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Bone 2
- 1. BONE 2 Osteoporosis Feature common disorder progressive reduction in bone mass mineralization is normal RF Female Asian or Caucasian Sedentary lifestyle Smoking Causes Primary senile post menopausal (fall oestrogen) genetic (vit. D rcptor polymorphy) 2ndary immobility insufficient Ca intake drugs (steroid) Patho decrease bone resorption by osteoclast decrease bone formation Effect = thinning & increase porosity of bone Complic. Bone pain & fracture Loss of height Deformity Dx Imaging (Dexa scan) - measure bone density FBC, ESR, U&E, Ca, Phos X ray Tx Exercise Oral calcium & vit. D H,R.T Calcitonin or biphosphonate Osteomalacia & Rickets Feature Inadequate mineralization Osteoid production is normal Ricket in children (deformities) lack of osteoid mineralization Osteomalacia = in adult (fracture) Causes Dietary lack or malabsorption Chronic renal failure Liver disease Inadeuate exposure to sunlight Deformity in Rickets Deformity of the skull Thickening of knees, wrist Enlargement of costochondral jnction Pigeon's chest (protrusion of sternum) Effect in Osteomalac. bone pain microfracture Tx Vitamin D BONE 2.mmap - 06/01/2010 - Mindjet