gamma rays ( often denoted by the Greek letter gamma, γ) is an energetic form of electromagnetic radiation produced by radioactivity or nuclear or subatomic processes such as electron-positron destruction
Ultrasound Physics Made easy - By Dr Chandni WadhwaniChandni Wadhwani
History of ultrasound, Principle of Ultrasound.
Ultrasound wave and its interactions
Ultrasound machine and its parts, Image display, Artifacts and their clinical importance
what is Doppler ultrasound, Elastography and Recent advances in field of ultrasound.
Safety issues in ultrasound.
The detailed information of UV Visible Spectroscopy, it includes the information regarding electronic transitions, Electromagnetic radiations, Various shifts.
UV - Visible Spectroscopy detailed information is included .The Spectroscopy study provide the information and the absorbance as well the concentration of the drugs is studied.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
4. • Radioactive decay
is a spontaneous process in which
nucleons are emitted from or transformed
within the nucleus, resulting in a change in the
identity of the nucleus, and usually
accompanied by the emission of one or more
types of radiation from the nucleus and/or
atom.
• Half-life
is the time required for half of the atoms
of a radioactive material to decay to another
nuclear form.
8. Ionizing vs. Non-Ionizing
Radiations
Ionizing Radiation
• A radiation that has
sufficient energy to
remove electrons from
atoms or molecules as
it passes through
matter.
• Examples: x-rays,
gamma rays, beta
particles, and alpha
particles
Non-Ionizing
Radiation
• A radiation that is
not as energetic as
ionizing radiation
and cannot remove
electrons from
atoms or molecules.
• Examples: light,
lasers, heat,
microwaves, and
radar
9. Radiation Origins
• Ionizing radiation can be generated by
electronic means (x-ray units)
• When electronic-product radiation is
produced, the source is turned on and off
like a light switch. Once the unit is off,
The x-ray unit does not continue to
generate radiation or become radioactive.
• With radioactive materials, there is a little
more involved. The source is always on
until it decays away.
10. Contamination
Contamination is the presence of a radioactive
material in any place where it is not desired,
and especially in any place where
its presence could be harmful.
Ohhhhh…my god!!!!
11. Three Steps to Control
the radiation exposure
1.TIME
2.DISTANCE
3.SHIELDING
Steps To Control
12. The total dose received by
the radiation worker is
directly proportional to the
total time spent in handling
the radiation source
Lesser time spent near the
radiation source lesser will be
the radiation dose.
TIME
13. As time spent in the radiation
field increases, the radiation
dose also increases
So minimize the time spent in
radiation by splitting the patient
(or) share the duty.
14. Technique to minimize time in a
radiation field should be practice
(or) recognized.
All radiation sources do not
produce constant exposure rate.
15. The radiation exposure can be
minimize by not energizing the x-ray
tube, when personal are nearer to the
machine .
We should have to plane the
radiation procedure practice ,the
procedure without radiation and
share the essential duties, to reduce
the radiation exposure time
16. • A radiographer is performing MCU
examination under fluoroscopy and
the equipment is ‘ON’ for 3 minutes
for each examination. the radiation
level at the location of the
radiographer is 100mR/h. how many
such procedure the radiographer can
carry out per week?
Time calculation :
17. Annual dose limit for radiographer
20mSv=2000mrem=2000mR
Per weekly dose =2000mR÷50week=40mR
exposure rate of location
radiographer=100mR/h
=100÷60mR/min
the exposure in each procedure :
= 100mR÷60min× 3min =5mR
in one week =40mR/5mR=8 procedure
CALCULATION:
18.
19. Minimize Exposure by
Maximizing Distance
As the distance from a radiation
exposure source doubles, the exposure
rate decreases by a factor of four.
20. Radiation intensity from a point
source decreases with distance ,due
to divergence of the beam .
It states that the exposure rate from
a point of source of radiation is
inversely proportional to the square
of the distance.
DISTANCE
21. The exposure rate in x₁ at distance
D₁, then the exposure rate x₂ at
another distance D₂ is given by
Doubling the distance from the x-
ray source decreases the x ray
beam intensity by a factor of 4.
22. • If exposure rate in 100 mR/hr at 1m,
then it will be 25mR/hr at 2m.
• Larger the distance, lesser will be
the radiation .if the distance is
shorter the distance exposure will be
higher .
• If exposure rate in 100 mR/hr at 3m
24. In diagnostic radiology at 1m from a
patient, the scattered radiation is
about o.1-0.5% of the primary beam.
Stand as for away as possible during
x ray procedure .
Person should stand at least 2m from
the x ray tube and the patient at
behind the shielded lead barrier or
out of the x ray room.
25. X ray room should be designed
maximum distance between source
to control consol .
Because most time the technologist
spent in the control consol for image
processing .
Un shielded radiation source should
not be manipulated by hand.
26. The exposure rate from a
fluoroscopic x ray machine is
5/min at 50cm .what would be
the exposure rates at (i)
40cm,and (ii)60cm?
DISTANCE CALCULATION
28. When maximum distance and
minimum time do not ensure an
acceptably low dose radiation
dose.
Adequate shielding must be
provided .
Use led shielding to reduce the
exposure to the patient and to staff
SHIELDING
33. • Lead apron –o.25-o.5mm
• 0.25mm- >90% scattered radiation
is attenuated.
• 0.5mm-95to99% scattered radiation
get attenuated.
• Lead barrier 2mm
• Gonad shield 0.5mm 95%of
scattered get attenuated.
SHIELDING DEVICE
34. • As Low As Reasonably Achievable
(ALARA).
• The term was introduced by ICRP-26 .
• It states that dose to patient and staff
should be kept as low as reasonably
achievable.
• Every reasonable effort must be made to
reduce radiation level below the stated
dose limit within economic and social
limit.
ALARA
36. Biological Effects
• What we know about the effects of
radiation come from a number of different
exposed populations:
–Atomic bomb survivors
–Accident victims
–Radium watch dial painters
The effects were both acute and delayed.