This document summarizes key information about different types of soft tissue tumors: 1) It defines soft tissue tumors as mesenchymal in origin and classifies them as either benign or malignant. Common risk factors include radiation, chemicals, viruses, and genetic predispositions. 2) It describes the main types of soft tissue tumors - adipose, smooth, skeletal, fibriohistio, and vascular - and examples of benign and malignant tumors in each category. 3) It provides brief descriptions of fibrous histiocytoma, liposarcoma, rhabdomyosarcoma, and synovial sarcoma - covering epidemiology, location, histological features, and diagnosis. Soft tissue sar

1. JOINTS 3 Tumour of
Soft Tissue
Def = tumour with mesenchymal origin
Class
Benign
Malignant (rare, often males)
Patho = poorly understood
RF
Radiation
Chem. (venyl chloride)
Viruses (e.g. kaposi)
Genetic (e.g. Li fraumeni)
Type
Adipose
lipoma
liposarcoma
Smooth
leiomyoma
leiomyosarcoma
Skeletal
rhabdomyoma
rhabdomyosarcoma
Fibriohistio
fibrous histiocytoma
malig. fib. histiocytoma
Vascular
hemangioma
angiosarcoma
Perip. nerve
neurofibroma
malig. perip. nerve
Synovial sarcoma
Fibrious
Histiocytoma
Most common soft tissue tumour
Site = deep soft tissue in the trunk
Epid. = elderly (> 50 yo)
Liposarcoma
2nd most common malignat soft tissue tumour
Epid. = older adult (> 40 yo)
Dx = presence of lipoblast
Rhabdomyosarcoma
Has skeletal muscle differentia.
Most common sarcoma in childhood
Dx = presence of rhabdomyoblast
Synovial
Sarcoma
Epid. = adolescent & young adult (15-40 yo)
Histo = epitheliod & spindle cell components
Site = prox. to joint but do not arise from synov.
Soft
Tissue
Sarcoma
Prognos.
factor
Histo. type
Grade, Stage, Location
Dx
Histo. examination
Immunohistochem.
vimentin
desmin
actin
Molec.
very important!!!
might hv gen. abnormality
e.g. Ewing (EWS/FLI1)
JOINTS 3.mmap - 06/01/2010 - Mindjet