Iain Chalmers argues that a significant amount of medical research is wasted due to issues such as: 1) Low priority questions being addressed instead of what matters most to clinicians and patients. 2) Many studies being poorly designed and not learning from existing evidence. 3) Important results from studies often not being published or reported, leading to bias. He advocates for greater public involvement in setting research agendas and priorities to better align research with patient and clinician needs and reduce waste estimated at over $85 billion per year. The James Lind Initiative seeks to address research waste and improve focus on shared uncertainties.