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Bone 1
- 1. BONE 1 Bone Recap Normal bone Organic matrix type 1 collagen proteoglycan Inorganic component Cells Osteoprogenitor (produce osteoblast) Osteoblast ( produce osteoid) woven bone lamellar bone Osteocytes Osteoclast (monocytes to breakdown osteoid) Tissues of bone Periosteum - fibrous tissue outermost cover of bone Compact bone - hard & dense bone tht cover bone Spongy bone lighter bone commonly found at the end & inner part Medullary cavity - located in the shaft of long bone Cartilage - provide smooth articulation betw. bones Structure Epiphysis - end of long bone Metaphysis - between epiphysis & diaphysis Diaphysis - the shaft Medullary canal - contain bone marrow Ossification Enchondral bone from cartilage during foetal, bone contain cartilage as develop, ossification occurs gradual replacement of cartilage SIte = long bone, facial bone, vertebra Intramembranous bone from connec. tissue periosteum become osteoblast Site = cranial bone Formation of bone Production of osteoid Mineralization of osteoid Remodeling by resorption & reformation Fx Vit. D = induce bone resorption by osteoclast PTH = induce bone resorption by osteoclast Calcitonin = suppress bone resorption by osteoclast Congenital Bone Disorder Achondroplasia Osteogenesis imperfecta Osteopetrosis Achondroplasia A common cause of dwarfism Patho = reduction in chondrocyte prolif. Effect = premature ossification --> dwarfism Types Hereditary - autosomal dominant Heterozygotes (normal mental & sexual) Homozygotes - die shortly after birth Feature Shortening of long bones Severe spinal canal stenosis (painful) Osteogenesis Imperfecta Def = disorder of collagen type 1 Feature Hereditary (most AD) can be lethal in utero Effect Fractures Blue sclera Dental abnormalities Hearing loss Osteopetrosis Def = disease which bone harden, become denser Feature Extremely rare inherited disease Known as marble bone disease Patho Osteoclast dysfunction (abnormal) --> Failure of bone resorption --> Increase in bone mass Result sclerosis & bone fracture hydrocephalus & cr. nerve palsy Patho 2 Bone fills the medullary cavity Result anaemia & neutopenia hepatosplenomegaly Tx = bone marrow transplant BONE 1.mmap - 06/01/2010 - Mindjet