Dr. Kim Solez presents A renaissance in renal pathology, nephrology and transplantation brought about by regenerative medicine: How to jump start the process.
Kim Solez Introduction to regenerative medicine Fall 2015Kim Solez ,
Dr. Kim Solez presents "Introduction to Regenerative Medicine" on September 10, 2015 in the Technology and Future of Medicine course LABMP 590 http://www.singularitycourse.com at the University of Alberta in Edmonton, Canada. Copyright (c) 2015, JustMachines Inc.
Kim Solez The bridge between transplant and regenerative med Tissue engineeri...Kim Solez ,
Dr. Kim Solez presents "The Bridge Between Transplantation & Regenerative Medicine: The Beginning of Tissue Engineering Pathology" at the ATI Fellows Lecture Series on August 18, 2015.
This document discusses genetic engineering and gene editing technologies like CRISPR-Cas9. It explores both the promise and ethical concerns of being able to directly alter genes. While gene editing could help address diseases and boost agriculture, there are risks of unintended consequences due to off-target mutations or unknown long term effects of disrupting the natural human genome. The document examines arguments on both sides and notes that while scientific research is important, manipulating human heredity remains an issue of ethics that requires careful consideration and debate.
1) Physical confinement prolongs the duration of mitosis in cells, with more confinement leading to longer mitosis. Confinement increases the frequency of mitotic arrest and cell death.
2) Microfluidic devices with variable channel widths were used to study mitosis in confined environments that mimic physiological spaces. Cancer cells and fibroblasts underwent prolonged and irregular mitosis in narrower channels.
3) The mechanisms of mitotic delay in confinement may involve insufficient space for chromosome alignment or incomplete attachment of the spindle to chromosomes. Future work aims to better understand these mechanisms and examine the effects of confinement on non-cancerous cells.
Kim Solez Renal transplant pathology and future perspectives corefall2016Kim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives. Nephrology core lecture series Fall 2016, on October 5, 2016, at the University of Alberta, Edmonton, Alberta, Canada. Copyright (c) 2016, JustMachines Inc.
Effects of Microgravity on Human Physiology - F. MunshiFaizan Munshi
The document summarizes several key effects of microgravity on human physiology based on numerous studies. It finds that microgravity leads to cellular changes like cytoskeleton thinning and increased senescence. It also causes musculoskeletal issues like muscle atrophy and bone loss. Further, microgravity compromises cardiovascular function and could impact male reproduction. The greatest health concerns are muscle atrophy and bone loss. Exercise and fluid loading are effective countermeasures but more research is still needed on microgravity's long term impacts and developing new countermeasures.
Kim Solez Introduction to regenerative medicine Fall 2015Kim Solez ,
Dr. Kim Solez presents "Introduction to Regenerative Medicine" on September 10, 2015 in the Technology and Future of Medicine course LABMP 590 http://www.singularitycourse.com at the University of Alberta in Edmonton, Canada. Copyright (c) 2015, JustMachines Inc.
Kim Solez The bridge between transplant and regenerative med Tissue engineeri...Kim Solez ,
Dr. Kim Solez presents "The Bridge Between Transplantation & Regenerative Medicine: The Beginning of Tissue Engineering Pathology" at the ATI Fellows Lecture Series on August 18, 2015.
This document discusses genetic engineering and gene editing technologies like CRISPR-Cas9. It explores both the promise and ethical concerns of being able to directly alter genes. While gene editing could help address diseases and boost agriculture, there are risks of unintended consequences due to off-target mutations or unknown long term effects of disrupting the natural human genome. The document examines arguments on both sides and notes that while scientific research is important, manipulating human heredity remains an issue of ethics that requires careful consideration and debate.
1) Physical confinement prolongs the duration of mitosis in cells, with more confinement leading to longer mitosis. Confinement increases the frequency of mitotic arrest and cell death.
2) Microfluidic devices with variable channel widths were used to study mitosis in confined environments that mimic physiological spaces. Cancer cells and fibroblasts underwent prolonged and irregular mitosis in narrower channels.
3) The mechanisms of mitotic delay in confinement may involve insufficient space for chromosome alignment or incomplete attachment of the spindle to chromosomes. Future work aims to better understand these mechanisms and examine the effects of confinement on non-cancerous cells.
Kim Solez Renal transplant pathology and future perspectives corefall2016Kim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives. Nephrology core lecture series Fall 2016, on October 5, 2016, at the University of Alberta, Edmonton, Alberta, Canada. Copyright (c) 2016, JustMachines Inc.
Effects of Microgravity on Human Physiology - F. MunshiFaizan Munshi
The document summarizes several key effects of microgravity on human physiology based on numerous studies. It finds that microgravity leads to cellular changes like cytoskeleton thinning and increased senescence. It also causes musculoskeletal issues like muscle atrophy and bone loss. Further, microgravity compromises cardiovascular function and could impact male reproduction. The greatest health concerns are muscle atrophy and bone loss. Exercise and fluid loading are effective countermeasures but more research is still needed on microgravity's long term impacts and developing new countermeasures.
Kim Solez Mallory Chipman AHHM pathology meets faatjKim Solez ,
Kim Solez and Mallory Chipman present in the AHHM Speaker Series "Pathology Meets the Future and All That Jazz: AI, Regenerative Medicine and You" at the University of Alberta Arts and Humanities in Health and Medicine program speaker series on December 8, 2016 . Copyright (c) 2016, JustMachines Inc.
Kim Solez Charles dickens and transplant pathologyKim Solez ,
Acceptance speech by Dr. Kim Solez receiving the Catalan Society of Transplantation Gold Medal on behalf of himself and Dr. Lorraine Racusen March 31, 2017
Solez Global Clinical Trial Committee Presentation Stem Cells and Future of T...Kim Solez ,
The Banff Foundation for Allograft Pathology was established in 2013 and organizes conferences to develop consensus classifications for interpreting transplant biopsies. The Banff Schema, first developed at a 1991 meeting in Banff, Canada, set worldwide standards for biopsy interpretation. The Foundation includes working groups that refine classifications based on research feedback. As technologies like stem cell-grown organs emerge, the Foundation must adapt to remain relevant by including new member specialties. The Banff process demonstrates how medical knowledge can advance through collaborative consensus-building.
This document is a poem reflecting on the author's experience with medical meetings over decades. It discusses:
1) Advice the author received early in their career to avoid meetings, as nothing important happens. The author ignored this advice.
2) Over time, the author enjoyed meetings more for social aspects of seeing colleagues, though work was also accomplished.
3) As the author's field changed to regenerative medicine, meetings took on renewed importance for learning and progress in the field to benefit patients. The author now sees meetings as crucial, rather than just social events.
There are a lot of orthopedic conditions and injuries that presently have limited treatment options available.
Here regenerative technologies comes up as a ray of hope among surgeons for the treatment by functionally repairing the tissues and organs using growth factors, stem cells and products developed by genetic engineering with the advancement in the stem cells research field .
The purpose of this presentation is to first provide idea about the orthopedic conditions along with the therapeutic potential of stem cells to treat these diseases.
This document describes the development and evaluation of an interactive stem cell workshop for A-Level biology students. The workshop was designed to provide a broad overview of stem cells, their properties, potential uses, and ethical issues. It was implemented using cooperative and problem-based learning strategies. Students worked in groups on a research task about potential stem cell applications. The workshop was tested in two settings - a museum and a classroom - and received positive feedback, though some changes were recommended. The goal was to improve student understanding of stem cells in an engaging way and contribute to stem cell education resources.
Cartilage Repair using Stem cell & OrthobiologicsVaibhav Bagaria
Regenerating Cartilage is a challenge. What's new in this field of cartilage regeneration and the current status of the stem cell use in this field is described.
Stem cells for artificial organ regenerationElvis Samuel
A stem cell is a cell with the unique ability to develop into specialized cell types in the body. This presentation details the regeneration of artificial organs using stem cells
Abdominal Pain as Initial Presentation of Lung Adenocarcinomaasclepiuspdfs
Isolated celiac lymph node metastasis (ICLNM), in general, is not common with a reported incidence of 5–10% for lung adenocarcinoma. Lung adenocarcinoma rarely metastasizes to the celiac lymph node leading to abdominal pain. It is not typical for ICLNM to be the initial presentation of lung adenocarcinoma as well. In this case, a 56-year-old man presented with a 4-week history of persistent periumbilical dull pain. Workup was remarkable for celiac lymph node mass which turned out to be adenocarcinoma with unknown primary cancer. Whole body position emission tomography scan and biopsy of the mass with immunohistochemistry could identify lung adenocarcinoma as the primary cancer. After a well-informed discussion of options for chemotherapy drugs with the patient, the decision was made to pursue bevacizumab combined with chemotherapeutics. He was charged home with abdominal pain relief and outpatient follow-up after short-course of chemotherapy.
Dr. Kim Solez presents the "Chair's Introduction" and "Medicine Writ Large: The Ultimate in Translational Medicine" at BIT's 4th Annual World Congress of Molecular and Cell Biology, Big Challenges, Huge Opportunities, in Dalian, China on April 26, 2014.
The document discusses the development of an implantable artificial kidney called the bioartificial kidney (BAK). It notes the high mortality rates of acute renal failure and end-stage renal disease. Researchers at UCSF have created a prototype BAK that aims to replace dialysis through a two-stage system using nano-scale filters and living kidney cells. The BAK is being tested and improved with the goal of beginning human clinical trials by 2017. It aims to allow patients a more normal lifestyle compared to traditional dialysis treatment.
Circulating microRNAs predict initial of NHL in a novel in vivo model: impact...Laura Berry
Presented at the 3rd qPCR and Digital PCR Congress: USA. To find out more, visit:
www.global-engage.com
Afshin Beheshti is an Assistant Professor at the Tufts University School of Medicine. In this presentation, Afshin discusses his investigation into age-dependent circulating microRNA signatures that may influence non-Hodgkin lymphoma.
The 16th Annual Scientific Meeting of the Society for Neuro-Oncology and AANS/CNS Section on Tumors was held November 17-20, 2011 in Orange County, CA. Over 1300 participants from 37 countries attended the four day meeting focused on the latest laboratory and clinical research in neuro-oncology. The meeting included education day sessions, morning and afternoon oral presentation sessions on various topics, keynote addresses, award presentations, and poster sessions to facilitate the multidisciplinary exchange of ideas. The successful annual meeting brought together neuro-oncologists, surgeons, pathologists, and other specialists to advance the research, diagnosis, care and treatment of brain tumors.
This document discusses stem cells and tissue homeostasis. It begins by explaining how tissues maintain homeostasis through regeneration after injury using stem cells. The history of regeneration research from the 18th century is then reviewed. Organ transplantation techniques from skin grafting to modern transplants are summarized. The document outlines the types of transplants including autografts, allografts, isografts, and xenografts. Milestones in stem cell research from the late 19th century to recent developments are listed. Limitations of organ transplantation including shortages are noted. The role of stem cell therapy in regenerating tissues is mentioned.
Stem cells have the ability to become specialized cells and work with tissues and organs. There are two types: embryonic stem cells which come from embryos and can differentiate into any cell type, and adult stem cells which are more limited in what cells they can become. Stem cell therapy involves inserting stem cells into injured areas to produce new cells and has been used to treat conditions such as cerebral palsy, Parkinson's disease, and cancers. For spinal cord injuries, researchers are exploring therapies using bone marrow stem cells, cord blood cells, and other cell types which show promise in repairing damage in clinical trials.
This document discusses acute kidney injury (AKI) in patients with COVID-19. It first defines AKI and describes its stages of severity. It then reviews the epidemiology of AKI in COVID-19, finding incidence rates ranging from 5-57% depending on location and study. The main proposed mechanisms of AKI in these patients include direct viral infection of kidney cells, cytokine storm effects, AKI related to acute respiratory distress syndrome, and kidney-lung crosstalk exacerbating injury. Risk factors for developing AKI include older age, male sex, hypertension, diabetes and pre-existing kidney disease. Treatment involves preventing AKI through fluids and avoiding nephrotoxins, with renal replacement therapy used in severe cases
Transition transplant path to tissue engineer path new banff class 2017 Kim Solez ,
Kim Solez "The transition between transplant pathology and tissue engineering pathology: Beginning a new Banff classification - 2017 Update". ATI Fellows Rounds Presentation Spept 12 2017
Solez Stem Cell and Future of TransplantationKim Solez ,
Dr. Kim Solez discusses "Confronting the Question of Stem Cells and the Future of Transplantation" for the Alberta Transplant Institute Fellows Lecture Series on September 2nd, 2014 at the University of Alberta in Edmonton, Canada.
Kim Solez Transplant Pathology Regen Med 2015Kim Solez ,
Dr. Kim Solez presents Transplantation Pathology, Regenerative Medicine, and Where We Go From Here at the Nephrology Core Lecture Series on January 7th, 2015 at the University of Alberta in Edmonton, Canada. See https://www.youtube.com/watch?v=5wfdhB_VyJw
Kim Solez Bridge between transplantation and regenerative medicine vancouver3Kim Solez ,
Dr. Kim Solez presents "Bridge between Transplantation and Regenerative Medicine" at the Banff Transplant Pathology meeting in Vancouver October 5, 2015. Copyright (c) 2015, JustMachines Inc.
Kim Solez Transition transplant path to tissue engineering path new banffKim Solez ,
Dr. Kim Solez Presents "Transition Between Transplant Pathology and Tissue Engineering Pathology: Beginning A New Banff Classification" at the Alberta Transplant Institute Fellows Lecture Series January 10, 2017 at the University of Alberta in Edmonton, Alberta, Canada. Copyright (c) 2017, JustMachines Inc.
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Kim Solez Mallory Chipman AHHM pathology meets faatjKim Solez ,
Kim Solez and Mallory Chipman present in the AHHM Speaker Series "Pathology Meets the Future and All That Jazz: AI, Regenerative Medicine and You" at the University of Alberta Arts and Humanities in Health and Medicine program speaker series on December 8, 2016 . Copyright (c) 2016, JustMachines Inc.
Kim Solez Charles dickens and transplant pathologyKim Solez ,
Acceptance speech by Dr. Kim Solez receiving the Catalan Society of Transplantation Gold Medal on behalf of himself and Dr. Lorraine Racusen March 31, 2017
Solez Global Clinical Trial Committee Presentation Stem Cells and Future of T...Kim Solez ,
The Banff Foundation for Allograft Pathology was established in 2013 and organizes conferences to develop consensus classifications for interpreting transplant biopsies. The Banff Schema, first developed at a 1991 meeting in Banff, Canada, set worldwide standards for biopsy interpretation. The Foundation includes working groups that refine classifications based on research feedback. As technologies like stem cell-grown organs emerge, the Foundation must adapt to remain relevant by including new member specialties. The Banff process demonstrates how medical knowledge can advance through collaborative consensus-building.
This document is a poem reflecting on the author's experience with medical meetings over decades. It discusses:
1) Advice the author received early in their career to avoid meetings, as nothing important happens. The author ignored this advice.
2) Over time, the author enjoyed meetings more for social aspects of seeing colleagues, though work was also accomplished.
3) As the author's field changed to regenerative medicine, meetings took on renewed importance for learning and progress in the field to benefit patients. The author now sees meetings as crucial, rather than just social events.
There are a lot of orthopedic conditions and injuries that presently have limited treatment options available.
Here regenerative technologies comes up as a ray of hope among surgeons for the treatment by functionally repairing the tissues and organs using growth factors, stem cells and products developed by genetic engineering with the advancement in the stem cells research field .
The purpose of this presentation is to first provide idea about the orthopedic conditions along with the therapeutic potential of stem cells to treat these diseases.
This document describes the development and evaluation of an interactive stem cell workshop for A-Level biology students. The workshop was designed to provide a broad overview of stem cells, their properties, potential uses, and ethical issues. It was implemented using cooperative and problem-based learning strategies. Students worked in groups on a research task about potential stem cell applications. The workshop was tested in two settings - a museum and a classroom - and received positive feedback, though some changes were recommended. The goal was to improve student understanding of stem cells in an engaging way and contribute to stem cell education resources.
Cartilage Repair using Stem cell & OrthobiologicsVaibhav Bagaria
Regenerating Cartilage is a challenge. What's new in this field of cartilage regeneration and the current status of the stem cell use in this field is described.
Stem cells for artificial organ regenerationElvis Samuel
A stem cell is a cell with the unique ability to develop into specialized cell types in the body. This presentation details the regeneration of artificial organs using stem cells
Abdominal Pain as Initial Presentation of Lung Adenocarcinomaasclepiuspdfs
Isolated celiac lymph node metastasis (ICLNM), in general, is not common with a reported incidence of 5–10% for lung adenocarcinoma. Lung adenocarcinoma rarely metastasizes to the celiac lymph node leading to abdominal pain. It is not typical for ICLNM to be the initial presentation of lung adenocarcinoma as well. In this case, a 56-year-old man presented with a 4-week history of persistent periumbilical dull pain. Workup was remarkable for celiac lymph node mass which turned out to be adenocarcinoma with unknown primary cancer. Whole body position emission tomography scan and biopsy of the mass with immunohistochemistry could identify lung adenocarcinoma as the primary cancer. After a well-informed discussion of options for chemotherapy drugs with the patient, the decision was made to pursue bevacizumab combined with chemotherapeutics. He was charged home with abdominal pain relief and outpatient follow-up after short-course of chemotherapy.
Dr. Kim Solez presents the "Chair's Introduction" and "Medicine Writ Large: The Ultimate in Translational Medicine" at BIT's 4th Annual World Congress of Molecular and Cell Biology, Big Challenges, Huge Opportunities, in Dalian, China on April 26, 2014.
The document discusses the development of an implantable artificial kidney called the bioartificial kidney (BAK). It notes the high mortality rates of acute renal failure and end-stage renal disease. Researchers at UCSF have created a prototype BAK that aims to replace dialysis through a two-stage system using nano-scale filters and living kidney cells. The BAK is being tested and improved with the goal of beginning human clinical trials by 2017. It aims to allow patients a more normal lifestyle compared to traditional dialysis treatment.
Circulating microRNAs predict initial of NHL in a novel in vivo model: impact...Laura Berry
Presented at the 3rd qPCR and Digital PCR Congress: USA. To find out more, visit:
www.global-engage.com
Afshin Beheshti is an Assistant Professor at the Tufts University School of Medicine. In this presentation, Afshin discusses his investigation into age-dependent circulating microRNA signatures that may influence non-Hodgkin lymphoma.
The 16th Annual Scientific Meeting of the Society for Neuro-Oncology and AANS/CNS Section on Tumors was held November 17-20, 2011 in Orange County, CA. Over 1300 participants from 37 countries attended the four day meeting focused on the latest laboratory and clinical research in neuro-oncology. The meeting included education day sessions, morning and afternoon oral presentation sessions on various topics, keynote addresses, award presentations, and poster sessions to facilitate the multidisciplinary exchange of ideas. The successful annual meeting brought together neuro-oncologists, surgeons, pathologists, and other specialists to advance the research, diagnosis, care and treatment of brain tumors.
This document discusses stem cells and tissue homeostasis. It begins by explaining how tissues maintain homeostasis through regeneration after injury using stem cells. The history of regeneration research from the 18th century is then reviewed. Organ transplantation techniques from skin grafting to modern transplants are summarized. The document outlines the types of transplants including autografts, allografts, isografts, and xenografts. Milestones in stem cell research from the late 19th century to recent developments are listed. Limitations of organ transplantation including shortages are noted. The role of stem cell therapy in regenerating tissues is mentioned.
Stem cells have the ability to become specialized cells and work with tissues and organs. There are two types: embryonic stem cells which come from embryos and can differentiate into any cell type, and adult stem cells which are more limited in what cells they can become. Stem cell therapy involves inserting stem cells into injured areas to produce new cells and has been used to treat conditions such as cerebral palsy, Parkinson's disease, and cancers. For spinal cord injuries, researchers are exploring therapies using bone marrow stem cells, cord blood cells, and other cell types which show promise in repairing damage in clinical trials.
This document discusses acute kidney injury (AKI) in patients with COVID-19. It first defines AKI and describes its stages of severity. It then reviews the epidemiology of AKI in COVID-19, finding incidence rates ranging from 5-57% depending on location and study. The main proposed mechanisms of AKI in these patients include direct viral infection of kidney cells, cytokine storm effects, AKI related to acute respiratory distress syndrome, and kidney-lung crosstalk exacerbating injury. Risk factors for developing AKI include older age, male sex, hypertension, diabetes and pre-existing kidney disease. Treatment involves preventing AKI through fluids and avoiding nephrotoxins, with renal replacement therapy used in severe cases
Transition transplant path to tissue engineer path new banff class 2017 Kim Solez ,
Kim Solez "The transition between transplant pathology and tissue engineering pathology: Beginning a new Banff classification - 2017 Update". ATI Fellows Rounds Presentation Spept 12 2017
Solez Stem Cell and Future of TransplantationKim Solez ,
Dr. Kim Solez discusses "Confronting the Question of Stem Cells and the Future of Transplantation" for the Alberta Transplant Institute Fellows Lecture Series on September 2nd, 2014 at the University of Alberta in Edmonton, Canada.
Kim Solez Transplant Pathology Regen Med 2015Kim Solez ,
Dr. Kim Solez presents Transplantation Pathology, Regenerative Medicine, and Where We Go From Here at the Nephrology Core Lecture Series on January 7th, 2015 at the University of Alberta in Edmonton, Canada. See https://www.youtube.com/watch?v=5wfdhB_VyJw
Kim Solez Bridge between transplantation and regenerative medicine vancouver3Kim Solez ,
Dr. Kim Solez presents "Bridge between Transplantation and Regenerative Medicine" at the Banff Transplant Pathology meeting in Vancouver October 5, 2015. Copyright (c) 2015, JustMachines Inc.
Kim Solez Transition transplant path to tissue engineering path new banffKim Solez ,
Dr. Kim Solez Presents "Transition Between Transplant Pathology and Tissue Engineering Pathology: Beginning A New Banff Classification" at the Alberta Transplant Institute Fellows Lecture Series January 10, 2017 at the University of Alberta in Edmonton, Alberta, Canada. Copyright (c) 2017, JustMachines Inc.
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Kim Solez The future and all that jazz tea talkKim Solez ,
The document discusses the changing relationship between humans and artificial intelligence (AI). It notes that AIs will not all be under human control, and instead will compete and cooperate with humans in diverse ways. Mechanisms need to be established to ensure this relationship benefits society. Over time, conventional humans will become less important compared to AIs. The author advocates accepting this change, sharing power with AIs, and including AIs in our circle of empathy. The document also outlines the author's plans to help advance tissue engineering pathology and mainstream AI education.
Solez Update on the Technology and Future of Medicine Course: Space, Regenera...Kim Solez ,
Dr. Kim Solez presents Update on the "Technology and Future of Medicine Course: Space, Regenerative Medicine, Large Touch Screens, and Leonard Cohen" on September 25, 2014 at Lab Medicine Pathology Grand Rounds at the University of Alberta in Edmonton, Canada.
Kim Solez Xenotransplantation- The Rest of the Story April 8 2022 6.pptxKim Solez ,
Nephrology Grand Rounds Presentation at the University of Alberta discussing the big picture issues surrounding xenotransplantation and its relation to stem cell generated organs and bioengineered organs in the future
Kim Solez TEP meets Human Cell Atlas a glimpse into future of pathology winte...Kim Solez ,
Dr. Kim Solez TEP meets Human Cell Atlas Project, a glimpse into future of pathology, Technology and Future of Medicine course February 15, 2018 http://www.singularitycourse.com Copyright (c) 2018, JustMachines Inc.
Kim Solez Tissue Engineering Pathology Meets Human Cell Atlas a Glimpse into ...Kim Solez ,
Dr. Kim Solez presents "Tissue Engineering Pathology Meets Aviv Regev's Human Cell Atlas: A Glimpse Into the Future of Pathology" on March 8th, 2017 at the University of Alberta in Edmonton, Alberta, Canada Copyright (c) 2017, JustMachines Inc.
Stem-cell therapy in medicine–how far we came and what we can expect?Apollo Hospitals
The name ‘stem-cell’ is making the news in recent times both for good and not. The current articles tries to give a snap shot of the scientific and clinical picture of stem-cells in medicine as of today and discuss what it have to offer in the to the mankind. The article discusses the characters and types of stem-cells, their current indication in therapeutics (both established and upcoming), as well as their use in research. It also gives a brief overview of the current laws guiding its use in clinical practice and the various cultural beliefs associated with the use of same.
Ishita Moghe Kim Solez Human cell atlas paradox and what you can do to promot...Kim Solez ,
Ishita Moghe Kim Solez Human cell atlas paradox and what you can do to promote it in context of world future 2018 human purpose. Slide set for Future Day presentation March 1st, 2018. Copyright (c) 2018, JustMachines Inc.
The Banff Classification of kidney transplant pathology began in 1991 to standardize the interpretation of transplant biopsies. It has since evolved and expanded to other organ transplants through biennial meetings. The classification uses lesion scoring and diagnostic categories but faces challenges in applying expensive new techniques like immunostaining in developing countries. Efforts are needed to share pathology resources and training to make the standards accessible worldwide.
This document discusses organ donation shortages in the US and emerging technologies like 3D bioprinting of organs and head transplants as potential solutions. It notes that over 120,000 people are on organ transplant waitlists in the US despite only 2.5 million annual deaths. 3D bioprinting of tissues and organs could help by producing customized organs without rejection risks. The document also discusses a planned first human head transplant by Dr. Sergio Canavero to treat a 30-year-old man's rare genetic disorder that cannot be addressed by gene editing alone. The head transplant would be an attempt to treat the man's condition which currently has a life expectancy of around 20 years.
Stem cell research holds promise to treat many medical conditions but also faces ethical controversies. While embryonic stem cells are fully pluripotent, their use raises concerns about human embryo destruction. Alternatives like induced pluripotency and somatic cell nuclear transfer aim to achieve the benefits of embryonic stem cells without using embryos. Government policies on funding stem cell research have varied between administrations and some regulations are criticized for being hastily made and hindering scientific progress. Overall, stem cell research could help millions but also generates religious and ethical debates around topics like cloning and embryo use that societies are still grappling with.
Kim Solez Seizing the opportunity of technology and the future of medicine c...Kim Solez ,
This document provides biographical details and career highlights of Kim Solez, including her educational background, positions held, awards received, and engagement with students over her career. It notes how early work with students in the 1970s led to an award for best research as a house officer. The document also discusses Solez's views on the future of medicine, including the possibility of eliminating all natural disease but still having social and ethical challenges, as well as new potential specialties in tissue engineering pathology and "apocalyptic pathology". Throughout, it emphasizes Solez's long-standing engagement with and mentorship of students.
Kim Solez Seizing the opportunity of technology and the future of medicine c...Kim Solez ,
Kim Solez Ishita Moghe Seizing the opportunity of technology and the future of medicine creating the possibility of a positive medical future for everyone Medical Grand Rounds Presentation Feb. 1, 2019.
Similar to Kim Solez A renaissance in renal pathology brought about by regenerative medicine (20)
Kim Solez The Ethics of Pig to Human Transplants, Artificial Intelligence, an...Kim Solez ,
Kim Solez is an internationally renowned renal transplant pathologist and educator with over 30 years of experience. He has trained numerous students and published over 230 journal articles. Solez is passionate about advancing regenerative medicine through techniques like xenotransplantation and stem cell-generated organs to address the massive organ shortage. He believes artificial intelligence can help solve some of the complex challenges in making these approaches successful at scale.
Kim Solez DALL-E and Kidney Pathology Machine Fantasies Give Hint About What...Kim Solez ,
The document discusses the author's experience using DALL-E, an AI image generation model, to try generating images related to kidney pathology. The author notes that every prompt results in negotiation with DALL-E, as it has rules to prevent harmful outputs. The author imagines that future versions of DALL-E may be able to generate high-quality pathology images. The document also shares stories about the author's past work with the National Kidney Foundation and an artist named Philippe Hebert.
Kim Solez Clinical Trials, Fundamental DIscoveries and Teaching Renal Transpl...Kim Solez ,
This document discusses the history and importance of tubulitis as a marker for acute T cell-mediated rejection (TCMR) in kidney transplant biopsies. It notes that Kim Solez first described tubulitis in 1985 in biopsies from a cyclosporine-treated protocol study. Tubulitis was later recognized as a crucial finding in the original 1993 Banff Classification article. The specificity of tubulitis for acute TCMR has made it a long-standing focus of morphometric analysis and machine learning in digital pathology. The success of identifying tubulitis has led to its continued importance in evaluating rejection over decades of clinical trials and transplant pathology practice.
Kim Solez How AI can improve human cooperation through suggesting followup ac...Kim Solez ,
The document discusses countering the idea of "AGI ruin", where artificial general intelligence makes humans obsolete. It suggests that instead of ruin, AGI could lead to unprecedented global cooperation that improves humanity. The best way for beneficial, cooperation-enabling ideas from AI to emerge is through a new type of large language model that possesses a true understanding of the world. Such an AI invention could win a Nobel Peace Prize if it helps increase human cooperation and avoids the lethal outcomes feared by some in the AI safety community.
Kim Solez How AI can improve human cooperation through suggesting followup ac...Kim Solez ,
The document discusses the potential outcomes of artificial general intelligence (AGI), including Eliezer Yudkowsky's idea of "AGI ruin" where humans become obsolete. However, AGI could also lead to greater global cooperation that improves humanity. The best way for AI to generate ideas to help human cooperation would be through large language models that have a true understanding of the world. This could help avoid the worst outcomes of AGI and instead create a more positive future of improved human cooperation.
Slide deck for annual meeting of Transplant Regenerative medicine Community of Practice of American Society of Transplantation at noon in Room 204 in John B. Hynes Convention Center. Everyone welcome! Many exciting initiatives to discuss!
Kim Solez Hooking-Up Physical Forces Optimism and Dark Energy Presentation Se...Kim Solez ,
Kim Solez Banff New Media Institute Presentation, "Smart, Sexy, Healthy" ThinkTank, Sept 6 2001
Hooking-Up, Physical Forces, Optimism and Dark Energy: Imagery, Hope, and Health.
Kim Solez combining resources in tx and regen med make no small plansKim Solez ,
This document discusses the future of combining regenerative medicine and transplantation through three main points:
1. Regenerative medicine promises to address longstanding limitations of organ transplantation by providing an inexhaustible source of organs, immunosuppression-free transplantation, and organs on demand.
2. Transplant pathologists are becoming tissue engineering pathologists and playing a role in regenerative medicine through organizations like Banff conferences.
3. A First World Congress of Regenerative and Transplant Medicine is being planned to bring together organizations in these fields to discuss their common future, with the goal of having the meeting in Boston in April 2021.
Solez Yagi Farris Barisoni Digital transplant pathology white paper2Kim Solez ,
This document discusses several digital pathology projects being conducted by Yukako Yagi and her team at Memorial Sloan Kettering Cancer Center. These include developing automated analysis of fluorescence in situ hybridization (FISH) images using deep learning, generating 3D digital images of whole tissue blocks using micro-computed tomography, and evaluating the use of multiplex immunofluorescence staining compared to double immunohistochemistry staining. The goal is to advance computational pathology through innovative applications of digital pathology techniques.
Kim Solez Yukako Yagi Digital transplant pathology white paper1Kim Solez ,
This document discusses digital transplant pathology and proposes initial projects for a working group. It describes how digital pathology can help address declining interest in pathology as a specialty. Only 25 pathology departments were fully digitized in 2018, rising to 30 in 2019. The percentage of US pathology trainees who are US medical graduates has declined in recent years. The document proposes that the working group focus on practical examples and first projects involving digital transplant pathology.
Kim Solez Yukako Yagi Digital transplant pathology white paperKim Solez ,
This document discusses digital transplant pathology and proposes initial projects for a working group. It begins with background on digital pathology and its potential to address declining interest in pathology. Only 30 of over 1000 pathology departments worldwide were fully digitized in 2019. The document then discusses exponentially advancing technologies and influential figures in the field. It proposes that the working group focus on practical digital pathology examples and first projects related to transplant pathology. One such example discussed is automated fluorescence in situ hybridization (FISH) quantification from whole slide images using deep learning.
Kim Solez 384 years of banff spirit new june 26 2019Kim Solez ,
Kim Solez 384 years of Banff spirit new June 26 2019 The most remarkable slide is number 137. "By Spring of 2019 every erroneous statement we complained about had been reversed. We celebrated by creating a new video trailer on our YouTube channel on June 25 2019." How about that!
Kim Solez C3 GN case with 6-8 nm fibrils Congo Red negative Part IIKim Solez ,
The needle core biopsy of the patient's left native kidney showed C3 glomerulopathy with a membranoproliferative glomerulonephritis pattern, which is a form of glomerulonephritis where there is proliferation of cells and increased thickness in the glomerular basement membrane of the kidney.
Kim Solez C3 GN case with 6-8 nm fibrils Congo Red negative Part IKim Solez ,
A 49-year-old female presented with decreased C4 and normal C3 levels. A kidney biopsy showed strong mesangial and vascular staining for C3 on immunofluorescence, but was negative for IgG, IgA, IgM, C1q, kappa, lambda, and albumin. This suggests a diagnosis of C3 glomerulopathy.
Kim Solez shortened slide set for opening reception Pittsburgh Banff meetingKim Solez ,
This document provides a timeline of events and influences in Kim Solez's life and career from 1895 to 2099:
- It outlines the origins of Kim's beliefs in gender and diversity from childhood experiences in the 1940s and highlights various mentors and influences over her career in nephrology pathology.
- Key developments include initiating the Banff Classification of Transplant Pathology in 1991 and directing digital pathology, artificial intelligence, and regenerative medicine research efforts to transition the field into the future.
- The timeline shows Kim's work to establish the future of nephrology through innovations in education, collaborations, and applying emerging technologies like digital pathology and artificial intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
3. Banff Classification of Kidney Transplant Pathology
Histologic criteria for the diagnosis of rejection and
other conditions in the transplanted kidney, began
1991, updated and expanded every two years in
consensus meeting.
4. 1991 First Conference
1993 First Kidney International publication
1995 Integration with CADI
1997 Integration with CCTT classification
1999 Second KI paper. Clinical practice guidelines. Implantation biopsies.
2001 Classification of antibody-mediated rejection: Regulatory agencies
participating
2003 Genomics focus, ptc cell accumulation scoring
2005 Gene chip analysis. Elimination of CAN, identification of chronic
antibody-mediated rejection.
2007 First meeting far from a town called “Banff” – La Coruna, Spain.
2009 Working groups. Meeting in Banff, Alberta, Canada
2013 Establishment of Banff Foundation for Allograft Pathology
5. Significance of ‘Banff papers’
• More than 5,000 citations of the 14 Banff meeting reports
• 915 Banff / Transplantation papers in PubMed
• Banff 2003 meeting report (ABMR criteria) = most cited AJT
paper
• 3 Banff meeting reports are among the top 4 cited AJT articles
7. The Banff Process
Consensus communication in renal transplantation
a
The Banff
lesions
g, i, t, v - score
The Banff
community
Pathologists
Nephrologists
Tx-Surgeons
Lab-Medicine
established by
consensus in 1991
The Banff
classification
Current consensus for
diagnostics
moderated
Banff meetings
thesis-antithesis-synthesis
tentative
thresholds
participate
refinementBanff Working
Groups
Feedback concerning weaknesses and strengths by results
from independent research
New members
Biostaticians
Molecular Biologists
“Omics”-specialists
Off-springs
Liver
Pancreas
Lung, Heart
CTA
8. Organizational structure of the Banff Foundation For Allograft Pathology
Board of Trustees:
K. Solez (Chair), L. Racusen, D. Glotz, J. Demetris, M. Mengel, M. Mihatsch, D. Seron
2015 Local Conference
chair: Michael Mengel
Organ Steering committee
Chairs:
Composite tissues: Linda Cendales
Heart : Patrick Bruneval
Kidney: Mark Haas
Liver: Jake Demetris
Lung: William Wallace and Carol
Farver
Pancreas: Cinthia Drachenberg
Banff Working Group (BWG) Leads:
Molecular transplantation pathology: Michael Mengel, Banu Sis
Isolated v-lesions: Banu Sis, Ed Kraus
Quality assurance in transplantation diagnostics: Michael Mengel and
Parmjeet Randhawa
C4d-negative ABMR: Mark Haas, Banu Sis, Alexandre Loupy
Fibrosis scoring: Robert Colvin, Brad Farris, Michael Mengel
Digital Pathology in Transplantation: Jake Demetris
2015 Scientific program committee:
Alex Loupy (Chair)
Mark Haas, Banu Sis, Kathryn Tinkham, Candice
Rofousse, Chris Bellamy, Lynn Cornell, Carmen
LeFaucheur
Composite tissues: Linda Cendales
Heart : Patrick Bruneval
Liver: Jake Demetris
Lung: William Wallace and Carol Farver
Pancreas/Islets: Cinthia Drachenberg and John
Papadimitriou
Secretary/Treasurer:
Michael Mengel
funding
collaboration
reports to
reports to
collaboration
collaboration
reports to
collaboration
progress
reports to Budged
proposal and
accountability
for meeting
costs
support
20. Many problems with stem cell generate
organs not being discussed. Do not exclude
yourself from the action in this area!
21. Many problems with stem cell generate
organs not being discussed. Need to get
those conversations to happen.
The recellularized organ clots like crazy, impossible to
regenerate more than 80% of endothelial surface. Artificial
heparized surface not fenestrated. Cell traffic abnormal.
Hard to get right types of cells to right places.
Podocytes seems to be terminally differentiated cells,
when attempt to culture them they turn into different type of
cell.
Kidney progenitor stem cell difficult to identify, kidney work
has lagged behind.
Easy to make stem cell generated kidneys that lack loop of
Henle. Could produce lethal polyuria. What is “function”?
Many old fashioned questions of physiology about how the
stem cell generated organ works, not just true for kidney,
true for every organ.
22. Transplant
pathologists will also
become tissue
engineering
pathologists,
pathologists who
analyse organs grown
from stem cells. This is
not something beyond
us, we can adapt to a
work life that includes
stem cells.. Someone
needs to cross the
disciplines,
23. Many of the questions
that need to be posed
about stem cell
generated organs are old
fashioned questions,
intact nephron
hypothesis, cell
regeneration, stunned
myocardium, contraction
band necrosis etc. Use
your nostalgia! Stimulate
conversations between
stem cell researchers and
transplant physicians.
24. Beginning at the Very Beginning!
“We are at the very beginning of time for the human race. It
is not unreasonable that we grapple with problems. But
there are tens of thousands of years in the future. Our
responsibility is to do what we can, learn what we can,
improve the solutions, and pass them on.” - Richard P.
Feynman, (1918-1988) Physicist, Nobel Prize Winner
"The sense of the future is behind all good policies. Unless
we have it, we can give nothing either wise or decent to
the world." - Snow CP, (1905-1980) Novelist and
Philosopher.
"To a large extent, the future lies before us like a vast
wilderness of unexplored reality. The God who created and
sustained the evolving universe through eons of progress
and development has not placed our generation at the tag
end of the creative process. God has placed us at a new
beginning. We are here for the future." - Sir John
Templeton (1912-2008 ), Financial Analyst
25. Beginning at the Very Beginning!
Like 1851 when the first International Classification of
Diseases was presented in the Grand Exhibition of
Technology at London’s Crystal Palace
Emphasis was on cause of death
26. Classification focus is on sustaining life.
Native and transplanted organ diseases can also occur in
tissue engineered organs.
The classification focus of the new pathology discipline of
Regenerative Medicine/Tissue Engineering Pathology is
exactly the opposite of traditional classification of disease
which starts with causes of death. In Regenerative
Medicine/Tissue Engineering Pathology the emphasis is on
the degree of normality necessary to sustain life:
Normal,
Abnormalities of unknown functional significance,
Abnormalities which will impair the main functions of the
organ,
Abnormalities leading to severe organ dysfunction where
function may not be great enough to sustain life.
27. Song et al. Interstitium, vessels, and glomeruli with missing cells.
Disordered tubule formation with multiple interconnecting
lumina of differing sizes. “Can you really call this a kidney?” (Yes!)
28. Song et al. In addition to missing cells and disordered structures,
you have cells in the wrong places. Podocytes in the interstitium.
29. Focus of Tissue Engineering Pathology
The focus of tissue engineering pathology will shift to
the question: “Is this organ structurally intact enough to
function safely and adequately in the recipient?” Using
the kidney as an example, the specific questions
become: (Images by Korey Fung)
1. Are there too many missing cells, distorted
structures for the organ to function adequately?
30. Focus of Tissue Engineering Pathology
The focus of tissue engineering pathology will shift to
the question: “Is this organ structurally intact enough to
function safely and adequately in the recipient?” Using
the kidney as an example, the specific questions
become: (Images by Korey Fung)
2. Are there too many cells in the wrong places (e.g.
podocytes in the interstitium)
31. Focus of Tissue Engineering Pathology
(Images by Korey Fung)
3. Are there missing/distorted structural elements that
represent a risk to the patient? (missing loops of Henle
causing lethal polyuria)
32. Focus of Tissue Engineering Pathology
Using the kidney as an example, the specific questions
become:
4. Is there too much endothelial disruption
for the organ to be properly perfused?
5. What are the risks of neoplastic transformation?
Classification categories should be not one-off, but
reproducible, generalizable.
Tissue engineering pathology has been up to now
really dull, since most reports were of scaffolds with no
inflammatory reaction "Move along, nothing to see
here" pathology, but from today becomes really
exciting with novel morphological changes and lives
hanging in the balance!
33.
34.
35.
36. Acceptance. Share power. The AIs will not all be under
our control. They will compete and cooperate with us
just like other people, except with greater diversity and
asymmetries
We need to set up mechanisms (social, legal, political,
cultural) to ensure that this works out well
Inevitably, conventional humans will be less important
Step 1: Lose your sense of entitlement
Step 2: Include AIs in your circle of empathy