- The English established their first permanent colony at Jamestown, Virginia in 1607 under the Virginia Company of London. The colony struggled initially with disease and lack of supplies. - Under the leadership of John Smith, the colony became organized and began growing tobacco for profit. However, after Smith left, the colony suffered through the "Starving Time" winter where few survived. - The colony stabilized with the arrival of more settlers and supplies. It established the first representative government in America, the House of Burgesses, and became the first English colony to have slaves and indentured servants arrive. Conflict with native Powhatan people continued sporadically.