Dr. Kim Solez The future and all that jazz tea talk for Thursday June 9th, 2016.

1. Kim Solez, MD

2. Acceptance. Share power. The AIs will not all be under
our control. They will compete and cooperate with us
just like other people, except with greater diversity and
asymmetries
We need to set up mechanisms (social, legal, political,
cultural) to ensure that this works out well
Inevitably, conventional humans will be less important
Step 1: Lose your sense of entitlement
Step 2: Include AIs in your circle of empathy

3. What Human Beings Will Look Like in
2045!

4. Nephrologists & Renal Pathologists May
Be Only People Still Employed in 2045!

5. 25 years ago Kim Solez and Lorraine Racusen
Directed the First Banff Meeting Which Created
the Banff Classification of Transplant Pathology

6. Banff Classification of Kidney Transplant Pathology
Histologic criteria for the diagnosis of rejection and
other conditions in the transplanted kidney, began
1991, updated and expanded every two years in
consensus meeting.

7.  1991 First Conference
 1993 First Kidney International publication
 1995 Integration with CADI
 1997 Integration with CCTT classification
 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies.
 2001 Classification of antibody-mediated rejection: Regulatory agencies
participating
 2003 Genomics focus, ptc cell accumulation scoring
 2005 Gene chip analysis. Elimination of CAN, identification of chronic
antibody-mediated rejection.
 2007 First meeting far from a town called “Banff” – La Coruna, Spain.
 2009 Working groups. Meeting in Banff, Alberta, Canada
 2013 Establishment of Banff Foundation for Allograft Pathology

8. Significance of ‘Banff papers’
• More than 5,000 citations of the 14 Banff meeting reports
• My work has 17,000 citations.
• 962 Banff / Transplantation papers in PubMed
• Banff 2003 meeting report (ABMR criteria) = most cited
American Journal of Transplantation paper
• 3 Banff meeting reports are among the top 4 cited AJT articles

9. Tissue Engineering Pathology Added Soon!
•

10. The Banff Process
Consensus communication in renal transplantation
a
The Banff
lesions
g, i, t, v - score
The Banff
community
Pathologists
Nephrologists
Tx-Surgeons
Lab-Medicine
established by
consensus in 1991
The Banff
classification
Current consensus for
diagnostics
moderated
Banff meetings
thesis-antithesis-synthesis
tentative
thresholds
participate
refinementBanff Working
Groups
Feedback concerning weaknesses and strengths by results
from independent research
New members
Biostaticians
Molecular Biologists
“Omics”-specialists
Off-springs
Liver
Pancreas
Lung, Heart
CTA

11. Organizational structure of the Banff Foundation For Allograft Pathology
Board of Trustees:
K. Solez (Chair), L. Racusen, D. Glotz, J. Demetris, M. Mengel, M. Mihatsch, D. Seron
2015 Local Conference
chair: Michael Mengel
Organ Steering committee
Chairs:
Composite tissues: Linda Cendales
Heart : Patrick Bruneval
Kidney: Mark Haas
Liver: Jake Demetris
Lung: William Wallace and Carol
Farver
Pancreas: Cinthia Drachenberg
Banff Working Group (BWG) Leads:
Molecular transplantation pathology: Michael Mengel, Banu Sis
Isolated v-lesions: Banu Sis, Ed Kraus
Quality assurance in transplantation diagnostics: Michael Mengel and
Parmjeet Randhawa
C4d-negative ABMR: Mark Haas, Banu Sis, Alexandre Loupy
Fibrosis scoring: Robert Colvin, Brad Farris, Michael Mengel
Digital Pathology in Transplantation: Jake Demetris
2015 Scientific program committee:
Alex Loupy (Chair)
Mark Haas, Banu Sis, Kathryn Tinkham, Candice
Rofousse, Chris Bellamy, Lynn Cornell, Carmen
LeFaucheur
Composite tissues: Linda Cendales
Heart : Patrick Bruneval
Liver: Jake Demetris
Lung: William Wallace and Carol Farver
Pancreas/Islets: Cinthia Drachenberg and John
Papadimitriou
Secretary/Treasurer:
Michael Mengel
funding
collaboration
reports to
reports to
collaboration
collaboration
reports to
collaboration
progress
reports to Budged
proposal and
accountability
for meeting
costs
support

12. The World is Changing Rapidly!

13. The World is Changing Rapidly!

14. The World is Changing Rapidly!

15. The World is Changing Rapidly!

16. The Technological
Singularity

17. Podocytes go wandering into the
interstitium! Song et al.

18. Song et al. Interstitium, vessels, and glomeruli with missing cells.
Disordered tubule formation with multiple interconnecting
lumina of differing sizes. “Can you really call this a kidney?” (Yes!)

27. Acceptance. Share power. The AIs will not all be under
our control. They will compete and cooperate with us
just like other people, except with greater diversity and
asymmetries
We need to set up mechanisms (social, legal, political,
cultural) to ensure that this works out well
Inevitably, conventional humans will be less important
Step 1: Lose your sense of entitlement
Step 2: Include AIs in your circle of empathy

28. Plans Invigorated by Mentoring
Award:
1. Tissue Engineering Pathology
2. Mainstreaming AI & Future
Education (Rich Sutton)
3. The Future and All That Jazz
(Mallory Chipman)

29. The Future and All That Jazz

30. Future and All That Jazz:
1. Two local prototype events January
19th and March 8th at Rouge Lounge.
2. Event planned in London August 16th-
17th.
3. Correcting imbalance between 9,000
people we are reaching & 80 million
reached by Big Bang Theory.

31. Life Sized Cutout of Sheldon
(Big Bang Theory) Reminds Us