1. The document discusses various terpenoids found in plants including iridoids, naphthoquinones, and modified terpenoids. It provides details on the extraction, chemical constituents, and uses of specific terpenoids like gentian, artemisia, taxus.
2. Gentian root contains the bitter iridoid glycoside gentiopicrin which is used as a tonic and for digestive issues. Artemisia contains the antimalarial sesquiterpene lactone artemisinin. Taxus bark contains the anticancer diterpenoids paclitaxel and docetaxel.
3. The document provides information to help identify and understand these important
This document provides information on the extraction and identification of several phytoconstituents including curcumin, artemisinin, atropine, citral, menthol, caffeine, and reserpine. For each constituent, it describes the biological source, properties, extraction method from the source, and thin layer chromatography conditions and results for identification, including mobile phase, detecting agent, and Rf value.
Unit II Introduction to secondary metabolite
Phenylpropanoids and Flavonoids: Lignans, Tea, Ruta
For video lecture join to youtube channel snehal chakorkar
The document discusses various concepts and techniques used in phytochemistry including modern extraction methods like maceration, percolation, Soxhlet extraction and supercritical fluid extraction. It also covers isolation and purification techniques like fractional crystallization, distillation and sublimation. Methods of separation like paper chromatography, thin layer chromatography, gas chromatography and various spectroscopy techniques for identification are summarized.
Unit II Introduction to secondary metabolite
Volatile oils
Mentha, Clove, Cinnamon, Fennel, Coriander.
For video lecture suscribe yutube channel snehal chakorkar
Isolation, Identification and Analysis of PhytoconstituentsDr. Siddhi Upadhyay
1) The document discusses the isolation, extraction and identification of various phytoconstituents like terpenoids, glycosides, alkaloids and resins.
2) Extraction methods like solvent extraction, fractional crystallization and chromatography are described for menthol, citral, artemisin, glycyrrhetinic acid, rutin, atropine, quinine, reserpine, caffeine and podophyllotoxin.
3) Identification tests include chemical tests and thin layer chromatography. Rf values are provided for comparison with reference standards.
Chaulmoogra oil is a fixed oil obtained from seeds of various Hydnocarpus species found in Myanmar. It contains chaulmoogric acid and hydnoctic acid as major constituents. Chaulmoogra oil has bactericidal effects against Mycobacterium leprae and M. tuberculosis, making it useful in the treatment of leprosy, tuberculosis, psoriasis, and rheumatism. It is administered by intramuscular or subcutaneous injection.
Unit II Introduction to secondary metabolite
Steroids, Cardiac Glycosides & Triterpenoids:
Liquorice, Dioscorea, Digitalis
For video lecture suscribe youtube channel snehal chakorkar.
This document provides information on the extraction and identification of several phytoconstituents including curcumin, artemisinin, atropine, citral, menthol, caffeine, and reserpine. For each constituent, it describes the biological source, properties, extraction method from the source, and thin layer chromatography conditions and results for identification, including mobile phase, detecting agent, and Rf value.
Unit II Introduction to secondary metabolite
Phenylpropanoids and Flavonoids: Lignans, Tea, Ruta
For video lecture join to youtube channel snehal chakorkar
The document discusses various concepts and techniques used in phytochemistry including modern extraction methods like maceration, percolation, Soxhlet extraction and supercritical fluid extraction. It also covers isolation and purification techniques like fractional crystallization, distillation and sublimation. Methods of separation like paper chromatography, thin layer chromatography, gas chromatography and various spectroscopy techniques for identification are summarized.
Unit II Introduction to secondary metabolite
Volatile oils
Mentha, Clove, Cinnamon, Fennel, Coriander.
For video lecture suscribe yutube channel snehal chakorkar
Isolation, Identification and Analysis of PhytoconstituentsDr. Siddhi Upadhyay
1) The document discusses the isolation, extraction and identification of various phytoconstituents like terpenoids, glycosides, alkaloids and resins.
2) Extraction methods like solvent extraction, fractional crystallization and chromatography are described for menthol, citral, artemisin, glycyrrhetinic acid, rutin, atropine, quinine, reserpine, caffeine and podophyllotoxin.
3) Identification tests include chemical tests and thin layer chromatography. Rf values are provided for comparison with reference standards.
Chaulmoogra oil is a fixed oil obtained from seeds of various Hydnocarpus species found in Myanmar. It contains chaulmoogric acid and hydnoctic acid as major constituents. Chaulmoogra oil has bactericidal effects against Mycobacterium leprae and M. tuberculosis, making it useful in the treatment of leprosy, tuberculosis, psoriasis, and rheumatism. It is administered by intramuscular or subcutaneous injection.
Unit II Introduction to secondary metabolite
Steroids, Cardiac Glycosides & Triterpenoids:
Liquorice, Dioscorea, Digitalis
For video lecture suscribe youtube channel snehal chakorkar.
Unit-III Pharmacognosy and Phytochemistry II.
Isolation, Identification and Analysis of Phytoconstituents
a) Terpenoids: Menthol, Citral, Artemisin
b) Glycosides: Glycyrhetinic acid & Rutin
c) Alkaloids: Atropine, Quinine, Reserpine, Caffeine
d) Resins: Podophyllotoxin, Curcumin
Benzoin is a balsamic resin obtained from incisions made on several species of Styrax trees native to Southeast Asia. There are two main types - Sumatra benzoin from Styrax benzoin and Siam benzoin from Styrax tonkinesis. Sumatra benzoin contains a higher amount of benzoic and cinnamic acids which give it an aromatic odor. Siam benzoin contains mainly coniferyl benzoate and has a vanilla-like odor. Both types are used as expectorants and antiseptics in preparations like compound tincture of benzoin. They are also used industrially to add fragrance to products.
ISOLATION IDENTIFICATION of alkaloids atropine and quinine.pptxSnehalKashid1
This document discusses the isolation, identification, and analysis of the alkaloids atropine and quinine. It describes how atropine is extracted from plants like belladonna through solvent extraction and crystallization. Tests for identifying atropine include TLC and the Vitalin-morin test. Uses of atropine include treating low heart rate and as an antidote. The isolation of quinine from cinchona bark is also outlined, involving extraction with benzene and crystallization of quinine sulfate. Quinine is used as an antimalarial and quinidine for cardiac arrhythmias.
This document summarizes formulations for various cosmetic preparations including lipsticks, shampoos, cold cream, vanishing cream, toothpastes, hair dyes, and sunscreens. It provides information on the definition, key ingredients, preparation methods, and evaluation of these products. The main formulations covered are lipsticks, shampoos, cold cream, and toothpastes. It also briefly discusses packaging materials science and factors that influence the choice of packaging for pharmaceutical products.
The document discusses various modern extraction methods used to isolate active constituents from plants. It describes extraction as removing constituents using solvents, with the goal of separating medicinally active portions from inactive components. Several solvent extraction techniques are outlined, including maceration, percolation, Soxhlet extraction, and ultrasound extraction. Key factors in solvent selection and achieving an efficient extraction are also summarized.
Utilization of radioactive isotopes in the investigation of biogenetic studiesMs. Pooja Bhandare
Isotopes: TWO TYPES OF ISOTOPES,Radioactive isotopes.
Stable isotopes, Radiolabelled Tracers ( Radiolabelled compounds), Radiotracer Technique, Steps in Tracer Technique,
Selection of Radioisotopes.
Preparation of Radioisotopes.
Introduction/Insertion of Radiolabelled compound in biological system (Plant part) Seperation and determination of labelled compound in various biochemical reaction, Preparation of labelled compounds : Insertion of Radiolabelled compound in plant part, Root feeding, Stem feeding, Direct Injection, Floating Methods, Spray technique, Separation or Isolation of Radiolabelled compound and detection of radioisotope labelled compound. Detection and assay of Radioactive labelled compound, Detector system used (Analysis of Isotopic content). Method in Tracer Technique,
Precursor – Product sequence
Double and Multiple Labelling
. Competitive Feeding,Sequential Analysis
Applications of Tracer Technique
Utilization of radioactive isotopes in biosynthetic pathwayPOOJA KHANPARA
This document discusses using radioactive isotopes to study biogenesis by grafting mutant plant strains and observing enzymatic reactions, including reactions involving methyl magnesium bromide, hydroxy magnesium bromide, and acetic acid.
Metabolic Pathways in Higher Plants and their DeterminationDr. Siddhi Upadhyay
a) Brief study of basic metabolic pathways and formation of different secondary metabolites through these pathways- Shikimic acid pathway, Acetate pathways and Amino acid pathway.
b) Study of utilization of radioactive isotopes in the investigation of Biogenetic studies.
Cyanogenetic glycosides are plant compounds containing hydrocyanic acid. Amygdalin, isolated from bitter almonds in 1830, is a prominent example. These glycosides contain derivatives of mandelonitrile that yield hydrocyanic acid and benzaldehyde upon hydrolysis. Over 110 plant families contain cyanogenetic glycosides, with Rosaceae being prominent. While not exhibiting specific pharmacological activity, some cyanogenetic glycosides like amygdalin and prunasin are used as flavorings. Identification involves hydrolysis releasing hydrocyanic acid, changing sodium picrate to sodium purpurate. Bitter almonds contain the cyanogenetic glycoside amygdalin, which produces hydrocyanic acid and benzaldehyde upon
Turmeric is obtained from the dried rhizomes of the plant Curcuma longa. It contains the yellow chemical curcumin, which makes up 50-60% of turmeric. Curcumin can be isolated from turmeric powder through extraction with alcohol or hexane followed by acetone. Curcumin is identified through chemical tests where it produces a crimson color with sulfuric acid or a reddish brown color with boric acid that turns greenish blue with alkali. Curcumin content can be analyzed using methods like HPLC, where it shows peaks at specific retention times when separated using a Nucleosil NH2 column with ethanol mobile phase and UV detection at 254nm.
This document provides a scheme for describing Cinchona bark, including its origin from various Cinchona species, macroscopic and microscopic features, and chemical tests. Key points include:
- Cinchona bark comes from dried stems and roots of Cinchona succirubra, C. ledgeriana, C. calisaya, and C. officinalis.
- Microscopic transverse section shows cork, cortex with starch granules and secretion canals, and phloem with phloem fibers and parenchyma containing calcium oxalate prisms.
- Powdered bark shows fragments of cork cells, idioblasts containing calcium oxalate microprisms, and phloem fibers and
This document discusses the isolation, identification, and analysis methods for several important phytoconstituents including menthol, citral, curcumin, atropine, quinine, reserpine, caffeine, artemisinin, glycyrrhizin, rutin, and podophyllotoxin. Extraction is typically done using solvent extraction methods like steam distillation or soxhlet extraction. Isolation involves separation techniques like chromatography. Identification tests include chemical color reactions and thin layer chromatography to determine Rf values. Analysis uses methods like gas chromatography, high performance liquid chromatography, and confirmation against reference standards.
The document summarizes information about the plant Catharanthus roseus, commonly known as Vinca or Periwinkle. It is native to Madagascar but cultivated in other tropical and subtropical regions. The plant contains important anticancer alkaloids vinblastine and vincristine in its leaves and roots. Vinblastine is used to treat Hodgkin's disease while vincristine is used for childhood leukemia. The flowers may also be used as a gentle laxative or gargle.
Swathi Gariganti is an assistant professor at Sree Dattha Institute of Pharmacy who teaches subjects related to pharmacognosy and phytochemistry. This document provides details about the plant Catharanthus roseus including its synonyms, biological source, geographical source, history of use, cultivation and collection methods, macroscopic and microscopic characters, chemical constituents, uses, and dose. It also summarizes information on the cultivation, collection, and chemical constituents of Rauwolfia serpentina.
This document discusses various terpenoid compounds found in plants, including iridoids, terpenes, and modified terpenoids. It provides classifications of terpenoids based on carbon atom count and discusses the occurrence, extraction, biosynthesis, and biological activities of specific compounds like iridoids, gentian, picrorhiza, quassia, tinospora, artemisia, taxus, and andrographis. Structures of important constituents from each plant are also shown.
Industrial production,estimation and utilization of DiosgeninNadeemSiddiqui37
The document discusses diosgenin, a precursor used in pharmaceuticals like oral contraceptives. It is commonly extracted from Dioscorea zingiberensis tubers using acid hydrolysis. The document outlines methods to extract and isolate diosgenin from plant materials like seeds and hairy roots, such as refluxing with sulfuric acid and eluting with hexane. Analytical methods to analyze diosgenin are also presented, including thin layer chromatography using antimony trichloride as a detecting agent. Diosgenin is useful as it can be used in progesterone semi-synthesis and produces estrogenic activity.
The document discusses Indian gum, also known as gum acacia or gum arabic. It is a dried exudate obtained from the stems and branches of the Acacia arabica tree. Chemically, it is a complex mixture of glycoproteins and polysaccharides. It is collected by making cuts in the bark of the tree, then dried and processed. Gum acacia is used extensively in pharmaceuticals as an emulsifier, thickening agent, and tablet binder. It is also used in food products and cosmetics for its adhesive and thickening properties.
Pharmacognosy of Rauwolfia serpentina, biological source, geographical source, marphology of roots and rhizome, microscopy of roots, chemical constituents- reserpine, uses -antihypertensive, isolation of reserpine, serpagandha, India snake root
This document defines key terms related to herbal medicines and describes herbal materials, preparations, and products. It defines an herb as a plant used for medicinal purposes. Herbal medicines use plants to treat or prevent illness. Herbal medicinal products contain exclusively herbal substances or preparations as the active ingredient. Herbal preparations, such as extracts or tinctures, are the basis for finished herbal products and are produced through various extraction or processing methods. Finished herbal products consist of one or more herbal preparations from one or more plant sources, with or without additional excipients. The document also discusses good agricultural practices for cultivating medicinal plants, including organic farming and pest management techniques.
This document discusses several classes of plant secondary metabolites including iridoids, naphthoquinones, gentian, artemisia, taxus, and carotenoids. Iridoids are monoterpenoids found in many plants and are derived from 8-oxogeranial. Naphthoquinones are related to naphthalene and include common isomers like 1,2-naphthoquinone and 1,4-naphthoquinone. Gentian contains iridoid glycosides like gentiopicrin which give it bitter properties. Artemisia contains essential oils and compounds like santonin. Taxus contains the potent anticancer compound taxol. Carotenoids
This document discusses terpenes and terpenoids. It defines terpenes and terpenoids, describes their classification based on carbon atoms and rings, and lists some general properties. Examples of specific terpenoids are then discussed in more detail, including their active ingredients, uses, and mechanisms of action. These include monoterpenoids like camphor and peppermint oil, sesquiterpenoids like clove, diterpenoids like taxus, and polyterpenoids like saffron. The document concludes by describing a study that isolated, purified, and characterized crocetin beta-D-glucosyl ester from saffron and explored its anti-cancer activities and binding properties.
Unit-III Pharmacognosy and Phytochemistry II.
Isolation, Identification and Analysis of Phytoconstituents
a) Terpenoids: Menthol, Citral, Artemisin
b) Glycosides: Glycyrhetinic acid & Rutin
c) Alkaloids: Atropine, Quinine, Reserpine, Caffeine
d) Resins: Podophyllotoxin, Curcumin
Benzoin is a balsamic resin obtained from incisions made on several species of Styrax trees native to Southeast Asia. There are two main types - Sumatra benzoin from Styrax benzoin and Siam benzoin from Styrax tonkinesis. Sumatra benzoin contains a higher amount of benzoic and cinnamic acids which give it an aromatic odor. Siam benzoin contains mainly coniferyl benzoate and has a vanilla-like odor. Both types are used as expectorants and antiseptics in preparations like compound tincture of benzoin. They are also used industrially to add fragrance to products.
ISOLATION IDENTIFICATION of alkaloids atropine and quinine.pptxSnehalKashid1
This document discusses the isolation, identification, and analysis of the alkaloids atropine and quinine. It describes how atropine is extracted from plants like belladonna through solvent extraction and crystallization. Tests for identifying atropine include TLC and the Vitalin-morin test. Uses of atropine include treating low heart rate and as an antidote. The isolation of quinine from cinchona bark is also outlined, involving extraction with benzene and crystallization of quinine sulfate. Quinine is used as an antimalarial and quinidine for cardiac arrhythmias.
This document summarizes formulations for various cosmetic preparations including lipsticks, shampoos, cold cream, vanishing cream, toothpastes, hair dyes, and sunscreens. It provides information on the definition, key ingredients, preparation methods, and evaluation of these products. The main formulations covered are lipsticks, shampoos, cold cream, and toothpastes. It also briefly discusses packaging materials science and factors that influence the choice of packaging for pharmaceutical products.
The document discusses various modern extraction methods used to isolate active constituents from plants. It describes extraction as removing constituents using solvents, with the goal of separating medicinally active portions from inactive components. Several solvent extraction techniques are outlined, including maceration, percolation, Soxhlet extraction, and ultrasound extraction. Key factors in solvent selection and achieving an efficient extraction are also summarized.
Utilization of radioactive isotopes in the investigation of biogenetic studiesMs. Pooja Bhandare
Isotopes: TWO TYPES OF ISOTOPES,Radioactive isotopes.
Stable isotopes, Radiolabelled Tracers ( Radiolabelled compounds), Radiotracer Technique, Steps in Tracer Technique,
Selection of Radioisotopes.
Preparation of Radioisotopes.
Introduction/Insertion of Radiolabelled compound in biological system (Plant part) Seperation and determination of labelled compound in various biochemical reaction, Preparation of labelled compounds : Insertion of Radiolabelled compound in plant part, Root feeding, Stem feeding, Direct Injection, Floating Methods, Spray technique, Separation or Isolation of Radiolabelled compound and detection of radioisotope labelled compound. Detection and assay of Radioactive labelled compound, Detector system used (Analysis of Isotopic content). Method in Tracer Technique,
Precursor – Product sequence
Double and Multiple Labelling
. Competitive Feeding,Sequential Analysis
Applications of Tracer Technique
Utilization of radioactive isotopes in biosynthetic pathwayPOOJA KHANPARA
This document discusses using radioactive isotopes to study biogenesis by grafting mutant plant strains and observing enzymatic reactions, including reactions involving methyl magnesium bromide, hydroxy magnesium bromide, and acetic acid.
Metabolic Pathways in Higher Plants and their DeterminationDr. Siddhi Upadhyay
a) Brief study of basic metabolic pathways and formation of different secondary metabolites through these pathways- Shikimic acid pathway, Acetate pathways and Amino acid pathway.
b) Study of utilization of radioactive isotopes in the investigation of Biogenetic studies.
Cyanogenetic glycosides are plant compounds containing hydrocyanic acid. Amygdalin, isolated from bitter almonds in 1830, is a prominent example. These glycosides contain derivatives of mandelonitrile that yield hydrocyanic acid and benzaldehyde upon hydrolysis. Over 110 plant families contain cyanogenetic glycosides, with Rosaceae being prominent. While not exhibiting specific pharmacological activity, some cyanogenetic glycosides like amygdalin and prunasin are used as flavorings. Identification involves hydrolysis releasing hydrocyanic acid, changing sodium picrate to sodium purpurate. Bitter almonds contain the cyanogenetic glycoside amygdalin, which produces hydrocyanic acid and benzaldehyde upon
Turmeric is obtained from the dried rhizomes of the plant Curcuma longa. It contains the yellow chemical curcumin, which makes up 50-60% of turmeric. Curcumin can be isolated from turmeric powder through extraction with alcohol or hexane followed by acetone. Curcumin is identified through chemical tests where it produces a crimson color with sulfuric acid or a reddish brown color with boric acid that turns greenish blue with alkali. Curcumin content can be analyzed using methods like HPLC, where it shows peaks at specific retention times when separated using a Nucleosil NH2 column with ethanol mobile phase and UV detection at 254nm.
This document provides a scheme for describing Cinchona bark, including its origin from various Cinchona species, macroscopic and microscopic features, and chemical tests. Key points include:
- Cinchona bark comes from dried stems and roots of Cinchona succirubra, C. ledgeriana, C. calisaya, and C. officinalis.
- Microscopic transverse section shows cork, cortex with starch granules and secretion canals, and phloem with phloem fibers and parenchyma containing calcium oxalate prisms.
- Powdered bark shows fragments of cork cells, idioblasts containing calcium oxalate microprisms, and phloem fibers and
This document discusses the isolation, identification, and analysis methods for several important phytoconstituents including menthol, citral, curcumin, atropine, quinine, reserpine, caffeine, artemisinin, glycyrrhizin, rutin, and podophyllotoxin. Extraction is typically done using solvent extraction methods like steam distillation or soxhlet extraction. Isolation involves separation techniques like chromatography. Identification tests include chemical color reactions and thin layer chromatography to determine Rf values. Analysis uses methods like gas chromatography, high performance liquid chromatography, and confirmation against reference standards.
The document summarizes information about the plant Catharanthus roseus, commonly known as Vinca or Periwinkle. It is native to Madagascar but cultivated in other tropical and subtropical regions. The plant contains important anticancer alkaloids vinblastine and vincristine in its leaves and roots. Vinblastine is used to treat Hodgkin's disease while vincristine is used for childhood leukemia. The flowers may also be used as a gentle laxative or gargle.
Swathi Gariganti is an assistant professor at Sree Dattha Institute of Pharmacy who teaches subjects related to pharmacognosy and phytochemistry. This document provides details about the plant Catharanthus roseus including its synonyms, biological source, geographical source, history of use, cultivation and collection methods, macroscopic and microscopic characters, chemical constituents, uses, and dose. It also summarizes information on the cultivation, collection, and chemical constituents of Rauwolfia serpentina.
This document discusses various terpenoid compounds found in plants, including iridoids, terpenes, and modified terpenoids. It provides classifications of terpenoids based on carbon atom count and discusses the occurrence, extraction, biosynthesis, and biological activities of specific compounds like iridoids, gentian, picrorhiza, quassia, tinospora, artemisia, taxus, and andrographis. Structures of important constituents from each plant are also shown.
Industrial production,estimation and utilization of DiosgeninNadeemSiddiqui37
The document discusses diosgenin, a precursor used in pharmaceuticals like oral contraceptives. It is commonly extracted from Dioscorea zingiberensis tubers using acid hydrolysis. The document outlines methods to extract and isolate diosgenin from plant materials like seeds and hairy roots, such as refluxing with sulfuric acid and eluting with hexane. Analytical methods to analyze diosgenin are also presented, including thin layer chromatography using antimony trichloride as a detecting agent. Diosgenin is useful as it can be used in progesterone semi-synthesis and produces estrogenic activity.
The document discusses Indian gum, also known as gum acacia or gum arabic. It is a dried exudate obtained from the stems and branches of the Acacia arabica tree. Chemically, it is a complex mixture of glycoproteins and polysaccharides. It is collected by making cuts in the bark of the tree, then dried and processed. Gum acacia is used extensively in pharmaceuticals as an emulsifier, thickening agent, and tablet binder. It is also used in food products and cosmetics for its adhesive and thickening properties.
Pharmacognosy of Rauwolfia serpentina, biological source, geographical source, marphology of roots and rhizome, microscopy of roots, chemical constituents- reserpine, uses -antihypertensive, isolation of reserpine, serpagandha, India snake root
This document defines key terms related to herbal medicines and describes herbal materials, preparations, and products. It defines an herb as a plant used for medicinal purposes. Herbal medicines use plants to treat or prevent illness. Herbal medicinal products contain exclusively herbal substances or preparations as the active ingredient. Herbal preparations, such as extracts or tinctures, are the basis for finished herbal products and are produced through various extraction or processing methods. Finished herbal products consist of one or more herbal preparations from one or more plant sources, with or without additional excipients. The document also discusses good agricultural practices for cultivating medicinal plants, including organic farming and pest management techniques.
This document discusses several classes of plant secondary metabolites including iridoids, naphthoquinones, gentian, artemisia, taxus, and carotenoids. Iridoids are monoterpenoids found in many plants and are derived from 8-oxogeranial. Naphthoquinones are related to naphthalene and include common isomers like 1,2-naphthoquinone and 1,4-naphthoquinone. Gentian contains iridoid glycosides like gentiopicrin which give it bitter properties. Artemisia contains essential oils and compounds like santonin. Taxus contains the potent anticancer compound taxol. Carotenoids
This document discusses terpenes and terpenoids. It defines terpenes and terpenoids, describes their classification based on carbon atoms and rings, and lists some general properties. Examples of specific terpenoids are then discussed in more detail, including their active ingredients, uses, and mechanisms of action. These include monoterpenoids like camphor and peppermint oil, sesquiterpenoids like clove, diterpenoids like taxus, and polyterpenoids like saffron. The document concludes by describing a study that isolated, purified, and characterized crocetin beta-D-glucosyl ester from saffron and explored its anti-cancer activities and binding properties.
The document discusses a study on Acalypha indica, a plant used in traditional medicine. The study aimed to determine the preliminary phytochemical constituents and antimicrobial activity of different extracts from the plant's leaves and stems. Methanolic extracts showed the highest antimicrobial activity against tested pathogens like Salmonella typhimurium. Phytochemical screening of the methanolic extracts revealed the presence of secondary metabolites like tannins, cardiac glycosides, alkaloids, flavonoids, terpenoids and saponins which may contribute to its antimicrobial properties. The results suggest Acalypha indica may be a potential source of natural compounds to develop treatments for drug-resistant bacterial infections.
Medicinal plants are important and basic drugs sources from ancient times. In this presentation we discussed some of the phytoconstituents of plants which are useful in daily life.
This document provides information on various types of carotenoids including their sources and health benefits. It defines carotenoids as pigments found in plants, algae, and bacteria that produce bright colors and act as antioxidants. It identifies common carotenoids such as alpha carotene, beta carotene, lutein and lycopene. Food sources of carotenoids are also listed, and carotenoids are classified as either xanthophylls or carotenes depending on their chemical structure and coloration.
Ac fr ogd2aew8qm0l2ba_twesyx-8uufb5o8id43nx4odtqgiwqlwng7a7eywwcxnpktqrsjavoy...muthulakshmi623285
Tannins are complex organic compounds found in plants that have astringent properties. They are classified as hydrolysable tannins or condensed tannins depending on their chemical structure and behavior during dry distillation. The document describes different types of tannins including Pterocarpus, Pale Catechu, and Black Catechu. It provides details on their biological sources, chemical constituents, identification tests, and common uses which are typically as astringents or in dyeing and tanning industries.
Tannins are polyphenolic compounds found in many plant species. They are classified as hydrolysable tannins, condensed tannins, or complex tannins depending on their chemical structure. Tannins have important industrial uses such as in tanning leather and producing inks, and medicinal properties including antiviral and anti-inflammatory effects. Common sources of tannins include plants like Hamamelis, Uncaria gambir, and galls formed on Quercus trees by insect larvae.
Tannins are phenolic compounds found in plants that can precipitate proteins. They are classified as true tannins, pseudotannins, hydrolysable tannins, and condensed tannins. Hydrolysable tannins include gallitannins and ellagitannins that break down into gallic acid or ellagic acid. Condensed tannins are polymeric flavan-3-ols like catechin. Tannins are identified through tests like reaction with iron salts or bromine water. They have industrial uses in tanning leather and making ink, and medicinal uses as astringents and antioxidants in conditions like diarrhea, burns, and inflamed skin. Major commercial sources
Tannins are polyphenolic compounds found in many plants that have astringent properties. They are classified as hydrolysable tannins or condensed tannins. Hydrolysable tannins contain a central core of glucose or another polyol esterified with gallic or ellagic acid. Condensed tannins are polymers of flavan-3-ol or flavan-3,4-diol units. Tannins have various functions in plants including protection from herbivores and pathogens. They also have medicinal properties as astringents, antidiarrheals, and antioxidants. Common plants containing hydrolysable tannins include myrobalan, bahera
Hiptage presentation for pharmacognosy and phytochemistrymuthulakshmi623285
This document summarizes information about the plant Hiptage madablota, including its traditional medicinal uses in Ayurveda. Key points:
- H. madablota is cultivated for its therapeutic potential and is used in traditional medicines to treat various diseases. It possesses several pharmacological activities such as antibacterial, anti-inflammatory, and hepatoprotective.
- An ethanolic extract of H. madablota roots was prepared and analyzed. Phytochemical investigation revealed the presence of proteins, phenolic compounds, flavonoids, tannins, glycosides, and saponins.
- In vitro antioxidant activity tests found the root extract exhibited significant dose-dependent inhibition of free radicals
Secondary metabolite part 4 by poja khanparaPOOJA KHANPARA
This document provides information about secondary metabolites called tannins. It discusses what tannins are, their functions in plants, classification into hydrolysable tannins, condensed tannins, and pseudotannins. Tests for identifying tannins are described. Examples of medicinal plants containing different types of tannins are given. The document also discusses properties and biological activities of tannins.
Tannins, resins, glycosides, volatile oils and carotenoids are secondary plant metabolites discussed in the document. Tannins are astringent polyphenols used in leather tanning. Resins like benzoin are mixtures of essential oils, terpenes and acids. Glycosides like sennoside are anthraquinone derivatives used as purgatives. Volatile oils such as ginger oil contain compounds like gingerol. Carotenoids are tetraterpenoid pigments including lycopene and lutein that have antioxidant properties. The document describes the source, chemistry and uses of various secondary metabolites.
This document provides information about tannins, which are astringent, polyphenolic secondary plant metabolites. It discusses:
1. Tannins are naturally occurring complex organic compounds that have astringent properties and form colloidal solutions with water. They precipitate proteins and help protect plants from external threats.
2. Tannins are classified based on their molecular weight and hydrolysis properties. The main types are hydrolysable tannins, condensed tannins, and complex tannins.
3. Tannins have various pharmacological effects including antioxidant, wound healing, antimicrobial, and cardioprotective activities. They are widely distributed in plants and localized in vacuoles,
This document discusses various types of tannins, including their definitions, classifications, properties, tests, sources, and uses. It describes hydrolysable tannins such as gallotannins and ellagitannins which are esters of sugars and phenolic acids. Condensed tannins are polymers of flavan-3-ol units linked by carbon-carbon bonds. Pseudotannins are lower molecular weight compounds that do not respond to the goldbeater's skin test. Examples of plant sources of tannins discussed include kino, myrobalan, catechu, nutgall, chestnut, and krameria.
Introduction, classification, biosynthesis, extraction, identification, occurrence in plants, role in plant life and chemical study of tannins in Kino, Myrobalan, Catechu, Nutgall, Castanea and krameria.
Estimation of Bioactive Compound of Catharanthus Roseus Leaf Extract by Phyto...ijtsrd
Plant derived compounds have played a vital role in the development of several chemotherapeutic agents. Catharanthus roseus is an important medicinal plant of the apocynaceae family. The leaf extract of Catharanthus roseus have many biological activities such as antibacterial, antioxidant and antidiabetes. The present study was aimed to carry out the phytochemical analysis and the GC-MS analyses of Cathranthus roseus leaf extract ensure biological activity in the presence bioactive compounds. The leaves designated to the presence of secondary metabolites (proteins, steroids, tannins,glycosides, reducing sugar, carbohydrates,saponins, sterols, terpenoids, acidic compounds, cardiac glycosides, phenols, alkaloids,flavonoids). In the GC-MS analysis the Cathranthus roseus extract result shows the presence of bioactive compounds which revealed a broad spectrum of many medicinal property and antioxidant activity were identified. This study is helped to identify bioactive compound formula and structure which can be used as pharmaceutical industries for drug discovery. S. Nathiya | N. Shaishta Jabeen | L. Jagapriya | B. Senthilkumar | K. Devi"Estimation of Bioactive Compound of Catharanthus Roseus Leaf Extract by Phytochemical Screening and GC-MS Analysis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-1 , December 2017, URL: http://www.ijtsrd.com/papers/ijtsrd5926.pdf http://www.ijtsrd.com/biological-science/zoology/5926/estimation-of-bioactive-compound-of-catharanthus-roseus-leaf-extract-by-phytochemical-screening-and-gc-ms-analysis/s-nathiya
This document lists various herbs and their properties. It describes herbs that contain alkaloids, volatile oils, and resins. For each herb, it provides 1-2 key details, such as the plant part used and active constituents. It also categorizes herbs as official or unofficial. Additionally, it covers various thallophyta like algae, fungi, and lichen, providing 1-3 details about each one.
Tannins are polyphenolic compounds found in many plants. They are classified as hydrolysable tannins, condensed tannins, or pseudo-tannins. Hydrolysable tannins are hydrolyzed by acids into gallic acid or ellagic acid, while condensed tannins are more resistant to hydrolysis. Tannins are extracted using mixtures of polar and non-polar solvents due to their high molecular weight. Identification tests for tannins include the gelatin test, Goldbeater's skin test, and reactions with ferrous sulfate or ferric chloride that produce colors. Pterocarpus marsupium, or Bijasal, is a plant source of k
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...rightmanforbloodline
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central19various
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
IRIDOIDS AND NAPHTHAQUINONES.pptx
1. DEPARTMENT
OF
PHARMACOGNOSY
SUB – PHYTOCHEMISTRY AND
PHARMACOGNOSY II
UNITII
IRIDOIDS AND NAPHTHAQUINONES
Prepared by : Snehal Uttam Kashid (Asso. professor)
Department of Pharmacognosy, SPMs college of
pharmacy, akluj
2. TERPENOIDS
Terpenes constitute one of the most important groups of essential
oils.
The isoprenoids, sometimes called terpenoids, are a large and
diverse class of naturally-occurring organic chemicals similar to
terpenes.
Derived from five-carbon isoprene units assembled and modified in
thousands of ways.
Terpenes may be classified by the number of terpene units in the
molecule; a prefix in the name indicates the number of terpene units
needed to assemble the molecule.
4. Iridoids
Iridoids are a type of monoterpenoids in the general form of cyclo-
pentanopyran, found in a wide variety of plants and some animals.
They are biosynthetically derived from 8-oxogeranial.
Iridoids are typically found in plants as glycosides, most often
bound to glucose.
It is also known as iridane skeleton (cis-2-oxa-bicyclo-[4,3,0]-
nonane )
It include Secoiridoids by cleavage of the 7,8 bond of the
cyclopentane ring.
This group contain about 500 known structures which comprises
a) More than 300 iridoid glycoside
b) More than 100 secoiridoids glycoside
c) Near about 100 non- glycosidic compound
5. Extraction
Delicate due to their great instability
Instability darkening that takes place soon after plant
collection in many species containing iridoids
Extraction with polar solvent alcohols of various concentration
Initial separation, re-dissolving the extraction residue in water,
then re-extracting this with immiscible solvents of increasing
polarity
Fractionation: chromatography on alumina on charcoal (with
risk of irreversible adsorption), on porous polymers (e.g.
XAD- 2) with polar eluents & more and more by polar reverse
phase HPLC
Purification TLC, HPLC
Detection Trim and Hill color reagent: Dilute solution of
CuSO4 and HCl, blue color
Detection spray: vanillin H2SO4, Hot HCl
8. 1. Gentian (bitter glycoside)
Synonyms: yellow gentian root, gentiana, radix gentianae, gentian
root, gall weed, bitter ward.
Biological Source: dried fermented roots and rhizomes of
Gentiana lutea
Family: Gentianaceae.
Geographical Source: Mountainous regions of Central and south
Europe, Turkey, Yugoslavia. Now: France, Italy, Germany.
9. Macroscopy of gentian
Color :- Brownish
Shape :- Sub-cylindrical , entire or longitudinally split pieces of
rhizomes and roots.
Size :- 15-20 cm or more in length and 2.5-8 cm in thickness at
crown.
Odour :- Characteristic odour
Taste: is sweet at first and then intensely bitter afterwards
The drug is brittle and breaks with a short fracture.
10. Cultivation and collection:
Cultivation:
G. lutea requires a moist soil , good drainage and a suitable soil
consisting of loam , peat and grit.
Seeds are slow to germination ,seedlings frequently taking several
years to appear.
Collection:
The plant is large perennial herb.
The drug is collected from 2-5 years old plant in autumn (Sept-
Dec).
Turf is stripped and the rhizomes are dug up.
It is cut into pieces of different length and dried quickly first in air
and then in sheds.
The drug becomes much dark in colour , looses some of its
bitterness and acquires a very distinctive odour.
11. Chemical constituents of
Gentian
It contain bitter glycoside, alkaloids, yellow colouring matter, sugars,
pectin and fixed oil.
Gentian consists the bitter glycoside Gentiopicrin (~2%) as a
principle active constituent which is water soluble. Having 12000
bitterness value.
Yellow colour of gentian is due to xanthones & gentisin (
gentiamarin)
On hydrolysis , it yields the aglycone gentiogenin and glucose.
Gentiopicrin is a secoiridoid , gentiopicroside , and it is decomposed
on fermentation and drying of the drug.
Other bitter compounds are Genticin , Amaropanin, Amarogentin
and Amaoswerin.
Gentian also contains Gentin , Gentisic acid 0.03% (2,5 -
dihydoxybenzoic acid), Tannins , Pectin's and calcium oxalates.
Gentian should yield 33-40% of water soluble extractive but highly
fermented root yields much less.
13. Chemical tests
1. Alcoholic extract when made alkaline. Shows blue or green
fluorescence.
2. Take moistened dry powder of gentian in test tube.
Cover test tube with filter paper soaked in dil .NaOH.
Keep test tube in water bath.
After sometimes expose filter paper to UV light.
It shows yellowish -green fluorescence.
15. Adulterants
Adulterations occur due to careless collection.
1) The rhizomes of Rumex alphinus give the test for anthraquinone
derivatives.
2) Veratrum album .
3) Gentiana purpurea
4) Gentiana pannanica
16.
17. Artemisia (sesquiterene)
Synonyms : Sweet worm wood,sweet annie, sweet
sagewort, annual mugwort or annual wormwood
Biological source: Leaves and the closed, unexpanded
flower heads of Artemisia annua, Artemisia bravifolia,
Artemisia cina, A.maritima and other species of
artimisia
Family : Compositae
18. Macroscopy
Geoghraphical source- native of china wildly cultivated
in pakistan, india west tibet,and turkey. In india
cultivated in kashmir punjab hariyana UP.
Colour -flowers are yellow, other parts are whitish gray.
Odour – aromatic, sweet
Taste – bitter,camphor like
Shape- flowers are ovel shape
19. Artemisia
Active constituents:
It is sesquiterene lactone with prominant antimalerial
activity.
Contain volatile oil(1-2%) and crystalline substance
santonin & artimisin.
Artemisinin, dihydro artemisisnin, artemisic acid.
Other constituents are cineol, pinene and resin,
20. Artemisia
Chemical test
Powdered drug 1gm boil it with alcohol
filter it add sodium hydroxide to the filtrate
warm it until red colour appears.
21. Uses
Artemisinin and its derivatives have been used for the
treatment of malaria
Parasitic worm (helminth) infections.
Having strong anthelmintic action against round worm
No or less effect against hook worm and tape worm.
Adultrants:
Artimisia vulgaris
22.
23. Taxus (Tricyclic diterpenoids)
Synonyms: Yew Himalayan yew, pacific yew
Biological Source: dried bark of Taxus baccata
(Europe) Taxus brevifolia & T. canadensis (North
america) Taxus cuspidata (Japan) Taxus wallichiana
(Himalaya).
Family: Taxaceae.
Geographical source: india (Himalaya), america,
canada
It required high altitude 2000 to 3500meters.
25. Morphology
They are relatively slow-growing and can be very long-
lived,
Plant height - 2.5–20 metres (8.2–65.6 ft),
trunk girth - averaging 5 metres (16 ft).
colour - reddish bark, dark-green leaves
Shape - lanceolate, flat.
26. Culivation and collection
The plant need to be mature( about I00 years) to be
large enough for exploitation of its bark.
At this age the tree will be some 6-9 m high, and have a
trunk of about 25 cm in diameter.
It requires the bark from about three mature 100-year-
old trees to provide one gram of taxol.
And a course of treatment may needs 2 gms of taxol.
27. Chemical Constituents
Tricyclic diterpenoids like:
Taxane skeleton, Taxusines, Taxagifen, Baccatin III,
Taxine, Taxol, Cephalomannine, Taxicine.
Taxol derivatives like paclitaxol, docetaxol
Other constituents are - polysacchrides, sterols,
proanthocynidines, bisflavonoids, fatty acids, lignans
and cynogenetic glycosides.
Paclitaxo
28. MOA of Taxanes
These drugs act by interfering with mitotic spindle
They prevent micotubule disassembly into tubulin
monomers
shows anti cancer action.
29. Uses of Paclitaxel
Paclitaxel: mitotic spindle poison
MOA: it promotes assembly of tubulin dimers into
microtubules which is stabilized by inhibiting their
depolymerization
uses - Advanced ovarian cancer, metastatic breast
cancer
Side effect of Paclitaxel - neutropenia, peripheral
neuropathy, CVS, alopecia
dose: 135-175 mg/m2
30. Uses of Docetaxel
Docetaxel: mitotic spindle poison
MOA: it promotes assembly of tubulin dimers into
microtubules which is stabilized by inhibiting their
depolymerization Uses - breast cancer
Side effect: severe neutropenia, hypersensitivity
reaction, water retention, cutaneous reaction.
Dose : 100 mg/m2
31. Uses
Ovarian cancer
Lung carcinoma
Gastric & Cervical cancers
Prostate & colon cancer
32. How it is given
Taxol is given as an injection or infusion into the vein
(intravenous, IV).
There is no pill form of Taxol.
Taxol is an irritant that can cause inflammation of the
vein through which it is given.
Because severe allergic reactions have occurred in
some people taking Taxol, patient will be asked to take
medications to prevent allergic reaction.
33. Bibliography
Kokate, C.K., Purohit, A.P. and Gohkale, S.B.
(2019) Pharmacognosy. In Terpenoids, 57th Edition,
Nirali Prakashan, Pune.
Pharmacognosy And Phytochemistry By Vinod Rangari.
2009 2nd edition, Career Publications.